公开(公告)号：US09994865B2

公开(公告)日：2018-06-12

申请号：US14895125

申请日：2014-06-04

Applicant: The Johns Hopkins University ,  Virginia Commonwealth University

Inventor： Paul B. Fisher ,  Swadesh K. Das ,  Mitchell E. Menezes ,  Devanand Sarkar ,  Martin G. Pomper

IPC: A61K48/00 ,  C12N15/85 ,  C12N15/64 ,  C07K14/47 ,  G01N33/50 ,  G01N33/574 ,  A61K38/16 ,  A61K38/17 ,  A61K38/20 ,  A61K41/00 ,  A61K49/00 ,  A61N7/00 ,  C07K14/36 ,  C07K14/465 ,  C07K14/54 ,  C12N7/00 ,  C12N15/86 ,  C12N15/62 ,  B82Y5/00 ,  B82Y15/00

CPC classification number: C12N15/85 ,  A61K38/164 ,  A61K38/1703 ,  A61K38/20 ,  A61K41/0028 ,  A61K48/00 ,  A61K48/0058 ,  A61K48/0075 ,  A61K49/00 ,  A61N7/00 ,  A61N2007/0039 ,  B82Y5/00 ,  B82Y15/00 ,  C07K14/36 ,  C07K14/465 ,  C07K14/47 ,  C07K14/54 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/035 ,  C12N7/00 ,  C12N15/625 ,  C12N15/64 ,  C12N15/86 ,  C12N2710/10043 ,  C12N2710/10343 ,  C12N2799/02 ,  C12N2799/022 ,  C12N2800/22 ,  C12N2810/855 ,  C12N2830/002 ,  C12N2830/008 ,  G01N33/50 ,  G01N33/574

Abstract: The presently disclosed subject matter relates to compositions and methods directed to cancer theranostic nucleic acid constructs that permit simultaneous cancer-specific viral replication, expression of a diagnostic gene product, and expression of a therapeutic gene.

公开(公告)号：US09701985B2

公开(公告)日：2017-07-11

申请号：US14895579

申请日：2014-06-04

Applicant: Virginia Commonwealth University

Inventor： Paul B. Fisher ,  Swadesh K. Das ,  Mitchell E. Menezes ,  Devanand Sarkar

IPC: C12N15/00 ,  C12N15/86 ,  G01N33/574 ,  A61K49/00 ,  C07K14/47 ,  C12N15/85 ,  G01N33/50

CPC classification number: C12N15/86 ,  A61K49/0008 ,  C07K14/47 ,  C12N15/85 ,  C12N15/8509 ,  C12N2710/10331 ,  C12N2710/10345 ,  C12N2830/008 ,  C12N2830/85 ,  G01N33/5088 ,  G01N33/57492

Abstract: Recombinant vectors in which expression of one or more elements (e.g. gene required for viral replication, detectable imaging agents, therapeutic agents, etc.) is driven by an mda-9/syntenin (mda-9) cancer selective promoter are provided, as are cells and transgenic animals that contain such vectors. The vectors are used in cancer therapy and/or diagnostics, especially to visualize (image) and treat metastasis (including in rapid in vitro assays), and the transgenic mice are used to monitor cancer progression and/or the efficacy of candidate therapeutic agents in screening assays.

公开(公告)号：US10166300B2

公开(公告)日：2019-01-01

申请号：US14895556

申请日：2014-06-04

Applicant: Virginia Commonwealth University ,  The Johns Hopkins University

Inventor： Paul B. Fisher ,  Swadesh K. Das ,  Mitchell E. Menezes ,  Devanand Sarkar ,  Martin G. Pomper

IPC: A61K51/00 ,  A61K9/14 ,  C12N15/63 ,  C07H21/04 ,  A61K48/00 ,  A61K41/00 ,  A61K49/00 ,  A61K51/04 ,  C12Q1/6897 ,  A61K9/00 ,  C12N15/86 ,  A61K38/20 ,  C12N7/00 ,  C12N15/87 ,  A61K51/12

Abstract: The presently disclosed subject matter generally relates to genetic constructs and methods for their use in cancer imaging, cancer treatment, and combined imaging and treatment protocols. In particular, the presently disclosed subject matter relates to tripartite cancer theranostic nucleic acid constructs that permit simultaneous cancer specific viral replication, expression of a diagnostic gene product, and expression of a therapeutic gene.

公开(公告)号：US20240360138A1

公开(公告)日：2024-10-31

申请号：US18537700

申请日：2023-12-12

Applicant: Virginia Commonwealth University ,  Sanford Burnham Prebys Medical Discovery Institute

Inventor： Paul B. Fisher ,  Maurizio Pellecchia ,  Swadesh K. Das ,  Timothy P. Kegelman ,  Bainan Wu ,  Surya K. De ,  Jun Wei ,  Mitchell E. Menezes ,  Luni Emdad

IPC: C07D487/04 ,  A61K31/519 ,  A61K45/06 ,  A61P35/04 ,  C07D495/14

CPC classification number: C07D487/04 ,  A61K31/519 ,  A61K45/06 ,  A61P35/04 ,  C07D495/14

Abstract: Provided herein are, inter alia, compositions that bind to a PDZI domain of MDA-9/Syntenin (syndecan binding protein: SDCBP), thereby inhibiting MDA-9/Syntenin activity, and methods of use of same. The compositions and methods provided herein are useful for treating cancer and preventing cancer metastasis, particularly in cancers that have increased MDA-9/Syntenin expression.

公开(公告)号：US11891399B2

公开(公告)日：2024-02-06

申请号：US17148813

申请日：2021-01-14

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY ,  SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

Inventor： Paul B. Fisher ,  Maurizio Pellecchia ,  Swadesh K. Das ,  Timothy P. Kegelman ,  Bainan Wu ,  Surya K. De ,  Jun Wei ,  Mitchell E. Menezes ,  Luni Emdad

IPC: C07D487/04 ,  C07D495/14 ,  A61P35/04 ,  A61K45/06 ,  A61K31/519

CPC classification number: C07D487/04 ,  A61K31/519 ,  A61K45/06 ,  A61P35/04 ,  C07D495/14 ,  A61K31/519 ,  A61K2300/00

Abstract: Provided herein are, inter alia, compositions that bind to a PDZ1 domain of MDA-9/Syntenin (syndecan binding protein: SDCBP), thereby inhibiting MDA-9/Syntenin activity, and methods of use of same. The compositions and methods provided herein are useful for treating cancer and preventing cancer metastasis, particularly in cancers that have increased MDA-9/Syntenin expression.

公开(公告)号：US11008325B2

公开(公告)日：2021-05-18

申请号：US16349467

申请日：2017-11-14

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY ,  SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

Inventor： Paul B. Fisher ,  Maurizio Pellecchia ,  Swadesh K. Das ,  Timothy P. Kegelman ,  Bainan Wu ,  Surya K. De ,  Jun Wei ,  Mitchell E. Menezes ,  Luni Emdad

IPC: C07D487/04 ,  C07D495/14 ,  A61P35/04 ,  A61K31/519 ,  A61K45/06

Abstract: Provided herein are, inter alia, compositions that bind to a PDZ1 domain of MDA-9/Syntenin (syndecan binding protein: SDCBP), thereby inhibiting MDA-9/Syntenin activity, and methods of use of same. The compositions and methods provided herein are useful for treating cancer and preventing cancer metastasis, particularly in cancers that have increased MDA-9/Syntenin expression.