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    SAMPLE CARRIER FOR DRIED BIOLOGICAL SAMPLES
    1.
    发明申请
    SAMPLE CARRIER FOR DRIED BIOLOGICAL SAMPLES 审中-公开
    用于干燥生物样品的样品载体

    公开(公告)号：US20150047441A1

    公开(公告)日：2015-02-19

    申请号：US14388274

    申请日：2013-03-04

    Applicant: Waters Technologies Corporation

    Inventor： Xin Zhang ,  Pamela C. Iraneta ,  Moon Chul Jung ,  Pamela J. Longenbach ,  Frank Marszalkowski, Jr.

    IPC: G01N1/30 ,  G01N1/10

    CPC classification number: G01N1/30 ,  B01L3/5088 ,  B01L2300/126 ,  B01L2300/161 ,  G01N1/10 ,  G01N33/5436 ,  G01N33/96 ,  G01N2291/02466

    Abstract: Described is a biological sample carrier based on a rigid hydrophilic object fabricated from a non-absorbing inert porous material. A biological fluid sample applied to the surface of the object is absorbed into the pores and constituents of the biological fluid sample remain in the pores after drying. Unlike a disc punched from a conventional dried blood spot (DBS) card, the object is easily handled. In contrast to DBS cards containing glass fiber structures that interact with basic analytes and other DBS card having adsorbing fibers that tend to separate blood constituents as the sample spreads through the fibers, the biological sample carrier is substantially inert to drug analytes.

    Abstract translation: 描述了基于由非吸收惰性多孔材料制造的刚性亲水物体的生物样品载体。 施加到物体表面的生物流体样品被吸收到孔中，并且干燥后生物流体样品的成分保留在孔中。 与传统的干血斑（DBS）卡片冲孔不同，该物体易于处理。 与含有与碱性分析物相互作用的玻璃纤维结构的DBS卡和具有吸附纤维的其它DBS卡相反，当样品扩散通过纤维时，其具有倾向于分离血液成分的生物样品载体对药物分析物基本上是惰性的。

    Apparatus and method for analyte extraction
    5.
    发明授权
    Apparatus and method for analyte extraction 有权

    公开(公告)号：US10384206B2

    公开(公告)日：2019-08-20

    申请号：US14434316

    申请日：2013-09-25

    Applicant: Waters Technologies Corporation

    Inventor： Pamela J. Longenbach ,  Moon Chul Jung ,  Frank John Marszalkowski, Jr.

    IPC: B01D35/00 ,  B01L3/00 ,  G01N30/06 ,  G01N1/40

    Abstract: Described is a matrix spot processing device comprising a tubular apparatus. An absorbent media is located either separate from, or attached to, the tubular apparatus. A sample is spotted on the absorbent media. A reservoir is in the tubular apparatus. A first region of the reservoir is constructed and arranged to have an extraction solvent. A second region of the reservoir, which may or may not be the same as the first region, is constructed and arranged to receive an extract generated from an interaction between the extraction solvent and the spotted sample at the absorbent media.

    MICROPIPET FOR ALIQUOTING SMALL VOLUMES OF FLUID
    6.
    发明申请
    MICROPIPET FOR ALIQUOTING SMALL VOLUMES OF FLUID 审中-公开
    用于排放流体小容量的微波炉

    公开(公告)号：US20160144356A1

    公开(公告)日：2016-05-26

    申请号：US14898295

    申请日：2014-05-07

    Applicant: WATERS TECHNOLOGIES CORPORATION

    Inventor： Moon Chul Jung ,  Pamela J. Longenbach ,  Pamela C. Iraneta ,  Kevin D. Wyndham

    IPC: B01L3/02

    CPC classification number: B01L3/022 ,  B01L3/0234 ,  B01L2200/0689 ,  B01L2300/0838 ,  B01L2400/0478

    Abstract: Described is a pipet, or micropipet, that can be used to dispense multiple aliquots of a biological fluid sample. The pipet includes a capillary tube, a plunger and a plunger stop mechanism having multiple stop positions that allow the plunger to move through the capillary tube in equal incremental steps. The plunger stop mechanism enables the pipet to dispense equal volume portions of fluid in the capillary tube. Advantageously, the pipet can be fabricated at low cost and may be provided as a single-use disposable device. The micropipet may be provided to users with a sample collection device such as a dried blood spot card having multiple collection regions. The pipet optionally includes a dispensing stage that maintains a predetermined separation between the tip of the pipet and a surface of a sample collection medium to limit wicking of the fluid when an aliquot is dispensed.

    Abstract translation: 描述了可以用于分配生物流体样品的多个等分试样的移液管或微量捕集器。 移液管包括毛细管，柱塞和具有多个停止位置的柱塞止动机构，其允许柱塞以相等的递增步骤移动穿过毛细管。 柱塞停止机构使得移液管能够分配毛细管中等体积的流体部分。 有利地，移液管可以以低成本制造并且可以被提供为一次性一次性装置。 微量吸管可以提供给具有样品收集装置的用户，例如具有多个收集区域的干血斑。 移液管可选地包括分配阶段，其在移液管的尖端和样品收集介质的表面之间保持预定的间隔，以在分配等分试样时限制流体的芯吸。

    INTEGRAL SAMPLE IDENTIFICATION THROUGHOUT A WORKFLOW PROCESS
    7.
    发明申请
    INTEGRAL SAMPLE IDENTIFICATION THROUGHOUT A WORKFLOW PROCESS 审中-公开
    通过工作流程的整体样本识别

    公开(公告)号：US20150285714A1

    公开(公告)日：2015-10-08

    申请号：US14679605

    申请日：2015-04-06

    Applicant: Waters Technologies Corporation

    Inventor： Pamela J. Longenbach ,  Moon Chul Jung ,  Frank John Marszalkowski, JR. ,  Geoff Gerhardt

    IPC: G01N1/10 ,  B01L3/00

    CPC classification number: B01L3/502 ,  B01L3/5453 ,  B01L2300/021 ,  B01L2300/044 ,  B01L2300/0681 ,  B01L2300/0832 ,  B01L2400/0478 ,  G01N1/38 ,  G01N2001/288

    Abstract: Provided are devices and methods for sample collection and processing. A tubular body has a chamber closed at a first end by a thin penetrable barrier and open at a second end opposite the first end. The tubular body further includes a partition that divides the chamber into two adjacent compartments, wherein a first compartment of the two adjacent compartments has the partition facing opposite the open end of the chamber and a second compartment of the two adjacent compartments has the partition facing opposite the closed end of the chamber. The partition has one or more holes to allow passage of fluid from the first compartment into the second compartment. A tracking identification may be permanently affixed to the first end of the tubular body.

    Abstract translation: 提供了用于样品收集和处理的装置和方法。 管状体具有在第一端处由薄的可穿透屏障封闭并且在与第一端相对的第二端处打开的腔室。 管状体还包括将腔室分成两个相邻隔室的隔板，其中两个相邻隔室的第一隔室具有面向腔室的开口端的隔板，并且两个相邻室的第二隔室具有面向相对的隔板 封闭的腔室。 分隔件具有一个或多个孔，以允许流体从第一隔室进入第二隔室。 跟踪识别可以永久地固定在管状体的第一端。

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