-
公开(公告)号：US12252557B2
公开(公告)日：2025-03-18
申请号：US16095919
申请日：2017-04-21
Applicant: Waters Technologies Corporation
Inventor： Matthew A. Lauber , Scott A. McCall , Babajide Okandeji , Pamela C. Iraneta
Abstract: The present invention provides novel methods for the chromatographic analysis of glycans using high purity chromatographic materials comprising a chromatographic surface wherein the chromatographic surface comprises a hydrophobic surface group and one or more ionizable modifier and a labeling reagent which is capable of providing amphipathic and strongly basic labeling moieties to a sample to be analyzed.
-
2.发明授权公开(公告)号：US11951417B2
公开(公告)日：2024-04-09
申请号：US17231808
申请日：2021-04-15
Applicant: Waters Technologies Corporation
Inventor： Pamela C. Iraneta , Stephen James Shiner , Raymond P. Fisk , Lavelay Kizekai
Abstract: This disclosure pertains to performance enhancing conditioning and storage solvents containing low levels of buffer and salt for reproducible and improved size exclusion chromatography (SEC). In some embodiments, the present disclosure pertains to storage solvents for protein-based size exclusion chromatography that include water, a water-miscible organic solvent, a phosphate salt, and a neutral salt. In some embodiments, the present disclosure pertains to columns for protein-based size exclusion chromatography that include porous particles and such a storage solvent.
-
公开(公告)号：US20220034852A1
公开(公告)日：2022-02-03
申请号：US17370589
申请日：2021-07-08
Applicant: Waters Technologies Corporation
Inventor： Matthew A. Lauber , Stephan M. Koza , Pamela C. Iraneta , Kevin D. Wyndham
IPC: G01N30/06 , G01N30/72 , C08F230/08 , B01D15/30 , C08L33/14 , C08F220/54 , C08F220/56 , B01J20/28 , B01J20/32 , C08F222/38 , B01J20/286
Abstract: The invention relates to poly-amide bonded hydrophilic interaction chromatography (HILIC) stationary phases and novel HILIC methods for use in the characterization of large biological molecules modified with polar groups, known to those skilled in the art as glycans. The invention particularly provides novel, poly-amide bonded materials designed for efficient separation of large biomolecules, e.g. materials having a large percentage of larger pores (i.e. wide pores). Furthermore, the invention advantageously provides novel HILIC methods that can be used in combination with the stationary phase materials described herein to effectively separate protein and peptide glycoforms by eliminating previously unsolved problems, such as on-column aggregation of protein samples, low sensitivity of chromatographic detection of the glycan moieties, and low resolution of peaks due to restricted pore diffusion and long intra/inter-particle diffusion distances.
-
公开(公告)号：US09927331B2
公开(公告)日：2018-03-27
申请号：US14388274
申请日：2013-03-04
Applicant: Waters Technologies Corporation
Inventor： Xin Zhang , Pamela C. Iraneta , Moon Chul Jung , Pamela J. Longenbach , Frank Marszalkowski, Jr.
IPC: B01L3/00 , G01N1/30 , G01N33/543 , G01N33/96 , G01N1/10
CPC classification number: G01N1/30 , B01L3/5088 , B01L2300/126 , B01L2300/161 , G01N1/10 , G01N33/5436 , G01N33/96 , G01N2291/02466
Abstract: Described is a biological sample carrier based on a rigid hydrophilic object fabricated from a non-absorbing inert porous material. A biological fluid sample applied to the surface of the object is absorbed into the pores and constituents of the biological fluid sample remain in the pores after drying. Unlike a disc punched from a conventional dried blood spot (DBS) card, the object is easily handled. In contrast to DBS cards containing glass fiber structures that interact with basic analytes and other DBS card having adsorbing fibers that tend to separate blood constituents as the sample spreads through the fibers, the biological sample carrier is substantially inert to drug analytes.
-
公开(公告)号：US20130134079A1
公开(公告)日：2013-05-30
申请号：US13677695
申请日：2012-11-15
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： Joseph A. Jarrell , Pamela C. Iraneta , Douglas P. Wittmer
IPC: B01D15/14
CPC classification number: B01D15/14 , G01N30/30 , G01N30/32 , G01N30/34 , G01N2030/8881 , G01N2030/342 , B01D15/40
Abstract: Described is a mobile phase solvent delivery module for liquid chromatography and supercritical fluid chromatography systems. The module includes a pump disposed in a fluid path that conducts a mobile phase solvent. The pump provides the mobile phase solvent at an increased pressure. The module also includes a purification cartridge disposed in the fluid path either before or after the pump. The purification cartridge has an inlet to receive the mobile phase solvent and an outlet to provide a purified mobile phase solvent, and includes a packing material for removing an impurity from the mobile phase solvent. In various embodiments, the module also includes one or more additional components to allow various techniques for regeneration or replacement of spent purification cartridges. For example, the module may also include one or more of a temperature control module, a fluidic switch and one or more additional purification cartridges.
Abstract translation: 描述了用于液相色谱和超临界流体色谱系统的流动相溶剂递送模块。 模块包括设置在流动路径中的泵，其传导流动相溶剂。 该泵在增加的压力下提供流动相溶剂。 该模块还包括在泵之前或之后设置在流体路径中的净化筒。 净化筒具有容纳流动相溶剂的入口和出口以提供纯化的流动相溶剂，并且包括用于从流动相溶剂中除去杂质的填充材料。 在各种实施例中，模块还包括一个或多个附加部件，以允许用于再生或更换废净化筒的各种技术。 例如，模块还可以包括温度控制模块，流体开关和一个或多个附加的净化盒中的一个或多个。
-
Patent Agency Ranking
公开(公告)号：US11577179B2
公开(公告)日：2023-02-14
申请号：US14897584
申请日：2014-06-10
Applicant: Waters Technologies Corporation
Inventor： Kevin D. Wyndham , Jacob N. Fairchild , Pamela C. Iraneta , Stephen J. Shiner , Darryl W. Brousmiche , Daniel P. Walsh
IPC: B01D15/08 , B01J20/28 , B01D15/32 , B01D15/40 , B01J20/286 , B01J20/283 , B01D15/30 , B01J20/32 , C07F7/12 , C07F7/18
Abstract: The present invention provides methods for performing supercritical fluid chromatography comprising loading a sample to be separated by supercritical fluid chromatography onto a stationary phase comprising a spherical, monodisperse, core-shell particulate material comprising a nonporous core and one or more layers of a porous shell material surrounding the core, wherein the particles are sized less than 2 microns; and performing supercritical fluid chromatography to separate the sample.
-
公开(公告)号：US20220032210A1
公开(公告)日：2022-02-03
申请号：US17500460
申请日：2021-10-13
Applicant: Waters Technologies Corporation
Inventor： Pamela C. Iraneta , Xin Zhang , Frank John Marszalkowski, JR.
IPC: B01D15/38 , B01J20/28 , B01J20/287 , B01J20/288 , B01J20/32
Abstract: Disclosed is a device for a solid phase extraction comprising two or more of the sorbents to remove phospholipids and salts from a sample, to thereby eliminate matrix effects during mass spectrometry analysis. In particular, the sorbents includes at least one sorbent which is water-wettable and contains at least one hydrophobic component and at least one hydrophilic component and at least one of sorbent having a specific affinity for a matrix interference like phospholipids. Further disclosed is a method using the device of the present invention.
-
公开(公告)号：US10974167B2
公开(公告)日：2021-04-13
申请号：US16202504
申请日：2018-11-28
Applicant: Waters Technologies Corporation
Inventor： Kevin D. Wyndham , Pamela C. Iraneta , Thomas H. Walter
Abstract: The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for its preparation and separations devices containing the chromatographic material; separations devices, chromatographic columns and kits comprising the same; and methods for the preparation thereof. The chromatographic materials of the invention are high purity chromatographic materials comprising a chromatographic surface wherein the chromatographic surface comprises a hydrophobic surface group and one or more ionizable modifier.
-
公开(公告)号：US10800799B2
公开(公告)日：2020-10-13
申请号：US15941338
申请日：2018-03-30
Applicant: Waters Technologies Corporation
Inventor： Pamela C. Iraneta , Thomas H. Walter , Xin Zhang , Daniel P. Walsh , Kevin D. Wyndham , Raymond P. Fisk
IPC: B01D15/00 , B01J20/00 , G01N1/00 , C07F9/10 , B01D15/32 , B01J20/28 , B01J20/287 , B01J20/32 , B01J20/10 , B01D15/22 , B01L3/00 , C07K1/30 , G01N30/88
Abstract: Methods, kits and devices for separating phospholipids and proteins from small molecules in biochemical samples can feature an apparatus having a wetting barrier, at least one frit and a separation media. For example, an apparatus can include at least one wall defining a chamber having an exit and an entrance; a wetting barrier disposed between the exit and entrance, so as to define a separation media space located between the wetting barrier and the exit and a sample receiving area located between the wetting barrier and the entrance; and a separation media disposed adjacent to the wetting barrier and having a specific affinity for phospholipids.
-
公开(公告)号：US20200300820A1
公开(公告)日：2020-09-24
申请号：US16082368
申请日：2017-03-07
Applicant: Waters Technologies Corporation
Inventor： Abhijit Tarafder , Pamela C. Iraneta
Abstract: Reduced column loading of a sample onto a chromatographic column may be mitigated by excluding diffuse portions of the sample from introduction to the column. Systems and methods are provided for detecting and removing the diffuse portions from the feed solution delivered to the chromatography column. The systems and methods herein permit use of a single detector to detect and remove the diffuse portions and can accommodate a recovery/collection/recycling mechanism permitting reuse of removed sample from the diverted diffuse portions.
-
-
-
-
-
-
-
-
-
Search Results
41
records
(took 0.018 seconds)
