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公开(公告)号：US5728753A
公开(公告)日：1998-03-17
申请号：US556016
申请日：1995-11-09
申请人： William Bonfield , Min Wang , Larry L. Hench
发明人： William Bonfield , Min Wang , Larry L. Hench
IPC分类号： A61L27/00 , A61K33/00 , A61K33/06 , A61K33/42 , A61L27/44 , C03C1/00 , C03C4/00 , C03C11/00 , C03C12/00 , C03C14/00 , C08K3/22 , C08K3/40 , C08L23/00 , C08K3/32
CPC分类号： C03C4/0007 , A61K33/00 , A61K33/06 , A61K33/42 , A61L27/446 , C03C1/006 , C03C11/00 , C03C12/00 , C03C14/00 , C08K3/22 , C08L23/06 , Y10S623/924
摘要： Composites suitable for use as prostheses for attachment to soft tissues, such as cartilage, tendons, skin, tympanic membrane and gingiva, as well as to cancellous or trabecular bone, are based on combination of a polyolefinic binder with certain bioactive glass materials. The composites bond actively with soft tissues and are readily formulated achieve mechanical properties comparable to those of the soft tissue of interest.
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公开(公告)号：US5962549A
公开(公告)日：1999-10-05
申请号：US987469
申请日：1997-12-09
申请人： William Bonfield , Min Wang , Larry L. Hench
发明人： William Bonfield , Min Wang , Larry L. Hench
IPC分类号： A61L27/00 , A61K33/00 , A61K33/06 , A61K33/42 , A61L27/44 , C03C1/00 , C03C4/00 , C03C11/00 , C03C12/00 , C03C14/00 , C08K3/22 , C08K3/40 , C08L23/00 , A61F2/00 , C08K3/32
CPC分类号： C03C4/0007 , A61K33/00 , A61K33/06 , A61K33/42 , A61L27/446 , C03C1/006 , C03C11/00 , C03C12/00 , C03C14/00 , C08K3/22 , C08L23/06 , Y10S623/924
摘要： Composites suitable for use as prostheses for attachment to soft tissues, such as cartilage, tendons, skin, tympanic membrane and gingiva, as well as to cancellous or trabecular bone, are based on combination of a polyolefinic binder with certain bioactive glass materials. The composites bond actively with soft tissues and are readily formulated achieve mechanical properties comparable to those of the soft tissue of interest.
摘要翻译： 适用于软骨组织如软骨，腱，皮肤，鼓膜和牙龈以及松质骨或小梁骨的假体的复合材料是基于聚烯烃粘合剂与某些生物活性玻璃材料的组合。 复合材料与软组织积极地结合，并且易于配制获得与所关注的软组织相当的机械性能。
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3.发明授权Bioactive and biodegradable composites of polymers and ceramics or glasses and method to manufacture such composites 失效聚合物和陶瓷或玻璃的生物活性和可生物降解复合材料以及制造这种复合材料的方法公开(公告)号：US07541049B1
公开(公告)日：2009-06-02
申请号：US08921533
申请日：1997-09-02
CPC分类号： A61L31/148 , A61L31/128 , A61L31/129
摘要： Surgical osteosynthesis composite material which has three components: biodegradable polymer reinforcement, bioceramic or bioglass filler reinforcement and biodegradable polymer matrix. This invention relates to biodegradable materials used for bone fracture fixation devices and methods of their manufacture. Unlike other known materials used prior to this application, the composites of this invention have two different reinforcing phases and one matrix phase. One reinforcing element is referred as the polymeric reinforcing element and the other as the ceramic reinforcing element.
摘要翻译： 具有三个组分的外科骨接合复合材料：可生物降解的聚合物增强，生物陶瓷或生物玻璃填料增强和可生物降解的聚合物基质。 本发明涉及用于骨折固定装置的可生物降解材料及其制造方法。 与本申请之前使用的其它已知材料不同，本发明的复合材料具有两个不同的增强相和一个基体相。 一个增强元件被称为聚合物增强元件，另一个称为陶瓷增强元件。
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4.发明授权Composite biomaterials comprising calcium phospate materials, collagen and glycosaminoglycans 有权复合生物材料包括钙磷酸盐材料，胶原和糖胺聚糖公开(公告)号：US07780994B2
公开(公告)日：2010-08-24
申请号：US10595587
申请日：2004-10-28
申请人： Andrew Lynn , Ruth Cameron , Serena Best , William Bonfield
发明人： Andrew Lynn , Ruth Cameron , Serena Best , William Bonfield
CPC分类号： A61L27/28 , A61C8/0006 , A61L24/0084 , A61L27/46
摘要： A process for the production of a composite material comprising collagen, brushite and one or more glycosaminoglycans, said process comprising the steps of providing an acidic aqueous solution comprising collagen, a calcium source and a phosphorous source and one or more glycosaminoglycans, and precipitating the collagen, the brushite and the one or more glycosaminoglycans together from the aqueous solution to form a triple co-precipitate.
摘要翻译： 一种生产复合材料的方法，该复合材料包括胶原蛋白，褐铁矿和一种或多种糖胺聚糖，所述方法包括以下步骤：提供包含胶原蛋白，钙源和磷源和一种或多种糖胺聚糖的酸性水溶液，并沉淀胶原蛋白 ，水凝胶和一种或多种糖胺聚糖一起从水溶液中形成三重共沉淀物。
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公开(公告)号：US20090022771A1
公开(公告)日：2009-01-22
申请号：US11908045
申请日：2006-03-06
IPC分类号： A61F2/28 , A61K31/726 , A61P19/00 , B29C67/20
CPC分类号： A61L27/46 , A61L27/56 , A61L2430/02
摘要： A process for the preparation of a composite biomaterial comprising an inorganic material and an organic material, the process comprising: (a) providing a first slurry composition comprising a liquid carrier, an inorganic material and an organic material; (b) providing a mould for the slurry; (c) depositing the slurry in the mould; (d) cooling the slurry deposited in the mould to a temperature at which the liquid carrier transforms into a plurality of solid crystals or particles; (e) removing at least some of the plurality of solid crystals or particles by sublimation and/or evaporation to leave a porous composite material comprising an inorganic material and an organic material; and (f) removing the material from the mould.
摘要翻译： 一种制备包含无机材料和有机材料的复合生物材料的方法，所述方法包括：（a）提供包含液体载体，无机材料和有机材料的第一浆料组合物; （b）为浆料提供模具; （c）将浆料沉积在模具中; （d）将沉积在模具中的浆料冷却至液体载体转变成多个固体晶体或颗粒的温度; （e）通过升华和/或蒸发除去多个固体晶体或颗粒中的至少一些，以留下包含无机材料和有机材料的多孔复合材料; 和（f）从模具中取出材料。
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公开(公告)号：US06582672B1
公开(公告)日：2003-06-24
申请号：US09581203
申请日：2000-08-08
IPC分类号： C01B2532
摘要： A process for the preparation of a single phase carbonate-substituted hydroxyapatite composition, which process comprises the steps of (i) preparing an aqueous solution containing Co32− and PO43− ions in the substantial absence of cations other than H+ ions: (ii) mixing the solution from step (i) with an aqueous solution or suspension of a calcium compound; and (iii) collecting and drying the precipitate formed in step (ii); the ratio of Ca/P in the calcium-containing solution or suspension and the phosphorus-containing solution, when mixed together, being maintained above 1.67. The product of the process is novel with a Ca/P molar ratio of greater than 1.67 and comprises up to 5% by weight of CO32− ions substituted in the B site or the B and A sites of the hydroxyapatite structure, with at least 50% of the CO32− ions being substituted on the B site. This product does not contain Na+ or NH4+ ions.
摘要翻译： 一种制备单相碳酸酯取代的羟基磷灰石组合物的方法，该方法包括以下步骤：（i）在基本上不存在除H +离子之外的阳离子的条件下制备含有Co32-和PO43-离子的水溶液：（ii）混合 来自步骤（i）的溶液与钙化合物的水溶液或悬浮液; 和（iii）收集和干燥步骤（ii）中形成的沉淀物; 含钙溶液或悬浮液中的Ca / P与含磷溶液混合时的比例保持在1.67以上。 该方法的产物是新型的，Ca / P摩尔比大于1.67，并且包含高达5重量％的在B位点或羟基磷灰石结构的B和A位置取代的CO32-离子，至少50 在B位置上被取代的CO32-离子的％。 该产品不含有Na +或NH4 +离子。
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公开(公告)号：US08613876B2
公开(公告)日：2013-12-24
申请号：US12216710
申请日：2008-07-09
IPC分类号： C04B35/622
CPC分类号： C03C4/0007 , A61L27/10 , A61L27/12 , A61L2400/18 , C03C11/007 , C04B38/02 , C04B38/10 , C04B2111/00836 , C04B2201/10 , C04B35/447 , C04B2103/40 , C04B35/10
摘要： A method for the production of a macroporous ceramic foam, wherein: (a) forming a ceramic slip comprising a substantially homogeneous mixture of a ceramic particulate, an organic binder in a liquid carrier, and optionally one or more surfactants, wherein at least one surfactant is present if the organic binder does not function as a surfactant, and wherein the ceramic slip preferably has a viscosity in the range of from 15 to 200 mPas−1; (b) foaming the ceramic slip; and (c) heating the foamed ceramic slip at a temperature sufficient to substantially burn out the organic binder. The macroporous ceramic foam is suitable for use in biomedical applications such as synthetic bones, tissue engineering scaffolds or drug delivery devices.
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公开(公告)号：US20100248368A1
公开(公告)日：2010-09-30
申请号：US12377221
申请日：2007-08-10
申请人： Andrew Lynn , William Bonfield , Zachary D. Wissner-Gross , Brendan A. Harley , Ioannis V. Yannas , Lorna J. Gibson
发明人： Andrew Lynn , William Bonfield , Zachary D. Wissner-Gross , Brendan A. Harley , Ioannis V. Yannas , Lorna J. Gibson
IPC分类号： C12N5/071
摘要： A process for the preparation of a composite biomaterial comprising: providing a first substantially solid component comprising one or more of collagen, a glycosaminoglycan, albumin, hyaluronan, chitosan, and synthetic polypeptides comprising a portion of the polypeptide sequence of collagen, and optionally an inorganic material, said component having at least a surface portion that is porous; providing a fluid composition comprising one or more of collagen, a glycosaminoglycan, albumin, hyaluronan, chitosan, and synthetic polypeptides comprising a portion of the polypeptide sequence of collagen, and a liquid carrier, and optionally an inorganic material; contacting said fluid composition with said porous surface portion of said first component; cooling said fluid composition to a temperature at which the liquid carrier transforms into a plurality of solid crystals or particles; removing at least some of the plurality of solid crystals or particles by sublimation and/or evaporation.
摘要翻译： 一种制备复合生物材料的方法，包括：提供包含胶原，糖胺聚糖，白蛋白，透明质酸，壳聚糖和包含胶原多肽序列的一部分的合成多肽中的一种或多种的第一基本上固体的组分，以及任选的无机 所述组分至少具有多孔的表面部分; 提供包含胶原，糖胺聚糖，白蛋白，透明质酸，壳聚糖和包含胶原多肽序列的一部分的合成多肽，液体载体和任选的无机材料中的一种或多种的流体组合物; 使所述流体组合物与所述第一组分的所述多孔表面部分接触; 将所述流体组合物冷却至液体载体转变成多个固体晶体或颗粒的温度; 通过升华和/或蒸发去除多个固体晶体或颗粒中的至少一些。
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公开(公告)号：US5017627A
公开(公告)日：1991-05-21
申请号：US191738
申请日：1988-05-02
CPC分类号： A61L27/44 , A61F2/30965 , A61L27/46 , A61F2/28 , A61F2310/00293
摘要： A composite of a homo- or co-polyolefin having an average molecular weight greater than 100,000 with from 30 to 50% by volume of a particulate inorganic solid for use in endoprosthesis.
摘要翻译： 平均分子量大于100,000的均聚或共聚烯烃与30至50体积％的用于内用假体的颗粒状无机固体的复合材料。
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公开(公告)号：US08318902B2
公开(公告)日：2012-11-27
申请号：US12377221
申请日：2007-08-10
申请人： Andrew Lynn , William Bonfield , Zachary D. Wissner-Gross , Brendan A. Harley , Ioannis V. Yannas , Lorna J. Gibson
发明人： Andrew Lynn , William Bonfield , Zachary D. Wissner-Gross , Brendan A. Harley , Ioannis V. Yannas , Lorna J. Gibson
IPC分类号： A61K38/17
摘要： A process for the preparation of a composite biomaterial comprising: providing a first substantially solid component comprising one or more of collagen, a glycosaminoglycan, albumin, hyaluronan, chitosan, and synthetic polypeptides comprising a portion of the polypeptide sequence of collagen, and optionally an inorganic material, said component having at least a surface portion that is porous; providing a fluid composition comprising one or more of collagen, a glycosaminoglycan, albumin, hyaluronan, chitosan, and synthetic polypeptides comprising a portion of the polypeptide sequence of collagen, and a liquid carrier, and optionally an inorganic material; contacting said fluid composition with said porous surface portion of said first component; cooling said fluid composition to a temperature at which the liquid carrier transforms into a plurality of solid crystals or particles; removing at least some of the plurality of solid crystals or particles by sublimation and/or evaporation.
摘要翻译： 一种制备复合生物材料的方法，包括：提供包含胶原，糖胺聚糖，白蛋白，透明质酸，壳聚糖和包含胶原多肽序列的一部分的合成多肽中的一种或多种的第一基本上固体的组分，以及任选的无机 所述组分至少具有多孔的表面部分; 提供包含胶原，糖胺聚糖，白蛋白，透明质酸，壳聚糖和包含胶原多肽序列的一部分的合成多肽，液体载体和任选的无机材料中的一种或多种的流体组合物; 使所述流体组合物与所述第一组分的所述多孔表面部分接触; 将所述流体组合物冷却至液体载体转变成多个固体晶体或颗粒的温度; 通过升华和/或蒸发去除多个固体晶体或颗粒中的至少一些。
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