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1.发明申请公开(公告)号：US20090087472A1
公开(公告)日：2009-04-02
申请号：US12145672
申请日：2008-06-25
申请人： William L. Murphy , Jae-Sam Lee , Mark D. Markel , Ben K. Graf
发明人： William L. Murphy , Jae-Sam Lee , Mark D. Markel , Ben K. Graf
CPC分类号： C07K14/51 , A61B17/80 , A61B17/866 , A61K38/1875 , A61L31/06 , A61L31/086 , A61L31/148 , A61L31/16 , A61L2300/252 , A61L2300/414 , C07K7/06 , C07K7/08 , C08L67/04
摘要： Controlled release of biopharmaceutical growth factors from a hydroxyapatite coating on a bioresorbable interference screw used in cruciate ligament reconstruction surgery on a human. Biologically active scaffolds, such as interference bone screws used for ligament fixation, made by growing calcium phosphate-based hydroxyapatite coatings on bioresorbable poly(α-hydroxy ester) scaffolds that provide controlled mineral dissolution and controlled release of bone morphogenetic protein-2. The biologically active scaffold provides improved bioavailability of BMP-2 growth factor that in turn provides enhanced graft-bone healing in the tibial bone tunnel. The coating method uses surface hydrolysis and modified simulated body fluid incubation which does not require solvent or heat and is conducted at room temperature.
摘要翻译： 将生物药物生长因子从羟基磷灰石涂层控制释放到用于人类十字韧带重建手术的生物可再吸收的干涉螺钉上。 生物活性支架，例如用于韧带固定的干涉骨螺钉，其通过在生物可再吸收的聚（α-羟基酯）支架上生长磷酸钙基羟基磷灰石涂层而提供，其提供受控的矿物溶解和骨形态发生蛋白-2的受控释放。 生物活性支架提供改善的BMP-2生长因子的生物利用度，其进而在胫骨骨隧道中提供增强的移植骨愈合。 涂覆方法使用表面水解和改性的模拟体液培养，其不需要溶剂或热量并在室温下进行。
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2.发明授权Controlled release of biopharmaceutical growth factors from hydroxyapatite coating on bioresorbable interference screws used in cruciate ligament reconstruction surgery 有权由羟基磷灰石涂层控制生物药物生长因子的释放用于十字韧带重建手术中的生物可吸收干扰螺钉公开(公告)号：US08075562B2
公开(公告)日：2011-12-13
申请号：US12145672
申请日：2008-06-25
申请人： William L. Murphy , Jae-Sam Lee , Mark D. Markel , Ben K. Graf
发明人： William L. Murphy , Jae-Sam Lee , Mark D. Markel , Ben K. Graf
CPC分类号： C07K14/51 , A61B17/80 , A61B17/866 , A61K38/1875 , A61L31/06 , A61L31/086 , A61L31/148 , A61L31/16 , A61L2300/252 , A61L2300/414 , C07K7/06 , C07K7/08 , C08L67/04
摘要： Controlled release of biopharmaceutical growth factors from a hydroxyapatite coating on a bioresorbable interference screw used in cruciate ligament reconstruction surgery on a human. Biologically active scaffolds, such as interference bone screws used for ligament fixation, made by growing calcium phosphate-based hydroxyapatite coatings on bioresorbable poly(α-hydroxy ester) scaffolds that provide controlled mineral dissolution and controlled release of bone morphogenetic protein-2. The biologically active scaffold provides improved bioavailability of BMP-2 growth factor that in turn provides enhanced graft-bone healing in the tibial bone tunnel. The coating method uses surface hydrolysis and modified simulated body fluid incubation which does not require solvent or heat and is conducted at room temperature.
摘要翻译： 将生物药物生长因子从羟基磷灰石涂层控制释放到用于人类十字韧带重建手术的生物可再吸收的干涉螺钉上。 生物活性支架，例如用于韧带固定的干涉骨螺钉，其通过在生物可再吸收的聚（α-羟基酯）支架上生长磷酸钙基羟基磷灰石涂层，其提供受控的矿物溶解和骨形态发生蛋白-2的控制释放。 生物活性支架提供改善的BMP-2生长因子的生物利用度，其进而在胫骨骨隧道中提供增强的移植骨愈合。 涂覆方法使用表面水解和改性的模拟体液培养，其不需要溶剂或热量并在室温下进行。
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公开(公告)号：US09636109B2
公开(公告)日：2017-05-02
申请号：US12507635
申请日：2009-07-22
申请人： William L. Murphy , Jae Sung Lee , Mark D. Markel , Ben K. Graf , Geoffrey Baer , Yan Lu
发明人： William L. Murphy , Jae Sung Lee , Mark D. Markel , Ben K. Graf , Geoffrey Baer , Yan Lu
IPC分类号： A61B17/04 , A61B17/06 , A61L27/32 , A61L27/54 , A61L27/58 , A61L29/10 , A61L29/14 , A61L29/16 , A61L31/08 , A61L31/14 , A61L31/16 , A61L17/00 , A61L17/06 , A61L17/14 , A61B17/00
CPC分类号： A61B17/06166 , A61B2017/00889 , A61B2017/00893 , A61L17/005 , A61L17/06 , A61L17/145 , A61L27/32 , A61L27/54 , A61L27/58 , A61L29/106 , A61L29/148 , A61L29/16 , A61L31/086 , A61L31/148 , A61L31/16
摘要： The present disclosure generally relates to biodegradable and bioresorbable materials having a mineral layer on the surface of the material. More particularly, the disclosure relates to biodegradable and bioresorbable orthopedic devices having a degradable mineral layer on the surface thereof that can be used as a delivery vehicle for biological substances. Also provided are various methods of using the mineralized devices in tissue regeneration, including bone tissue engineering, and methods for producing the mineralized devices.
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4.发明授权Decorating hydroxyapatite biomaterials with modular biologically active molecules 有权用模块化生物活性分子装饰羟基磷灰石生物材料公开(公告)号：US08420774B2
公开(公告)日：2013-04-16
申请号：US12628666
申请日：2009-12-01
申请人： William L. Murphy , Jae Sung Lee , Mark D. Markel , Ben K. Graf
发明人： William L. Murphy , Jae Sung Lee , Mark D. Markel , Ben K. Graf
摘要： A modular peptide design strategy wherein the modular peptide has two functional units separated by a spacer portion is disclosed. More particularly, the design strategy combines a hydroxyapatite-binding portion and a biomolecule-derived portion. The modular peptides have improved non-covalent binding to the surface of the HA-based materials, and are capable of initiating osteogenesis, angiogenesis, and/or osteogenic differentiation.
摘要翻译： 公开了一种模块化肽设计策略，其中模块化肽具有由间隔物部分分开的两个功能单元。 更具体地，设计策略将羟基磷灰石结合部分和衍生生物分子的部分组合。 模块化肽具有改善的与HA基材料表面的非共价结合，并且能够启动成骨，血管生成和/或成骨分化。
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公开(公告)号：US20110022085A1
公开(公告)日：2011-01-27
申请号：US12507635
申请日：2009-07-22
申请人： William L. Murphy , Jae Sung Lee , Mark D. Markel , Ben K. Graf , Geoffrey Baer , Yan Lu
发明人： William L. Murphy , Jae Sung Lee , Mark D. Markel , Ben K. Graf , Geoffrey Baer , Yan Lu
IPC分类号： A61B17/04
CPC分类号： A61B17/06166 , A61B2017/00889 , A61B2017/00893 , A61L17/005 , A61L17/06 , A61L17/145 , A61L27/32 , A61L27/54 , A61L27/58 , A61L29/106 , A61L29/148 , A61L29/16 , A61L31/086 , A61L31/148 , A61L31/16
摘要： The present disclosure generally relates to biodegradable and bioresorbable materials having a mineral layer on the surface of the material. More particularly, the disclosure relates to biodegradable and bioresorbable orthopedic devices having a degradable mineral layer on the surface thereof that can be used as a delivery vehicle for biological substances. Also provided are various methods of using the mineralized devices in tissue regeneration, including bone tissue engineering, and methods for producing the mineralized devices.
摘要翻译： 本公开通常涉及在材料表面上具有矿物层的可生物降解和生物可再吸收的材料。 更具体地说，本公开内容涉及在其表面上具有可降解矿物层的可生物降解和生物可吸收的矫形装置，其可用作生物物质的递送载体。 还提供了在组织再生中使用矿化装置的各种方法，包括骨组织工程，以及用于生产矿化装置的方法。
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公开(公告)号：US08778869B2
公开(公告)日：2014-07-15
申请号：US12796743
申请日：2010-06-09
申请人： William L. Murphy , Mark D. Markel , Ben K. Graf , Yan Lu , Jae Sung Lee
发明人： William L. Murphy , Mark D. Markel , Ben K. Graf , Yan Lu , Jae Sung Lee
CPC分类号： A61K31/7088 , A61K38/1825 , A61K38/1875 , A61L27/12 , A61L27/34 , A61L27/54 , A61L27/58 , A61L2300/258 , A61L2300/414 , A61L2300/426 , A61L2300/43
摘要： A system for growing tissue based upon layers of an inorganic extracellular matrix, wherein each layer of the inorganic matrix is designed to dissolve at a separate rate and result in sequential growth factor delivery upon its dissolution.
摘要翻译： 一种用于基于无机细胞外基质层生长组织的系统，其中无机基质的每一层被设计成以分开的速率溶解并在其溶解时产生连续的生长因子递送。
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公开(公告)号：US20110305760A1
公开(公告)日：2011-12-15
申请号：US12796743
申请日：2010-06-09
申请人： William L. Murphy , Mark D. Markel , Ben K. Graf , Yan Lu , Jae Sung Lee
发明人： William L. Murphy , Mark D. Markel , Ben K. Graf , Yan Lu , Jae Sung Lee
CPC分类号： A61K31/7088 , A61K38/1825 , A61K38/1875 , A61L27/12 , A61L27/34 , A61L27/54 , A61L27/58 , A61L2300/258 , A61L2300/414 , A61L2300/426 , A61L2300/43
摘要： A system for growing tissue based upon layers of an inorganic extracellular matrix, wherein each layer of the inorganic matrix is designed to dissolve at a separate rate and result in sequential growth factor delivery upon its dissolution.
摘要翻译： 一种用于基于无机细胞外基质层生长组织的系统，其中无机基质的每一层被设计成以分开的速率溶解并在其溶解时产生连续的生长因子递送。
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8.发明申请DECORATING HYDROXYAPATITE BIOMATERIALS WITH MODULAR BIOLOGICALLY ACTIVE MOLECULES 有权用模块生物活性分子装饰羟肟酸生物体公开(公告)号：US20110129611A1
公开(公告)日：2011-06-02
申请号：US12628666
申请日：2009-12-01
申请人： William L. Murphy , Jae Sung Lee , Mark D. Markel , Ben K. Graf
发明人： William L. Murphy , Jae Sung Lee , Mark D. Markel , Ben K. Graf
摘要： A modular peptide design strategy wherein the modular peptide has two functional units separated by a spacer portion is disclosed. More particularly, the design strategy combines a hydroxyapatite-binding portion and a biomolecule-derived portion. The modular peptides have improved non-covalent binding to the surface of the HA-based materials, and are capable of initiating osteogenesis, angiogenesis, and/or osteogenic differentiation.
摘要翻译： 公开了一种模块化肽设计策略，其中模块化肽具有由间隔物部分分开的两个功能单元。 更具体地，设计策略将羟基磷灰石结合部分和衍生生物分子的部分组合。 模块化肽具有改善的与HA基材料表面的非共价结合，并且能够启动成骨，血管生成和/或成骨分化。
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公开(公告)号：US07337751B2
公开(公告)日：2008-03-04
申请号：US10903116
申请日：2004-07-29
IPC分类号： A01K15/04
CPC分类号： A61B5/4528 , A61B5/1071 , A61B5/6828 , A61D3/00
摘要： A goniometer (also sometimes referred to as an arthrometer, fleximeter, or pronometer) for measuring the range of motion of an animal knee includes an anchor platform to which an animal's upper leg (femur) may be affixed, and a mobile platform to which the animal's lower leg (shin and tibia) may be affixed so that the upper and lower leg are situated along a common axis. The mobile platform is preferably movable in two degrees of freedom (translational and rotational) about the anchor platform so that the relative motion of the platforms causes the upper and lower leg to move about the intermediate knee joint. A force transducer (such as a spring scale) and/or a torque transducer (such as a common torque wrench) may be used to obtain measurements of the laxity of the knee joint.
摘要翻译： 用于测量动物膝盖的运动范围的测角器（有时也称为测量计，屈光计或发音计）包括可以固定动物的大腿（股骨）的锚平台，以及移动平台 动物的小腿（胫骨和胫骨）可以被固定，使得上腿和下腿沿着共同的轴线定位。 移动平台优选地围绕锚平台在两个自由度（平移和旋转）中移动，使得平台的相对运动导致上下腿围绕中间膝关节移动。 可以使用力传感器（例如弹簧秤）和/或扭矩传感器（例如公共扭矩扳手）来获得膝关节松弛度的测量。
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