利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

105 条记录 (耗时 0.025 秒)

    Labeling reagent
    3.
    发明申请
    Labeling reagent 有权
    标记试剂

    公开(公告)号：US20070196852A1

    公开(公告)日：2007-08-23

    申请号：US11707399

    申请日：2007-02-16

    申请人： Dieter Heindl ,  Frank Bergmann ,  Hans-Peter Josel ,  Dirk Kessler ,  Gunter Lampert ,  Christian Weilke

    发明人： Dieter Heindl ,  Frank Bergmann ,  Hans-Peter Josel ,  Dirk Kessler ,  Gunter Lampert ,  Christian Weilke

    IPC分类号： C12Q1/68 ,  C07H19/04 ,  C07H21/04

    CPC分类号： C07H19/23 ,  C07H19/04 ,  C07H21/00 ,  C07H21/04 ,  Y02P20/55

    摘要： The current invention restates substituted indole nucleosides as both terminal as well as internal building blocks of labeled oligonucleotide probes for the detection, analysis and quantitation of nucleic acids. The substituent comprises a linker and a detectable group or a linker and a reactive group for post synthesis coupling. These modified nucleosides grant access to a wide application area. These new substituted indole nucleosides can be used as labeling reagents for the facile preparation of e.g. optimized hybridization probes, Taqman-probes, or molecular beacon probes.

    摘要翻译： 本发明将取代的吲哚核苷作为两个末端以及用于核酸检测，分析和定量的标记的寡核苷酸探针的内部构建块重述。 取代基包括接头和可检测的基团或接头以及用于后合成偶联的反应性基团。 这些修饰的核苷允许进入广泛的应用领域。 这些新的取代的吲哚核苷可以用作标记试剂，用于容易地制备例如 优化的杂交探针，Taqman探针或分子信标探针。

    Labeling reagent
    4.
    发明授权
    Labeling reagent 有权
    标记试剂

    公开(公告)号：US07759470B2

    公开(公告)日：2010-07-20

    申请号：US11707399

    申请日：2007-02-16

    申请人： Dieter Heindl ,  Frank Bergmann ,  Hans-Peter Josel ,  Dirk Kessler ,  Gunter Lampert ,  Christian Weilke

    发明人： Dieter Heindl ,  Frank Bergmann ,  Hans-Peter Josel ,  Dirk Kessler ,  Gunter Lampert ,  Christian Weilke

    IPC分类号： C07G3/00 ,  C07H21/02 ,  C07H21/04 ,  C07H19/04 ,  C12Q1/68

    CPC分类号： C07H19/23 ,  C07H19/04 ,  C07H21/00 ,  C07H21/04 ,  Y02P20/55

    摘要： The current invention restates substituted indole nucleosides as both terminal as well as internal building blocks of labeled oligonucleotide probes for the detection, analysis and quantitation of nucleic acids. The substituent comprises a linker and a detectable group or a linker and a reactive group for post synthesis coupling. These modified nucleosides grant access to a wide application area. These new substituted indole nucleosides can be used as labeling reagents for the facile preparation of e.g. optimized hybridization probes, Taqman-probes, or molecular beacon probes.

    摘要翻译： 本发明将取代的吲哚核苷作为两个末端以及用于核酸检测，分析和定量的标记的寡核苷酸探针的内部构建块重述。 取代基包括接头和可检测的基团或接头以及用于后合成偶联的反应性基团。 这些修饰的核苷允许进入广泛的应用领域。 这些新的取代的吲哚核苷可以用作标记试剂，用于容易地制备例如 优化的杂交探针，Taqman探针或分子信标探针。

    Rhodamine derivatives and the use thereof
    10.
    发明授权
    Rhodamine derivatives and the use thereof 有权
    罗丹明衍生物及其用途

    公开(公告)号：US06184379B2

    公开(公告)日：2001-02-06

    申请号：US09324265

    申请日：1999-06-02

    申请人： Hans-Peter Josel ,  Rupert Herrmann ,  Dieter Heindl ,  Klaus Muhlegger ,  Gregor Sagner ,  Karl Heinz Drexhage ,  Jorg Frantzeskos ,  Jutta Arden-Jacob

    发明人： Hans-Peter Josel ,  Rupert Herrmann ,  Dieter Heindl ,  Klaus Muhlegger ,  Gregor Sagner ,  Karl Heinz Drexhage ,  Jorg Frantzeskos ,  Jutta Arden-Jacob

    IPC分类号： C07D49147

    CPC分类号： C09B11/24 ,  Y10S436/80

    摘要： The invention concerns rhodamine derivatives of the general formulae in which Ca-Cd each denote a C atom, and Ca and Cb as well as Cc and Cd are either linked together by a single bond or by a double bond; X1 to X16 denote independently of one another halogen, sulfonic acid, hydrogen or an alkyl residue with 1-20 C atoms in which the alkyl residue can be substituted with one or several halogen or sulfonic acid residues; R1 and R2 are either identical or different and denote either hydrogen, alkyl with 1-20 C atoms, polyoxyhydrocarbyl units, phenyl or phenylalkyl with 1-3 carbon atoms in the alkyl chain in which the alkyl and/or phenyl residues can be substituted by one or several hydroxy, halogen, sulfonic acid, amino, carboxy or alkoxycarbonyl groups where alkoxy can have 1-4 carbon atoms, R1 contains at least one activatable group, R2 and X4 can be optionally linked together via a bridge composed of 0-2 C atoms. In contrast to the prior art, these compounds are characterized in that A1, A2 and A3 can independently of one another denote hydrogen, cyano, halogen and sulfonic acid; B1 denotes either halogen, cyano or hydrogen; B2 denotes hydrogen, amide, halogen and an alkyl residue with 1-20 C atoms. In addition the invention concerns activated rhodamine derivatives, correspondingly conjugated biomolecules and their use in diagnostic systems.

    摘要翻译： 本发明涉及一般式的罗丹明衍生物，其中Ca-Cd各自表示C原子，Ca和Cb以及C c和Cd通过单键或双键连接在一起; X1至X16彼此独立地表示卤素，磺酸，氢或具有1-20个C原子的烷基残基，其中烷基残基可被一个或几个卤素或磺酸残基取代; R 1和R 2可以相同或不同，表示氢，具有1-20个C原子的烷基，聚氧烃基单元，烷基链中具有1-3个碳原子的苯基或苯基烷基，其中烷基和/或苯基残基可被 一个或几个羟基，卤素，磺酸，氨基，羧基或烷氧基羰基，其中烷氧基可以具有1-4个碳原子，R 1包含至少一个可活化基团，R 2和X 4可以任选地通过由0-2 C原子。 与现有技术相反，这些化合物的特征在于，A1，A2和A3可以彼此独立地表示氢，氰基，卤素和磺酸; B1表示卤素，氰基或氢; B2表示氢，酰胺，卤素和具有1-20个C原子的烷基。 此外，本发明涉及活化的罗丹明衍生物，相应的共轭生物分子及其在诊断系统中的用途。