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1.发明授权
公开(公告)号：US4219336A
公开(公告)日：1980-08-26
申请号：US892359
申请日：1978-03-31
CPC分类号： C12Q1/28 , G01N33/725 , C12Q2326/00 , Y10S436/904
摘要： A diagnostic agent for the detection of occult blood in feces comprising hydrogen peroxide and, as a chromogen, guaiaconic acid A, optionally with a stabilizer. The invention provides, as a novel substance, guaiaconic acid A having a specific extinction E.sub.1 cm.sup.1% at 600 nm of at least 200, determined by the reaction with peroxidase and hydrogen peroxide, having infra-red bands at1600 cm.sup.-1 (m);1505 cm.sup.-1 (v.s.);1260 cm.sup.-1 (s;b);1115 cm.sup.-1 (m);1025 cm.sup.-1 (m); and1200 cm.sup.-1 (s;b)and having an R.sub.F value of 0.45 (toluene/dioxan/glacial acetic acid; 90:25:10 v/v/v).
摘要翻译： 用于检测粪便中的潜血的诊断剂，其包含过氧化氢和任选地与稳定剂作为色原，愈创木酸A。 本发明提供作为新物质，通过与过氧化物酶和过氧化氢的反应确定在600nm处具有600nm以上的具有特定消光度E1cm1％的愈创木酸A至少为200，在1600cm -1处具有红外线
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2.发明授权Oxidation indicators comprising 3,3',5,5'-tetraalkylbenzidine compounds 失效包含3,3'，5,5'-四烷基联苯胺化合物的氧化指示剂
公开(公告)号：US4385114A
公开(公告)日：1983-05-24
申请号：US236487
申请日：1981-02-23
IPC分类号： C07C211/50 , C07C67/00 , C07C209/00 , C07C209/54 , C12Q1/00 , C12Q1/26 , C12Q1/28 , G01N21/78 , G01N31/00 , G01N31/22 , G01N33/50 , C12Q1/60 , C12Q1/62
CPC分类号： C12Q1/26 , C12Q1/28 , G01N31/228 , C12Q2326/10 , C12Q2326/12 , Y10S435/805 , Y10S436/81 , Y10T436/144444 , Y10T436/206664
摘要： The detection and determination of (a) hydrogen peroxide or of a substance which reacts with the formation of hydrogen peroxide or (b) of peroxidase or a peroxidatively active substance, is carried out by contacting an unknown sample with a chromogen and, in case (a), with a peroxidatively active substance or in case (b) with hydrogen peroxide or a substance which reacts with the formation of hydrogen peroxide, and evaluating the coloration produced by the reaction, wherein, as the chromogen, there is used at least one 3,3',5,5'-tetraalkylbenzidine compound of the formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which can be the same or different, are straight-chained or branched alkyl radicals containing up to 6 and preferably up to 4 carbon atoms.
摘要翻译： （a）过氧化氢或与过氧化氢或过氧化物酶或过氧化物活性物质的（b）反应形成的物质的检测和测定是通过将未知样品与色原体接触进行的，如果（ a），具有过氧化活性物质或在（b）过氧化氢或与形成过氧化氢反应的物质的情况下，以及评价由反应产生的着色，其中作为色原，使用至少一种 具有下式的3,3'，5,5'-四烷基联苯胺化合物：其中R 1，R 2，R 3和R 4可以相同或不同，是含有至多6个的直链或支链烷基，优选 最多4个碳原子。
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公开(公告)号：US4250256A
公开(公告)日：1981-02-10
申请号：US44629
申请日：1979-06-01
申请人： Hans Wielinger , Walter Rittersdorf , Manfred Bleisteiner , Gerd Zimmermann , Wolfgang Werner , Wolfgang Vomel
发明人： Hans Wielinger , Walter Rittersdorf , Manfred Bleisteiner , Gerd Zimmermann , Wolfgang Werner , Wolfgang Vomel
CPC分类号： C12M41/36 , C12M23/14 , Y10S435/805 , Y10S435/81
摘要： Microbiological test device having a nutrient card or cards and a covering layer thereover which is permeable to nutrients but impermeable to bacteria. The covering layer is made from an aqueous dispersion of a water insoluble resin and a pore former.
摘要翻译： 微生物测试装置具有营养物质卡或其上的覆盖层，其可渗透营养物质，但对细菌不可渗透。 覆盖层由水不溶性树脂和成孔剂的水分散体制成。
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公开(公告)号：US4551428A
公开(公告)日：1985-11-05
申请号：US260616
申请日：1981-05-05
申请人： Dieter Berger , Gunter Frey , Wolfgang-Reinhold Knappe , Manfred Kuhr , Walter Rittersdorf , Wolfgang Werner
发明人： Dieter Berger , Gunter Frey , Wolfgang-Reinhold Knappe , Manfred Kuhr , Walter Rittersdorf , Wolfgang Werner
IPC分类号： C07D295/12 , C07C67/00 , C07C231/00 , C07C231/12 , C07C233/47 , C07C233/81 , C07C233/83 , C07C233/87 , C07C241/00 , C07C245/20 , C07C313/00 , C07C323/48 , C07K1/00 , C07K1/113 , C12Q1/34 , C12Q1/37 , C12Q1/44 , G01N33/50 , G01N33/68 , C12Q1/02 , C12Q1/04 , C12Q1/06 , C12Q1/38
CPC分类号： C12Q1/34 , C12Q2334/30 , C12Q2334/50 , C12Q2334/70 , Y10S435/805 , Y10S435/81
摘要： Esters and agents including the esters, useful as substrates for esterolytic and/or proteolytic enzymes, said esters being compounds of the general formula: ##STR1## in which R".sub.1, R".sub.2, R".sub.3 and R".sub.4, which may be the same or different, are hydrogen atoms or lower alkyl, lower alkoxy, alkylamino or dialkylamino radicals or in which two adjacent substituents can also represent a fused benzene ring, A is a residue of an amino acid or of a peptide and B is a nitrogen protective group conventional in peptide chemistry or derived therefrom; and the method of preparation and use.
摘要翻译： 酯和试剂，包括可用作酯水解和/或蛋白水解酶底物的酯，所述酯是下列通式的化合物：其中R'1，R'2，R'3和R“ 4可以相同或不同，是氢原子或低级烷基，低级烷氧基，烷基氨基或二烷基氨基，或者其中两个相邻的取代基也可以表示稠合苯环，A是氨基酸或肽的残基 并且B是肽化学中常规的或由其衍生的氮保护基; 以及制备和使用的方法。
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5.发明授权Bis-(2,4-dinitrophenyl)-methyl-pyridinium and quinolinium compounds 失效双（2,4-二硝基苯基） - 甲基 - 吡啶鎓和喹啉鎓化合物
公开(公告)号：US4245096A
公开(公告)日：1981-01-13
申请号：US34720
申请日：1979-04-30
IPC分类号： C07D213/04 , C07D213/20 , C07D213/24 , C07D213/26 , C07D215/10 , C07D217/10 , C09B11/00 , C09B11/26 , G01N31/22 , G01N33/62 , G01N33/84 , C07D215/12
CPC分类号： C07D213/20 , C07D213/24 , C07D215/10 , C07D217/10
摘要： Bis-(2,4-dinitrophenyl)-methylpyridinium compounds useful as a pH indicator or for the detection of ammonia having the formula: ##STR1## wherein one of R.sub.1 and R.sub.2 is a bis-(2,4-dinitrophenyl)-methyl radical and the other is a lower alkyl radical;R.sub.2 can also be hydrogen atom or trifluoromethyl;R.sub.3 and R.sub.4 are hydrogen or, together with the carbon atoms to which they are attached, represent a benzene ring; andX.sup..crclbar. is an appropriate acid anionor said compounds are betaines.
摘要翻译： 可用作pH指示剂或用于检测具有下式的氨的双（2,4-二硝基苯基） - 甲基吡啶鎓化合物：其中R1和R2之一是双 - （2,4-二硝基苯基） - 甲基 另一个是低级烷基; R2也可以是氢原子或三氟甲基; R3和R4是氢或与它们相连的碳原子一起代表苯环; 并且X（ - ）是适当的酸性阴离子或所述化合物是甜菜碱。
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6.发明授权
公开(公告)号：US4212844A
公开(公告)日：1980-07-15
申请号：US943518
申请日：1978-09-18
CPC分类号： G01N33/52 , Y10T436/148888
摘要： Rapid diagnostic compositions and methods for the determination of uric acid in body fluids by inversion colorimetry, wherein the indicator used is a radical of the general formula: ##STR1## in which R is a lower alkyl radical and Me is an alkali metal atom or an ammonium group.
摘要翻译： 用于通过反转比色法测定体液中的尿酸的快速诊断组合物和方法，其中使用的指示剂是以下通式的基团：其中R是低级烷基，Me是碱金属原子或 铵基。
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公开(公告)号：US4013416A
公开(公告)日：1977-03-22
申请号：US661687
申请日：1976-02-26
IPC分类号： C07D327/04 , C07D307/88 , C09B11/00 , C09B11/08 , G01N31/00 , G01N33/52 , G01N33/68 , G01N31/22 , G01N33/16
CPC分类号： C09B11/08 , G01N33/6839
摘要： Protein in body fluids, e.g., urine, is detected by contacting a sample of the body fluid with a diagnostic agent comprising an absorbent carrier impregnated with a pH indicator of the octahalosulfophthalein group, a buffer, and at least one linear or branched chain polypropylene glycol immiscible with water; the resulting test papers are highly sensitive to protein without being subject to interfering effects by nitrogen-containing compounds.
摘要翻译： 通过使体液样品与包含浸渍有八氢硫代沙丁胺基的pH指示剂的缓冲剂载体的诊断剂，缓冲液和至少一种直链或支链聚丙二醇来检测体液（例如尿液）中的蛋白质 与水不混溶; 所得到的试纸对蛋白质高度敏感，不受含氮化合物的干扰作用。
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公开(公告)号：US4749648A
公开(公告)日：1988-06-07
申请号：US606984
申请日：1984-05-04
申请人： Dieter Berger , Gunter Frey , Wolfgang-Reinhold Knappe , Manfred Kuhr , Walter Rittersdorf , Wolfgang Werner
发明人： Dieter Berger , Gunter Frey , Wolfgang-Reinhold Knappe , Manfred Kuhr , Walter Rittersdorf , Wolfgang Werner
IPC分类号： C07D295/12 , C07C67/00 , C07C231/00 , C07C231/12 , C07C233/47 , C07C233/81 , C07C233/83 , C07C233/87 , C07C241/00 , C07C245/20 , C07C313/00 , C07C323/48 , C07K1/00 , C07K1/113 , C12Q1/34 , C12Q1/37 , C12Q1/44 , G01N33/50 , G01N33/68 , C12Q1/04 , C12Q1/06 , C12Q1/38
CPC分类号： C12Q1/34 , C12Q2334/30 , C12Q2334/50 , C12Q2334/70 , Y10S435/805 , Y10S435/81
摘要： Esters and agents including the esters, useful as substrates for esterolytic and/or proteolytic enzymes, said esters being compounds of the general formula: ##STR1## in which R".sub.1, R".sub.2, R".sub.3 and R".sub.4, which may be the same or different, are hydrogen atoms or lower alkyl, lower alkoxy, alkylamino or dialkylamino radicals or in which two adjacent substituents can also represent a fused benzene ring, A is a residue of an amino acid or of a peptide and B is a nitrogen protective group conventional in peptide chemistry or derived therefrom and the method of preparation and use.
摘要翻译： 酯和试剂，包括可用作酯水解和/或蛋白水解酶底物的酯，所述酯是下列通式的化合物：其中R'1，R'2，R'3和R“ 4可以相同或不同，是氢原子或低级烷基，低级烷氧基，烷基氨基或二烷基氨基，或者其中两个相邻的取代基也可以表示稠合苯环，A是氨基酸或肽的残基 并且B是肽化学中常规的或由其衍生的氮保护基及其制备和使用方法。
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9.发明授权Method for the determination of redox reactions using iodate to eliminate ascorbic acid interference 失效使用碘酸盐测定氧化还原反应以消除抗坏血酸干扰的方法
公开(公告)号：US4743559A
公开(公告)日：1988-05-10
申请号：US941406
申请日：1986-12-15
CPC分类号： C12Q1/28 , C12Q1/54 , Y10S436/825 , Y10S436/904 , Y10T436/144444 , Y10T436/206664 , Y10T436/25125
摘要： The present invention provides a process for the detection of redox reactions by introducing a redox reagent system into a test system, wherein a soluble iodate is additionally added to the test system in an amount which is in excess of the highest amount of disturbing reducing agents present in the test system.The present invention also provides a diagnostic agent for the detection of redox reactions containing a redox reagent system, wherein the test system used additionally contains an iodate which is soluble therein in an amount which is in excess of the highest amount of disturbing reducing agents present in the test system.
摘要翻译： 本发明提供了一种通过将氧化还原试剂系统引入到测试系统中来检测氧化还原反应的方法，其中将可溶性碘酸盐另外加入到测试系统中，其量超过存在的最高量的扰动还原剂 在测试系统中。 本发明还提供了用于检测含有氧化还原试剂体系的氧化还原反应的诊断剂，其中所用的测试系统另外含有可溶于其中的碘酸盐，其量超过存在于最高量的干扰还原剂的量 测试系统。
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10.发明授权
公开(公告)号：US4223089A
公开(公告)日：1980-09-16
申请号：US34719
申请日：1979-04-30
IPC分类号： G01N33/50 , C07D213/20 , C07D213/26 , C07D215/10 , C07D217/10 , C12Q1/34 , C12Q1/58 , G01N31/22 , G01N31/14 , G01N21/06 , G01N33/16
CPC分类号： C07D213/20 , C07D213/26 , C07D215/10 , C07D217/10 , C12Q1/34 , C12Q1/58 , G01N31/22 , Y10S435/805 , Y10T436/171538 , Y10T436/175383
摘要： Diagnostic device for the determination of ammonia having a handle, an ammonia indicator layer thereon and an alkaline buffer-containing reaction layer positioned above the indicator layer a distance of 10 to 200 microns by a spacer member. The reaction layer is readily separated from the indicator layer to reveal the latter at the end of the ammonia test.
摘要翻译： 用于测定具有把手的氨，其上的氨指示剂层和含有碱性缓冲液的反应层的诊断装置，其通过间隔构件定位在指示剂层上方的距离为10至200微米。 在氨测试结束时，反应层容易从指示剂层分离出来，以显示反应层。
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