公开(公告)号：US20060261058A1

公开(公告)日：2006-11-23

申请号：US11456997

申请日：2006-07-12

申请人： Michael Collins ,  Wyatt Hargett ,  James Thomas ,  Michael Collins ,  E. Barnhardt

发明人： Michael Collins ,  Wyatt Hargett ,  James Thomas ,  Michael Collins ,  E. Barnhardt

IPC分类号： B01L9/00

CPC分类号： H05B6/806 ,  F26B3/347 ,  F26B5/048 ,  F26B9/003 ,  F26B21/14 ,  G01N1/44 ,  G01N30/06 ,  G01N2030/567

摘要： An instrument and associated method are disclosed for preparing samples for column chromatography. The method includes the steps of applying microwave energy to a sample composition containing at least one solvent to encourage a chemical reaction and generate desired products, thereafter mixing an absorbent media with the sample to absorb the solvent, the media being compatible with liquid chromatography that will separate the expected products, being chemically inert to the expected products, and being added in an amount sufficient to provide a substantially dry mixture of the media and the sample, but less than an amount that overly broadens the resolution of the sample during liquid chromatography, thereafter applying microwave energy to the dry mixture of the media and the sample to thereby encourage the solvent to evaporate under the influence of the microwave energy, and thereafter adding the dry mixture of the media and the remaining sample to a liquid chromatography column and separating the components of the remaining sample for identification and purification purposes.

摘要翻译： 公开了用于制备用于柱色谱法的样品的仪器和相关方法。 该方法包括以下步骤：向含有至少一种溶剂的样品组合物施加微波能量以促进化学反应并产生所需产物，然后将吸收介质与样品混合以吸收溶剂，该介质与液相色谱相容， 将期望的产品分离，对预期产品具有化学惰性，并且以足以提供介质和样品的基本上干燥的混合物的量加入，但小于在液相色谱法过度扩大样品分辨率的量， 然后将微波能量施加到介质和样品的干燥混合物中，从而促使溶剂在微波能量的影响下蒸发，然后将介质和剩余样品的干混合物加入液相色谱柱中， 剩余样品的组分用于鉴定和纯化目的。

公开(公告)号：US20050210987A1

公开(公告)日：2005-09-29

申请号：US11127646

申请日：2005-05-12

申请人： William Jennings ,  Wyatt Hargett ,  James Thomas

发明人： William Jennings ,  Wyatt Hargett ,  James Thomas

IPC分类号： G01L19/00 ,  B01J3/00 ,  B01J3/03 ,  B01J3/04 ,  B01J19/12 ,  G01L7/00 ,  G01L19/14 ,  G01M3/32 ,  H05B6/64 ,  H05B6/80

CPC分类号： H05B6/806 ,  B01J19/126 ,  B01J2219/1233 ,  B01J2219/1269 ,  G01L19/0007 ,  G01M3/3272 ,  H05B6/6408

摘要： A pressure-measuring vessel system for microwave assisted chemical processes is disclosed. The vessel system includes a pressure resistant vessel that is otherwise transparent to microwave radiation, a pressure-resistant closure for the mouth of the vessel, with portions of the closure including a pressure resistant synthetic membrane, a pressure transducer external to the vessel, and a tube extending from the transducer, through the membrane and into the vessel for permitting the pressure inside the vessel to be applied against the transducer while the closure and membrane otherwise maintain the pressure resistant characteristics of the vessel.

摘要翻译： 公开了一种用于微波辅助化学工艺的压力测量容器系统。 容器系统包括对微波辐射透明的耐压容器，用于容器口部的耐压封闭件，封闭件的一部分包括耐压合成膜，容器外部的压力传感器和 管从换能器延伸通过膜并进入容器，以允许容器内的压力施加在换能器上，同时封闭件和膜另外保持容器的耐压特性。

公开(公告)号：US20050045625A1

公开(公告)日：2005-03-03

申请号：US10605021

申请日：2003-09-02

申请人： Michael Collins ,  Wyatt Hargett ,  Edward King ,  Joseph Lambert ,  James Thomas

发明人： Michael Collins ,  Wyatt Hargett ,  Edward King ,  Joseph Lambert ,  James Thomas

IPC分类号： B01J3/00 ,  B01J4/02 ,  B01J19/12 ,  H05B6/80 ,  H05B6/64

CPC分类号： B01J19/126 ,  B01J4/02 ,  B01J2219/00164 ,  B01J2219/1218 ,  B01J2219/1239 ,  B01J2219/126 ,  H05B6/6408 ,  H05B6/806

摘要： A controlled-flow microwave instrument is disclosed for chemical synthesis using heterogeneous or highly viscous starting materials. The instrument includes a microwave source for generating electromagnetic radiation in the microwave frequencies, a microwave cavity in wave communication with the source for exposing compositions placed therein to microwave radiation, a microwave-transparent pressure resistant reaction vessel in the cavity, a source reservoir for starting materials and related compositions, a pump in communication with the source reservoir for pumping heterogeneous or highly viscous materials from the source reservoir to the reaction vessel, and a pressure-resistant valve between the pump and the reaction vessel for isolating the reaction vessel from the pump and the source reservoir during application of microwave energy to compositions in the vessel and from any resulting high pressure generated therein.

摘要翻译： 公开了一种用于使用异质或高粘度起始材料的化学合成的受控流微波仪器。 该仪器包括用于产生微波频率的电磁辐射的微波源，与源相接触的用于将放置在其中的组合物暴露于微波辐射的微波空腔中的微波空腔，腔中的微波透明耐压反应容器，用于起动的源储存器 材料和相关组合物，与源储存器连通的泵，用于将来自源储器的非均相或高粘度物质泵送到反应容器;以及泵和反应容器之间的耐压阀，用于将反应容器与泵 以及在将微波能量应用于容器中的组合物和由其中产生的任何所得到的高压时的源储存器。

公开(公告)号：US20070295594A1

公开(公告)日：2007-12-27

申请号：US11853110

申请日：2007-09-11

申请人： Wyatt Hargett ,  James Thomas

发明人： Wyatt Hargett ,  James Thomas

IPC分类号： B01J19/08

CPC分类号： H05B6/806 ,  B01J19/0046 ,  B01J19/126 ,  B01J2219/00162 ,  B01J2219/002 ,  B01J2219/00231 ,  B01J2219/0024 ,  B01J2219/00283 ,  B01J2219/0034 ,  B01J2219/00353 ,  B01J2219/00477 ,  B01J2219/00495 ,  B01J2219/00601 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/0869 ,  B01J2219/1215 ,  B01J2219/1239 ,  B01J2219/1275 ,  C40B60/14 ,  H05B6/6408

摘要： A method and associated instrument are disclosed for increasing the sequential rate at which a series of microwave assisted chemical reactions that potentially generate high pressure can be carried out. The method includes the steps of opening a pressure-resistant valve on a microwave-transparent pressure-resistant vessel to define a unpressurized pathway through the valve into the vessel, inserting a tube through the pathway in the valve and into the vessel, transferring at least one composition into the vessel through the tube, removing the tube from the vessel and from the pathway in the valve, closing the valve to seal the vessel against pressure release, and exposing the vessel and its contents to microwave radiation. The instrument includes a source of microwave radiation, a cavity in microwave communication with the source, an attenuator that forms at least a portion of the cavity, a pressure-resistant microwave-transparent reaction vessel having portions in the cavity and portions in the attenuator, a pressure-resistant valve on the mouth of the vessel, a reciprocating tube for passing through the valve and into the vessel when the valve is open, and means for mechanically inserting and retracting the tube through the valve and into the vessel when the vessel is in the cavity and the attenuator.

摘要翻译： 公开了一种方法和相关联的仪器，用于增加可以进行可能产生高压的一系列微波辅助化学反应的顺序速率。 该方法包括以下步骤：在微波透明耐压容器上打开耐压阀，以限定通过阀进入容器的非加压路径，将管穿过阀中的通道插入容器中，至少转移 一个组合物通过管子进入容器，从容器中取出管子并从阀门中的通道中取出管子，关闭阀门以密封容器以抵抗压力释放，并将容器及其内容物暴露于微波辐射。 仪器包括微波辐射源，与源极微波连通的空腔，形成空腔的至少一部分的衰减器，具有空腔中的部分和衰减器中的部分的耐压微波透明反应容器， 容器口上的耐压阀，当阀打开时通过阀门并进入容器的往复式管，以及用于当管是容器时通过阀机械地插入和收回管并进入容器的装置 在腔和衰减器中。

公开(公告)号：US20060038118A1

公开(公告)日：2006-02-23

申请号：US10923243

申请日：2004-08-20

申请人： Michael Collins ,  Wyatt Hargett ,  James Thomas ,  Michael Collins ,  E. Barnhardt

发明人： Michael Collins ,  Wyatt Hargett ,  James Thomas ,  Michael Collins ,  E. Barnhardt

IPC分类号： H05H3/02

CPC分类号： H05B6/806 ,  F26B3/347 ,  F26B5/048 ,  F26B9/003 ,  F26B21/14 ,  G01N1/44 ,  G01N30/06 ,  G01N2030/567

摘要： An instrument and associated method are disclosed for preparing samples for column chromatography. The method includes the steps of applying microwave energy to a sample composition containing at least one solvent to encourage a chemical reaction and generate desired products, thereafter mixing an absorbent media with the sample to absorb the solvent, the media being compatible with liquid chromatography that will separate the expected products, being chemically inert to the expected products, and being added in an amount sufficient to provide a substantially dry mixture of the media and the sample, but less than an amount that overly broadens the resolution of the sample during liquid chromatography, thereafter applying microwave energy to the dry mixture of the media and the sample to thereby encourage the solvent to evaporate under the influence of the microwave energy, and thereafter adding the dry mixture of the media and the remaining sample to a liquid chromatography column and separating the components of the remaining sample for identification and purification purposes.

摘要翻译： 公开了用于制备用于柱色谱法的样品的仪器和相关方法。 该方法包括以下步骤：向含有至少一种溶剂的样品组合物施加微波能量以促进化学反应并产生所需产物，然后将吸收介质与样品混合以吸收溶剂，该介质与液相色谱相容， 将期望的产品分离，对预期产品具有化学惰性，并且以足以提供介质和样品的基本上干燥的混合物的量加入，但小于在液相色谱法过度扩大样品分辨率的量， 然后将微波能量施加到介质和样品的干燥混合物中，从而促使溶剂在微波能量的影响下蒸发，然后将介质和剩余样品的干混合物加入液相色谱柱中， 剩余样品的组分用于鉴定和纯化目的。

公开(公告)号：US20050121307A1

公开(公告)日：2005-06-09

申请号：US10707376

申请日：2003-12-09

申请人： Wyatt Hargett ,  James Thomas

发明人： Wyatt Hargett ,  James Thomas

IPC分类号： B01J19/00 ,  B01J19/12 ,  C40B60/14 ,  H05B6/64 ,  H05B6/80 ,  B01J19/08

CPC分类号： H05B6/806 ,  B01J19/0046 ,  B01J19/126 ,  B01J2219/00162 ,  B01J2219/002 ,  B01J2219/00231 ,  B01J2219/0024 ,  B01J2219/00283 ,  B01J2219/0034 ,  B01J2219/00353 ,  B01J2219/00477 ,  B01J2219/00495 ,  B01J2219/00601 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/0869 ,  B01J2219/1215 ,  B01J2219/1239 ,  B01J2219/1275 ,  C40B60/14 ,  H05B6/6408

摘要： A method and associated instrument are disclosed for increasing the sequential rate at which a series of microwave assisted chemical reactions that potentially generate high pressure can be carried out. The method includes the steps of opening a pressure-resistant valve on a microwave-transparent pressure-resistant vessel to define a unpressurized pathway through the valve into the vessel, inserting a tube through the pathway in the valve and into the vessel, transferring at least one composition into the vessel through the tube, removing the tube from the vessel and from the pathway in the valve, closing the valve to seal the vessel against pressure release, and exposing the vessel and its contents to microwave radiation. The instrument includes a source of microwave radiation, a cavity in microwave communication with the source, an attenuator that forms at least a portion of the cavity, a pressure-resistant microwave-transparent reaction vessel having portions in the cavity and portions in the attenuator, a pressure-resistant valve on the mouth of the vessel, a reciprocating tube for passing through the valve and into the vessel when the valve is open, and means for mechanically inserting and retracting the tube through the valve and into the vessel when the vessel is in the cavity and the attenuator.

摘要翻译： 公开了一种方法和相关联的仪器，用于增加可以进行可能产生高压的一系列微波辅助化学反应的顺序速率。 该方法包括以下步骤：在微波透明耐压容器上打开耐压阀，以限定通过阀进入容器的非加压路径，将管穿过阀中的通道插入容器中，至少转移 一个组合物通过管子进入容器，从容器中取出管子并从阀门中的通道中取出管子，关闭阀门以密封容器以抵抗压力释放，并将容器及其内容物暴露于微波辐射。 仪器包括微波辐射源，与源极微波连通的空腔，形成空腔的至少一部分的衰减器，具有空腔中的部分和衰减器中的部分的耐压微波透明反应容器， 容器口上的耐压阀，当阀打开时通过阀门并进入容器的往复式管，以及用于当管是容器时通过阀机械地插入和收回管并进入容器的装置 在腔和衰减器中。

公开(公告)号：US20080053989A1

公开(公告)日：2008-03-06

申请号：US11853102

申请日：2007-09-11

申请人： Wyatt Hargett ,  James Thomas

发明人： Wyatt Hargett ,  James Thomas

IPC分类号： H05B6/64

CPC分类号： H05B6/806 ,  B01J19/0046 ,  B01J19/126 ,  B01J2219/00162 ,  B01J2219/002 ,  B01J2219/00231 ,  B01J2219/0024 ,  B01J2219/00283 ,  B01J2219/0034 ,  B01J2219/00353 ,  B01J2219/00477 ,  B01J2219/00495 ,  B01J2219/00601 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/0869 ,  B01J2219/1215 ,  B01J2219/1239 ,  B01J2219/1275 ,  C40B60/14 ,  H05B6/6408

摘要： A method and associated instrument are disclosed for increasing the sequential rate at which a series of microwave assisted chemical reactions that potentially generate high pressure can be carried out. The method includes the steps of opening a pressure-resistant valve on a microwave-transparent pressure-resistant vessel to define a unpressurized pathway through the valve into the vessel, inserting a tube through the pathway in the valve and into the vessel, transferring at least one composition into the vessel through the tube, removing the tube from the vessel and from the pathway in the valve, closing the valve to seal the vessel against pressure release, and exposing the vessel and its contents to microwave radiation. The instrument includes a source of microwave radiation, a cavity in microwave communication with the source, an attenuator that forms at least a portion of the cavity, a pressure-resistant microwave-transparent reaction vessel having portions in the cavity and portions in the attenuator, a pressure-resistant valve on the mouth of the vessel, a reciprocating tube for passing through the valve and into the vessel when the valve is open, and means for mechanically inserting and retracting the tube through the valve and into the vessel when the vessel is in the cavity and the attenuator.

摘要翻译： 公开了一种方法和相关联的仪器，用于增加可以进行可能产生高压的一系列微波辅助化学反应的顺序速率。 该方法包括以下步骤：在微波透明耐压容器上打开耐压阀，以限定通过阀进入容器的非加压路径，将管穿过阀中的通道插入容器中，至少转移 一个组合物通过管子进入容器，从容器中取出管子并从阀门中的通道中取出管子，关闭阀门以密封容器以抵抗压力释放，并将容器及其内容物暴露于微波辐射。 仪器包括微波辐射源，与源极微波连通的空腔，形成空腔的至少一部分的衰减器，具有空腔中的部分和衰减器中的部分的耐压微波透明反应容器， 容器口上的耐压阀，当阀打开时通过阀门并进入容器的往复式管，以及用于当管是容器时通过阀机械地插入和收回管并进入容器的装置 在腔和衰减器中。

公开(公告)号：US20060039838A1

公开(公告)日：2006-02-23

申请号：US10923302

申请日：2004-08-20

申请人： E. Barnhardt ,  Wyatt Hargett ,  James Thomas

发明人： E. Barnhardt ,  Wyatt Hargett ,  James Thomas

IPC分类号： B01J19/00

CPC分类号： H05B6/806 ,  B01J19/0013 ,  B01J19/126 ,  B01J2219/00094 ,  B01J2219/1209 ,  B01J2219/1239 ,  B01J2219/1269

摘要： An instrument and associated method are disclosed for performing microwave assisted organic chemical synthesis at low temperatures. The instrument includes a reaction vessel formed of a microwave transparent material that defines an interior reaction chamber for carrying out microwave assisted reactions in the chamber, a cooling jacket immediately surrounding the reaction vessel for cooling the vessel and the vessel contents during the application of microwave energy to contents in the vessel when a microwave transparent media used as a fluid coolant is present in the jacket. The instrument includes means for supplying a microwave transparent fluid coolant to the cooling jacket and means for venting the fluid coolant from the cooling jacket, a fluid coolant reservoir in communication with the cooling jacket, and a pump in communication with the reservoir and the cooling jacket for circulating fluid coolant from the fluid coolant reservoir through the cooling jacket and around the reaction vessel.

摘要翻译： 公开了用于在低温下进行微波辅助有机化学合成的仪器和相关方法。 仪器包括由微波透明材料形成的反应容器，该反应容器限定用于在室中进行微波辅助反应的内部反应室，在施加微波能量期间立即围绕反应容器冷却容器和容器内容物的冷却套管 当夹套中存在用作流体冷却剂的微波透明介质时，容器内的物质。 仪器包括用于向冷却套管供应微波透明流体冷却剂的装置和用于从冷却套管排出流体冷却剂的装置，与冷却套管连通的流体冷却剂储存器以及与储存器和冷却套管连通的泵 用于使来自流体冷却剂储存器的流体冷却剂通过冷却套管和反应容器周围循环。

公开(公告)号：US20060006170A1

公开(公告)日：2006-01-12

申请号：US11228767

申请日：2005-09-16

申请人： Michael Collins ,  Wyatt Hargett ,  Edward King ,  Joseph Lambert ,  James Thomas

发明人： Michael Collins ,  Wyatt Hargett ,  Edward King ,  Joseph Lambert ,  James Thomas

IPC分类号： H05B6/64

CPC分类号： B01J19/126 ,  B01J4/02 ,  B01J2219/00164 ,  B01J2219/1218 ,  B01J2219/1239 ,  B01J2219/126 ,  H05B6/6408 ,  H05B6/806

摘要： A controlled-flow microwave instrument for chemical synthesis that includes heterogeneous or highly viscous materials includes a fluid reservoir for supplying or receiving fluids, a fluid pump in fluid communication with the reservoir for pumping fluids to or from the reservoir, a microwave transparent reaction vessel in fluid communication with the pump for supplying or receiving fluids to or from the pump and the reservoir, a pressure sensor in fluid communication with the reservoir and the vessel for measuring the pressure of fluids in the instrument at the sensor, and a processor in signal communication with the pressure sensor and the pump for controlling the pump and the flow of fluids in the instrument based at least in part on the pressure measured at the sensor.

公开(公告)号：US20050230381A1

公开(公告)日：2005-10-20

申请号：US11151500

申请日：2005-06-13

申请人： Michael Collins ,  Wyatt Hargett ,  Edward King ,  Joseph Lambert ,  James Thomas

发明人： Michael Collins ,  Wyatt Hargett ,  Edward King ,  Joseph Lambert ,  James Thomas

IPC分类号： B01J3/00 ,  B01J4/02 ,  B01J19/12 ,  H05B6/80 ,  H05B6/64

CPC分类号： B01J19/126 ,  B01J4/02 ,  B01J2219/00164 ,  B01J2219/1218 ,  B01J2219/1239 ,  B01J2219/126 ,  H05B6/6408 ,  H05B6/806

摘要： A controlled-flow microwave instrument for chemical synthesis using heterogeneous or highly viscous starting materials includes a microwave source for generating electromagnetic radiation in the microwave frequencies, a microwave cavity in wave communication with the source for exposing compositions placed therein to microwave radiation, a microwave-transparent pressure resistant reaction vessel in the cavity, a source reservoir for starting materials and related compositions, a pump in communication with the source reservoir for pumping heterogeneous or highly viscous materials from the source reservoir to the reaction vessel, and a pressure-resistant valve between the pump and the reaction vessel for isolating the reaction vessel from the pump and the source reservoir during application of microwave energy to compositions in the vessel and from any resulting high pressures generated therein.

摘要翻译： 用于使用异质或高粘度起始材料的化学合成的受控流微波仪器包括用于产生微波频率的电磁辐射的微波源，与所述源波浪连通的微波腔，用于将放置在其中的组合物暴露于微波辐射中; 在空腔中的透明耐压反应容器，用于起始材料和相关组合物的源储存器，与源储存器连通的泵，用于将来自源储器的非均质或高粘度物质泵送到反应容器，以及在源储存器之间的耐压阀， 泵和反应容器，用于在将微波能量应用于容器中的组合物和从其中产生的任何所得到的高压时将反应容器与泵和源储存器隔离。