IMMUNOGENIC APOPTOSIS INDUCING COMPOSITIONS AND METHODS OF USE THEREOF
    4.
    发明申请
    IMMUNOGENIC APOPTOSIS INDUCING COMPOSITIONS AND METHODS OF USE THEREOF 审中-公开
    免疫组织化学诱导组合物及其使用方法

    公开(公告)号:US20130273113A1

    公开(公告)日:2013-10-17

    申请号:US13836617

    申请日:2013-03-15

    IPC分类号: A61K39/39

    摘要: The present invention provides methods and compositions for the stimulation of immune responses. In particular, the present invention provides nanoemulsion compositions and methods of using the same for the induction of immune responses (e.g., immunologic cell death/apoptosis (e.g., for the induction of innate and/or adaptive immune responses)). Compositions and methods of the invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., for infectious disease, cancer, autoimmunity, and/or tissue injury (e.g., via alteration of host immune responses))) and research applications.

    摘要翻译: 本发明提供了用于刺激免疫应答的方法和组合物。 特别地,本发明提供纳米乳剂组合物及其使用于诱导免疫应答的方法(例如,免疫细胞死亡/凋亡(例如,用于诱导先天和/或适应性免疫应答))。 本发明的组合物和方法尤其可用于临床(例如治疗和预防性药物(例如用于感染性疾病,癌症,自身免疫和/或组织损伤(例如通过改变宿主免疫应答)))和 研究应用。

    DENDRIMER COMPOSITIONS AND METHODS OF SYNTHESIS
    7.
    发明申请
    DENDRIMER COMPOSITIONS AND METHODS OF SYNTHESIS 有权
    DENDRIMER组合物和合成方法

    公开(公告)号:US20120259098A1

    公开(公告)日:2012-10-11

    申请号:US13502004

    申请日:2010-10-07

    摘要: The present invention relates to novel dendrimer compounds and methods of synthesizing the same. In particular, the present invention is directed to novel polyamidoamine (PAMAM) dendrimers, novel dendrimer branching units, methods for synthesizing such novel PAMAM dendrimers and functionalized dendrimers, as well as systems and methods utilizing the dendrimers (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease diagnosis and/or therapy, etc.))).

    摘要翻译: 本发明涉及新颖的树枝状大分子化合物及其合成方法。 特别地,本发明涉及新颖的聚酰胺胺(PAMAM)树枝状大分子,新型树枝状大分子支化单元,合成这种新型PAMAM树枝状聚合物和官能化树枝状聚合物的方法,以及利用树枝状大分子的系统和方法(例如,在诊断和/或治疗 设置(例如,用于递送治疗剂,成像和/或靶向剂(例如,在疾病诊断和/或治疗等中))。

    ANALYTICAL SYSTEM WITH PHOTONIC CRYSTAL SENSOR
    9.
    发明申请
    ANALYTICAL SYSTEM WITH PHOTONIC CRYSTAL SENSOR 有权
    光电晶体传感器分析系统

    公开(公告)号:US20100065732A1

    公开(公告)日:2010-03-18

    申请号:US12616457

    申请日:2009-11-11

    IPC分类号: H01J49/26 G01N21/55 G01N33/53

    摘要: A system for determining whether interaction occurs between a trial substance and a target substance. The system includes a photonic crystal sensor having a photonic crystal structure and a defect member disposed adjacent the photonic crystal structure. The defect member defines an operative surface able to receive the target substance and the trial substance. The system further includes a light source that inputs a light signal to the photonic crystal structure and the defect member. The light signal is internally reflected, and a resultant output signal is outputted. The output signal relates to whether the trial substance interacts with the target substance at the operative surface. Furthermore, the system includes an identity detector that identifies the trial substance that interacts with the target substance.

    摘要翻译: 用于确定试验物质与目标物质之间是否发生相互作用的系统。 该系统包括具有光子晶体结构的光子晶体传感器和邻近光子晶体结构设置的缺陷部件。 缺陷构件限定能够接收目标物质和试验物质的手术表面。 该系统还包括将光信号输入到光子晶体结构和缺陷部件的光源。 光信号被内部反射,并输出合成的输出信号。 输出信号涉及试验物质在操作表面与目标物质的相互作用。 此外,该系统包括识别与目标物质相互作用的试验物质的身份检测器。