专利检索 ap:("Xianqi Kong" OR "Nigel Levens" OR "Serge Lamothe" OR "Ahmed Aman") AND inv:"Xianqi Kong" 第 1 页

1.

发明申请
ORGANIC NUTRIENT SALTS, METHODS OF PREPARATION AND USES 审中-公开
标题翻译：有机营养盐，制备方法和用途

公开(公告)号：US20110313040A1

公开(公告)日：2011-12-22

申请号：US13129243

申请日：2009-11-13

申请人： Xianqi Kong , Nigel Levens , Serge Lamothe , Ahmed Aman

发明人： Xianqi Kong , Nigel Levens , Serge Lamothe , Ahmed Aman

IPC分类号： A61K31/205 , C07C303/44 , A23L1/304 , A61P25/00 , A61P25/28 , A23L1/237 , C07C309/14 , C07C303/02

CPC分类号： C07C309/14 , A23L33/10 , A23L33/175 , A23V2002/00 , A23V2200/322 , A23V2250/0644 , A23V2250/0612

摘要： The invention relates to organic nutrient salts, to compositions containing the same, to their preparation as well as their use. Preferred compositions include nutraceutical compositions and dietary supplements for use in neuroprotection and for improving or protecting cognitive and memory function.

摘要翻译： 本发明涉及有机营养盐，含有它们的组合物，其制备方法及其用途。优选的组合物包括用于神经保护和用于改善或保护认知和记忆功能的营养组合物和膳食补充剂。

2.

发明申请
METHODS, COMPOUNDS, AND COMPOSITIONS FOR DELIVERING 1,3-PROPANEDISULFONIC ACID 有权
标题翻译：用于递送1,3-丙二酸的方法，化合物和组合物

公开(公告)号：US20120208850A1

公开(公告)日：2012-08-16

申请号：US13389606

申请日：2010-08-06

申请人： Xianqi Kong , Nigel Levens , Abderrahim Bouzide , Stephane Ciblat , Richard Frenette , Johanne Renaud

发明人： Xianqi Kong , Nigel Levens , Abderrahim Bouzide , Stephane Ciblat , Richard Frenette , Johanne Renaud

IPC分类号： A61K31/255 , C07C309/69 , A61K31/27 , A61K31/265 , C07D327/00 , A61K31/385 , C07D311/00 , A61K31/366 , C07D401/12 , A61K31/444 , A61P13/12 , A61P3/06 , A61P3/00 , A61P3/10 , A61P5/50 , A61P1/18 , C07C309/65

CPC分类号： C07C309/65 , A61K31/255 , A61K31/351 , A61K31/365 , A61K31/366 , C07C309/05 , C07C311/06 , C07C311/51 , C07C2601/04 , C07C2601/14 , C07D213/64 , C07D213/65 , C07D231/12 , C07D307/00 , C07D307/33 , C07D307/58 , C07D307/77 , C07D309/22 , C07D319/06 , C07D327/00 , C07D327/10 , C07F9/091 , C07F9/4006 , C07F9/4043

摘要： The invention relates to methods, compounds, and compositions for delivering 1,3-propanedisulfonic acid (1,3PDS) in a subject, preferably a human subject. The invention encompasses compounds that will yield or generate 1,3PDS, either in vitro or in vivo. The invention also relates to sulfonate ester prodrugs of 1,3PDS as well as Gemini dimmers and oligomers of 1,3PDS for the prevention or treatment of associated diseases and conditions.

摘要翻译： 本发明涉及在受试者，优选人受试者中递送1,3-丙二磺酸（1,3PDS）的方法，化合物和组合物。本发明包括在体外或体内产生或产生1,3PDS的化合物。本发明还涉及1,3PDS的磺酸酯前药以及用于预防或治疗相关疾病和病症的1,3PDS的双子座二聚体和寡聚体。

3.

发明授权
Methods, compounds, and compositions for delivering 1,3-propanedisulfonic acid 有权
标题翻译：用于递送1,3-丙二磺酸的方法，化合物和组合物

公开(公告)号：US09051248B2

公开(公告)日：2015-06-09

申请号：US13389606

申请日：2010-08-06

申请人： Xianqi Kong , Nigel Levens , Abderrahim Bouzide , Stephane Ciblat , Richard Frenette , Johanne Renaud

发明人： Xianqi Kong , Nigel Levens , Abderrahim Bouzide , Stephane Ciblat , Richard Frenette , Johanne Renaud

IPC分类号： C07C309/65 , C07D319/06 , A61K31/366 , A61K31/365 , A61K31/255 , C07D309/22 , A61K31/351 , C07C309/05 , C07C311/06 , C07C311/51 , C07D213/64 , C07D213/65 , C07D231/12 , C07D307/33 , C07D307/58 , C07D307/77 , C07D327/10 , C07F9/09 , C07F9/40

CPC分类号： C07C309/65 , A61K31/255 , A61K31/351 , A61K31/365 , A61K31/366 , C07C309/05 , C07C311/06 , C07C311/51 , C07C2601/04 , C07C2601/14 , C07D213/64 , C07D213/65 , C07D231/12 , C07D307/00 , C07D307/33 , C07D307/58 , C07D307/77 , C07D309/22 , C07D319/06 , C07D327/00 , C07D327/10 , C07F9/091 , C07F9/4006 , C07F9/4043

摘要： The invention relates to methods, compounds, and compositions for delivering 1,3-propanedisulfonic acid (1,3PDS) in a subject, preferably a human subject. The invention encompasses compounds that will yield or generate 1,3PDS, either in vitro or in vivo. The invention also relates to sulfonate ester prodrugs of 1,3PDS as well as Gemini dimmers and oligomers of 1,3PDS for the prevention or treatment of associated diseases and conditions.

摘要翻译： 本发明涉及在受试者，优选人受试者中递送1,3-丙二磺酸（1,3PDS）的方法，化合物和组合物。本发明包括在体外或体内产生或产生1,3PDS的化合物。本发明还涉及1,3PDS的磺酸酯前药以及用于预防或治疗相关疾病和病症的1,3PDS的双子座二聚体和寡聚体。

4.

发明申请
METHODS AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES 失效
标题翻译：用于治疗淀粉样相关疾病的方法和组合物

公开(公告)号：US20100113591A1

公开(公告)日：2010-05-06

申请号：US12613412

申请日：2009-11-05

申请人： Xianqi Kong , David Migneault , Isabelle Valade , Xinfu Wu , Francine Gervais

发明人： Xianqi Kong , David Migneault , Isabelle Valade , Xinfu Wu , Francine Gervais

IPC分类号： A61K31/27 , C07C309/04 , A61K31/16 , C07C53/00 , A61K31/215 , C07C309/65 , A61K31/165 , A61P25/28 , A61P9/00 , A61P17/00

CPC分类号： C07C309/14 , C07C307/02 , C07C309/13 , C07C309/15 , C07C309/19 , C07C309/23 , C07C309/46 , C07C309/69 , C07C311/32 , C07C311/46 , C07C323/25 , C07C323/58 , C07C335/12 , C07C335/32 , C07C381/02 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07C2603/74 , C07D209/08 , C07D209/14 , C07D209/18 , C07D209/20 , C07D209/44 , C07D209/48 , C07D211/46 , C07D211/64 , C07D211/70 , C07D217/04 , C07D217/10 , C07D235/28 , C07D257/04 , C07D295/084 , C07D295/088 , C07D317/50 , C07D401/04 , C07D403/04 , C07D403/06 , C07D453/02 , C07D471/04 , C07F9/1651 , C07F9/2458 , C07K5/0812

摘要： Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.

摘要翻译： 描述了治疗或预防淀粉样蛋白相关疾病的方法，化合物，药物组合物和试剂盒。

5.

发明申请
Phosphono-carboxylate compounds for treating amyloidosis 审中-公开
标题翻译：用于治疗淀粉样变性的膦酰羧酸盐化合物

公开(公告)号：US20080004244A1

公开(公告)日：2008-01-03

申请号：US11888989

申请日：2007-08-02

申请人： Walter Szarek , Xianqi Kong , Gregory Thatcher , Boris Gorine

发明人： Walter Szarek , Xianqi Kong , Gregory Thatcher , Boris Gorine

IPC分类号： A61K31/662 , A61P25/00

CPC分类号： A61K31/662 , A61K31/66 , A61K31/675

摘要： Therapeutic compounds and methods for modulating amyloid deposition in a subject, whatever its clinical setting, are described. Amyloid deposition is modulated by the administration to a subject of an effective amount of a therapeutic compound comprising a phosphonate group and a carboxylate group, a congener thereof, or a pharmaceutically acceptable salt or ester thereof. In preferred embodiments, an interaction between an amyloidogenic protein and a basement membrane constituent is modulated.

摘要翻译： 描述了治疗化合物和调节受试者淀粉样蛋白沉积的方法，无论其临床情况如何。通过施用有效量的包含膦酸酯基和羧酸酯基的治疗化合物，其同类物或其药学上可接受的盐或酯来调节淀粉样蛋白沉积。在优选的实施方案中，调节淀粉样蛋白形成蛋白质与基底膜成分之间的相互作用。

6.

发明授权
Pharmaceutical drug candidates and methods for preparation thereof 有权
标题翻译：药物候选药物及其制备方法

公开(公告)号：US07253306B2

公开(公告)日：2007-08-07

申请号：US10871543

申请日：2004-06-18

申请人： Xianqi Kong , David Migneault , Xinfu Wu

发明人： Xianqi Kong , David Migneault , Xinfu Wu

IPC分类号： C07C309/00

CPC分类号： A61K31/185

摘要： The present invention is directed to methods of preparation of sulfonate derivatized compounds, e.g., 3-amino-1-propanesulfonic acid and 1,3-propanedisulfonic acid disodium salt with increased purity, with reduced potential for toxic by-products, and that are pharmaceutically useful, e.g., for the treatment of amyloidosis.

摘要翻译： 本发明涉及制备磺酸衍生化合物的方法，例如3-氨基-1-丙磺酸和1,3-丙烷二磺酸二钠盐，其纯度提高，有毒副产物的潜力降低，且为药学上有用的，例如用于治疗淀粉样变性。