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    CRT responder model using EGM information
    1.
    发明授权
    CRT responder model using EGM information 有权
    CRT响应者模型使用EGM信息

    公开(公告)号：US08265738B1

    公开(公告)日：2012-09-11

    申请号：US13020574

    申请日：2011-02-03

    申请人： Xiaoyi Min ,  Josh Reiss

    发明人： Xiaoyi Min ,  Josh Reiss

    IPC分类号： A61B5/0452

    CPC分类号： A61N1/3627 ,  A61B5/0452 ,  A61B5/091 ,  A61N1/3684 ,  A61N1/37247 ,  A61N1/3962

    摘要： An exemplary method includes detecting a QRS complex using cutaneous electrodes, during the QRS complex, detecting an R-wave of a ventricle using an intracardiac electrode, determining if the R-wave occurred during a first, predetermined percentage of the QRS complex width and, based at least in part on the determining, deciding whether a patient is likely to respond to cardiac resynchronization therapy. Such a method may set the predetermined percentage to approximately 50%. An exemplary model includes a parameter for a percentage for the timing of an EGM R-wave with respect to the total width of an ECG QRS complex. Various other exemplary methods, devices, systems, etc. are also disclosed.

    摘要翻译： 一种示例性方法包括在QRS复合物期间使用皮肤电极检测QRS复合物，使用心内电极检测心室的R波，确定在QRS复合宽度的第一，预定百分比期间是否发生R波， 至少部分地基于确定，决定患者是否可能对心脏再同步治疗做出反应。 这种方法可以将预定百分比设置为大约50％。 示例性模型包括关于EGM R波的定时相对于ECG QRS复合体的总宽度的百分比的参数。 还公开了各种其它示例性方法，装置，系统等。

    CRT responder model using EGM information
    3.
    发明授权
    CRT responder model using EGM information 有权
    CRT响应者模型使用EGM信息

    公开(公告)号：US07912544B1

    公开(公告)日：2011-03-22

    申请号：US11738426

    申请日：2007-04-20

    申请人： Xiaoyi Min ,  Josh Reiss

    发明人： Xiaoyi Min ,  Josh Reiss

    IPC分类号： A61N1/18

    CPC分类号： A61N1/3627 ,  A61B5/0452 ,  A61B5/091 ,  A61N1/3684 ,  A61N1/37247 ,  A61N1/3962

    摘要： An exemplary method includes detecting a QRS complex using cutaneous electrodes, during the QRS complex, detecting an R-wave of a ventricle using an intracardiac electrode, determining if the R-wave occurred during a first, predetermined percentage of the QRS complex width and, based at least in part on the determining, deciding whether a patient is likely to respond to cardiac resynchronization therapy. Such a method may set the predetermined percentage to approximately 50%. An exemplary model includes a parameter for a percentage for the timing of an EGM R-wave with respect to the total width of an ECG QRS complex. Various other exemplary methods, devices, systems, etc. are also disclosed.

    摘要翻译： 一种示例性方法包括在QRS复合物期间使用皮肤电极检测QRS复合物，使用心内电极检测心室的R波，确定在QRS复合宽度的第一，预定百分比期间是否发生R波， 至少部分地基于确定，决定患者是否可能对心脏再同步治疗做出反应。 这种方法可以将预定百分比设置为大约50％。 示例性模型包括关于EGM R波的定时相对于ECG QRS复合体的总宽度的百分比的参数。 还公开了各种其它示例性方法，装置，系统等。

    System and method for efficiently distinguishing among cardiac ischemia, hypoglycemia and hyperglycemia using an implantable medical device and an external system
    4.
    发明授权
    System and method for efficiently distinguishing among cardiac ischemia, hypoglycemia and hyperglycemia using an implantable medical device and an external system 有权
    使用可植入医疗器械和外部系统有效区分心脏缺血，低血糖和高血糖的系统和方法

    公开(公告)号：US07756572B1

    公开(公告)日：2010-07-13

    申请号：US11740175

    申请日：2007-04-25

    申请人： Mohssen Fard ,  Xiaoyi Min ,  Peter Boileau ,  Jong Gill ,  Bing Zhu ,  Jay Snell ,  Laleh Jalali ,  Josh Reiss ,  Gene Bornzin

    发明人： Mohssen Fard ,  Xiaoyi Min ,  Peter Boileau ,  Jong Gill ,  Bing Zhu ,  Jay Snell ,  Laleh Jalali ,  Josh Reiss ,  Gene Bornzin

    IPC分类号： A61B5/0468

    CPC分类号： A61N1/36585 ,  A61B5/0452 ,  A61B5/0468 ,  A61B5/14532 ,  A61N1/36557

    摘要： Techniques are described for efficiently detecting and distinguishing among cardiac ischemia, hypoglycemia or hyperglycemia based on intracardiac electrogram (IEGM) signals. In one example, a preliminary indication of an episode of cardiac ischemia is detected based on shifts in ST segment elevation within the IEGM. In response, the implanted device then records additional IEGM data for transmission to an external system. The external system analyzes the additional IEGM data to confirm the detection of cardiac ischemia using a more sophisticated analysis procedure exploiting additional detection parameters. In particular, the external system uses detection parameters capable of distinguishing hypoglycemia, hyperglycemia and hyperkalemia from cardiac ischemia, such as QTmax and QTend intervals. Alternatively, the more sophisticated analysis procedure may be performed by the device itself, if it is so equipped. Other examples described herein pertain instead to the detection of atrial fibrillation.

    摘要翻译： 描述了基于心脏电图（IEGM）信号来有效检测和区分心脏缺血，低血糖或高血糖的技术。 在一个实例中，基于IEGM内的ST段抬高的移动来检测心脏缺血发作的初步指示。 作为响应，植入的装置然后记录附加的IEGM数据以传输到外部系统。 外部系统使用更复杂的分析程序利用额外的检测参数来分析额外的IEGM数据，以确认心脏缺血的检测。 特别地，外部系统使用能够区分低血糖，高血糖和高血钾从心脏缺血的检测参数，例如QTmax和QTend间期。 或者，如果装置如此装备，则可以由装置本身执行更复杂的分析程序。 本文描述的其它实例代替心房颤动的检测。

    Systems and methods for assessing heart failure and controlling cardiac resynchronization therapy using hybrid impedance measurement configurations
    6.
    发明授权
    Systems and methods for assessing heart failure and controlling cardiac resynchronization therapy using hybrid impedance measurement configurations 有权
    用于评估心力衰竭并使用混合阻抗测量配置控制心脏再同步治疗的系统和方法

    公开(公告)号：US08750981B2

    公开(公告)日：2014-06-10

    申请号：US13217554

    申请日：2011-08-25

    申请人： Gene A. Bornzin ,  Xiaoyi Min ,  Laurence S. Sloman ,  Steve Koh

    发明人： Gene A. Bornzin ,  Xiaoyi Min ,  Laurence S. Sloman ,  Steve Koh

    IPC分类号： A61B5/05 ,  A61B5/053 ,  A61N1/36 ,  A61N1/368 ,  A61B5/0205

    CPC分类号： A61B5/053 ,  A61B5/0205 ,  A61B5/0538 ,  A61B5/686 ,  A61N1/36185 ,  A61N1/3627 ,  A61N1/3686

    摘要： Techniques are provided for use with an implantable medical device for detecting and assessing heart failure and for controlling cardiac resynchronization therapy (CRT) based on impedance signals obtained using hybrid impedance configurations. The hybrid configurations exploit right atrial (RA)-based impedance measurement vectors and/or left ventricular (LV)-based impedance measurement vectors. In one example, current is injected between the device case and a ring electrode in the right ventricle (RV) or RA. RA-based impedance values are measured along vectors between the device case and an RA electrode. LV-based impedance values are measured along vectors between the device case and one or more electrodes of the LV. Heart failure and other cardiac conditions are detected and tracked using the measured impedance values. CRT delay parameters are also optimized based impedance. In this manner, multiple hybrid impedance measurement configurations are exploited whereby different vectors are used to inject current and measure impedance.

    摘要翻译： 提供技术用于可植入医疗装置，用于基于使用混合阻抗配置获得的阻抗信号来检测和评估心力衰竭并用于控制心脏再同步治疗（CRT）。 混合配置利用基于右心房（RA）的阻抗测量向量和/或左心室（LV））的阻抗测量向量。 在一个示例中，电流注入到装置壳体和右心室（RV）或RA中的环形电极之间。 基于RA的阻抗值是沿器件壳体和RA电极之间的矢量测量的。 基于LV的阻抗值在器件壳体和LV的一个或多个电极之间的矢量上测量。 使用测量的阻抗值检测和跟踪心力衰竭和其他心脏状况。 CRT延迟参数也是基于阻抗的优化。 以这种方式，利用多个混合阻抗测量配置，由此使用不同的矢量来注入电流并测量阻抗。

    Implantable lead assembly having a plurality of inductors
    8.
    发明授权
    Implantable lead assembly having a plurality of inductors 有权
    具有多个电感器的可植入引线组件

    公开(公告)号：US08600520B2

    公开(公告)日：2013-12-03

    申请号：US13449897

    申请日：2012-04-18

    申请人： Phong D. Doan ,  Xiaoyi Min ,  Virote Indravudh

    发明人： Phong D. Doan ,  Xiaoyi Min ,  Virote Indravudh

    IPC分类号： A61N1/00

    CPC分类号： A61N1/05 ,  A61N1/086 ,  A61N1/3605 ,  A61N1/362 ,  H01F5/02 ,  H01F2005/025 ,  Y10T29/49002 ,  Y10T29/49071

    摘要： In accordance with an embodiment, an implantable lead assembly is provided comprised of an elongated body including a distal end, a proximal end having a header connector portion for coupling the elongated body with an implantable medical device, and an intermediate segment located between the distal and proximal ends. An intermediate electrode is disposed at the intermediate segment along the elongated body. A conductor is disposed in the elongated body and electrically coupled with the header connector portion and the intermediate electrode. The conductor wound within the intermediate segment to form first and second inductive coils that are axially separated from each other by an inter-coil gap, wherein the first and second inductive coils have different self-resonant frequencies.

    摘要翻译： 根据一个实施例，提供一种可植入引线组件，其包括细长主体，其包括远端，近端具有用于将细长主体与可植入医疗装置连接的插头连接器部分，以及位于远端和 近端 中间电极沿着细长体设置在中间部分。 导体设置在细长主体中并与插头连接器部分和中间电极电耦合。 导体缠绕在中间段内以形成通过线圈间隙彼此轴向分离的第一和第二感应线圈，其中第一和第二感应线圈具有不同的自谐振频率。

    SYSTEMS AND METHODS FOR DETERMINING INDUCTANCE AND CAPACITANCE VALUES FOR USE WITH LC FILTERS WITHIN IMPLANTABLE MEDICAL DEVICE LEADS TO REDUCE LEAD HEATING DURING MRI
    10.
    发明申请
    SYSTEMS AND METHODS FOR DETERMINING INDUCTANCE AND CAPACITANCE VALUES FOR USE WITH LC FILTERS WITHIN IMPLANTABLE MEDICAL DEVICE LEADS TO REDUCE LEAD HEATING DURING MRI 有权
    用于确定电导率和电容值的系统和方法，用于在可植入医疗器械中使用LC过滤器，在MRI期间减少引线加热

    公开(公告)号：US20130123876A1

    公开(公告)日：2013-05-16

    申请号：US11955268

    申请日：2007-12-12

    申请人： Xiaoyi Min

    发明人： Xiaoyi Min

    IPC分类号： A61N1/375

    CPC分类号： A61N1/056 ,  A61N1/086 ,  A61N1/3718 ,  G01R33/3685

    摘要： Techniques are provided for configuring filters for reducing heating within pacing/sensing leads of a pacemaker or implantable cardioverter-defibrillator that might occur due to induced currents during a magnetic resonance imaging (MRI) procedure or in the presence of other sources of strong radio frequency (RF) fields. In particular, techniques are provided for selecting inductors and capacitors for use in LC filters while taking into account the tolerances of the component devices, as well as the target impedance of the components and the particular RF frequencies to be filtered.

    摘要翻译： 提供了用于配置用于减少起搏器或植入式心律转复除颤器的起搏/感测引线内的加热的技术，其可能由于在磁共振成像（MRI）程序期间的感应电流或其它强射频源的存在而发生 RF）字段。 特别地，提供了用于选择用于LC滤波器的电感器和电容器的技术，同时考虑到组件装置的公差以及组件的目标阻抗和要滤波的特定RF频率。