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公开(公告)号：US08873961B2
公开(公告)日：2014-10-28
申请号：US13205879
申请日：2011-08-09
申请人： Ying Luo , Xuezhe Zheng , Guoliang Li , Kannan Raj , Ashok V. Krishnamoorthy
发明人： Ying Luo , Xuezhe Zheng , Guoliang Li , Kannan Raj , Ashok V. Krishnamoorthy
CPC分类号： H04J14/02 , G02B6/29308 , G02B6/2931
摘要： An optical de-multiplexer (de-MUX) that includes an optical device that images and diffracts an optical signal using a reflective geometry is described, where a free spectral range (FSR) of the optical device associated with a given diffraction order abuts FSRs associated with adjacent diffraction orders. Moreover, the channel spacings within diffraction orders and between adjacent diffraction orders are equal to the predefined channel spacing associated with the optical signal. As a consequence, the optical device has a comb-filter output spectrum, which reduces a tuning energy of the optical device by eliminating spectral gaps between diffraction orders of the optical device.
摘要翻译： 描述了包括使用反射几何形状对光信号进行成像和衍射的光学装置的光学去多路复用器（de-MUX），其中与给定衍射级相关联的光学装置的自由光谱范围（FSR）与相关联的FSR相邻 具有相邻衍射级。 此外，衍射级之间和相邻衍射级之间的沟道间隔等于与光信号相关联的预定的沟道间隔。 因此，光学器件具有梳状滤波器输出光谱，其通过消除光学器件的衍射级之间的光谱间隙来减少光学器件的调谐能量。
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公开(公告)号：US20130195446A1
公开(公告)日：2013-08-01
申请号：US13361873
申请日：2012-01-30
申请人： Xuezhe Zheng , Ying Luo , Guoliang Li , Ashok V. Krishnamoorthy
发明人： Xuezhe Zheng , Ying Luo , Guoliang Li , Ashok V. Krishnamoorthy
CPC分类号： H04J14/02 , G02B6/29308 , H04B10/506 , H04B10/572
摘要： An optical source uses feedback to maintain a substantially fixed spacing between adjacent wavelengths in a set of wavelengths in a wavelength comb output by the optical source. In particular, a set of light sources in the optical source provide optical signals having the set of wavelengths. Moreover, the optical signals are output at diffraction angles of an optical device in the optical source (such as an echelle grating), and optical detectors in the optical source determine optical metrics associated with the optical signals. Furthermore, control logic in the optical source provides control signals to the set of light sources based on the determined optical metrics.
摘要翻译： 光源使用反馈来维持由光源输出的波长梳输出中的一组波长中的相邻波长之间的基本上固定的间隔。 特别地，光源中的一组光源提供具有该组波长的光信号。 此外，光信号以光源（例如梯形光栅）中的光学装置的衍射角输出，并且光源中的光学检测器确定与光信号相关联的光学度量。 此外，光源中的控制逻辑基于所确定的光学量度向光源组提供控制信号。
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公开(公告)号：US20130039661A1
公开(公告)日：2013-02-14
申请号：US13205879
申请日：2011-08-09
申请人： Ying Luo , Xuezhe Zheng , Guoliang Li , Kannan Raj , Ashok V. Krishnamoorthy
发明人： Ying Luo , Xuezhe Zheng , Guoliang Li , Kannan Raj , Ashok V. Krishnamoorthy
CPC分类号： H04J14/02 , G02B6/29308 , G02B6/2931
摘要： An optical de-multiplexer (de-MUX) that includes an optical device that images and diffracts an optical signal using a reflective geometry is described, where a free spectral range (FSR) of the optical device associated with a given diffraction order abuts FSRs associated with adjacent diffraction orders. Moreover, the channel spacings within diffraction orders and between adjacent diffraction orders are equal to the predefined channel spacing associated with the optical signal. As a consequence, the optical device has a comb-filter output spectrum, which reduces a tuning energy of the optical device by eliminating spectral gaps between diffraction orders of the optical device.
摘要翻译： 描述了包括使用反射几何形状对光信号进行成像和衍射的光学装置的光学去多路复用器（de-MUX），其中与给定衍射级相关联的光学装置的自由光谱范围（FSR）与相关联的FSR相邻 具有相邻衍射级。 此外，衍射级之间和相邻衍射级之间的沟道间隔等于与光信号相关联的预定通道间隔。 因此，光学器件具有梳状滤波器输出光谱，其通过消除光学器件的衍射级之间的光谱间隙来减少光学器件的调谐能量。
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公开(公告)号：US20130016744A1
公开(公告)日：2013-01-17
申请号：US13182243
申请日：2011-07-13
申请人： Guoliang Li , Xuezhe Zheng , Ashok V. Krishnamoorthy , Ying Luo
发明人： Guoliang Li , Xuezhe Zheng , Ashok V. Krishnamoorthy , Ying Luo
IPC分类号： H01S3/10
CPC分类号： H01S5/1039 , B82Y20/00 , H01S5/026 , H01S5/0261 , H01S5/1025 , H01S5/1032 , H01S5/142 , H01S5/3412 , H01S2301/163
摘要： A laser source includes an optical cavity having a length exceeding a first predefined distance (such as 6 mm), where a wavelength spacing between optical modes associated with the optical cavity is less than a second predefined distance (such as 100 pm). Moreover, a gain medium in the laser source amplifies the optical signal. Furthermore, tunable-grating waveguides in the laser source, which are optically coupled to ends of the optical cavity, reflect a portion of the optical signal back into the optical cavity, and at least one of the tunable-grating waveguides transmits a remainder of the optical signal out of the optical cavity.
摘要翻译： 激光源包括具有超过第一预定距离（例如6mm）的长度的光学腔，其中与光腔相关联的光学模式之间的波长间隔小于第二预定距离（例如100μm）。 此外，激光源中的增益介质放大光信号。 此外，光学耦合到光学腔的端部的激光源中的可调光栅波导将光信号的一部分反射回到光腔中，并且至少一个可调谐光栅波导将剩余的 光信号出光腔。
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公开(公告)号：US08737846B2
公开(公告)日：2014-05-27
申请号：US13361873
申请日：2012-01-30
申请人： Xuezhe Zheng , Ying Luo , Guoliang Li , Ashok V. Krishnamoorthy
发明人： Xuezhe Zheng , Ying Luo , Guoliang Li , Ashok V. Krishnamoorthy
CPC分类号： H04J14/02 , G02B6/29308 , H04B10/506 , H04B10/572
摘要： An optical source uses feedback to maintain a substantially fixed spacing between adjacent wavelengths in a set of wavelengths in a wavelength comb output by the optical source. In particular, a set of light sources in the optical source provide optical signals having the set of wavelengths. Moreover, the optical signals are output at diffraction angles of an optical device in the optical source (such as an echelle grating), and optical detectors in the optical source determine optical metrics associated with the optical signals. Furthermore, control logic in the optical source provides control signals to the set of light sources based on the determined optical metrics.
摘要翻译： 光源使用反馈来维持由光源输出的波长梳输出中的一组波长中的相邻波长之间的基本上固定的间隔。 特别地，光源中的一组光源提供具有该组波长的光信号。 此外，光信号以光源（例如梯形光栅）中的光学装置的衍射角输出，并且光源中的光学检测器确定与光信号相关联的光学度量。 此外，光源中的控制逻辑基于所确定的光学量度向光源组提供控制信号。
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公开(公告)号：US08543354B2
公开(公告)日：2013-09-24
申请号：US12914969
申请日：2010-10-28
申请人： Ying Luo , Rebecca K. Gottlieb , Meena Ramachandran , Chia-Hung Chiu , Nandita Dangui-Patel , Michael Kremliovsky , Jefferson Rose
发明人： Ying Luo , Rebecca K. Gottlieb , Meena Ramachandran , Chia-Hung Chiu , Nandita Dangui-Patel , Michael Kremliovsky , Jefferson Rose
IPC分类号： G06F17/18
CPC分类号： G01N33/66 , A61B5/0017 , A61B5/002 , A61B5/14532 , A61B5/1486 , A61B5/1495 , A61B5/6849 , A61B5/7207
摘要： Disclosed are methods, apparatuses, etc. for glucose sensor signal stability analysis. In certain example embodiments, a series of samples of at least one sensor signal that is responsive to a blood glucose level of a patient may be obtained. Based at least partly on the series of samples, at least one metric may be determined to assess an underlying trend of a change in responsiveness of the at least one sensor signal to the blood glucose level of the patient over time. A reliability of the at least one sensor signal to respond to the blood glucose level of the patient may be assessed based at least partly on the at least one metric assessing an underlying trend. Other example embodiments are disclosed herein.
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公开(公告)号：US20110320166A1
公开(公告)日：2011-12-29
申请号：US12914969
申请日：2010-10-28
申请人： Ying Luo , Rebecca K. Gottlieb , Meena Ramachandran , Chia-Hung Chiu , Nandita Dangui-Patel , Michael Kremliovsky , Jefferson Rose
发明人： Ying Luo , Rebecca K. Gottlieb , Meena Ramachandran , Chia-Hung Chiu , Nandita Dangui-Patel , Michael Kremliovsky , Jefferson Rose
CPC分类号： G01N33/66 , A61B5/0017 , A61B5/002 , A61B5/14532 , A61B5/1486 , A61B5/1495 , A61B5/6849 , A61B5/7207
摘要： Disclosed are methods, apparatuses, etc. for glucose sensor signal stability analysis. In certain example embodiments, a series of samples of at least one sensor signal that is responsive to a blood glucose level of a patient may be obtained. Based at least partly on the series of samples, at least one metric may be determined to assess an underlying trend of a change in responsiveness of the at least one sensor signal to the blood glucose level of the patient over time. A reliability of the at least one sensor signal to respond to the blood glucose level of the patient may be assessed based at least partly on the at least one metric assessing an underlying trend. Other example embodiments are disclosed herein.
摘要翻译： 公开了用于葡萄糖传感器信号稳定性分析的方法，装置等。 在某些示例性实施例中，可以获得响应于患者的血糖水平的至少一个传感器信号的一系列样本。 至少部分地基于一系列样本，可以确定至少一个度量以评估至少一个传感器信号对患者随着时间的血糖水平的响应性的变化的潜在趋势。 可以至少部分地基于评估潜在趋势的至少一个度量来评估至少一个传感器信号对患者的血糖水平的响应的可靠性。 本文公开了其它示例性实施例。
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公开(公告)号：US20080108098A1
公开(公告)日：2008-05-08
申请号：US11867504
申请日：2007-10-04
IPC分类号： C12Q1/48
CPC分类号： C12N9/1205 , C12Q1/485 , G01N33/5041 , G01N2500/02
摘要： The present invention provides compositions and methods for modulating cell proliferation, survival, morphology, and migration. Nucleic acids encoding proteins, and proteins so encoded which are capable of modulating proliferation, survival, morphology, and migration in mammalian cells are provided. Compositions and methods for the treatment of disorders related to cell proliferation, survival, morphology and migration are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions are methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating proliferation, survival, morphology, and migration in mammalian cells.
摘要翻译： 本发明提供调节细胞增殖，存活，形态和迁移的组合物和方法。 提供了编码蛋白质的核酸和如此编码的能够调节哺乳动物细胞中增殖，存活，形态和迁移的蛋白质。 还提供了用于治疗与细胞增殖，存活，形态和迁移相关的病症的组合物和方法。 还提供了预防和预防这种疾病的方法。 还提供组合物是用于诊断和预测这些疾病的方法。 进一步提供了用于鉴定能够调节哺乳动物细胞中增殖，存活，形态和迁移的生物活性剂的测定。
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公开(公告)号：US20070275419A1
公开(公告)日：2007-11-29
申请号：US10527257
申请日：2002-09-09
IPC分类号： G01N33/574 , C07H21/04 , C12P21/06 , C07K14/82 , C07K16/30
CPC分类号： C07K14/47
摘要： The invention provides a new tumor tag, RL5 protein, the polynucleotide encoding RL5 protein, and the method of producing RL5 protein by recombinant technology. The invention also discloses the use of RL5 protein and the polynucleotides encoding RL5 protein, e.g., in diagnosing and treating tumor, as well as the pharmaceutical composition containing RL5 protein or the antibody against it.
摘要翻译： 本发明提供新的肿瘤标签RL5蛋白，编码RL5蛋白的多核苷酸，以及通过重组技术产生RL5蛋白的方法。 本发明还公开了使用RL5蛋白和编码RL5蛋白的多核苷酸，例如诊断和治疗肿瘤，以及含有RL5蛋白或抗体的抗体的药物组合物。
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10.发明申请Cell cycle proteins associated with rad9, compositions and methods of use 有权与rad9相关的细胞周期蛋白，组合物和使用方法公开(公告)号：US20070238134A9
公开(公告)日：2007-10-11
申请号：US10220375
申请日：2001-03-02
CPC分类号： C07K14/4738 , C12N9/16 , C12Y301/03016 , G01N33/5011 , G01N33/6872 , G01N2333/4739 , G01N2333/8114
摘要： The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.
摘要翻译： 本发明涉及对细胞周期有影响或与细胞周期有关的新型多肽，核酸和相关分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本发明还提供了鉴定介导细胞周期生物活性的新型组合物的方法，以及这些组合物在疾病诊断和治疗中的应用。
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