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    ELECTROCHEMICAL DETECTION CELL FOR LIQUID CHROMATOGRAPHY SYSTEM
    2.
    发明申请
    ELECTROCHEMICAL DETECTION CELL FOR LIQUID CHROMATOGRAPHY SYSTEM 有权
    用于液相色谱系统的电化学检测细胞

    公开(公告)号：US20130091936A1

    公开(公告)日：2013-04-18

    申请号：US13689885

    申请日：2012-11-30

    申请人： Jun CHENG ,  Petr JANDIK ,  Christopher A. POHL

    发明人： Jun CHENG ,  Petr JANDIK ,  Christopher A. POHL

    IPC分类号： G01N27/30

    CPC分类号： G01N27/30 ,  G01N27/301 ,  G01N27/4166 ,  G01N30/64

    摘要： A detection cell for a chromatography system includes a cell body having an inlet, an outlet, and a counter electrode, a working electrode, a sample flow passageway extending between the inlet and the outlet and in fluid contact with the counter and working electrodes, and a palladium/noble metal reference electrode system. A method of using the detection cell is also described.

    摘要翻译： 用于色谱系统的检测电池包括具有入口，出口和对电极的电池体，工作电极，在入口和出口之间延伸并与计数器和工作电极流体接触的样品流动通道，以及 钯/贵金属参考电极系统。 还描述了使用检测单元的方法。

    CAPILLARY ION CHROMATOGRAPHY
    3.
    发明申请
    CAPILLARY ION CHROMATOGRAPHY 有权
    毛细管离子色谱

    公开(公告)号：US20130180922A1

    公开(公告)日：2013-07-18

    申请号：US13787296

    申请日：2013-03-06

    申请人： Yan LIU ,  Victor Manuel Berber BARRETO ,  Christopher A. POHL ,  Nebojsa AVDALOVIC

    发明人： Yan LIU ,  Victor Manuel Berber BARRETO ,  Christopher A. POHL ,  Nebojsa AVDALOVIC

    IPC分类号： B01D15/36

    CPC分类号： B01D15/363 ,  B01D15/361 ,  B01D15/367 ,  G01N30/96 ,  G01N2030/965

    摘要： An apparatus for capillary ion chromatography comprising a suppressor comprising flow-through ion exchange packing in a housing and capillary tubing formed of a permselective ion exchange membrane, and at least partially disposed in said ion exchange packing. Also, a recycle conduit for aqueous liquid from the detector to the packing. Further, the capillary tubing may have weakly acidic or weakly basic functional groups. Also, a method for using the apparatus.

    摘要翻译： 一种用于毛细管离子色谱的装置，其包括抑制器，该抑制器包括在壳体中的流通离子交换填料和由选择性选择性离子交换膜形成的毛细管，并且至少部分地设置在所述离子交换填料中。 另外，从检测器到包装的水性液体循环管道。 此外，毛细管可具有弱酸性或弱碱性官能团。 另外，使用该装置的方法。

    HIGH PRESSURE DEGAS ASSEMBLY FOR CHROMATOGRAPHY SYSTEM AND METHOD
    6.
    发明申请
    HIGH PRESSURE DEGAS ASSEMBLY FOR CHROMATOGRAPHY SYSTEM AND METHOD 审中-公开
    高压度组件用于色谱系统和方法

    公开(公告)号：US20130213225A1

    公开(公告)日：2013-08-22

    申请号：US13846420

    申请日：2013-03-18

    申请人： Yan LIU ,  Christopher A. POHL ,  Michael J. MCADAMS ,  Hamish SMALL ,  Zongqing LU ,  Milton LIU ,  Khosro MOSHFEGH

    发明人： Yan LIU ,  Christopher A. POHL ,  Michael J. MCADAMS ,  Hamish SMALL ,  Zongqing LU ,  Milton LIU ,  Khosro MOSHFEGH

    IPC分类号： B01D19/00

    CPC分类号： B01D19/0073 ,  B01D19/0031 ,  B01D19/0036 ,  G01N30/32 ,  G01N30/96 ,  G01N2030/146

    摘要： A degas assembly including a low pressure fluid channel for carrying a wash fluid at a first pressure, a pressurized channel for carrying eluent including a gas at a second pressure higher than the first pressure, and a degas separator defining a fluid barrier between the low pressure fluid channel and pressurized fluid channel, the separator configured to retain liquid in the pressurized fluid channel and allow gas to flow through the separator to the low pressure fluid channel. The pressurized fluid channel may extend along an outer periphery of the low pressure fluid channel. The eluent may be received from an eluent generator at a pressure of at least about 3300 psi, and in various embodiments up to about 5000 psi. A liquid chromatography system and method are also disclosed.

    摘要翻译： 一种脱气组件，包括用于在第一压力下承载洗涤流体的低压流体通道，用于承载包含在高于第一压力的第二压力的气体的洗脱液的加压通道，以及限定低压下的流体阻挡层的脱气分离器 流体通道和加压流体通道，分离器构造成将液体保持在加压流体通道中并允许气体通过分离器流动到低压流体通道。 加压流体通道可以沿着低压流体通道的外周延伸。 洗脱液可以在至少约3300psi的压力下从洗脱液发生器接收，并且在各种实施方案中可高达约5000psi。 还公开了液相色谱系统和方法。

    BUFFER KIT AND METHOD OF GENERATING A LINEAR pH GRADIENT
    7.
    发明申请
    BUFFER KIT AND METHOD OF GENERATING A LINEAR pH GRADIENT 有权
    缓冲袋和产生线性pH梯度的方法

    公开(公告)号：US20140179008A1

    公开(公告)日：2014-06-26

    申请号：US13724873

    申请日：2012-12-21

    申请人： Shanhua LIN ,  Christopher A. POHL

    发明人： Shanhua LIN ,  Christopher A. POHL

    IPC分类号： C09K15/30

    CPC分类号： C09K15/30 ,  B01D15/168 ,  B01D15/362 ,  G01N30/34 ,  Y10T436/10 ,  Y10T436/108331 ,  Y10T436/173845 ,  Y10T436/18

    摘要： A buffer kit includes a first eluent and second eluent. The first eluent solution includes at least four buffer salts where at least three of the four buffer salts are a monovalent buffer salt, have a net negative charge or a net neutral zwitterionic charge, and include a sulfonate group and an amine. The second eluent solution includes at least four buffer salts where at least three of the four buffer salts are a monovalent buffer salt, have a net negative charge or a net neutral zwitterionic charge, and include a sulfonate group and an amine. The first eluent solution has a first pH and the second eluent solution has a second pH where the first pH and second pH are different values. The buffer kit provides a linear pH gradient that forms an approximately straight line from at least the first pH to the second pH.

    摘要翻译： 缓冲试剂盒包括第一洗脱液和第二洗脱液。 第一洗脱溶液包括至少四种缓冲盐，其中四种缓冲盐中的至少三个是一价缓冲盐，具有净负电荷或净中性两性离子电荷，并且包括磺酸盐基和胺。 第二洗脱溶液包括至少四种缓冲盐，其中四种缓冲盐中的至少三个是单价缓冲盐，具有净负电荷或净中性两性离子电荷，并且包括磺酸盐基和胺。 第一洗脱溶液具有第一pH，第二洗脱液具有第二pH，其中第一pH和第二pH是不同的值。 缓冲试剂盒提供线性pH梯度，其从至少第一pH至第二pH形成近似的直线。

    SEPARATION OF GLYCANS BY MIXED-MODE LIQUID CHROMATOGRAPHY
    8.
    发明申请
    SEPARATION OF GLYCANS BY MIXED-MODE LIQUID CHROMATOGRAPHY 有权
    通过混合模式液相色谱法分离甘油

    公开(公告)号：US20140178912A1

    公开(公告)日：2014-06-26

    申请号：US13724178

    申请日：2012-12-21

    申请人： Xiaodong LIU ,  Udayanath AICH ,  Christopher A. POHL

    发明人： Xiaodong LIU ,  Udayanath AICH ,  Christopher A. POHL

    IPC分类号： C08B37/00 ,  B01J43/00 ,  B01J41/20

    CPC分类号： C08B37/0063 ,  B01D15/3847 ,  B01J20/286 ,  B01J20/3285 ,  B01J41/20 ,  B01J43/00 ,  B01J2220/54 ,  C07K1/165 ,  G01N30/482 ,  B01D15/363 ,  B01D15/305 ,  B01D15/325 ,  B01D15/362

    摘要： An exemplary multimodal chromatographic medium of the invention includes one or more strong anion exchange, weak anion exchange, strong cation exchange and/or weak cation exchange binding sites in combination with one or more reverse phase and/or hydrophilic interaction chromatography binding site. In an exemplary embodiment, the sites interact with one or more glycans in a mixture of glycans in a manner that allows separation of glycans in the mixture and analysis of the glycan mixture. The media are incorporated into devices and systems for chromatographic analysis. Also provided are methods of using the multimodal media of the invention to analyze glycans.

    摘要翻译： 本发明的示例性多峰色谱介质包含与一个或多个反相和/或亲水相互作用色谱结合位点结合的一个或多个强阴离子交换，弱阴离子交换，强阳离子交换和/或弱阳离子交换结合位点。 在一个示例性实施方案中，所述位点以聚糖混合物中的一种或多种聚糖与允许混合物中聚糖分离和聚糖混合物分析的方式相互作用。 将介质并入用于色谱分析的装置和系统中。 还提供了使用本发明的多峰介质来分析聚糖的方法。

    GLYCIDOL FUNCTIONALIZED ANION EXCHANGE STATIONARY PHASES
    9.
    发明申请
    GLYCIDOL FUNCTIONALIZED ANION EXCHANGE STATIONARY PHASES 有权
    甘氨酸官能化阴离子交换剂固定相

    公开(公告)号：US20140069870A1

    公开(公告)日：2014-03-13

    申请号：US13610495

    申请日：2012-09-11

    申请人： Christopher A. POHL

    发明人： Christopher A. POHL

    IPC分类号： B01J41/20 ,  B01D15/36

    CPC分类号： B01J41/20 ,  B01D15/363 ,  B01J20/288 ,  B01J20/3251 ,  B01J20/3289 ,  B01J41/09

    摘要： Treatment of anion exchange materials containing hydroxyl containing moieties in the beta position relative to the quaternary center in the hydroxide form with glycidol substantially alters the selectivity of the anion exchange material. Furthermore, sequential treatments of first a hydroxide containing solution to put the anion exchange material in the hydroxide form followed by treatment with glycidol in an alternating sequence progressively changes selectivity in a predictable manner allowing facile manipulation of selectivity. Unique to the selectivities achievable with this chemistry is the ability to reverse the elution order of sulfate and carbonate. With all other known systems, carbonate elutes ahead of sulfate and sometimes compromises the ability to quantitate sulfate. With glycidol treatment, carbonate can be moved after sulfate which eliminates interference issues for samples containing significantly more carbonate than sulfate. This modification is useful for columns operated with a hydroxide or carbonate eluent system.

    摘要翻译： 含有羟基的阴离子交换材料相对于具有缩水甘油的氢氧化物形式的季中心的β位置的处理基本上改变了阴离子交换材料的选择性。 此外，首先连续处理含氢氧化物溶液以将阴离子交换材料置于氢氧化物形式，然后以交替的顺序用缩水甘油处理，以可预测的方式逐渐改变选择性，从而容易地操纵选择性。 通过该化学可以实现的选择性独特的是反转硫酸盐和碳酸盐的洗脱顺序的能力。 使用所有其他已知的系统，碳酸盐在硫酸盐之前洗脱，有时会损害硫酸盐的定量能力。 通过缩水甘油处理，碳酸盐可以在硫酸盐之后移动，消除了含有比硫酸盐显着更多的碳酸盐的样品的干扰问题。 该修饰对于用氢氧化物或碳酸盐洗脱液系统操作的柱是有用的。