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公开(公告)号：US20120071524A1
公开(公告)日：2012-03-22
申请号：US13216927
申请日：2011-08-24
申请人： Yan Lu , Chien-Ming Li , Zhao Wang , Jianjun Chen , Wei Li , James T. DALTON , Duane D. Miller , Charles Duke , Sunjoo Ahn
发明人： Yan Lu , Chien-Ming Li , Zhao Wang , Jianjun Chen , Wei Li , James T. DALTON , Duane D. Miller , Charles Duke , Sunjoo Ahn
IPC分类号： A61K31/427 , C07D263/32 , C07D413/12 , C07D233/22 , C07D403/04 , A61P35/02 , A61K31/426 , A61K31/421 , A61K31/4178 , A61K31/4174 , A61P35/00 , C07D277/42 , C07D403/12
CPC分类号： A61K31/425 , A61K45/06 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/56 , C07D417/04 , A61K2300/00
摘要： The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma, metastatic melanoma, drug resistant melanoma, prostate cancer and drug resistant prostate cancer.
摘要翻译： 本发明涉及具有抗癌活性的新化合物，制备这些化合物的方法及其用于治疗癌症和药物抗性肿瘤的用途，例如， 黑素瘤，转移性黑素瘤，耐药性黑素瘤，前列腺癌和耐药前列腺癌。
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公开(公告)号：US08822513B2
公开(公告)日：2014-09-02
申请号：US13216927
申请日：2011-08-24
申请人： Yan Lu , Chien-Ming Li , Zhao Wang , Jianjun Chen , Wei Li , James T. Dalton , Duane D. Miller , Charles Duke , Sunjoo Ahn
发明人： Yan Lu , Chien-Ming Li , Zhao Wang , Jianjun Chen , Wei Li , James T. Dalton , Duane D. Miller , Charles Duke , Sunjoo Ahn
IPC分类号： A61K31/4178 , A61K31/422 , A61K31/427 , C07D403/12 , C07D413/12
CPC分类号： A61K31/425 , A61K45/06 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/56 , C07D417/04 , A61K2300/00
摘要： The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma, metastatic melanoma, drug resistant melanoma, prostate cancer and drug resistant prostate cancer.
摘要翻译： 本发明涉及具有抗癌活性的新化合物，制备这些化合物的方法及其用于治疗癌症和药物抗性肿瘤的用途，例如， 黑素瘤，转移性黑素瘤，耐药性黑素瘤，前列腺癌和耐药前列腺癌。
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公开(公告)号：US20110257196A1
公开(公告)日：2011-10-20
申请号：US12981233
申请日：2010-12-29
申请人： Yan Lu , Chien-Ming Li , Zhao Wang , Jianjun Chen , Wei Li , James T. Dalton , Duane D. Miller , Charles Duke , Sunjoo Ahn
发明人： Yan Lu , Chien-Ming Li , Zhao Wang , Jianjun Chen , Wei Li , James T. Dalton , Duane D. Miller , Charles Duke , Sunjoo Ahn
IPC分类号： A61K31/505 , A61K31/421 , C07D239/28 , C07D213/78 , A61K31/4418 , C07D307/68 , A61K31/341 , C07D277/56 , A61K31/426 , C07D333/38 , A61K31/381 , C07D211/10 , A61K31/451 , C07D261/18 , A61K31/42 , C07D231/14 , A61K31/415 , C07D233/90 , A61P35/00 , C07D263/34
CPC分类号： C07D233/64 , A61K31/4164 , A61K31/425 , A61K45/06 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/56 , C07D417/04 , A61K2300/00
摘要： The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma, metastatic melanoma, drug resistant melanoma, prostate cancer and drug resistant prostate cancer.
摘要翻译： 本发明涉及具有抗癌活性的新化合物，制备这些化合物的方法及其用于治疗癌症和药物抗性肿瘤的用途，例如， 黑素瘤，转移性黑素瘤，耐药性黑素瘤，前列腺癌和耐药前列腺癌。
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公开(公告)号：US09334242B2
公开(公告)日：2016-05-10
申请号：US12981233
申请日：2010-12-29
申请人： Yan Lu , Chien-Ming Li , Zhao Wang , Jianjun Chen , Wei Li , James T. Dalton , Duane D. Miller , Charles Duke , Sunjoo Ahn
发明人： Yan Lu , Chien-Ming Li , Zhao Wang , Jianjun Chen , Wei Li , James T. Dalton , Duane D. Miller , Charles Duke , Sunjoo Ahn
IPC分类号： C07D233/64 , A61K31/4164 , A61K31/425 , A61K45/06 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/56 , C07D417/04
CPC分类号： C07D233/64 , A61K31/4164 , A61K31/425 , A61K45/06 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/56 , C07D417/04 , A61K2300/00
摘要： The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma, metastatic melanoma, drug resistant melanoma, prostate cancer and drug resistant prostate cancer.
摘要翻译： 本发明涉及具有抗癌活性的新化合物，制备这些化合物的方法及其用于治疗癌症和药物抗性肿瘤的用途，例如， 黑素瘤，转移性黑素瘤，耐药性黑素瘤，前列腺癌和耐药前列腺癌。
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公开(公告)号：US20090326020A1
公开(公告)日：2009-12-31
申请号：US12485881
申请日：2009-06-16
申请人： Duane D. Miller , Wei Li , Zhao Wang , Yan Lu , Jianjun Chen , James T. Dalton , Chien-Ming Li
发明人： Duane D. Miller , Wei Li , Zhao Wang , Yan Lu , Jianjun Chen , James T. Dalton , Chien-Ming Li
IPC分类号： A61K31/425 , C12N5/02 , C07D263/34 , A61K31/421 , C07D233/22 , A61K31/415 , C07D277/00
CPC分类号： C07D403/04 , A61K31/421 , A61K31/426
摘要： Compounds according to formula (I) are disclosed where Q is S, N, or O; X is optional, and can be O═, S═, ═N—NH2, ═N—OH, or —OH; Y is optional and can be —N(H)—, O, or C1 to C20 hydrocarbon; and R1 and R2 are each independently substituted or unsubstituted single-, fused- or multiple-ring aryl or (hetero)cyclic ring systems. Methods of making these compounds, pharmaceutical compositions containing the compounds, and their use, particularly for treating or preventing cancer, are also disclosed.
摘要翻译： 公开了根据式（I）的化合物，其中Q是S，N或O; X是任选的，并且可以是O-，S-，-N-NH 2，-N-OH或-OH; Y是任选的，可以是-N（H） - ，O或C 1 -C 20烃; 且R 1和R 2各自独立地为取代或未取代的单，稠环或多环芳基或（杂）环系。 还公开了制备这些化合物的方法，含有这些化合物的药物组合物及其用途，特别是用于治疗或预防癌症的方法。
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公开(公告)号：US08592465B2
公开(公告)日：2013-11-26
申请号：US12485881
申请日：2009-06-16
申请人： Duane D. Miller , Wei Li , Zhao Wang , Yan Lu , Jianjun Chen , James T. Dalton , Chien-Ming Li
发明人： Duane D. Miller , Wei Li , Zhao Wang , Yan Lu , Jianjun Chen , James T. Dalton , Chien-Ming Li
IPC分类号： C07D277/04 , C07D277/24 , A61K31/426
CPC分类号： C07D403/04 , A61K31/421 , A61K31/426
摘要： Compounds according to formula (I) are disclosed where Q is S, N, or O; X is optional, and can be O═, S═, ═N—NH2, ═N—OH, or —OH; Y is optional and can be —N(H)—, O, or C1 to C20 hydrocarbon; and R1 and R2 are each independently substituted or unsubstituted single-, fused- or multiple-ring aryl or (hetero)cyclic ring systems. Methods of making these compounds, pharmaceutical compositions containing the compounds, and their use, particularly for treating or preventing cancer, are also disclosed.
摘要翻译： 公开了根据式（I）的化合物，其中Q是S，N或O; X是任选的，并且可以是O =，S =，= N-NH 2，= N-OH或-OH; Y是任选的，可以是-N（H） - ，O或C 1 -C 20烃; 且R 1和R 2各自独立地为取代或未取代的单，稠环或多环芳基或（杂）环系。 还公开了制备这些化合物的方法，含有这些化合物的药物组合物及其用途，特别是用于治疗或预防癌症的方法。
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公开(公告)号：US10155728B2
公开(公告)日：2018-12-18
申请号：US15858183
申请日：2017-12-29
申请人： Yan Lu , James T Dalton , Wei Li , Duane D Miller
发明人： Yan Lu , James T Dalton , Wei Li , Duane D Miller
IPC分类号： C07D401/02 , C07D401/10 , C07D401/14 , A61K31/437 , A61K31/4353 , C07D235/18 , A61K31/4184 , C07D403/04 , C07D417/12 , C07D471/04 , C07D277/24 , A61K31/426 , A61K45/06
摘要： The present invention relates to colchicine-binding site compounds having anti-cancer activity, compositions comprising the same, and their use for treating various forms of cancer.
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公开(公告)号：US20180118693A1
公开(公告)日：2018-05-03
申请号：US15858183
申请日：2017-12-29
申请人： Yan Lu , James T. Dalton , Wei Li , Duane D. Miller
发明人： Yan Lu , James T. Dalton , Wei Li , Duane D. Miller
IPC分类号： C07D235/18 , A61K31/437 , A61K45/06 , C07D277/24 , C07D471/04 , C07D417/12 , A61K31/4184 , C07D403/04 , A61K31/426
CPC分类号： C07D235/18 , A61K31/4184 , A61K31/426 , A61K31/437 , A61K45/06 , C07D277/24 , C07D403/04 , C07D417/12 , C07D471/04 , A61K2300/00
摘要： The present invention relates to colchicine-binding site compounds having anti-cancer activity, compositions comprising the same, and their use for treating various forms of cancer.
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9.发明申请Enzymatic Production or Chemical Synthesis and Uses for 5,7-Dienes and UVB Conversion Products Thereof 审中-公开酶制备或化学合成及其用于5,7-二烯和UVB转化产物公开(公告)号：US20120258938A1
公开(公告)日：2012-10-11
申请号：US13460375
申请日：2012-04-30
申请人： Andrej Slominski , Robert C. Tuckey , Edith Tang , Elaine Tieu , Minh Nguyen , Zorica Janjetovic , Jianjun Chen , Wei Li , Yan Lu , Duane D. Miller , Jordan K. Zjawiony , Arnold E. Postlethwaite
发明人： Andrej Slominski , Robert C. Tuckey , Edith Tang , Elaine Tieu , Minh Nguyen , Zorica Janjetovic , Jianjun Chen , Wei Li , Yan Lu , Duane D. Miller , Jordan K. Zjawiony , Arnold E. Postlethwaite
IPC分类号： C12P15/00 , A61K31/593 , A61K8/67 , A61P17/00 , A61P17/06 , A61P35/00 , A61P37/06 , A61P29/00 , A61P25/00 , A61P1/00 , A61P3/10 , A61P3/04 , A61P9/10 , A61Q19/00 , C12N5/07 , A61P19/06 , C07C401/00
摘要： Provided herein are steroidal compounds that are androsta-5,7-dienes or pregna-5,7-dienes and ultraviolet B (UVB) conversion products thereof and cholecalciferol derivatives hydroxylated at one or more of C1, C17, C20, C23, C24, C25, and C26 which includes pharmaceutical, cosmeceutical or nutraceutical compositions of the steroidal compounds as shown in Tables 1A, 2A and 3. Also provided is a method for producing hydroxylated metabolites of cholecalciferol via CYP11A1, CYP24, CYP27A1, or CYP27B1 enzyme systems where the hydroxylase has an activity to hydroxylate position C1 or C20 or other position of the sidechain of a secosteroid or its 5,7-dieneal precursor and the hydroxylated metabolites so produced. Methods are provided for inhibiting proliferation of either a normally or abnormally proliferating cell, for modifying immune activity, or for treating a condition associated with the proliferating or quiescent cell or immune cells by contacting the cell with or administering any of the compounds described herein.
摘要翻译： 本文提供的是甾族-5,7-二烯或前 - 5,7-二烯的甾族化合物和其紫外线B（UVB）转化产物和在C1，C17，C20，C23，C24， C25和C26，其包括如表1A，2A和3所示的甾体化合物的药物，药妆或营养组合物。还提供了通过CYP11A1，CYP24，CYP27A1或CYP27B1酶系统生产胆钙化甾醇的羟化代谢物的方法，其中 羟化酶具有羟基化位置C1或C20或类固醇或其5,7-二醛前体的侧链的其它位置和如此生成的羟基化代谢物的活性。 提供了通过使细胞与本文所述的任何化合物接触或施用任何本文所述的化合物来抑制正常或异常增殖细胞增殖，改善免疫活性或用于治疗与增殖或静止细胞或免疫细胞相关的病症的方法。
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10.发明申请THIAZOLIDINONE AMIDES, THIAZOLIDINE CARBOXYLIC ACID AMIDES, AND SERINE AMIDES, INCLUDING POLYAMINE CONJUGATES THEREOF, AS SELECTIVE ANTI-CANCER AGENTS 审中-公开噻唑烷酮酰胺，噻唑烷羧酸和氨基酸，包括其中的聚氨酯结合物，作为选择性抗癌剂公开(公告)号：US20080255213A1
公开(公告)日：2008-10-16
申请号：US12102575
申请日：2008-04-14
申请人： Duane D. Miller , James T. Dalton , Wei Li , Lu Yan
发明人： Duane D. Miller , James T. Dalton , Wei Li , Lu Yan
IPC分类号： A61K31/426 , C07D277/04 , C12N5/00 , A61P35/00
CPC分类号： C07D277/06 , C07D277/12 , C07D417/04 , C12N5/0693 , C12N2501/06
摘要： Substituted thiazolidinone carboxylic acid amides and substituted thiazolidine carboxylic acid amides having a structure where the various substituent groups are as defined in the specification. Methods of making these compounds, pharmaceutical compositions containing the compounds, and their use, particularly for treating or preventing cancer, are also disclosed.
摘要翻译： 取代的噻唑烷酮羧酸酰胺和具有各种取代基如说明书中所定义的结构的取代的噻唑烷羧酸酰胺。 还公开了制备这些化合物的方法，含有这些化合物的药物组合物及其用途，特别是用于治疗或预防癌症的方法。
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