Abstract:
The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma, metastatic melanoma, drug resistant melanoma, prostate cancer and drug resistant prostate cancer.
Abstract:
The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma, metastatic melanoma, drug resistant melanoma, prostate cancer and drug resistant prostate cancer.
Abstract:
Data representative of print shop performance is acquired and analyzed for maximizing the job flow rate through the print shop. The data acquisition comprises characterizing the shop, characterizing the job flow through the shop, analyzing a current state, and assessing possible future states for maximizing the job flow. The data acquisition, analysis and adjustment of shop operations is effected in real time.
Abstract:
Prenylated stilbene compounds and the use of such compounds in the treatment of diseases and medical disorders, for example cancer, skin ageing, inflammation, bacterial or fungal infection and immunosuppression.
Abstract:
The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma, metastatic melanoma, drug resistant melanoma, prostate cancer and drug resistant prostate cancer.
Abstract:
Indole derivatives and analogous compounds and pharmaceutical compositions comprising the same are provided. Also provided are methods of using these compounds to inhibit tubulin polymerization in a cell associated with a proliferative disease or to treat cancer, metastatic cancer, resistant cancer or multidrug resistant cancer, including inter-alia: prostate cancer, breast cancer, melanoma, colon cancer and bladder cancer.
Abstract:
A business method for defining, controlling, and optimizing a flow of value down a workflow pipeline includes creating a phase-gate workflow pipeline for one or more projects in which completion of one or more predetermined activities of each project advances the project to a succeeding phase in the pipeline. Each of the activities for each project in the pipeline is mapped to a value metric that is a function of a risk discount factor using an option valuation technique. The projects and/or portfolio of projects are then analyzed to determine the flow of value down the pipeline and managed based on analysis of this flow of value.
Abstract:
Use of a compound of formula (I), wherein Ar is an aromatic ring system comprising one or more optionally substituted phenyl rings optionally linked to or fused with one or more other optionally substituted phenyl rings or one or more 5 or 6-membered, optionally substituted heterocyclic rings wherein the heteroatom is oxygen; and wherein the ring system comprises 1-4 phenyl rings and wherein Ar can be linked to another Ar via a group X wherein the Ar is independently selected; where X is optionally substituted C.sub.1-20 alkylene, C.sub.2-20 alkenylene or C.sub.2-20 alkynylene; R is hydrogen; C.sub.1-20 alkenyl, C.sub.2-20 alkynyl, C.sub.2-20 alkanoyl, C.sub.2-20 alkynoyl, each of which can be optionally substituted; R.sub.1 is independently selected and is hydrogen; optionally substituted C.sub.1-12 alkyl, C.sub.2-12 alkenyl, C.sub.2-12 alkynyl; --COOR'--NR'R', halogen, --OR', --COR', --CONR'R', .dbd.O, --SR', --SO.sub.3 R', --SO.sub.2 NR'R', --SOR', --SO.sub.2 R', --NO.sub.2, --CN, glycoside, silyl; where R' is independently hyrogen; alkyl, alkenyl or akynyl each optionally substituted; and where two groups R.sub.1 can be joined; wherein the optional substituents are one or more independently selected from C.sub.1-10 alkyl, C.sub.2-10 alkenyl, C.sub.2-10 alkynyl; --COOR"--NR"R", halogen, OR", --COR", --CONR"R", --SR", .dbd.O, --SO.sub.3 R", --SO.sub.2 NR"R", --SOR", --SO.sub.2 ", --NO.sub.2, --CN; wherein R" is independently hydrogen, alkyl, alkenyl, or alkynyl; n=1, 2 or 3; m=1, 2, 3 or 4; or a pharmaceutically acceptable derivative thereof in the manufacture of a medicament for inhibiting the action of Ca.sup.2+ -ATPase enzymes. Certain compounds of formula (I) and 8-lavandulyl flavone pharmaceutical formulations are new.
Abstract:
Indole derivatives and analog compounds and pharmaceutical compositions comprising the same are provided. Also provided are methods of using these compounds to inhibit tubulin polymerization in a cell associated with a proliferative disease or to treat a cancer.
Abstract:
A convertible burner for gas-fueled cigarette pocket lighters for use with flint and wheel ignition, the burner including a burner body having a central gas fuel passageway and an air inlet channel in fluid communication with the central passageway and may have a plurality of integrally formed passageways around the periphery of the burner body. An air control structure in the form of a collar is movable to a first position with respect to the burner body to close the air inlet channel and form a post-mix burner for flint and wheel ignition, and to a second position with respect to the burner body to admit air via the air inlet channel to form a pre-mix burner after ignition. The relative movement can be longitudinal or peripheral, and the peripheral movement can be circumferential. In one embodiment, the collar surrounds and is immediately adjacent to the air inlet channel.