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公开(公告)号：US20080199437A1
公开(公告)日：2008-08-21
申请号：US10552485
申请日：2005-07-22
申请人： Yoshimasa Sakamoto , Yuichi Ono , Toshio Imai , Yasuko Nakagawa
发明人： Yoshimasa Sakamoto , Yuichi Ono , Toshio Imai , Yasuko Nakagawa
CPC分类号： C12N5/0623 , A61K35/30 , C07K16/286 , C12Q1/6881 , C12Q1/6883 , C12Q2600/158 , G01N33/5023 , G01N33/56966 , G01N33/6896 , G01N2500/00 , G01N2800/2835
摘要： The present invention relates to polynucleotide probes and antibodies for detecting Lrp4/Corin dopaminergic neuron progenitor cell markers, which enable the efficient separation of dopaminergic neuron progenitor cells; and methods for selecting the progenitor cells by the use thereof.
摘要翻译： 本发明涉及用于检测Lrp4 / Corin多巴胺能神经元祖细胞标记物的多核苷酸探针和抗体，其能够有效分离多巴胺能神经元祖细胞; 以及通过其使用来选择祖细胞的方法。
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公开(公告)号：US08932592B2
公开(公告)日：2015-01-13
申请号：US13504742
申请日：2010-10-28
IPC分类号： A61K39/395 , C07K16/24 , C12N15/13 , C12N5/10 , C12P21/02
CPC分类号： C07K16/24 , C07K2317/24 , C07K2317/34 , C07K2317/76 , Y10S514/894
摘要： The present invention features compositions and methods related to humanized antibodies and FKN-binding fragments thereof that bind fractalkine.
摘要翻译： 本发明的特征在于与人源化抗体相关的组合物和方法，其结合分子链的FKN结合片段。
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公开(公告)号：US20140193421A1
公开(公告)日：2014-07-10
申请号：US14240090
申请日：2012-08-30
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C07K2319/55
摘要： An object of the present invention is to provide a monoclonal antibody binding to human XCR1, wherein the antibody binds to linear or discontinuous epitopes which comprise at least three amino acids selected from the group consisting of the 8th, 11th, 12th, 13th, 14th, 16th, 17th, 22nd, 23rd, 176th, and 177th amino acids in the amino acid sequence of SEQ ID NO: 91.
摘要翻译： 本发明的目的是提供与人XCR1结合的单克隆抗体，其中所述抗体结合至包含至少三个氨基酸的线性或不连续表位，所述氨基酸选自第8,11,12,13,13和14， 16位，17位，22位，23位，第176位和第177位氨基酸。
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公开(公告)号：US20120213799A1
公开(公告)日：2012-08-23
申请号：US13504742
申请日：2010-10-28
IPC分类号： A61K39/395 , C12N15/13 , A61P29/00 , A61P1/04 , A61P19/02 , C12N1/00 , A61P1/16 , A61P25/00 , C12N15/63 , C12N5/10 , C12P21/02 , C07K16/24 , A61P37/00
CPC分类号： C07K16/24 , C07K2317/24 , C07K2317/34 , C07K2317/76 , Y10S514/894
摘要： The present invention features compositions and methods related to humanized antibodies and FKN-binding fragments thereof that bind fractalkine.
摘要翻译： 本发明的特征在于与人源化抗体相关的组合物和方法，其结合分子链的FKN结合片段。
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公开(公告)号：US20140045215A1
公开(公告)日：2014-02-13
申请号：US13924433
申请日：2013-06-21
申请人： Toshio Imai , Brad Kline , Tetsu Kawano , Luigi Grasso , Yoshimasa Sakamoto , Jared Spidel , Miyuki Nishimura , Kenzo Muramoto , Tatsuo Horizoe
发明人： Toshio Imai , Brad Kline , Tetsu Kawano , Luigi Grasso , Yoshimasa Sakamoto , Jared Spidel , Miyuki Nishimura , Kenzo Muramoto , Tatsuo Horizoe
IPC分类号： C07K16/24
CPC分类号： C07K16/24 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C07K2317/92 , G01N33/6863 , G01N2333/521
摘要： The present invention relates to novel humanized, chimeric and murine antibodies that have binding specificity for the human CC chemokine ligand 20 (CCL20). The present invention further relates to heavy chains and light chains of said antibodies. The invention also relates to isolated nucleic acids, recombinant vectors and host cells that comprise a sequence which encodes a heavy chain and/or a light chain of said antibodies, and to a method of preparing said antibodies. The anti-CCL20 antibodies of the invention can be used in therapeutic applications to treat, for example, inflammatory and autoimmune disorders and cancer.
摘要翻译： 本发明涉及对人CC趋化因子配体20（CCL20）具有结合特异性的新型人源化，嵌合和鼠抗体。 本发明还涉及所述抗体的重链和轻链。 本发明还涉及分离的核酸，重组载体和宿主细胞，其包含编码所述抗体的重链和/或轻链的序列，以及制备所述抗体的方法。 本发明的抗CCL20抗体可用于治疗例如炎性和自身免疫性疾病和癌症的治疗应用。
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公开(公告)号：US09371389B2
公开(公告)日：2016-06-21
申请号：US14240090
申请日：2012-08-30
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C07K2319/55
摘要： An object of the present invention is to provide a monoclonal antibody binding to human XCR1, wherein the antibody binds to linear or discontinuous epitopes which comprise at least three amino acids selected from the group consisting of the 8th, 11th, 12th, 13th, 14th, 16th, 17th, 22nd, 23rd, 176th, and 177th amino acids in the amino acid sequence of SEQ ID NO: 91.
摘要翻译： 本发明的目的是提供与人XCR1结合的单克隆抗体，其中所述抗体结合至包含至少三个氨基酸的线性或不连续表位，所述氨基酸选自第8,11,12,13,13和14， 16位，17位，22位，23位，第176位和第177位氨基酸。
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公开(公告)号：US08491901B2
公开(公告)日：2013-07-23
申请号：US13300352
申请日：2011-11-18
申请人： Toshio Imai , Brad Kline , Tetsu Kawano , Luigi Grasso , Yoshimasa Sakamoto , Jared Spidel , Miyuki Nishimura , Kenzo Muramoto , Tatsuo Horizoe
发明人： Toshio Imai , Brad Kline , Tetsu Kawano , Luigi Grasso , Yoshimasa Sakamoto , Jared Spidel , Miyuki Nishimura , Kenzo Muramoto , Tatsuo Horizoe
IPC分类号： A61K39/395 , C07K16/24
CPC分类号： C07K16/24 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C07K2317/92 , G01N33/6863 , G01N2333/521
摘要： The present invention relates to novel humanized, chimeric and murine antibodies that have binding specificity for the human CC chemokine ligand 20 (CCL20). The present invention further relates to heavy chains and light chains of said antibodies. The invention also relates to isolated nucleic acids, recombinant vectors and host cells that comprise a sequence which encodes a heavy chain and/or a light chain of said antibodies, and to a method of preparing said antibodies. The anti-CCL20 antibodies of the invention can be used in therapeutic applications to treat, for example, inflammatory and autoimmune disorders and cancer.
摘要翻译： 本发明涉及对人CC趋化因子配体20（CCL20）具有结合特异性的新型人源化，嵌合和鼠抗体。 本发明还涉及所述抗体的重链和轻链。 本发明还涉及分离的核酸，重组载体和宿主细胞，其包含编码所述抗体的重链和/或轻链的序列，以及制备所述抗体的方法。 本发明的抗CCL20抗体可用于治疗例如炎性和自身免疫性疾病和癌症的治疗应用。
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公开(公告)号：US20120148592A1
公开(公告)日：2012-06-14
申请号：US13300352
申请日：2011-11-18
申请人： Toshio Imai , Brad Kline , Tetsu Kawano , Luigi Grasso , Yoshimasa Sakamoto , Jared Spidel , Miyuki Nishimura , Kenzo Muramoto , Tatsuo Horizoe
发明人： Toshio Imai , Brad Kline , Tetsu Kawano , Luigi Grasso , Yoshimasa Sakamoto , Jared Spidel , Miyuki Nishimura , Kenzo Muramoto , Tatsuo Horizoe
IPC分类号： A61K39/395 , C12N15/13 , C12N15/63 , C12P21/08 , C12N5/071 , A61P35/00 , A61P29/00 , A61P19/02 , A61P31/20 , A61P19/10 , C12N1/21 , C12N1/15 , C12N1/19 , C12N5/10 , C07K16/18
CPC分类号： C07K16/24 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C07K2317/92 , G01N33/6863 , G01N2333/521
摘要： The present invention relates to novel humanized, chimeric and murine antibodies that have binding specificity for the human CC chemokine ligand 20 (CCL20). The present invention further relates to heavy chains and light chains of said antibodies. The invention also relates to isolated nucleic acids, recombinant vectors and host cells that comprise a sequence which encodes a heavy chain and/or a light chain of said antibodies, and to a method of preparing said antibodies. The anti-CCL20 antibodies of the invention can be used in therapeutic applications to treat, for example, inflammatory and autoimmune disorders and cancer.
摘要翻译： 本发明涉及对人CC趋化因子配体20（CCL20）具有结合特异性的新型人源化，嵌合和鼠抗体。 本发明还涉及所述抗体的重链和轻链。 本发明还涉及分离的核酸，重组载体和宿主细胞，其包含编码所述抗体的重链和/或轻链的序列，以及制备所述抗体的方法。 本发明的抗CCL20抗体可用于治疗例如炎性和自身免疫性疾病和癌症的治疗应用。
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公开(公告)号：US07129063B2
公开(公告)日：2006-10-31
申请号：US10298417
申请日：2002-11-15
申请人： Miyuki Nishimura , Mayumi Asano , Yuichi Ono , Koji Morimoto , Masakazu Takeuchi , Yoko Inoue , Toshio Imai , Yoshimi Takai
发明人： Miyuki Nishimura , Mayumi Asano , Yuichi Ono , Koji Morimoto , Masakazu Takeuchi , Yoko Inoue , Toshio Imai , Yoshimi Takai
CPC分类号： C07K14/47 , C07K14/705
摘要： A mouse cDNA library from gene fragments encoding proteins localizing at cell-cell junctions was screened by a technique visualizing localization of a protein to to identify a junction-enriched and -associated protein, JEAP. GenBank homology search was performed based on the sequence. Based on the obtained sequence, a mouse cDNA library was screened to identify JEAP-2. By using prepared antibodies against these proteins, it was revealed that these proteins express specifically at tight junctions, in particular, tight junctions in exocrine glands.
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公开(公告)号：US07824676B2
公开(公告)日：2010-11-02
申请号：US11522043
申请日：2006-09-15
申请人： Miyuki Nishimura , Mayumi Asano , Yuichi Ono , Koji Morimoto , Masakazu Takeuchi , Yoko Inoue , Toshio Imai , Yoshimi Takai
发明人： Miyuki Nishimura , Mayumi Asano , Yuichi Ono , Koji Morimoto , Masakazu Takeuchi , Yoko Inoue , Toshio Imai , Yoshimi Takai
IPC分类号： C07K16/18
CPC分类号： C07K14/47 , C07K14/705
摘要： A mouse cDNA library from gene fragments encoding proteins localizing at cell-cell junctions was screened by a technique visualizing localization of a protein to identify a junction-enriched and -associated protein, JEAP. GenBank homology search was performed based on the sequence. Based on the obtained sequence, a mouse cDNA library was screened to identify JEAP-2. By using prepared antibodies against these proteins, it was revealed that these proteins express specifically at tight junctions, in particular, tight junctions in exocrine glands.
摘要翻译： 通过技术可视化蛋白质的定位技术筛选编码在细胞连接处定位的蛋白质的蛋白质的基因片段的小鼠cDNA文库，以鉴定连接蛋白和相关蛋白JEAP。 GenBank同源性检索是根据序列进行的。 基于获得的序列，筛选小鼠cDNA文库以鉴定JEAP-2。 通过使用针对这些蛋白质的制备的抗体，显示这些蛋白质在紧密连接处特别是在外分泌腺中的紧密连接处特异性表达。
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