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1.发明授权公开(公告)号：US06790318B2
公开(公告)日：2004-09-14
申请号：US10260449
申请日：2002-09-27
IPC分类号： B01D1100
CPC分类号： B01D11/00 , A61F2/16 , C08J7/047 , C08J2383/04 , C08J2401/02
摘要： A process for removing contaminants and/or leachables from polymeric materials useful in the manufacture of biocompatible medical devices such as intraocular lenses, corneal inlays and contact lenses using continuous soxhlet extraction.
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公开(公告)号：US06918931B2
公开(公告)日：2005-07-19
申请号：US10657639
申请日：2003-09-08
申请人： Yu-Chin Lai , Dominic V. Ruscio
发明人： Yu-Chin Lai , Dominic V. Ruscio
CPC分类号： G02B1/043 , A61L27/16 , A61L27/18 , C07F7/1804 , C08G77/388 , C09B69/106 , C08L83/04 , C08L33/04
摘要： Yellow dye moiety-containing prepolymers with blue light absorbing priorities and methods for producing the same for use in the production of relatively high refractive index polymeric compositions are described herein. Polymeric compositions so produced are useful in the production of ophthalmic devices such as for example intraocular lenses and corneal inlays.
摘要翻译： 本文描述了具有蓝光吸收优点的含黄染料部分的预聚物及其生产用于生产相对高折射率聚合物组合物的方法。 如此生产的聚合物组合物可用于眼科装置的生产，例如眼内透镜和角膜嵌体。
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公开(公告)号：US5358995A
公开(公告)日：1994-10-25
申请号：US883449
申请日：1992-05-15
IPC分类号： G02C7/04 , A61L27/00 , A61L27/16 , A61L27/52 , C08F230/08 , C08F290/00 , C08F290/06 , C08L83/04 , C08L83/07 , G02B1/04
CPC分类号： G02B1/043 , A61L27/16 , A61L27/52 , C08F230/08 , Y10T428/31855 , Y10T428/31909
摘要： A novel silicone-containing, hydrogel material is disclosed comprising an acrylic-capped polysiloxane prepolymer, polymerized with a bulky polysiloxanylalkyl (meth)acrylate monomer and at least one hydrophilic monomer.
摘要翻译： 公开了一种新的含有机硅的水凝胶材料，其包含用大体积的（甲基）丙烯酸聚硅氧烷基烷基酯单体和至少一种亲水性单体聚合的丙烯酸封端的聚硅氧烷预聚物。
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4.发明授权Process for manufacturing intraocular lenses with blue light absorption characteristics 有权制造具有蓝光吸收特性的眼内透镜的方法公开(公告)号：US07276544B2
公开(公告)日：2007-10-02
申请号：US10657356
申请日：2003-09-08
申请人： Yu-Chin Lai , Dominic V. Ruscio , George F. Green
发明人： Yu-Chin Lai , Dominic V. Ruscio , George F. Green
CPC分类号： A61F2/1613 , A61F2/142 , A61F2/145 , A61F2/1659 , A61F2240/001 , C08F2/48 , C08F2/50 , G02B1/041
摘要： A process for producing intraocular lenses (IOLs) capable of absorbing blue light and ultraviolet light using photo curing. Intraocular lenses so produced block blue light and ultraviolet light from reaching the retina of an eye implanted with the IOL. By blocking blue light and ultraviolet light from reaching the retina, the IOL thereby prevents potential damage to the retina.
摘要翻译： 一种使用光固化能够吸收蓝光和紫外光的人工晶状体（IOL）的制造方法。 如此制造的人工晶状体阻挡蓝色光和紫外光到达植入IOL的眼睛的视网膜。 通过阻挡蓝光和紫外光到达视网膜，因此IOL可防止对视网膜的潜在损伤。
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5.发明授权公开(公告)号：US06565776B1
公开(公告)日：2003-05-20
申请号：US09593656
申请日：2000-06-12
申请人： Hongwen Li , Dominic V. Ruscio , Yu Chin Lai , Horngyih Huang
发明人： Hongwen Li , Dominic V. Ruscio , Yu Chin Lai , Horngyih Huang
IPC分类号： B29D1100
CPC分类号： B29D11/00548 , B29C33/3842 , B29C33/56 , B29C35/0888 , B29C2035/0827 , B29C2035/0833 , B29L2011/0041 , Y10S425/808
摘要： This invention relates to the preparation of molds for the production of contact lenses and other ophthalmic articles. By using an inorganic material to coat the optical surfaces and sidewalls of mold parts made from clear-resin materials, manufacturers can produce lens molds with greater dimensional stability and chemical resistance. In addition to protecting the clear resin from interaction with otherwise reactive monomers from which the molded article is made, such coatings can also be used to achieve preferential release of the molded article. The resulting mold is especially useful for providing an economical way to improve manufacturing quality of contact lenses.
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公开(公告)号：US5387632A
公开(公告)日：1995-02-07
申请号：US285473
申请日：1994-08-03
IPC分类号： G02C7/04 , A61L27/00 , A61L27/16 , A61L27/52 , C08F230/08 , C08F290/00 , C08F290/06 , C08L83/04 , C08L83/07 , G02B1/04 , C08F130/08
CPC分类号： G02B1/043 , A61L27/16 , A61L27/52 , C08F230/08 , Y10T428/31855 , Y10T428/31909
摘要： A novel silicone-containing, hydrogel material is disclosed comprising an acrylic-capped polysiloxane prepolymer, polymerized with a bulky polysiloxanylalkyl (meth)acrylate monomer and at least one hydrophilic monomer.
摘要翻译： 公开了一种含有机硅的水凝胶材料，其包含用大体积的（甲基）丙烯酸聚硅氧烷基烷基酯单体和至少一种亲水性单体聚合的丙烯酸封端的聚硅氧烷预聚物。
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7.发明申请DRUG DELIVERY DEVICE COMPRISING CROSSLINKED POLYURETHANE-SILOXANE-CONTAINING COPOLYMERS 审中-公开包含交联聚氨酯 - 含硅氧烷共聚物的药物递送装置公开(公告)号：US20080299176A1
公开(公告)日：2008-12-04
申请号：US11755211
申请日：2007-05-30
申请人： Yu-Chin Lai , Ruiwen Shi , O. William Lever, JR. , Dominic V. Ruscio , Yan Huang
发明人： Yu-Chin Lai , Ruiwen Shi , O. William Lever, JR. , Dominic V. Ruscio , Yan Huang
IPC分类号： A61F2/14 , A61K31/335 , A61K31/337 , A61K31/433 , A61K31/56 , A61K31/58 , A61K36/06 , A61K47/48 , A61P27/00
CPC分类号： A61K36/06 , A61F9/0017 , A61K31/335 , A61K31/337 , A61K31/433 , A61K31/56 , A61K31/58
摘要： A drug delivery device for placement in the eye includes a drug core comprising a hydrophobic pharmaceutically active agent, and a holder that holds the drug core. The holder is made of a material impermeable to passage of the active agent and includes an opening for passage of the pharmaceutically agent therethrough to eye tissue. The device includes polyurethane-siloxane-containing copolymers crosslinked with hydrophilic monomers.
摘要翻译： 用于放置在眼睛中的药物递送装置包括包含疏水性药物活性剂的药物核心和保持药物核心的保持器。 保持器由不透过活性剂通过的材料制成，并且包括用于药剂通过其通过眼组织的开口。 该装置包括与亲水性单体交联的聚氨酯 - 含硅氧烷共聚物。
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公开(公告)号：US07241312B2
公开(公告)日：2007-07-10
申请号：US11235497
申请日：2005-09-26
申请人： Yu-Chin Lai , Dominic V. Ruscio
发明人： Yu-Chin Lai , Dominic V. Ruscio
CPC分类号： A61L27/54 , A61L2300/442 , A61L2430/16 , G02B1/043 , C08L83/04
摘要： A process for producing silicone intraocular lenses (IOLs) capable of absorbing blue light. Intraocular lenses so produced block blue light from reaching the retina of an eye implanted with the IOL. By blocking blue light from reaching the retina, the IOL thereby prevents potential damage to the retina.
摘要翻译： 能够吸收蓝光的硅酮眼内透镜（IOL）的制造方法。 如此产生的人工晶状体阻挡蓝光到达植入IOL的眼睛的视网膜。 通过阻挡蓝光到达视网膜，IOL因此防止对视网膜的潜在损伤。
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9.发明授权High refractive index silicone-containing prepolymers with blue light absorption capability 失效具有蓝光吸收能力的高折射率含硅氧烷预聚物公开(公告)号：US07033391B2
公开(公告)日：2006-04-25
申请号：US10657355
申请日：2003-09-08
申请人： Yu-Chin Lai , Dominic V. Ruscio
发明人： Yu-Chin Lai , Dominic V. Ruscio
IPC分类号： A61F2/16
CPC分类号： C08G77/50 , C08G77/14 , C08G77/20 , C08G77/48 , C08G77/70 , C08K3/36 , C08L83/04 , G02B1/043 , C08L83/00
摘要： A process for producing silicone-containing prepolymers capable of absorbing blue light for use in the production of relatively high refractive index polymeric compositions is described herein. Polymeric compositions so produced are useful in the production of ophthalmic devices such as for example intraocular lenses and corneal inlays.
摘要翻译： 本文描述了一种制备能够吸收用于生产相对高折射率聚合物组合物的蓝光的含硅氧烷预聚物的方法。 如此生产的聚合物组合物可用于眼科装置的生产，例如眼内透镜和角膜嵌体。
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10.发明授权Lens molds with protective coatings for production of contact lenses and other ophthalmic products 失效具有用于生产隐形眼镜和其他眼科产品的保护涂层的镜片模具公开(公告)号：US06913715B2
公开(公告)日：2005-07-05
申请号：US10387888
申请日：2003-03-12
申请人： Hongwen Li , Dominic V. Ruscio , Yu Chin Lai , Horngyih Huang
发明人： Hongwen Li , Dominic V. Ruscio , Yu Chin Lai , Horngyih Huang
IPC分类号： G02C7/02 , B29C33/38 , B29C33/40 , B29C33/56 , B29C35/08 , B29C39/26 , B29C45/00 , B29L11/00 , B29D11/00
CPC分类号： B29D11/00548 , B29C33/3842 , B29C33/56 , B29C35/0888 , B29C2035/0827 , B29C2035/0833 , B29L2011/0041 , Y10S425/808
摘要： This invention relates to the preparation of molds for the production of contact lenses and other ophthalmic articles. By using an inorganic material to coat the optical surfaces and sidewalls of mold parts made from clear-resin materials, manufacturers can produce lens molds with greater dimensional stability and chemical resistance. In addition to protecting the clear resin from interaction with otherwise reactive monomers from which the molded article is made, such coatings can also be used to achieve preferential release of the molded article. The resulting mold is especially useful for providing an economical way to improve manufacturing quality of contact lenses.
摘要翻译： 本发明涉及用于制造隐形眼镜和其它眼用物品的模具的制备。 通过使用无机材料涂覆由透明树脂材料制成的模具部件的光学表面和侧壁，制造商可以生产具有更大尺寸稳定性和耐化学性的透镜模具。 除了保护透明树脂与制备模塑制品的其它反应性单体的相互作用之外，还可以使用这种涂层来实现模制品的优先释放。 所得模具对于提供经济的方式来提高隐形眼镜的制造质量特别有用。
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