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    IC-processed polymer nano-liquid chromatoraphy system on-a-chip and method of making it
    1.
    发明授权
    IC-processed polymer nano-liquid chromatoraphy system on-a-chip and method of making it 有权
    IC加工聚合物纳米液体色谱体系及其制备方法

    公开(公告)号：US08323488B2

    公开(公告)日：2012-12-04

    申请号：US13037192

    申请日：2011-02-28

    申请人： Yu-Chong Tai ,  Qing He ,  Jun Xie ,  Changlin Pang ,  Terry D. Lee ,  Damien Rodger ,  Matthieu Liger

    发明人： Yu-Chong Tai ,  Qing He ,  Jun Xie ,  Changlin Pang ,  Terry D. Lee ,  Damien Rodger ,  Matthieu Liger

    IPC分类号： B01D15/08 ,  B01D15/10 ,  B01D15/00

    CPC分类号： H05K3/284 ,  G01N30/6047 ,  G01N30/6095 ,  G01N2030/645 ,  G03F1/80 ,  G01N2030/625

    摘要： Embodiments in accordance with the present invention relate to packed-column nano-liquid chromatography (nano-LC) systems integrated on-chip, and methods for producing and using same. The microfabricated chip includes a column, flits/filters, an injector, and a detector, fabricated in a process compatible with those conventionally utilized to form integrated circuits. The column can be packed with supports for various different stationary phases to allow performance of different forms of nano-LC, including but not limited to reversed-phase, normal-phase, adsorption, size-exclusion, affinity, and ion chromatography. A cross-channel injector injects a nanolitre/picolitre-volume sample plug at the column inlet. An electrochemical/conductivity sensor integrated at the column outlet measures separation signals. A self-aligned channel-strengthening technique increases pressure rating of the microfluidic system, allowing it to withstand the high pressure normally used in high performance liquid chromatography (HPLC). On-chip sample injection, separation, and detection of mixture of anions in water is successfully demonstrated using ion-exchange nano-LC.

    摘要翻译： 根据本发明的实施方案涉及集成在片上的填充柱纳米液相色谱（nano-LC）系统及其制造和使用方法。 微制造的芯片包括以常规用于形成集成电路的方法兼容的工艺制造的柱，过滤器，注射器和检测器。 该柱可以填充有用于各种不同固定相的载体，以允许不同形式的纳米LC的性能，包括但不限于反相，正相，吸附，尺寸排阻，亲和力和离子色谱。 交叉通道注射器在柱入口处注入纳升/皮升体积的样品塞。 集成在色谱柱出口处的电化学/电导率传感器测量分离信号。 自对准的通道加强技术提高了微流体系统的压力等级，使其能够承受通常用于高效液相色谱（HPLC）的高压。 使用离子交换纳米LC成功地证明了在水中阴离子的混合物的片上样品注入，分离和检测。

    Micromachined tissue anchors for securing implants without sutures
    2.
    发明申请
    Micromachined tissue anchors for securing implants without sutures 审中-公开
    微加工组织锚，用于固定植入物，无缝线

    公开(公告)号：US20060247664A1

    公开(公告)日：2006-11-02

    申请号：US11371219

    申请日：2006-03-07

    申请人： Ellis Meng ,  Yu-Chong Tai ,  Damien Rodger ,  Po-Jui Chen ,  Mark Humayun

    发明人： Ellis Meng ,  Yu-Chong Tai ,  Damien Rodger ,  Po-Jui Chen ,  Mark Humayun

    IPC分类号： A61F2/02 ,  A61B3/16

    CPC分类号： A61B3/16 ,  A61B5/6821 ,  A61B5/6882

    摘要： Systems and methods for attaching an implant device to tissue by mechanically (and non-invasively) anchoring the device to the tissue. The systems and methods provide a safe, practical way to attach an implant device to tissue in a non-invasive, or less invasive manner. According to the present invention, an implant device includes one or more protruding anchor-like structures for securely attaching to tissue. One or more device features, such as sensing elements, may be incorporated on the implant device. The anchor structures are configured and arranged to match the topology and features of the tissue environment where implant is to occur.

    摘要翻译： 通过机械地（而非侵入式）将装置固定在组织上来将植入装置附着到组织的系统和方法。 该系统和方法提供了以非侵入性或较小侵入性方式将植入装置附接到组织的安全且实用的方式。 根据本发明，植入装置包括用于牢固地附接到组织的一个或多个突出的锚固结构。 可以在植入装置上并入一个或多个装置特征，例如感测元件。 锚结构被配置和布置成匹配将要进行植入的组织环境的拓扑和特征。

    Implantable Intraocular Pressure Drain
    3.
    发明申请
    Implantable Intraocular Pressure Drain 失效
    植入式眼内压排水

    公开(公告)号：US20120289883A1

    公开(公告)日：2012-11-15

    申请号：US13555329

    申请日：2012-07-23

    申请人： Ellis Fan-chuin Meng ,  Po-Jui Chen ,  Damien Rodger ,  Yu-Chong Tai ,  Mark Humayun

    发明人： Ellis Fan-chuin Meng ,  Po-Jui Chen ,  Damien Rodger ,  Yu-Chong Tai ,  Mark Humayun

    IPC分类号： A61F9/00 ,  A61M1/00

    CPC分类号： A61F9/00781 ,  A61B3/16 ,  A61B5/4836 ,  A61B5/6821 ,  A61B2562/0247 ,  A61B2562/028 ,  A61B2562/12 ,  F16K99/0009 ,  F16K99/0057 ,  F16K2099/0086

    摘要： An implanted parylene tube shunt relieves intra-ocular pressure. The device is implanted with an open end in the anterior chamber of the eye, allowing excess fluid to be drained through the tube out of the eye. In one embodiment, only a first end of the tube implanted into the anterior chamber of the eye is open. Intra-ocular pressure (IOP) is then monitored, for example utilizing an implanted sensor. When IOP exceeds a critical valve, a practitioner intervenes, puncturing with a laser a thinned region of the tube lying outside the eye, thereby initiating drainage of fluid and relieving pressure. In accordance with alternative embodiments, the both ends of the tube are open, and the tube includes a one-way valve configured to permit drainage where IOP exceeds the critical value. The tube may include projecting barbs to anchor the tube in the eye without the need for sutures.

    摘要翻译： 植入的聚对二甲苯管分流器可减轻眼内压力。 该装置在眼睛的前房中植入开放端，允许多余的液体通过管排出眼睛。 在一个实施例中，仅植入眼睛前房的管的第一端是开放的。 然后监测眼内压（IOP），例如利用植入的传感器。 当IOP超过临界阀时，从业者介入，用激光穿刺位于眼睛外部的管的薄的区域，从而引起流体排出并释放压力。 根据替代实施例，管的两端是开放的，并且管包括被配置为允许IOP超过临界值的排水的单向阀。 管可以包括突出的倒钩以将管锚定在眼睛中而不需要缝线。

    Implantable intraocular pressure drain
    6.
    发明授权
    Implantable intraocular pressure drain 有权
    植入式眼内压排水

    公开(公告)号：US08246569B1

    公开(公告)日：2012-08-21

    申请号：US11205757

    申请日：2005-08-16

    申请人： Ellis Fan-chuin Meng ,  Po-Jui Chen ,  Damien Rodger ,  Yu-Chong Tai ,  Mark Humayun

    发明人： Ellis Fan-chuin Meng ,  Po-Jui Chen ,  Damien Rodger ,  Yu-Chong Tai ,  Mark Humayun

    IPC分类号： A61M5/00

    CPC分类号： A61F9/00781 ,  A61B3/16 ,  A61B5/4836 ,  A61B5/6821 ,  A61B2562/0247 ,  A61B2562/028 ,  A61B2562/12 ,  F16K99/0009 ,  F16K99/0057 ,  F16K2099/0086

    摘要： An implanted parylene tube shunt relieves intra-ocular pressure. The device is implanted with an open end in the anterior chamber of the eye, allowing excess fluid to be drained through the tube out of the eye. In one embodiment, only a first end of the tube implanted into the anterior chamber of the eye is open. Intra-ocular pressure (IOP) is then monitored, for example utilizing an implanted sensor. When IOP exceeds a critical value, a practitioner intervenes, puncturing with a laser a thinned region of the tube lying outside the eye, thereby initiating drainage of fluid and relieving pressure. In accordance with alternative embodiments, the both ends of the tube are open, and the tube includes a one-way valve configured to permit drainage where IOP exceeds the critical value. The tube may include projecting barbs to anchor the tube in the eye without the need for sutures.

    摘要翻译： 植入的聚对二甲苯管分流器可减轻眼内压力。 该装置在眼睛的前房中植入开放端，允许多余的液体通过管排出眼睛。 在一个实施例中，仅植入眼睛前房的管的第一端是开放的。 然后监测眼内压（IOP），例如利用植入的传感器。 当眼压超过临界值时，从业人员介入，用激光穿刺位于眼睛外部的管的薄化区域，从而引起流体排出并释放压力。 根据替代实施例，管的两端是开放的，并且管包括被配置为允许IOP超过临界值的排水的单向阀。 管可以包括突出的倒钩以将管锚定在眼睛中而不需要缝线。

    Method for decreasing chemical diffusion in parylene and trapping at parylene-to-parylene interfaces
    10.
    发明申请
    Method for decreasing chemical diffusion in parylene and trapping at parylene-to-parylene interfaces 审中-公开
    用于减少聚对二甲苯中的化学扩散并在聚对二甲苯接枝界面捕获的方法

    公开(公告)号：US20060255293A1

    公开(公告)日：2006-11-16

    申请号：US11408809

    申请日：2006-04-21

    申请人： Yu-Chong Tai ,  Damien Rodger ,  Wen Li ,  Angela Tooker

    发明人： Yu-Chong Tai ,  Damien Rodger ,  Wen Li ,  Angela Tooker

    IPC分类号： G21G5/00 ,  C23C16/00

    CPC分类号： B05D3/0254 ,  B05D1/60 ,  H01L21/312 ,  H01L21/76801 ,  H01L21/76826 ,  H01L21/76828

    摘要： Systems and methods for improving the adherence of poorly-adherent parylene-to-parylene films or layers and/or altering the water and chemical permeability of the parylene layers. A device having two or more parylene layers is heated in a reduced pressure treatment chamber at a temperature above the deposition temperature of the parylene (e.g., from about room temperature to several hundreds of degrees Celsius) for an extended period of time (e.g., a few hours up to several days). The methods of the present invention have been shown to convert poorly-adherent and/or water-permeable films to optimally-adherent and/or relatively water-impermeable films.

    摘要翻译： 用于改善不良的对二甲苯对聚对二甲苯薄膜或层的粘附性和/或改变聚对二甲苯层的水和化学渗透性的系统和方法。 具有两个或更多个聚对二甲苯层的装置在减压处理室中在高于聚对二甲苯的沉积温度（例如从约室温至几百摄氏度）的温度下加热一段时间（例如， 几个小时到几天）。 已经显示出本发明的方法将不良粘附和/或水渗透膜转化成最佳粘附和/或相对不透水的膜。