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    Immunological assay and chip
    2.
    发明授权
    Immunological assay and chip 有权
    免疫测定和芯片

    公开(公告)号：US07670854B2

    公开(公告)日：2010-03-02

    申请号：US11905648

    申请日：2007-10-03

    申请人： Yukari Hataoka

    发明人： Yukari Hataoka

    IPC分类号： G01N33/558

    CPC分类号： G01N33/54366 ,  B01L3/5027 ,  B01L3/502753 ,  B01L2200/0621 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0409 ,  B01L2400/0418 ,  B01L2400/0487

    摘要： The present invention provides an immunological assay suitable to be carried out on a chip. After an antigen-antibody complex in which an antigen 2 to be measured and an antibody 3 have bound to each other was obtained in a reaction chamber 7, the amount of the antigen-antibody complex or the antibody that has not bound to the antigen to be measured by using a measurement solution obtained by using the sample solution 8 as a solvent. According to the present invention, the measurement solution for detecting the signal that reflects the amount of the substance to be measured can be obtained without using a buffer solution free from a substance to be measured, such as protein. Thus, it is not necessary to supply a buffer solution from the outside of the chip or to allow the buffer solution to be retained on the chip beforehand. Accordingly, an immunological assay can be carried out easily on a chip.

    摘要翻译： 本发明提供适合于在芯片上进行的免疫学测定。 在反应室7中获得其中待测抗原2和抗体3彼此结合的抗原 - 抗体复合物后，抗原 - 抗体复合物或未结合抗原的抗体至 通过使用通过使用样品溶液8作为溶剂获得的测量溶液来测量。 根据本发明，可以在不使用蛋白质等不含被测定物质的缓冲溶液的情况下，获得检测反映待测物质量的信号的测定方法。 因此，不需要从芯片的外部供给缓冲溶液，也可以预先使缓冲溶液保持在芯片上。 因此，可以在芯片上容易地进行免疫学测定。

    Blood processing apparatus and blood introducing method
    4.
    发明申请
    Blood processing apparatus and blood introducing method 有权
    血液处理装置及血液导入方法

    公开(公告)号：US20060263247A1

    公开(公告)日：2006-11-23

    申请号：US11494749

    申请日：2006-07-28

    申请人： Nobuhiko Ozaki ,  Hiroaki Oka ,  Tetsuo Yukimasa ,  Hidenobu Yaku ,  Maki Yotsuhashi ,  Yukari Hataoka

    发明人： Nobuhiko Ozaki ,  Hiroaki Oka ,  Tetsuo Yukimasa ,  Hidenobu Yaku ,  Maki Yotsuhashi ,  Yukari Hataoka

    IPC分类号： G01N33/00

    CPC分类号： G01N35/00069 ,  Y10T436/111666 ,  Y10T436/2575

    摘要： The present invention provides a blood processing apparatus that can introduce a metered quantity of a blood sample into a chamber and does not require an opening linked to the chamber to be closed after the introduction of the blood sample. An introducing chamber, an injection port, and an air port are formed in a rotatable platform of a blood processing apparatus. The injection port links the introducing chamber with the outside of the rotatable platform. A blood sample is introduced from the injection port into the introducing chamber. A blood coagulant is held on the port wall surface of the air port and/or around a portion of the surface of the rotatable platform where the air port is open.

    摘要翻译： 本发明提供一种血液处理装置，其能够将计量量的血液样品引入腔室中，并且在引入血液样本之后不需要连接到待关闭的腔室的开口。 在血液处理装置的可旋转平台中形成有引入室，注射口和空气口。 注入口将引入室与可旋转平台的外部连接。 血液样品从注射口引入引入室。 血液凝结剂被保持在空气端口的端口壁表面上和/或在空气端口打开的可旋转平台的表面的一部分周围。

    Immunological assay and chip
    6.
    发明申请
    Immunological assay and chip 有权
    免疫测定和芯片

    公开(公告)号：US20080312097A1

    公开(公告)日：2008-12-18

    申请号：US11905648

    申请日：2007-10-03

    申请人： Yukari Hataoka

    发明人： Yukari Hataoka

    IPC分类号： C40B30/04 ,  C40B60/12

    CPC分类号： G01N33/54366 ,  B01L3/5027 ,  B01L3/502753 ,  B01L2200/0621 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0409 ,  B01L2400/0418 ,  B01L2400/0487

    摘要： The present invention provides an immunological assay suitable to be carried out on a chip. After an antigen-antibody complex in which an antigen 2 to be measured and an antibody 3 have bound to each other was obtained in a reaction chamber 7, the amount of the antigen-antibody complex or the antibody that has not bound to the antigen to be measured by using a measurement solution obtained by using the sample solution 8 as a solvent. According to the present invention, the measurement solution for detecting the signal that reflects the amount of the substance to be measured can be obtained without using a buffer solution free from a substance to be measured, such as protein. Thus, it is not necessary to supply a buffer solution from the outside of the chip or to allow the buffer solution to be retained on the chip beforehand. Accordingly, an immunological assay can be carried out easily on a chip.

    摘要翻译： 本发明提供适合于在芯片上进行的免疫学测定。 在反应室7中获得其中待测抗原2和抗体3彼此结合的抗原 - 抗体复合物后，抗原 - 抗体复合物或未结合抗原的抗体至 通过使用通过使用样品溶液8作为溶剂获得的测量溶液来测量。 根据本发明，可以在不使用蛋白质等不含被测定物质的缓冲溶液的情况下，获得检测反映待测物质量的信号的测定方法。 因此，不需要从芯片的外部供给缓冲溶液，也可以预先使缓冲溶液保持在芯片上。 因此，可以在芯片上容易地进行免疫学测定。

    Immunological assay and chip
    9.
    发明授权
    Immunological assay and chip 有权
    免疫测定和芯片

    公开(公告)号：US07566572B2

    公开(公告)日：2009-07-28

    申请号：US11896014

    申请日：2007-08-29

    申请人： Yukari Hataoka

    发明人： Yukari Hataoka

    IPC分类号： G01N33/558

    CPC分类号： G01N33/54386 ,  B01L3/5027 ,  B01L2200/0647 ,  B01L2200/16 ,  B01L2300/0636 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0409 ,  B01L2400/0418 ,  B01L2400/0487

    摘要： The present invention provides an immunological assay suitable to be carried out on a chip. After an antigen-antibody complex in which an antigen to be measured and an antibody have bound to each other was obtained in a reaction chamber, the reaction chamber is washed using a sample solution and thereby the antigen-antibody complex and the antibody that has not bound to the antigen to be measured are separated from each other. According to the present invention, the reaction chamber can be washed to an extent that allows a signal reflecting the amount of the antigen to be measured to be detected with accuracy comparable to the case of using a wash solution without using a wash solution that is typified by Tris-HCl buffer that does not contain any antigens to be measured such as protein. Thus, it is not necessary to supply a wash solution from the outside of the chip or to allow a wash solution to be retained on the chip beforehand. Accordingly, an immunological assay can be carried out easily on a chip.

    摘要翻译： 本发明提供适合于在芯片上进行的免疫学测定。 在反应室中获得其中待测抗原和抗体相互结合的抗原 - 抗体复合物之后，使用样品溶液洗涤反应室，从而将抗原 - 抗体复合物和不具有抗体的抗体 与要测量的抗原结合的物质彼此分离。 根据本发明，反应室可以被洗涤到允许反映测量抗原量的信号被检测的程度，其精度可与使用洗涤溶液的情况相当，而不使用代表性的洗涤溶液 通过不含任何待测抗原的Tris-HCl缓冲液，如蛋白质。 因此，不需要从芯片的外部供给洗涤溶液，或者可以预先将清洗液保留在芯片上。 因此，可以在芯片上容易地进行免疫学测定。

    Immunological assay and chip
    10.
    发明申请
    Immunological assay and chip 有权
    免疫测定和芯片

    公开(公告)号：US20080138831A1

    公开(公告)日：2008-06-12

    申请号：US11896014

    申请日：2007-08-29

    申请人： Yukari Hataoka

    发明人： Yukari Hataoka

    IPC分类号： G01N33/53 ,  C12M3/00

    CPC分类号： G01N33/54386 ,  B01L3/5027 ,  B01L2200/0647 ,  B01L2200/16 ,  B01L2300/0636 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0409 ,  B01L2400/0418 ,  B01L2400/0487

    摘要： The present invention provides an immunological assay suitable to be carried out on a chip. After an antigen-antibody complex in which an antigen to be measured and an antibody have bound to each other was obtained in a reaction chamber, the reaction chamber is washed using a sample solution and thereby the antigen-antibody complex and the antibody that has not bound to the antigen to be measured are separated from each other. According to the present invention, the reaction chamber can be washed to an extent that allows a signal reflecting the amount of the antigen to be measured to be detected with accuracy comparable to the case of using a wash solution without using a wash solution that is typified by Tris-HCl buffer that does not contain any antigens to be measured such as protein. Thus, it is not necessary to supply a wash solution from the outside of the chip or to allow a wash solution to be retained on the chip beforehand. Accordingly, an immunological assay can be carried out easily on a chip.

    摘要翻译： 本发明提供适合于在芯片上进行的免疫学测定。 在反应室中获得其中待测抗原和抗体相互结合的抗原 - 抗体复合物之后，使用样品溶液洗涤反应室，从而将抗原 - 抗体复合物和不具有抗体的抗体 与要测量的抗原结合的物质彼此分离。 根据本发明，反应室可以被洗涤到允许反映测量抗原量的信号被检测的程度，其精度可与使用洗涤溶液的情况相当，而不使用代表性的洗涤溶液 通过不含任何待测抗原的Tris-HCl缓冲液，如蛋白质。 因此，不需要从芯片的外部供给洗涤溶液，或者可以预先将清洗液保留在芯片上。 因此，可以在芯片上容易地进行免疫学测定。