Methods for treating inflammatory and autoimmune diseases
    1.
    发明申请
    Methods for treating inflammatory and autoimmune diseases 审中-公开
    治疗炎症和自身免疫性疾病的方法

    公开(公告)号:US20050261246A1

    公开(公告)日:2005-11-24

    申请号:US11071994

    申请日:2005-03-04

    IPC分类号: A61K31/4741 A61K31/675

    CPC分类号: A61K31/4741 A61K31/675

    摘要: The present invention provides methods for treating inflammatory conditions, rheumatoid diseases, autoimmune conditions, and conditions associated with bone loss, comprising administering to a subject with an inflammatory condition an amount effective to treat the condition of a compound selected from the group consisting of narcistatin, pancratistatin, pancratastatin-7′ phosphate and pancratastatin-3′,4′ cyclic phosphate, or pharmaceutically acceptable salts thereof.

    摘要翻译: 本发明提供治疗炎性病症,类风湿病,自身免疫病症和与骨丢失有关的病症的方法,其包括对患有炎性病症的个体施用有效治疗选自以下的化合物的病症的量的方法:非激素抑制素, pancratistatin,pancratastatin-7'磷酸盐和pancratastatin-3',4'环磷酸盐或其药学上可接受的盐。

    Biocarrier and method of using the same
    3.
    发明授权
    Biocarrier and method of using the same 有权
    生物载体及其使用方法

    公开(公告)号:US09393194B2

    公开(公告)日:2016-07-19

    申请号:US12953110

    申请日:2010-11-23

    申请人: Yung Chang Yu-Ju Shih

    发明人: Yung Chang Yu-Ju Shih

    摘要: The present invention discloses a biocarrier for delivery of a bioactive substance near/into a target cell, comprising a bioactive substance-loaded core with a first electricity, and one or more block copolymer, each block copolymer comprising a zwitterionic block and an anchoring block with an initial electricity opposite to the first electricity, wherein the anchoring block binds to the core by electrostatic attraction, and the zwitterionic block extends outwardly to increase the biocarrier stability in mammalian blood. Additionally, the present invention also discloses a method of using the biocarrier.

    摘要翻译: 本发明公开了一种用于在靶细胞附近/进入生物活性物质的生物载体,其包含具有第一电的生物活性物质负载芯和一种或多种嵌段共聚物,每个嵌段共聚物包含两性离子嵌段和具有 与第一次电相反的初始电力,其中锚定块通过静电吸引与核结合,并且两性离子嵌段向外延伸以增加哺乳动物血液中的生物载体稳定性。 另外,本发明还公开了使用该生物载体的方法。

    Filter Medium For Leukocyte Removal
    6.
    发明申请
    Filter Medium For Leukocyte Removal 审中-公开
    过滤培养基去除白细胞

    公开(公告)号:US20120067821A1

    公开(公告)日:2012-03-22

    申请号:US13095976

    申请日:2011-04-28

    摘要: The present invention discloses a filter medium for removing leukocytes from a leukocyte-containing sample, comprising: a substrate and a first polymer. The first polymer forms cross-linked networks or polymer brushes on the substrate and comprising charged groups or latent charged groups to control the electrical characteristic of the first polymer. The surface of the substrate formed with the first polymer possesses a specific charge distribution having charged domains and zwitterionic non-charged domains.

    摘要翻译: 本发明公开了一种用于从含白细胞的样品中除去白细胞的过滤介质,包括:基底和第一聚合物。 第一聚合物在衬底上形成交联网络或聚合物刷,并且包括带电基团或潜电荷基团以控制第一聚合物的电特性。 用第一聚合物形成的基材的表面具有具有带电域和两性离子非带电畴的特定电荷分布。

    Antibiofouling Nonionic-Zwitterionic Copolymer
    7.
    发明申请
    Antibiofouling Nonionic-Zwitterionic Copolymer 有权
    抗生素非离子 - 两性离子共聚物

    公开(公告)号:US20110160392A1

    公开(公告)日:2011-06-30

    申请号:US12648761

    申请日:2009-12-29

    IPC分类号: C08L77/00

    摘要: The present invention discloses statistical antibiofouling nonionic-zwitterionic copolymers. The antibiofouling nonionic-zwitterionic copolymers are with the LCST (Lower Critical Solution Temperature) and/or UCST (Upper Critical Solution Temperature), and with increasing content of the nonionic monomers, the LCST and/or UCST of copolymers varies.

    摘要翻译: 本发明公开了统一的抗结块非离子 - 两性离子共聚物。 抗污垢非离子 - 两性离子共聚物与LCST(较低临界溶液温度)和/或UCST(上临界溶液温度)一起使用,随着非离子单体含量的增加,共聚物的LCST和/或UCST变化。

    Multifunctional Aptamer-Nucleic Acid Nanostructures for Tumor-Targeted Killing
    8.
    发明申请
    Multifunctional Aptamer-Nucleic Acid Nanostructures for Tumor-Targeted Killing 审中-公开
    用于肿瘤靶向杀伤的多功能靶向 - 核酸纳米结构

    公开(公告)号:US20140031416A1

    公开(公告)日:2014-01-30

    申请号:US13974427

    申请日:2013-08-23

    申请人: Yung Chang Hao Yan

    发明人: Yung Chang Hao Yan

    IPC分类号: C12N15/115

    摘要: The present invention provides compositions comprising a ligand-nucleic acid nanostructure that promote tumor cell-specific killing and methods of using the compositions. Specially, the invention provides aptamer-nucleic acid nanostructures for treating tumors in a mammal. The methods of making the compositions are also provided.

    摘要翻译: 本发明提供了包含促进肿瘤细胞特异性杀伤的配体 - 核酸纳米结构的组合物和使用该组合物的方法。 特别地,本发明提供用于治疗哺乳动物肿瘤的适体 - 核酸纳米结构。 还提供了制备组合物的方法。