公开(公告)号：US06675835B2

公开(公告)日：2004-01-13

申请号：US09901824

申请日：2001-07-10

申请人： Yuri Gerner ,  Carl W. Sims ,  Thomas Thielen

发明人： Yuri Gerner ,  Carl W. Sims ,  Thomas Thielen

IPC分类号： F16L5504

CPC分类号： B01D19/0031 ,  G01N30/32 ,  G01N30/36 ,  G01N2030/027 ,  G01N2030/322 ,  Y10S138/11

摘要： A flow-dampening degassing apparatus for transport of liquid chromatography fluids therethrough includes a substantially burdoin-shaped flexible tube disposed in a reduced-pressure chamber, the tube being sufficiently flexible to expand in a cross-sectional direction upon incursion of a fluid pulsation to thereby increase an inner volume of the tube and correspondingly reduce fluid pressure therein. In a particular embodiment, the tube is fabricated from a gas-permeable and liquid-impermeable material for degassing transported fluids in the reduced-pressure chamber.

摘要翻译： 用于运输液相色谱流体的流动阻尼脱气装置通过其包括设置在减压室中的基本上为腔形的柔性管，该管在流体脉动侵入时具有足够的柔性以在横截面方向上膨胀，从而 增加管的内部体积并相应地减少其中的流体压力。 在特定实施例中，管由气体可渗透且不透液体的材料制成，用于对减压室中输送的流体进行脱气。

公开(公告)号：US07144443B2

公开(公告)日：2006-12-05

申请号：US10981934

申请日：2004-11-05

申请人： Yuri Gerner ,  Carl W. Sims ,  Thomas Thielen

发明人： Yuri Gerner ,  Carl W. Sims ,  Thomas Thielen

IPC分类号： B01D19/00

CPC分类号： B01D19/0031 ,  B01D15/16 ,  B01D19/0036

摘要： An elongated flow-through degassing apparatus includes an elongated gas and liquid impermeable outer tube and one or more gas-permeable, liquid-impermeable elongated inner tubes extending within the outer tube and at least partially through a chamber defined within the outer tube. The apparatus also includes inlet and outlet connection structures operably coupled to respective portions of the outer tube and the inner tubes to further enable a sealed engagement between the outer tube and the inner tubes, and to provide for connection devices to operably couple the degassing apparatus of the present invention to respective spaced apart components. The degassing apparatus is sufficiently flexible so as to be readily manipulatable into desired configurations.

摘要翻译： 细长的流通脱气装置包括细长的气体和液体不可渗透的外管以及在外管内延伸的至少部分通过限定在外管内的腔室的一个或多个气体可透过的液体不可渗透的细长内管。 该装置还包括可操作地连接到外管和内管的相应部分的入口和出口连接结构，以进一步实现外管和内管之间的密封接合，并且为连接装置提供可操作地连接脱气装置 本发明涉及各间隔开的部件。 脱气装置具有足够的柔性，以便容易地操纵成所需的构型。

公开(公告)号：US06837992B2

公开(公告)日：2005-01-04

申请号：US10355323

申请日：2003-01-31

申请人： Yuri Gerner ,  Carl W. Sims ,  Thomas Thielen

发明人： Yuri Gerner ,  Carl W. Sims ,  Thomas Thielen

IPC分类号： B01D61/00 ,  B01D19/00 ,  B01D71/36 ,  B01F5/00 ,  G01N30/02 ,  G01N30/26 ,  G01N30/32 ,  G01N30/34 ,  G01N30/36 ,  B01D15/08

CPC分类号： G01N30/32 ,  B01D19/0031 ,  G01N30/34 ,  G01N30/36 ,  G01N2030/027 ,  G01N2030/322

摘要： An integrated mobile phase degassing and blending apparatus for transport of liquid chromatography fluids therethrough includes a component having a first portion and a second portion, with the first portion defining an enclosed degassing chamber, and the second portion including a mobile phase blending device, wherein the degassing chamber and the mobile phase blending device are operably coupled to one another such that the liquid chromatography fluids pass directly into the blending device from the degassing chamber. In a particular embodiment, the degassing chamber is specifically configured to accommodate multiple distinct flexible degassing tubes.

摘要翻译： 用于运输液相色谱流体的整合流动相脱气和混合装置包括具有第一部分和第二部分的部件，其中第一部分限定封闭的脱气室，第二部分包括流动相混合装置，其中 脱气室和流动相共混装置可操作地彼此耦合，使得液相色谱流体从脱气室直接进入共混装置。 在特定实施例中，脱气室被特别地构造成容纳多个不同的柔性脱气管。

公开(公告)号：US06949132B2

公开(公告)日：2005-09-27

申请号：US10702013

申请日：2003-11-05

申请人： Thomas Thielen ,  Yuri Gerner ,  Carl W. Sims

发明人： Thomas Thielen ,  Yuri Gerner ,  Carl W. Sims

IPC分类号： B01D19/00

CPC分类号： B01D19/0031 ,  B01D15/16 ,  B01D19/0036

摘要： An elongated flow-through vacuum degassing apparatus includes an elongated gas and liquid impermeable outer tube and one or more gas-permeable, liquid-impermeable elongated inner tubes extending coaxially within the outer tube. The degassing apparatus further includes a vacuum source adaptor extending from a side wall of the outer tube and co-extensively with a vacuum source coupling aperture in the outer tube so as to create a sealed axial vacuum chamber between the outer tube and the inner tubes. The apparatus also includes inlet and outlet connection structures operably coupled to respective portions of the outer tube and the inner tubes to further enable a sealed engagement between the outer tube and the inner tubes, and to provide for connection devices for operably coupling the degassing apparatus of the present invention to respective components in a chromatographic system. The degassing apparatus is sufficiently flexible so as to be readily manipulatable into desired configurations.

摘要翻译： 细长的流过真空脱气装置包括细长的气体和液体不可渗透的外管以及在外管内同轴延伸的一个或多个透气的液体不可渗透的细长内管。 脱气装置还包括从外管的侧壁延伸并与外管中的真空源联接孔共同延伸的真空源适配器，以在外管和内管之间形成密封的轴向真空室。 该装置还包括可操作地连接到外管和内管的相应部分的入口和出口连接结构，以进一步实现外管和内管之间的密封接合，并提供连接装置，用于将脱气装置 本发明涉及色谱系统中各组分。 脱气装置具有足够的柔性，以便容易地操纵成所需的构型。

公开(公告)号：US06678051B2

公开(公告)日：2004-01-13

申请号：US09765497

申请日：2001-01-18

申请人： Yuri Gerner ,  Carl W. Sims ,  Thomas Thielen

发明人： Yuri Gerner ,  Carl W. Sims ,  Thomas Thielen

IPC分类号： G01N2100

CPC分类号： G01N21/05 ,  G01N21/0317 ,  G01N2021/0346 ,  G01N2201/064

摘要： A flow cell for transporting fluid in a radiant energy field includes a cell structure having an open channel, and one or more end caps having a protrusion extending therefrom, wherein the protrusion may be inserted into the open channel to create a fluid seal. In a particular embodiment, the end caps include open channels for transporting fluid and radiant energy therethrough, and the open channel in the cell structure includes an efficient radiant energy transmission lining that is spaced from the end cap protrusions, thereby forming a gap volume in the flow cell open channel, which gap volume may be calibrated such that radiant energy losses may be standardized in respective flow cells transporting fluids having various indexes of refraction.

摘要翻译： 用于在辐射能场中输送流体的流动池包括具有开放通道的单元结构，以及具有从其延伸的突起的一个或多个端盖，其中所述突起可以插入开放通道中以形成流体密封。 在特定实施例中，端盖包括用于传输流体和辐射能量的开放通道，并且电池结构中的开放通道包括与端盖突起间隔开的有效的辐射能传输衬里，从而在 流动池开放通道，该间隙体积可以被校准，使得辐射能损失可以在传输具有各种折射率的流体的相应流动池中被标准化。

公开(公告)号：US08440003B2

公开(公告)日：2013-05-14

申请号：US13172133

申请日：2011-06-29

申请人： Yuri Gerner ,  Quan Liu ,  Carl W. Sims

发明人： Yuri Gerner ,  Quan Liu ,  Carl W. Sims

IPC分类号： B01D53/22 ,  B01D19/00 ,  B01D61/36

CPC分类号： B01D19/0063 ,  B01D19/0005 ,  B01D19/0031 ,  B01D61/362 ,  B01D61/366 ,  B01D69/06 ,  B01D2313/19 ,  B01D2313/23

摘要： A liquid degassing apparatus is arranged to limit pervaporation through a membrane by attenuating pressure oscillations developed by a vacuum pump. The attenuation is obtained through a combination of one or more flow restrictors and added volume chambers fluidly interposed between the degassing chamber and the vacuum pump. The pressure oscillation attenuation may further inhibit cross-contamination of pervaporated solvents among a plurality of distinct degassing chambers.

摘要翻译： 液体脱气装置被布置成通过减弱由真空泵产生的压力振荡来限制通过膜的渗透。 通过一个或多个限流器和流体介于脱气室和真空泵之间的附加体积室的组合获得衰减。 压力振荡衰减可以进一步抑制多个不同脱气室之间的蒸发溶剂的交叉污染。

公开(公告)号：US07427312B2

公开(公告)日：2008-09-23

申请号：US11457386

申请日：2006-07-13

申请人： Yuri Gerner ,  Carl W. Sims ,  Jonathan Thompson

发明人： Yuri Gerner ,  Carl W. Sims ,  Jonathan Thompson

IPC分类号： B01D53/22

CPC分类号： B01D19/0031

摘要： An apparatus for removing gas bubbles from a fluid includes a fluid inlet and a separation chamber that is in fluid communication with the fluid inlet. The separation chamber has first and second end portions, with the first end portion being operably oriented gravitationally above the second end portion. The apparatus further includes a first gas-permeable, liquid-impermeable membrane disposed in the separation chamber and extending substantially along a first axis defined as extending between the first and second end portions. A permeate side of the membrane is exposed to an environment having a second partial pressure of a target gas, which second partial pressure is lower than a first partial pressure of the gas in the fluid.

摘要翻译： 用于从流体中除去气泡的装置包括流体入口和与流体入口流体连通的分离室。 分离室具有第一和第二端部，其中第一端部可重力地在第二端部上方定向地定向。 该装置还包括设置在分离室中的第一透气性液体不可渗透膜，并且基本上沿着限定为在第一和第二端部之间延伸的第一轴延伸。 膜的渗透侧暴露于具有目标气体的第二分压的环境中，该第二分压低于流体中气体的第一分压。

公开(公告)号：US20080006578A1

公开(公告)日：2008-01-10

申请号：US11482369

申请日：2006-07-07

申请人： Carl W. Sims ,  Jonathan Thompson ,  Yuri Gerner

发明人： Carl W. Sims ,  Jonathan Thompson ,  Yuri Gerner

IPC分类号： C02F1/44

CPC分类号： G01N30/28 ,  B01D61/362 ,  B01D2311/13

摘要： A method for controlling pervaporation through a membrane includes assessing the vapor pressure of each component material of a mobile phase disposed on a retentate side of the membrane, and maintaining a designed environment on a permeate side of the membrane. The environment maintained on the permeate side of the membrane contains partial pressures of selected component materials of the mobile phase at a level substantially equal to or greater than the respective vapor pressures thereof.

摘要翻译： 用于控制通过膜的渗透蒸发的方法包括评估设置在膜的滞留侧上的流动相的每种组分材料的蒸汽压，并且在膜的渗透侧保持设计的环境。 保持在膜的渗透侧的环境包含流动相的所选组分材料的分压，其水平基本上等于或大于其各自的蒸气压。

公开(公告)号：US06666074B2

公开(公告)日：2003-12-23

申请号：US10444595

申请日：2003-05-23

申请人： Yuri Gerner ,  Carl W. Sims ,  Kurt P. Hamberg

发明人： Yuri Gerner ,  Carl W. Sims ,  Kurt P. Hamberg

IPC分类号： G01N3000

CPC分类号： G01N30/30 ,  G01N2030/027 ,  G01N2030/3046 ,  G01N2030/3084

摘要： A system for conducting high-temperature liquid chromatographic analysis includes a mobile phase transport tube configured to operably convey mobile phase from a source to respective chromatographic instruments in the system, a pre-heater apparatus operably coupled to the mobile phase transport tube for heating the mobile phase to a desired temperature, a chromatographic column operably coupled to the pre-heater apparatus, and including temperature-maintaining means for maintaining the column at a pre-determined temperature and a counter-flow heat exchanger operably exchanging heat from outlet mobile phase to inlet mobile phase through conductive heat transfer means. In a particular embodiment, the mobile phase passing through the chromatographic column is maintained in a substantially adiabatic environment.

摘要翻译： 用于进行高温液相色谱分析的系统包括流动相输送管，其被配置为可操作地将来自源的流动相输送到系统中的相应色谱仪器;可操作地耦合到流动相输送管的预热器装置，用于加热移动 相位到期望的温度，可操作地耦合到预热器装置的色谱柱，并且包括用于将色谱柱保持在预定温度的温度保持装置和可操作地从出口流动相到入口交换热的逆流热交换器 流动相通过导电传热装置。 在一个具体实施方案中，通过色谱柱的流动相保持在基本上绝热的环境中。

公开(公告)号：US06494938B2

公开(公告)日：2002-12-17

申请号：US09735333

申请日：2000-12-12

申请人： Carl W. Sims ,  Yuri Gerner ,  Kurt P. Hamberg

发明人： Carl W. Sims ,  Yuri Gerner ,  Kurt P. Hamberg

IPC分类号： B01D1900

CPC分类号： B01D19/0063 ,  B01D19/0031 ,  G01N2030/027

摘要： A flow-through vacuum degassing unit for degassing a liquid includes a vacuum chamber adapted to be connected to a source for creating a vacuum in the chamber, an inlet and an outlet connection for admitting and discharging liquid to be degassed, a tube for conducting the liquid through the chamber, wherein the tube is a gas permeable polymeric resin material, and a control circuit for operating the source for creating a vacuum in the chamber responsive to a sensed vacuum level in the chamber.

摘要翻译： 用于对液体进行脱气的流通式真空脱气装置包括适于连接到源的真空室，用于在腔室中产生真空，用于允许和排出要脱气的液体的入口和出口连接件， 液体，其中管是气体可渗透的聚合物树脂材料，以及用于操作源的控制电路，用于响应于腔室中检测到的真空水平在腔室中产生真空。