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公开(公告)号：US08101139B2
公开(公告)日：2012-01-24
申请号：US12133606
申请日：2008-06-05
IPC分类号： B01L3/00
CPC分类号： B01L3/502707 , B01F5/0604 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01F2215/0431 , B01L3/502746 , B01L2200/12 , B01L2300/0838 , B01L2300/0867 , B01L2300/0874 , B01L2400/086 , B01L2400/088 , B33Y10/00 , B33Y40/00 , B33Y80/00 , Y10T137/218 , Y10T137/2224
摘要： Devices that include hosts having internal microcapillary networks are disclosed. The microcapillary networks are formed from interconnected passageways. The interconnected passageways may be formed by removing a fugitive material from a cured host material that forms the host. The resultant host material has many applications, including use as a microfluidic device in applications ranging from fluid mixing to structural repair.
摘要翻译： 公开了包括具有内部微毛细管网络的主机的设备。 微毛细管网络由互连的通道形成。 可以通过从形成主体的固化的主体材料中除去短暂的材料来形成互连的通道。 所得到的主体材料具有许多应用，包括在从液体混合到结构修复的应用中用作微流体装置。
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公开(公告)号：US20090191402A1
公开(公告)日：2009-07-30
申请号：US12359631
申请日：2009-01-26
CPC分类号： B32B37/12 , B29C73/163 , B29C73/22 , B32B5/02 , B32B5/022 , B32B5/024 , B32B7/12 , B32B27/12 , B32B27/18 , B32B27/283 , B32B27/40 , B32B2037/1253 , B32B2250/05 , B32B2250/24 , B32B2250/40 , B32B2262/0261 , B32B2307/51 , B32B2307/7242 , B32B2307/7246 , B32B2307/7265 , B32B2307/762 , B32B2309/027 , B32B2309/08 , B32B2309/105 , B32B2571/00 , Y10T156/10 , Y10T428/249921 , Y10T428/25
摘要： A laminate material may include a first flexible layer, and a self-healing composite layer in contact with the first flexible layer. The composite layer includes an elastomer matrix, a plurality of first capsules including a polymerizer, and a corresponding activator for the polymerizer. The laminate material may self-heal when subjected to a puncture or a tear.
摘要翻译： 层压材料可以包括第一柔性层和与第一柔性层接触的自修复复合层。 复合层包括弹性体基质，包括聚合反应器的多个第一胶囊和用于聚合反应器的相应的活化剂。 当受到穿刺或撕裂时，层压材料可以自愈。
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公开(公告)号：US07206423B1
公开(公告)日：2007-04-17
申请号：US09568435
申请日：2000-05-10
申请人： Albert S. Feng , Douglas Jones , Bruce C. Wheeler , Robert C. Bilger , Charissa R. Lansing , William D. O'Brien
发明人： Albert S. Feng , Douglas Jones , Bruce C. Wheeler , Robert C. Bilger , Charissa R. Lansing , William D. O'Brien
IPC分类号： H04R25/00
CPC分类号： H04B13/005 , H04R25/502
摘要： Disclosed is a hearing aid that includes a first component operable to receive an input and a second component operable to provide an output to at least one ear of a user of the hearing aid. The first component and the second component are electrically coupled together by a closed electrical circuit including at least one electrical conduction pathway formed by skin of the user between the first component and the second component. An electrical signal is transmitted from the first component to the second component with the closed electrical circuit. Communication between the first and second components can be one-way or two-way.
摘要翻译： 公开了一种助听器，其包括可操作以接收输入的第一部件和可操作以向助听器的使用者的至少一个耳朵提供输出的第二部件。 第一部件和第二部件通过包括在第一部件和第二部件之间由使用者的皮肤形成的至少一个导电通路的闭合电路电耦合在一起。 电信号由闭合电路从第一部件传输到第二部件。 第一和第二组件之间的通信可以是单向或双向。
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公开(公告)号：US06838404B2
公开(公告)日：2005-01-04
申请号：US10044831
申请日：2002-01-09
申请人： Patrick J. Hentges , Laura H. Greene , Margaret Mary Pafford , Glenn Westwood , Walter G. Klemperer
发明人： Patrick J. Hentges , Laura H. Greene , Margaret Mary Pafford , Glenn Westwood , Walter G. Klemperer
CPC分类号： H01L39/2496 , C23C18/00
摘要： A method of making a superconducting structure includes depositing a metal alkoxide on a surface of a metal and hydrolyzing the metal alkoxide on the surface to form a pinhole-free film. The metal is a superconductor. The metal alkoxide may be a compound of formula (I): M4(OPrn)16 (I); where M is zirconium or hafnium, and the purity of the compound is at least 97% as measured by NMR spectroscopy.
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公开(公告)号：US20160030457A1
公开(公告)日：2016-02-04
申请号：US14783344
申请日：2014-04-08
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
发明人： Paul J. HERGENROTHER , David A. BOOTHMAN , Joseph S. BAIR , Lifen CAO , Jinming GAO , Xiumei HUANG , Xiuquan LUO , Xinpeng MA , Zachary R. MOORE , Elizabeth I. PARKINSON
IPC分类号： A61K31/706 , A61K31/4745 , A61K45/06 , A61K31/353 , A61K31/131
CPC分类号： A61K31/706 , A61K31/131 , A61K31/353 , A61K31/4738 , A61K31/4745 , A61K45/06 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , A61K2300/00
摘要： The therapies described herein can be selectively lethal toward a variety of different cancer cell types and cancer conditions in a subject. The combination therapies described herein can be useful for the management, treatment, control, or adjunct treatment of diseases, where the selective lethality is beneficial in chemotherapeutic therapy, particularly where the disease is accompanied by elevated levels of NQO1.
摘要翻译： 本文所述的疗法可以选择性地对受试者中各种不同的癌细胞类型和癌症状况致命。 本文所述的联合治疗可用于治疗，治疗，控制或辅助治疗疾病，其中选择性致死性在化学治疗中是有益的，特别是在疾病伴随着NQO1水平升高的情况下。
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公开(公告)号：US07799251B2
公开(公告)日：2010-09-21
申请号：US11558084
申请日：2006-11-09
IPC分类号： C08J9/26
CPC分类号： B01L3/502707 , B01F5/0604 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01F2215/0431 , B01L3/502746 , B01L2200/12 , B01L2300/0838 , B01L2300/0867 , B01L2300/0874 , B01L2400/086 , B01L2400/088 , B33Y10/00 , B33Y40/00 , B33Y80/00 , Y10T137/218 , Y10T137/2224
摘要： Devices that include hosts having internal microcapillary networks are disclosed. The microcapillary networks are formed from interconnected passageways. The interconnected passageways may be formed by removing a fugitive material from a cured host material that forms the host. The resultant host material has many applications, including use as a microfluidic device in applications ranging from fluid mixing to structural repair.
摘要翻译： 公开了包括具有内部微毛细管网络的主机的设备。 微毛细管网络由互连的通道形成。 可以通过从形成主体的固化的主体材料中除去短暂的材料来形成互连的通道。 所得到的主体材料具有许多应用，包括在从液体混合到结构修复的应用中用作微流体装置。
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7.发明授权公开(公告)号：US07790061B2
公开(公告)日：2010-09-07
申请号：US11560610
申请日：2006-11-16
申请人： Gregory Gratson , Jennifer A. Lewis
发明人： Gregory Gratson , Jennifer A. Lewis
摘要： The invention provides polyelectrolyte inks comprising a solvent, a cationic polyelectrolyte, dissolved in the solvent, and an anionic polyelectrolyte, dissolved in the solvent. The concentration of at least one of the polyelectrolytes in the solvent is in a semidilute regime.
摘要翻译： 本发明提供了包含溶解在溶剂中的溶剂，阳离子聚电解质和溶解在溶剂中的阴离子聚电解质的聚电解质油墨。 溶剂中至少一种聚电解质的浓度为半溶液状态。
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8.发明授权BCL2 derived genetic elements associated with sensitivity to chemotherapeutic drugs 失效BCL2衍生的遗传元件与化疗药物的敏感性相关
公开(公告)号：US5789389A
公开(公告)日：1998-08-04
申请号：US405702
申请日：1995-03-17
摘要： The invention provides genetic suppressor elements that are derived from the apoptosis-related gene BCL2. The invention provides genetic suppressor elements that are capable of inhibiting BCL2 gene expression and BCL2-mediated suppression of apoptosis in mammalian cells. The GSEs provided by the invention are also useful for sensitizing cancer cells to the cytotoxic effects of chemotherapeutic drugs. The invention provides methods for identifying and obtaining such elements, and therapeutic methods of using such elements for treatment of cancer cells and animals bearing malignant tumors.
摘要翻译： 本发明提供衍生自凋亡相关基因BCL2的遗传抑制因子。 本发明提供能够抑制BCL2基因表达和BCL2介导的哺乳动物细胞凋亡抑制的遗传抑制因子。 本发明提供的GSEs也可用于使癌细胞对化疗药物的细胞毒性作用敏感。 本发明提供了用于鉴定和获得这些元件的方法，以及使用这些元件治疗携带恶性肿瘤的癌细胞和动物的治疗方法。
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公开(公告)号：US20240103016A1
公开(公告)日：2024-03-28
申请号：US18266149
申请日：2021-12-08
IPC分类号： G01N33/68 , G01N33/543
CPC分类号： G01N33/689 , G01N33/54387 , G01N2470/06 , G01N2800/52
摘要： Provided herein are methods, devices, kits, and articles of manufacture for detecting pregnancy-associated plasma protein-A (PAPP-A) in a biological sample, for instance a whole blood or serum sample obtained from a pregnant subject, and estimating gestational age (GA) based on the detection of PAPP-A, such that clinical or personal decisions informed by GA can be made without ultrasound.
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10.发明授权公开(公告)号：US09919031B2
公开(公告)日：2018-03-20
申请号：US13624365
申请日：2012-09-21
申请人： Geoffrey Goldspink , Paul Goldspink
发明人： Geoffrey Goldspink , Paul Goldspink
IPC分类号： A61K38/18 , A61K38/30 , A61K31/7088
CPC分类号： A61K38/18 , A61K31/7088 , A61K38/30
摘要： The invention relates to the use of a Mechano Growth Factor (MGF) polypeptide or a polynucleotide encoding an MGF polypeptide in the manufacture of a medicament for the prevention or limitation of myocardial damage in response to ischemia or mechanical overload of the heart by preventing or limiting apoptosis in the myocardium.
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