公开(公告)号：US07001353B2

公开(公告)日：2006-02-21

申请号：US09913857

申请日：2000-12-18

申请人： Antonio Bosetto ,  Francesco Paolini

发明人： Antonio Bosetto ,  Francesco Paolini

IPC分类号： A61M37/00 ,  A61M1/14 ,  B01D11/00 ,  C02F1/00

CPC分类号： A61M1/16 ,  A61M1/3609 ,  A61M1/3658 ,  A61M2230/65

摘要： A method is described for determining recirculation of blood in a vascular access of a patient undergoing dialysis treatment using a dialysis machine with an arterial line for withdrawing blood from the patient's body, a dialysis filter, and a venous line for returning blood to the patient's body. The method induces a disturbance in the blood flowing in the venous line. The disturbance is of a magnitude capable of bringing the system into a transient state and determining blood recirculation in the vascular access during the transient state as a function of the magnitude of the disturbance induced in the arterial line. In particular, the disturbance relates to the variation of the hemoglobin concentration in the blood flowing in the venous line. The variation is caused by controlling a change in the ultrafiltration flow in the dialysis filter.

摘要翻译： 描述了一种用于确定使用透析机进行透析治疗的患者的血管通路中的血液再循环的方法，所述透析机具有用于从患者身体抽出血液的血管，透析过滤器和用于将血液返回到患者体内的静脉管线 。 该方法引起在静脉血管中流动的血液中的干扰。 扰动是能够使系统进入瞬态并且在过渡状态期间确定血管通路中的血液再循环作为动脉线路中引起的干扰的幅度的函数的大小。 特别地，扰动涉及在静脉线中流动的血液中的血红蛋白浓度的变化。 该变化是通过控制透析过滤器中的超滤流量的变化引起的。

公开(公告)号：US20040206703A1

公开(公告)日：2004-10-21

申请号：US10844422

申请日：2004-05-13

申请人： Gambro Hospal (Schweiz) AG

发明人： Antonio Bosetto ,  Francesco Paolini

IPC分类号： B01D011/00

CPC分类号： A61M1/1656 ,  A61M1/1666 ,  A61M1/167 ,  B01F3/088 ,  Y10S210/929

摘要： A method for preparing a medical liquid from a liquid, such as water, and two concentrated solutions comprises the following steps: circulating the liquid in a conduit (15), at a flowrate Q0; injecting into the conduit (15), at a flowrate Q1, a first concentrated solution containing a first ionic substance A and a second ionic substance B, the ionic substances A and B having, respectively, in the first concentrated solution, a concentration nullAsolnull and a first concentration nullB1solnull; injecting into the conduit (15), at a flowrate Q2, a second concentrated solution containing the first ionic substance A and the second ionic substance B, the first ionic substance A having, in the second concentrated solution, the same concentration nullAsolnull as in the first concentrated solution, and the second ionic substance B having, in the second concentrated solution, a second concentration nullB2solnull different than the first concentration nullB1solnull in the first concentrated solution; regulating the injection flowrate Q1 and the injection flowrate Q2 of the first and second concentrated solutions in such a way that at any given time the diluted solution resulting from the mixing of the liquid and the concentrated solutions has a desired concentration nullAdesnull of first substance A and a desired concentration nullBdesnull of second substance B.

摘要翻译： 从液体如水和两种浓缩溶液制备医用液体的方法包括以下步骤：以流量Q0在管道（15）中循环液体; 以流量Q1注入导管（15），含有第一离子物质A和第二离子物质B的第一浓缩溶液，离子物质A和B分别在第一浓缩溶液中具有浓度[Asol ]和第一浓度[B1sol] 以流量Q2注入导管（15），含有第一离子物质A和第二离子物质B的第二浓缩溶液，第二离子物质A在第二浓缩溶液中具有相同的浓度[Asol] 在第一浓缩溶液中，第二离子物质B在第二浓缩溶液中具有与第一浓缩溶液中的第一浓度[B1sol]不同的第二浓度[B2sol] 以这样的方式调节第一和第二浓缩溶液的注入流量Q1和注入流量Q2，使得在任何给定时间，由液体和浓缩溶液的混合产生的稀释溶液具有所需的第一物质的浓度[Ades] A和第二物质B的期望浓度[Bdes]

公开(公告)号：US07067061B2

公开(公告)日：2006-06-27

申请号：US10844422

申请日：2004-05-13

申请人： Antonio Bosetto ,  Francesco Paolini

发明人： Antonio Bosetto ,  Francesco Paolini

IPC分类号： B01D61/26 ,  B01D35/00 ,  A61M37/00 ,  B01D61/28 ,  B01D61/32

CPC分类号： A61M1/1656 ,  A61M1/1666 ,  A61M1/167 ,  B01F3/088 ,  Y10S210/929

摘要： A method for preparing a medical liquid from a liquid, such as water, and two concentrated solutions comprises the following steps: circulating the liquid in a conduit (15), at a flowrate Q0; injecting into the conduit (15), at a flowrate Q1, a first concentrated solution containing a first ionic substance A and a second ionic substance B, the ionic substances A and B having, respectively, in the first concentrated solution, a concentration [Asol] and a first concentration [B1sol]; injecting into the conduit (15), at a flowrate Q2, a second concentrated solution containing the first ionic substance A and the second ionic substance B, the first ionic substance A having, in the second concentrated solution, the same concentration [Asol] as in the first concentrated solution, and the second ionic substance B having, in the second concentrated solution, a second concentration [B2sol] different than the first concentration [B1sol] in the first concentrated solution; regulating the injection flowrate Q1 and the injection flowrate Q2 of the first and second concentrated solutions in such a way that at any given time the diluted solution resulting from the mixing of the liquid and the concentrated solutions has a desired concentration [Ades] of first substance A and a desired concentration [Bdes] of second substance B.

摘要翻译： 从液体如水和两种浓缩溶液制备医用液体的方法包括以下步骤：以流量Q 0在管道（15）中循环液体; 以流量Q 1，含有第一离子物质A和第二离子物质B的第一浓缩溶液将第一浓缩溶液中的离子物质A和B分别注入管道（15）中， Asol]和第一浓度[B 1 sol]; 以流量Q 2，含有第一离子物质A和第二离子物质B的第二浓缩溶液注入到管道（15）中，第一离子物质A在第二浓缩溶液中具有相同的浓度[Asol] 与第一浓缩溶液一样，第二离子物质B在第二浓缩溶液中具有与第一浓缩溶液中的第一浓度[B 1 sol]不同的第二浓度[B 2 sol] 调节第一和第二浓缩溶液的注入流量Q 1和注入流速Q 2，使得在任何给定时间，由液体和浓缩溶液的混合产生的稀释溶液具有所需的浓度[Ades] 第一物质A和第二物质B的所需浓度[Bdes]

公开(公告)号：US06932786B2

公开(公告)日：2005-08-23

申请号：US09914348

申请日：2000-12-22

申请人： Sara Giacomelli ,  Ivan Rossi ,  Enrico Canini

发明人： Sara Giacomelli ,  Ivan Rossi ,  Enrico Canini

IPC分类号： A61M1/14 ,  A61M1/16 ,  A61M1/36 ,  A61M37/00 ,  C02F1/44

CPC分类号： A61M1/3669 ,  A61M1/16 ,  A61M1/3656 ,  A61M1/367 ,  A61M2205/13 ,  A61M2205/50

摘要： A device for monitoring the access to the cardiovascular system of a patient undergoing an extracorporeal treatment of blood in a machine (1) comprising a treatment device (4) and an extracorporeal circuit (2), comprises: a voltage generator (16) for generating a potential difference between a part of the machine (1) and a first point (B) of a venous branch (8) of the extracorporeal circuit (2), connecting the patient to the treatment device (4); a detector (17) for detecting the value (dV) of a quantity that correlates with the electric current along at least one section (10a; 10b; 10c) of the venous branch (10) between the first point (B) and a venous needle (13) fitted at the end of the venous branch (8) and inserted in the vascular system of the patient (P); calculating means (15) for comparing the detected value (dV) with a reference range (I).

摘要翻译： 一种用于监测在包括治疗装置（4）和体外电路（2）的机器（1）中进行血液体外处理的患者的心血管系统的通路的装置，包括：电压发生器（16），用于产生 所述机器（1）的一部分与所述体外回路（2）的静脉分支（8）的第一点（B）之间的电位差，将所述患者连接到所述治疗装置（4）; 检测器（17），用于检测与第一点（B）之间的静脉分支（10）的至少一个部分（10a; 10b; 10c）的电流相关的量的值（dV） 以及安装在静脉分支（8）的端部并插入患者（P）的血管系统中的静脉针（13）; 用于将检测值（dV）与参考范围（I）进行比较的计算装置（15）。

公开(公告)号：US07147616B2

公开(公告)日：2006-12-12

申请号：US09979307

申请日：2001-01-12

申请人： Renato Pedrazzi ,  Paolo Rovatti

发明人： Renato Pedrazzi ,  Paolo Rovatti

IPC分类号： A61M37/00 ,  C02F1/44 ,  A61L2/16 ,  A61L101/00

CPC分类号： A61M1/3643 ,  A61M1/16 ,  A61M1/1601 ,  A61M1/3644 ,  A61M1/3646 ,  A61M1/365 ,  A61M1/3652 ,  A61M2205/3331 ,  A61M2205/3351 ,  A61M2205/3355

摘要： A method for emptying a blood circuit of an apparatus for the extracorporeal treatment of blood after interrupting a treatment session. The apparatus has a blood treatment device with first and second compartments separated by a semi permeable membrane, an arterial pipe connected to an inlet of the first compartment, a venous pipe connected to an outlet of the first compartment and a second end, and a used liquid circuit having a drain pipe connected to an outlet of the second compartment. The method involves the closing of the blood circuit on itself. The blood circuit includes the arterial pipe, the first compartment of the blood treatment apparatus, and the venous pipe, in order to form a closed loop circuit after the arterial and venous pipes have been disconnected from the vascular system of the patient. The blood circuit contains a liquid, which is transferred from the closed loop circuit into the used liquid circuit. The liquid transferred into the used liquid circuit is then drained using the drain pipe.

摘要翻译： 一种在中断治疗会话后排空体外血液处理装置的血液回路的方法。 该装置具有血液处理装置，其具有由半透膜隔开的第一和第二隔室，连接到第一隔室的入口的动脉管，连接到第一隔室的出口的静脉管和第二端， 液体回路具有连接到第二隔室的出口的排放管。 该方法涉及自身闭合血液回路。 血液回路包括动脉管，血液处理装置的第一隔室和静脉管，以便在动脉和静脉管与患者的血管系统断开之后形成闭环回路。 血液回路包含液体，其从闭环回路传送到使用过的液体回路中。 然后使用排水管排出转移到废液回路中的液体。

公开(公告)号：US06966979B2

公开(公告)日：2005-11-22

申请号：US10772340

申请日：2004-02-06

申请人： Renato Pedrazzi

发明人： Renato Pedrazzi

IPC分类号： A61M1/16 ,  A61M1/34 ,  A61M1/36 ,  A61M39/28 ,  B01D61/00 ,  B01D65/00

CPC分类号： A61M1/342 ,  A61M1/1607 ,  A61M1/1609 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3441 ,  A61M1/361 ,  A61M1/3612 ,  A61M1/3669 ,  A61M39/28 ,  A61M2230/30

摘要： An infusion control device controls infusion of a liquid in an extracorporeal blood circuit having an arterial pipe connected to an inlet of a blood compartment of a filter and a venous pipe connected to an outlet of the blood compartment. The arterial pipe is also connected to a pre-dilution pipe of an infusion circuit, and the venous pipe is also connected to a post-dilution pipe of said infusion circuit. The infusion control device regulates and distributes an infusion flow rate in the arterial and venous pipes based on a monitoring of quantities that are directly correlated with the operating conditions of the filter.

摘要翻译： 输液控制装置控制在体外血液循环中的液体输注，其具有连接到过滤器的血液室的入口的动脉管和连接到血液室的出口的静脉管。 动脉管还连接到输注电路的预稀释管，静脉管也连接到所述输注电路的后稀释管。 输液控制装置基于与过滤器的操作条件直接相关的量的监测来调节和分配动脉和静脉管中的输注流速。

公开(公告)号：US07131956B1

公开(公告)日：2006-11-07

申请号：US09787624

申请日：2000-07-28

申请人： Paolo Pirazzoli ,  Antonio Bosetto ,  Francesco Paolini

发明人： Paolo Pirazzoli ,  Antonio Bosetto ,  Francesco Paolini

IPC分类号： A61M37/00 ,  C02F1/44 ,  C02F1/00 ,  B01D35/14 ,  A31M1/36

CPC分类号： A61M1/16 ,  A61M1/1601 ,  A61M1/1647 ,  A61M1/3403 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3441 ,  A61M1/361 ,  A61M1/3639 ,  A61M2205/18 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/50 ,  A61M2205/702 ,  A61M2205/707 ,  A61M2205/7563 ,  A61M2230/207

摘要： A dialysis machine comprises: means for calculating (60) a filtration factor (FF) as a function of the ultrafiltration rate (UFR) and of a plasma flow rate (Qp); first comparison means (65) for comparing the filtration factor (FF) with a limit value of admissibility; and signaling means (70) for generating a signal (A) indicating the result of the comparison.

摘要翻译： 一种透析机包括：用于根据超滤速率（UFR）和等离子体流速（Q >P）计算（60）过滤因子（FF）的装置; 用于将过滤因子（FF）与可接受性的极限值进行比较的第一比较装置（65） 以及用于产生指示比较结果的信号（A）的信令装置（70）。

公开(公告)号：US20040154967A1

公开(公告)日：2004-08-12

申请号：US10772340

申请日：2004-02-06

申请人： GAMBRO HOSPAL (Schweiz) AG

发明人： Renato Pedrazzi

IPC分类号： B01D061/00 ,  B01D065/00

CPC分类号： A61M1/342 ,  A61M1/1607 ,  A61M1/1609 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3441 ,  A61M1/361 ,  A61M1/3612 ,  A61M1/3669 ,  A61M39/28 ,  A61M2230/30

摘要： An infusion control device controls infusion of a liquid in an extracorporeal blood circuit having an arterial pipe connected to an inlet of a blood compartment of a filter and a venous pipe connected to an outlet of the blood compartment. The arterial pipe is also connected to a pre-dilution pipe of an infusion circuit, and the venous pipe is also connected to a post-dilution pipe of said infusion circuit. The infusion control device regulates and distributes an infusion flow rate in the arterial and venous pipes based on a monitoring of quantities that are directly correlated with the operating conditions of the filter.

摘要翻译： 输液控制装置控制在体外血液循环中的液体输注，其具有连接到过滤器的血液室的入口的动脉管和连接到血液室的出口的静脉管。 动脉管还连接到输注电路的预稀释管，静脉管也连接到所述输注电路的后稀释管。 输液控制装置基于与过滤器的操作条件直接相关的量的监测来调节和分配动脉和静脉管中的输注流速。

公开(公告)号：US20060191850A1

公开(公告)日：2006-08-31

申请号：US11402024

申请日：2006-04-12

申请人： Antonio Bosetto ,  Francesco Paolini

发明人： Antonio Bosetto ,  Francesco Paolini

IPC分类号： B01D61/26

CPC分类号： A61M1/1656 ,  A61M1/1666 ,  A61M1/167 ,  B01F3/088 ,  Y10S210/929

摘要： A method for preparing a medical liquid from a liquid, such as water, and two concentrated solutions comprises the following steps: circulating the liquid in a conduit (15), at a flowrate Q0; injecting into the conduit (15), at a flowrate Q1, a first concentrated solution containing a first ionic substance A and a second ionic substance B, the ionic substances A and B having, respectively, in the first concentrated solution, a concentration [Asol] and a first concentration [B1sol]; injecting into the conduit (15), at a flowrate Q2, a second concentrated solution containing the first ionic substance A and the second ionic substance B, the first ionic substance A having, in the second concentrated solution, the same concentration [Asol] as in the first concentrated solution, and the second ionic substance B having, in the second concentrated solution, a second concentration [B2sol] different than the first concentration [B1sol] in the first concentrated solution; regulating the injection flowrate Q1 and the injection flowrate Q2 of the first and second concentrated solutions in such a way that at any given time the diluted solution resulting from the mixing of the liquid and the concentrated solutions has a desired concentration [Ades] of first substance A and a desired concentration [Bdes] of second substance B.

摘要翻译： 从液体如水和两种浓缩溶液制备医用液体的方法包括以下步骤：以流量Q 0在管道（15）中循环液体; 以流量Q 1，含有第一离子物质A和第二离子物质B的第一浓缩溶液将第一浓缩溶液中的离子物质A和B分别注入管道（15）中， Asol]和第一浓度[B1sol]; 以流量Q 2，含有第一离子物质A和第二离子物质B的第二浓缩溶液注入到管道（15）中，第一离子物质A在第二浓缩溶液中具有相同的浓度[Asol] 与第一浓缩溶液一样，第二离子物质B在第二浓缩溶液中具有与第一浓缩溶液中的第一浓度[B1sol]不同的第二浓度[B2sol] 调节第一和第二浓缩溶液的注入流量Q 1和注入流速Q 2，使得在任何给定时间，由液体和浓缩溶液的混合产生的稀释溶液具有所需的浓度[Ades] 第一物质A和第二物质B的所需浓度[Bdes]