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公开(公告)号：US11324766B2
公开(公告)日：2022-05-10
申请号：US17320003
申请日：2021-05-13
申请人： Glycosyn LLC
IPC分类号： A61K31/702 , A61K9/00 , A61K45/06 , A61K35/745 , A61K35/742 , A61K35/74 , A23L33/125 , A23L33/00 , A23L2/52 , A61K35/747
摘要： The invention provides compositions and methods for utilizing oligosaccharides, such as isolated human milk oligosaccharides, to attenuate a respiratory pathogen infection-induced host inflammation and/or to promote recovery from a respiratory pathogen infection-induced host inflammation in a subject.
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公开(公告)号：US11274325B2
公开(公告)日：2022-03-15
申请号：US16221193
申请日：2018-12-14
申请人： Glycosyn LLC
摘要： Provided herein, inter alia, are methods, bacteria, nucleic acids, and polypeptides for producing sialylated oligosaccharides.
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3.发明授权Use of purified 2′-fucosyllactose, 3-fucosyllactose and lactodifucotetraose as prebiotics 有权使用纯化的2'-岩藻糖基乳糖，3-岩藻糖基乳糖和乳糖四糖作为益生元公开(公告)号：US09567361B2
公开(公告)日：2017-02-14
申请号：US13469499
申请日：2012-05-11
IPC分类号： A01N63/00 , C07H3/06 , A61K31/702
CPC分类号： A61K31/702 , A23L2/52 , A23L33/10 , A23L33/21 , A23L33/28 , A23L33/40 , A23V2002/00 , C07H3/06 , Y02A50/473 , Y02A50/481
摘要： The invention provides compositions and methods for utilizing synthetic human milk oligosaccharides as prebiotics.
摘要翻译： 本发明提供了利用合成人乳寡糖作为益生元的组合物和方法。
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4.发明申请Alpha (1,2) Fucosyltransferases Suitable for Use in the Production of Fucosylated Oligosaccharides 有权α（1,2）岩藻糖基转移酶适用于生产岩藻糖基化寡糖公开(公告)号：US20140031541A1
公开(公告)日：2014-01-30
申请号：US13557655
申请日：2012-07-25
CPC分类号： C12P19/18 , C12N9/1051 , C12N15/52 , C12N15/72 , C12Y204/01069 , C40B30/02 , G06F19/16
摘要： The invention provides compositions and methods for engineering E. coli or other host production bacterial strains to produce fucosylated oligosaccharides, and the use thereof in the prevention or treatment of infection.
摘要翻译： 本发明提供用于制备大肠杆菌或其他宿主生产细菌菌株以产生岩藻糖基化寡糖的组合物和方法，以及其在预防或治疗感染中的用途。
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5.发明授权公开(公告)号：US11453900B2
公开(公告)日：2022-09-27
申请号：US15509820
申请日：2015-09-09
申请人： Glycosyn LLC
摘要： The invention relates to methods and compositions for the production of fucosylated oligosaccharides.
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公开(公告)号：US20210353654A1
公开(公告)日：2021-11-18
申请号：US17320152
申请日：2021-05-13
申请人： Glycosyn LLC
IPC分类号： A61K31/702 , A61P31/14 , A23L33/125 , A23C9/20
摘要： The invention provides compositions and methods for utilizing oligosaccharides, such as isolated human milk oligosaccharides, to attenuate a respiratory pathogen infection and/or to promote recovery from a respiratory pathogen infection in the respiratory system and/or the GI tract of a subject.
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公开(公告)号：US20210261995A1
公开(公告)日：2021-08-26
申请号：US17241441
申请日：2021-04-27
申请人： Glycosyn LLC
IPC分类号： C12P19/00 , C12N9/00 , C12N9/10 , C12N9/38 , C12P19/18 , C12P19/26 , C07H3/06 , C07H13/04 , C12N15/70 , C12N9/14
摘要： The invention provides compositions and methods for engineering bacteria to produce fucosylated oligosaccharides, and the use thereof in the prevention or treatment of infection.
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公开(公告)号：US09758803B2
公开(公告)日：2017-09-12
申请号：US14776216
申请日：2014-03-14
申请人： Glycosyn LLC
IPC分类号： C07H5/04 , C12P19/02 , C12N1/20 , C12N15/00 , C07K14/245 , C12P19/04 , C12P19/18 , C12P19/26 , C12N9/10 , C12N15/52 , C07H1/00 , C07H13/04 , C07H5/06
CPC分类号： C12P19/02 , C07H1/00 , C07H5/06 , C07H13/04 , C07K14/245 , C12N9/1051 , C12N9/1081 , C12N15/52 , C12P19/04 , C12P19/18 , C12P19/26
摘要： The invention provides compositions and methods for engineering bacteria to produce sialylated and N-acetylglucosamine-containing oligosaccharides, and the use thereof in the prevention or treatment of infection.
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公开(公告)号：US10415069B2
公开(公告)日：2019-09-17
申请号：US15700978
申请日：2017-09-11
申请人： Glycosyn LLC
IPC分类号： C12P19/02 , C07H5/06 , C07H13/04 , C07H1/00 , C12N9/10 , C12P19/18 , C12P19/04 , C07K14/245 , C12N15/52 , C12P19/16 , C12P19/26
摘要： The invention provides compositions and methods for engineering bacteria to produce sialylated and N-acetylglucosamine-containing oligosaccharides, and the use thereof in the prevention or treatment of infection.
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10.发明授权公开(公告)号：US10286001B2
公开(公告)日：2019-05-14
申请号：US15419241
申请日：2017-01-30
摘要： The invention provides compositions and methods for utilizing synthetic human milk oligosaccharides as prebiotics.
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