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634 条记录 (耗时 0.042 秒)

    Chemokine panec-1 antibodies
    1.
    发明授权
    Chemokine panec-1 antibodies 有权
    趋化因子panec-1抗体

    公开(公告)号：US07803373B2

    公开(公告)日：2010-09-28

    申请号：US12153507

    申请日：2008-05-20

    申请人： Roger T. Coleman ,  Olga Bandman ,  Craig G. Wilde

    发明人： Roger T. Coleman ,  Olga Bandman ,  Craig G. Wilde

    IPC分类号： A61K39/00 ,  A61K39/395 ,  C07K16/24 ,  C07K16/00

    CPC分类号： C07K16/24 ,  A61K38/00 ,  C07K1/22 ,  C07K14/523 ,  C12Q1/68 ,  C12Q2600/118 ,  G01N33/6863 ,  G01N33/6893 ,  G01N2800/067

    摘要： The present invention provides nucleotide and amino acid sequences that identify and encode novel expressed chemokines (PANEC-1 and PANEC-2) from human pancreas cells. The present invention also provides for antisense molecules to the nucleotide sequences which encode PANEC-1 and PANEC-2, expression vectors for the production of purified PANEC-1 and PANEC-2, antibodies capable of binding specifically to PANEC-1 and PANEC-2, hybridization probes or oligonucleotides for the detection of PANEC-1- or PANEC-2-encoding nucleotide sequences, genetically engineered host cells for the expression of PANEC-1 and PANEC-2, diagnostic tests for chemokine activation based on PANEC-1- and PANEC-2-encoding nucleic acid molecules and antibodies capable of binding specifically to the protein.

    摘要翻译： 本发明提供鉴定和编码来自人胰腺细胞的新型表达趋化因子（PANEC-1和PANEC-2）的核苷酸和氨基酸序列。 本发明还提供编码PANEC-1和PANEC-2的核苷酸序列的反义分子，用于产生纯化的PANEC-1和PANEC-2的表达载体，能够特异性结合PANEC-1和PANEC-2的抗体 ，用于检测PANEC-1或PANEC-2编码核苷酸序列的杂交探针或寡核苷酸，用于表达PANEC-1和PANEC-2的遗传工程改造的宿主细胞，基于PANEC-1的趋化因子激活的诊断试验和 编码PANEC-2的核酸分子和能够特异性结合蛋白质的抗体。

    Novel human sodium-dependent phosphate cotransporter
    5.
    发明申请
    Novel human sodium-dependent phosphate cotransporter 审中-公开

    公开(公告)号：US20030022325A1

    公开(公告)日：2003-01-30

    申请号：US09965522

    申请日：2001-09-26

    申请人： Incyte Pharmaceuticals, Inc.

    发明人： Preeti Lal ,  Olga Bandman

    IPC分类号： C12N009/00 ,  C07H021/04 ,  C12P021/02 ,  C12N001/21 ,  C12N005/06

    CPC分类号： C07K14/705 ,  A61K38/00 ,  C07K14/47 ,  G01N33/6872

    摘要： The present invention provides a human sodium-dependent phosphate cotransporter (NAPTR) and polynucleotides which identify and encode NAPTR. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NAPTR and a method for producing NAPTR. The invention also provides for agonists, antibodies, or antagonists specifically for NAPTR. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NAPTR for the treatment of diseases associated with the expression of NAPTR. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NAPTR. The invention also provides a method for treating disorders associated with decreased phosphate levels by administering NAPTR and a method for treating disorders associated with increased phosphate levels by administering antagonists to NAPTR.

    Histone-like protein
    6.
    发明申请
    Histone-like protein 审中-公开
    组蛋白样蛋白

    公开(公告)号：US20030008311A1

    公开(公告)日：2003-01-09

    申请号：US10162794

    申请日：2002-06-04

    申请人： Incyte Genomics, Inc., formerly known as Incyte Pharmaceuticals, Inc.

    发明人： Olga Bandman ,  Surya K. Goli ,  Hong Zhang

    IPC分类号： C12Q001/68 ,  C07H021/04 ,  C12N009/22 ,  C12P021/02 ,  C12N005/06

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： The present invention provides a human histone-like protein (HLP) and polynucleotides which identify and encode HLP. In addition, the invention provides expression vectors and host cells, agonists, antibodies, and antagonists. The invention also provides methods for producing HTP and for treating disorders associated with the expression of HLP.

    摘要翻译： 本发明提供了人类组蛋白样蛋白（HLP）和识别和编码HLP的多核苷酸。 此外，本发明提供表达载体和宿主细胞，激动剂，抗体和拮抗剂。 本发明还提供了生产HTP并用于治疗与HLP表达相关的疾病的方法。

    Human protein phosphatase
    7.
    发明申请
    Human protein phosphatase 审中-公开
    人类蛋白磷酸酶

    公开(公告)号：US20020173022A1

    公开(公告)日：2002-11-21

    申请号：US10072130

    申请日：2002-02-05

    申请人： Incyte Pharmaceuticals, Inc.

    发明人： Olga Bandman ,  Surya K. Goli ,  Preeti Lal ,  Neil C. Corley ,  Hong Zhang

    IPC分类号： C12N009/16 ,  C07H021/04 ,  C12P021/02 ,  C12N005/06

    CPC分类号： C12N9/16 ,  A61K38/00

    摘要： The invention provides a human protein phosphatase (PROPHO) and polynucleotides which identify and encode PROPHO. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of PROPHO.

    摘要翻译： 本发明提供了人蛋白磷酸酶（PROPHO）和识别和编码PROPHO的多核苷酸。 本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。 本发明还提供了治疗与PROPHO表达相关的疾病的方法。

    Novel human mitochondrial membrane protein
    9.
    发明申请
    Novel human mitochondrial membrane protein 审中-公开
    新型人线粒体膜蛋白

    公开(公告)号：US20020128463A1

    公开(公告)日：2002-09-12

    申请号：US10038302

    申请日：2002-01-04

    申请人： Incyte Pharmaceuticals, Inc.

    发明人： Jennifer L. Hillman ,  Surya K. Goli

    IPC分类号： C12Q001/68 ,  G01N033/574 ,  C07H021/04 ,  C12P021/04 ,  C12P021/02 ,  C12N005/06

    CPC分类号： C07K14/47

    摘要： The present invention provides a human mitochondrial membrane protein (HuTIM17) and polynucleotides which identify and encode HuTIM17. The invention also provides expression vectors and host cells and a method for producing HuTIM17. The invention also provides for antibodies or antagonists specifically binding HuTIM17, and their use in the prevention and treatment of cancer. The invention also provides diagnostic assays. The invention also provides for the use of HuTIM17 in identifying antifungal and antiprotozoal therapeutics.

    摘要翻译： 本发明提供了人线粒体膜蛋白（HuTIM17）和识别和编码HuTIM17的多核苷酸。 本发明还提供了表达载体和宿主细胞以及生产HuTIM17的方法。 本发明还提供了特异性结合HuTIM17的抗体或拮抗剂及其在预防和治疗癌症中的用途。 本发明还提供诊断测定。 本发明还提供了使用HuTIM17鉴定抗真菌和抗原虫治疗药物。

    Novel human apoptosis regulator
    10.
    发明申请
    Novel human apoptosis regulator 审中-公开
    新型人细胞凋亡调节剂

    公开(公告)号：US20020102710A1

    公开(公告)日：2002-08-01

    申请号：US09957295

    申请日：2001-09-19

    申请人： Incyte Pharmaceuticals, Inc.

    发明人： Olga Bandman ,  Surya K. Goli ,  Jennifer L. Hillman

    IPC分类号： C12N009/64 ,  A01K067/00 ,  C07H021/04 ,  C12P021/02 ,  C12N005/06 ,  C12N001/21

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： The present invention provides a human apoptosis regulator protein (APRG) and polynucleotides which identify and encode APRG. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding APRG and a method for producing APRG. The invention also provides for agonists, antibodies, or antagonists specifically binding APRG, and their use, in the prevention and treatment of diseases associated with expression of APRG. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding APRG for the treatment of diseases associated with the expression of APRG. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding APRG.

    摘要翻译： 本发明提供了鉴定和编码APRG的人细胞凋亡调节蛋白（APRG）和多核苷酸。 本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码APRG的核酸序列和生产APRG的方法。 本发明还提供了特异性结合APRG的激动剂，抗体或拮抗剂及其在预防和治疗与APRG表达相关的疾病中的用途。 此外，本发明提供了反义分子用于编码APRG的多核苷酸用于治疗与APRG表达相关的疾病的用途。 本发明还提供利用多核苷酸或其片段或其补体以及特异性结合APRG的抗体的诊断测定法。