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公开(公告)号:US20240246920A1
公开(公告)日:2024-07-25
申请号:US17797362
申请日:2021-02-05
IPC分类号: C07D249/08 , A61K31/4196 , A61K31/438 , A61K31/454 , A61K31/506 , A61K31/5377 , A61K31/551 , A61P31/10 , C07D401/06 , C07D401/14 , C07D403/12 , C07D403/14 , C07D417/14 , C07D471/10 , C07D487/04
CPC分类号: C07D249/08 , A61K31/4196 , A61K31/438 , A61K31/454 , A61K31/506 , A61K31/5377 , A61K31/551 , A61P31/10 , C07D401/06 , C07D401/14 , C07D403/12 , C07D403/14 , C07D417/14 , C07D471/10 , C07D487/04
摘要: Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts thereof:
wherein R1, R2, Q1, Q2, L1 and n are as defined herein. The compounds have antifungal properties and are useful in the treatment of fungal infections, including infections that are resistant to conventions anti-fungal agents.-
公开(公告)号:US20240245338A1
公开(公告)日:2024-07-25
申请号:US18684351
申请日:2022-08-11
CPC分类号: A61B5/319 , G06F30/20 , G06T17/20 , G06T2210/41
摘要: A computer-implemented method of determining one or more target sites usable for treatment of ventricular tachycardia is proposed including receiving three-dimensional model data indicative of a cardiac model modelling an anatomy of a heart of a subject with fibrosis, wherein the cardiac model includes at least one myocardial segment associated with and/or modelled as electrically conducting myocardial tissue and at least one fibrotic segment associated with and/or modelled as insulating fibrotic tissue, simulating the evolution of a cardiac activation wave across the at least one myocardial segment and the at least one fibrotic segment, and determining at least one split location, at which an isosurface of the simulated wave is split into two or more sections, the at least one split location being indicative of a location for the simulated wave hitting a boundary between the at least one fibrotic segment and the at least one myocardial segment.
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公开(公告)号:US20240207015A1
公开(公告)日:2024-06-27
申请号:US18288233
申请日:2022-04-25
CPC分类号: A61C1/0084 , A61C1/0007 , A61C1/10 , A61C17/20
摘要: This invention relates to a coolant for cooling a device for use in dentistry, the coolant comprising a Newtonian fluid having a viscosity greater than water. The invention also relates to a method of cooling a device for use in dentistry utilising the coolant, the coolant for use in a method of cooling a device for use in dentistry and an apparatus and kit comprising the coolant.
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公开(公告)号:US20240158507A1
公开(公告)日:2024-05-16
申请号:US18514189
申请日:2023-11-20
IPC分类号: C07K16/28 , A61K39/00 , A61K39/395 , A61K45/06 , A61P35/00 , A61P37/00 , C07K7/08 , C07K16/30
CPC分类号: C07K16/2827 , A61K39/00 , A61K39/0005 , A61K39/3955 , A61K45/06 , A61P35/00 , A61P37/00 , C07K7/08 , C07K16/30 , C07K16/3015 , C07K16/3023 , A61K38/00 , A61K2039/507 , A61K2039/57
摘要: The present invention is directed to synergic or additive therapies comprising the administration of a VISTA antagonist and a PD-1, PD-L1 or POD-L3 antagonist; or the combination of a VISTA agonist and a -1, PD-L1 or POD-L3 agonist which combinations respectively elicit an additive or synergistic effect at promoting T cell immunity or inhibiting T cell immunity, i.e., CD4, CD8 or Th1 immunity. The agonists and antagonists may be in the same or separate compositions and may be administered together or separately administered in either order.
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公开(公告)号:US11921183B2
公开(公告)日:2024-03-05
申请号:US15553933
申请日:2016-02-25
发明人: Ralph Sinkus , Ondrej Holub , Simon Lambert , Rachel Clough
IPC分类号: G01R33/563 , A61B5/00 , A61B5/055 , G01R33/28
CPC分类号: G01R33/56358 , A61B5/0051 , A61B5/055 , G01R33/28 , G01R33/56308
摘要: A magnetic resonance (MR) compatible transducer for magnetic resonance elastography applications has a cantilevered drive element a free end of which is arranged in use to move reciprocally, and a flexible non-conductive connection rod slidably disposed within a flexible non-conductive sleeve. The connection rod is affixed at a proximal end to the cantilevered drive element via a proximal flexible connection piece that in use accommodates the slight rotational movement of the cantilevered drive element as it reciprocates about its secured end, whilst translating the rotational reciprocation of the cantilevered drive element into a pure translational reciprocation of the connection rod within the sleeve. The distal end of the connection rod is affixed against a protrusion connected to another cantilevered driven element, upon which is mounted a piston element that in use contacts the subject. The distal end of the connection rod is provided with a distal flexible connection piece that forms the connection between the end of the connection rod and the cantilevered driven element, again to account for the pure translational movement of the rod being converted to rotational movement of the cantilevered driven element about its cantilever pivot point.
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公开(公告)号:US20240024369A1
公开(公告)日:2024-01-25
申请号:US18283660
申请日:2022-03-24
发明人: Fiona Watt , Christina PHILIPPEOS , Magnus LYNCH
CPC分类号: A61K35/33 , C12N5/0656 , A61K9/0014 , A61P17/02 , C12N2501/734 , C12N2501/73
摘要: Provided herein is method of treating a skin condition in a subject, comprising isolating cells comprising primary dermal fibroblasts from a skin sample obtained from the subject, and administering the freshly-isolated cells to skin of the subject. Also provided are freshly isolated cell preparations comprising primary dermal fibroblasts and uses thereof.
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7.
公开(公告)号:US20240010838A1
公开(公告)日:2024-01-11
申请号:US18347349
申请日:2023-07-05
发明人: Ingvar HELGASON , Dusko ILIC
CPC分类号: C08L89/06 , C12N5/0629 , C12N11/02 , C12N5/0625 , C12N5/0698 , C14C3/02 , C14C13/00 , C12N2501/155 , C12N2501/385 , C12N2502/13 , C12N2506/45 , C12N2533/30 , C12N2502/091 , C12N2502/094 , C12N2533/54
摘要: Disclosed herein are synthetic leathers, artificial epidermal layers, artificial dermal layers, layered structures, products produced therefrom and methods of producing the same.
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公开(公告)号:US11802293B2
公开(公告)日:2023-10-31
申请号:US17072676
申请日:2020-10-16
发明人: Ralph Michael Linden
CPC分类号: C12N15/86 , A61K48/0008 , A61P1/16 , A61P25/00 , A61P27/02 , A61P27/06 , C07K14/005 , C12N2750/14122 , C12N2750/14142 , C12N2750/14143
摘要: Disclosed herein is a recombinant adeno-associated virus (AAV) vector comprising (a) a variant AAV2 capsid protein, wherein the variant AAV2 capsid protein comprises at least four amino acid substitutions with respect to a wild type AAV2 capsid protein; wherein the at least four amino acid substitutions are present at the following positions in an AAV2 capsid protein sequence: 457, 492, 499 and 533; and (b) a heterologous nucleic acid comprising a nucleotide sequence encoding a gene product.
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公开(公告)号:US20230341330A1
公开(公告)日:2023-10-26
申请号:US17796412
申请日:2021-01-28
IPC分类号: G01N21/65 , G01N33/483
CPC分类号: G01N21/65 , G01N33/4833
摘要: Methods and systems for obtaining biochemical and/or structural information relating to tissues using Raman spectroscopy. Polarised light is directed to tissue using a probe. The light is reflected from the tissue, producing Raman scattering. The Raman scattering is collected by the system and split into two polarised components. The two polarised components are simultaneously imaged using a spectrometer to produce two Raman spectra. The Raman spectra are then processed and analysed using a computer program to obtain biochemical and/or structural information relating to the tissue.
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公开(公告)号:US20230323298A1
公开(公告)日:2023-10-12
申请号:US18158146
申请日:2023-01-23
发明人: John MAHER , Ana Catarina , Richard Esmond BEATSON
IPC分类号: A61K35/17 , A61K31/7068 , C12N5/0783
CPC分类号: C12N5/0636 , A61K31/7068 , A61K35/17 , C12N5/0637 , C12N2500/42 , C12N2501/15 , C12N2501/20 , C12N2501/2302 , C12N2501/999 , C12N2506/11
摘要: A method for expanding a population of γδ T-cells is provided in which isolated activated Peripheral Blood Mononuclear Cells (PBMCs) are cultured in a medium comprising transforming growth factor beta (TGF-β) under conditions in which the production of effector γδ T-cells having therapeutic activity against malignant disease is favored. The use of TGF-β in the production of effector cells in particular Vγ9Vδ2 T-cells is also described and claimed.
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