公开(公告)号：US20070002582A1

公开(公告)日：2007-01-04

申请号：US11323319

申请日：2005-12-30

申请人： Phillip Burwell ,  James Chen ,  Zihong Guo ,  Steven Daly ,  David Shine ,  Gary Lichttenegger ,  Jennifer Matson ,  Jean Bishop ,  Nick Yeo ,  Hugh Narciso

发明人： Phillip Burwell ,  James Chen ,  Zihong Guo ,  Steven Daly ,  David Shine ,  Gary Lichttenegger ,  Jennifer Matson ,  Jean Bishop ,  Nick Yeo ,  Hugh Narciso

IPC分类号： A61B1/06

CPC分类号： A61N5/062 ,  A61N2005/0652

摘要： A method of manufacture and medical apparatus that provides an apparatus useful in illuminating at least a portion of a lumen of a body. The apparatus includes an elongated flexible member and a polymer encasement portion encasing a plurality of light emitters. The light emitters may be electrically coupled to one another without the use of wire bonds, and in some embodiments may be coupled without intervening electrical paths or traces. A maximum cross-sectional dimension of the polymer encasement portion may be less than twice a dimension of one of the light emitters. In some embodiments the maximum cross-sectional dimension is less than or equal to the sum of the dimension of one of the light emitters and a marginal dimension by which an outer portion of the polymer encasement portion extends beyond the light emitter. Light emitters may be arranged linearly, helically or in partially overlapping back-to-back relation.

摘要翻译： 一种制造方法和医疗装置，其提供用于照亮身体的内腔的至少一部分的装置。 该装置包括细长的柔性构件和封装多个发光体的聚合物封装部分。 光发射器可以在不使用引线键的情况下彼此电耦合，并且在一些实施例中可以耦合而没有中间的电路径或迹线。 聚合物封装部分的最大横截面尺寸可以小于一个发光体的尺寸的两倍。 在一些实施例中，最大横截面尺寸小于或等于光发射器之一的尺寸之和和聚合物封装部分的外部部分延伸超过光发射器的边缘尺寸之和。 光发射器可以线性地，螺旋状地或以部分重叠的背靠背关系布置。

公开(公告)号：US20060067889A1

公开(公告)日：2006-03-30

申请号：US10951037

申请日：2004-09-27

申请人： Alexander Pallenberg ,  James Chen

发明人： Alexander Pallenberg ,  James Chen

IPC分类号： A61K49/00 ,  A61K39/395 ,  A61K31/555 ,  C07K16/46

CPC分类号： A61K49/0036 ,  A61K31/555 ,  A61K41/0057 ,  A61K41/0071 ,  A61K41/0076 ,  A61K49/0054 ,  C09B47/00

摘要： Provided herein are conjugates, kits, articles of manufacture and methods for detection, diagnosis and treatment by photodynamic therapy of certain undesired biological substrate targets, including, but not limited to bacteria, viruses, and other pathogenic microorganisms, tumors and hyperproliferative tissue. In particular, the conjugates provided include a fluorophore or photosensitizer linked to a targeting moiety and a quenching agent in such a way that activation of the fluorophore or the photosensitizer is quenched unless the targeting moiety is bound to a target, whereupon the quenching agent dissociates or moves away from the photosensitizer, enabling activation of the photosensitizer upon irradiation with light of a suitable wavelength.

摘要翻译： 本文提供了缀合物，试剂盒，制品和用于通过光动力学治疗某些不期望的生物底物靶（包括但不限于细菌，病毒和其它病原微生物，肿瘤和过度增生组织）进行检测，诊断和治疗的方法。 特别地，提供的缀合物包括与靶向部分和猝灭剂连接的荧光团或光敏剂，使得荧光团或光敏剂的活化被淬灭，除非靶向部分结合到靶上，随后猝灭剂解离或 远离光敏剂，能够在用合适波长的光照射时激活光敏剂。

公开(公告)号：US06899723B2

公开(公告)日：2005-05-31

申请号：US09905501

申请日：2001-07-13

申请人： James Chen

发明人： James Chen

IPC分类号： A61B18/20 ,  A61K31/122 ,  A61K31/195 ,  A61K31/395 ,  A61K31/498 ,  A61K31/5415 ,  A61K41/00 ,  A61K47/48 ,  A61N5/06 ,  A61P7/00 ,  A61P9/00 ,  A61P9/10 ,  A61P9/14 ,  A61P29/00 ,  A61P35/00 ,  A61P35/02 ,  A61P37/00 ,  A61N5/067

CPC分类号： A61K41/0057 ,  A61K41/0061 ,  A61K41/0071 ,  A61K47/6817 ,  A61K47/6835 ,  A61K47/6849 ,  A61K47/6867 ,  A61N5/062

摘要： The present invention is drawn to methods and compounds for photodynamic therapy (PDT) of a target tissue or compositions in a mammalian subject, using a light source that preferably transmits light to a treatment site transcutaneously. The method provides for administering to the subject a therapeutically effective amount of a targeted substance, which is either a targeted photosensitizing agent, or a photosensitizing agent delivery system, or a targeted prodrug. This targeted substance preferably selectively binds to the target tissue. Light at a wavelength or waveband corresponding to that which is absorbed by the targeted substance is then administered. The light intensity is relatively low, but a high total fluence is employed to ensure the activation of the targeted photosensitizing agent or targeted prodrug product. Transcutaneous PDT is useful in the treatment of specifically selected target tissues, such as vascular endothelial tissue, the abnormal vascular walls of tumors, solid tumors of the head and neck, tumors of the gastrointestinal tract, tumors of the liver, tumors of the breast, tumors of the prostate, tumors of the lung, nonsolid tumors, malignant cells of the hematopoietic and lymphoid tissue and other lesions in the vascular system or bone marrow, and tissue or cells related to autoimmune and inflammatory disease.

摘要翻译： 本发明涉及使用优选将光透射至治疗部位的光源的哺乳动物受试者中靶组织或组合物的光动力疗法（PDT）的方法和化合物。 该方法提供向受试者施用治疗有效量的靶向物质，其为靶向光敏剂或光敏剂递送系统或靶向前药。 该靶向物质优选选择性地结合靶组织。 然后施用对应于被靶向物质吸收的波长或波段的光。 光强度相对较低，但采用高总能量密度来确保目标光敏剂或靶向前药产品的活化。 经皮PDT可用于特异性选择的靶组织如血管内皮组织，肿瘤异常血管壁，头颈部实体瘤，胃肠道肿瘤，肝肿瘤，乳腺肿瘤， 前列腺肿瘤，肺肿瘤，非固体肿瘤，造血和淋巴组织的恶性细胞以及血管系统或骨髓中的其他损伤，以及与自身免疫性和炎性疾病相关的组织或细胞。

公开(公告)号：US20050085455A1

公开(公告)日：2005-04-21

申请号：US10687579

申请日：2003-10-16

申请人： James Chen

发明人： James Chen

IPC分类号： A61M37/00 ,  A61N5/06 ,  A61N7/00 ,  A61K31/555 ,  A61N1/30

CPC分类号： A61N5/0601 ,  A61M37/0092 ,  A61N5/062 ,  A61N7/00 ,  A61N2005/063 ,  A61N2005/0652 ,  A61N2005/0653 ,  A61N2005/0658 ,  A61N2007/0008

摘要： The present invention is drawn to methods and compounds for transcutaneous photodynamic therapy (“PDT”) of target adipocyte cells or adipose tissue in a mammalian subject, which includes administering to the subject a therapeutically effective amount of a photosensitizing agent or a photosensitizing agent delivery system or a prodrug, where the photosensitizing agent or photosensitizing agent delivery system or prodrug selectively binds to the target tissue; and irradiating at least a portion of the subject with light at a wavelength absorbed by the photosensitizing agent or if prodrug, by a prodrug product thereof, where the light is provided by a light source, and where the irradiation is at low fluence rate that results in the activation of the photosensitizing agent or prodrug product. These methods of transcutaneous PDT are useful for the reduction of adipose tissue and adipocytes.

摘要翻译： 本发明涉及用于哺乳动物受试者的目标脂肪细胞或脂肪组织的经皮光动力学治疗（“PDT”）的方法和化合物，其包括向受试者施用治疗有效量的光敏剂或光敏剂递送系统 或前药，其中光敏剂或光敏剂递送系统或前药选择性地结合靶组织; 并用受光敏剂吸收的波长的光照射受试者的至少一部分，或者如果其前体药物通过光源提供光的前药，并且其中照射是低的注射率，则结果 在光敏剂或前药产物的活化中。 经皮PDT的这些方法可用于减少脂肪组织和脂肪细胞。

公开(公告)号：US20020010500A1

公开(公告)日：2002-01-24

申请号：US09103761

申请日：1998-06-24

申请人： Light Sciences Corporation

发明人： JAMES C. CHEN

IPC分类号： A61N005/067

CPC分类号： A61N5/062 ,  A61B2018/2211 ,  A61B2018/2261 ,  A61N5/0601 ,  A61N2005/0652

摘要： Light is administered during photodynamic therapy (PDT) for an extended period of time at a plurality of sites distributed within the abnormal tissue of a tumor. A clinical study has shown that a substantially greater volume of abnormal tissue in a tumor is destroyed by the extended administration of light therapy from a plurality of probes than would have been expected based upon the teaching of the prior art. In this process, a plurality of light emitting optical fibers or probes are deployed in a spaced-apart array. After a photoreactive agent is absorbed by the abnormal tissue, the light therapy is administered for at least three hours. The greater volume of necrosis in the tumor is achieved due to one or more concomitant effects, including: the inflammation of damaged abnormal tissue and resultant immunological response of the patient's body; the diffusion and circulation of activated photoreactive agent outside the expected fluence zone, which is believed to destroy the abnormal tissue; a retrograde thrombosis or vascular occlusion outside of the expected fluence zone; and, the collapse of the vascular system that provides oxygenated blood to portions of the tumor outside the expected fluence zone. In addition, is possible that molecular oxygen diffusing and circulating into the expected fluence zone is converted to singlet oxygen during the extended light therapy, causing a gradient of hypoxia and anoxia that destroys the abnormal tissue outside the expected fluence zone.

摘要翻译： 在光动力学治疗（PDT）期间，在分布在肿瘤的异常组织内的多个部位，长时间给予光。 临床研究已经表明，通过基于现有技术的教导所预期的多个探针的光疗法的延长施用，肿瘤中的大量异常组织被破坏。 在该过程中，多个发光光纤或探针以间隔开的阵列展开。 光反应剂被异常组织吸收后，给予光疗至少3小时。 由于一种或多种伴随的作用，实现了肿瘤中更大量的坏死，包括：损伤的异常组织的炎症和患者身体的免疫反应; 活化光反应剂在预期通量区外的扩散和循环，据信会破坏异常组织; 预期注量区以外的逆行血栓形成或血管闭塞; 以及向期望注量区外的肿瘤部分提供氧合血液的血管系统的崩溃。 另外，扩展光疗期间扩散并循环到预期注量区的分子氧可能被转化为单线态氧，导致在预期注量区外部破坏异常组织的缺氧和缺氧的梯度。

公开(公告)号：US20070260295A1

公开(公告)日：2007-11-08

申请号：US11416783

申请日：2006-05-03

申请人： James Chen ,  Steven Daly ,  Zihong Guo ,  Llew Keltner ,  Jeffrey Storm

发明人： James Chen ,  Steven Daly ,  Zihong Guo ,  Llew Keltner ,  Jeffrey Storm

IPC分类号： A61N5/06

CPC分类号： A61N5/062 ,  A61B50/30 ,  A61N5/0601 ,  A61N2005/0645 ,  A61N2005/0652

摘要： A light transmission system to provide photodynamic treatment to a patient includes a single use integrated control module and catheter assembly having a plurality of light emitting diodes (LEDs) to transmit light toward target cells within a patient. The integrated light catheter and control module are used in combination with a light activated drug. Selected operating parameters may be programmed into the control module, or it may be wirelessly programmable in situ prior to use to allow user flexibility to tailor treatment for a particular patient or condition. Among the features that prevent reuse are that the control module lacks access to recharge the power source, and it may include a deactivation module that destroys circuitry or software when triggered. To prevent patient interference when in use, the control module may also be configured to selectively deactivate.

摘要翻译： 向患者提供光动力治疗的光传输系统包括具有多个发光二极管（LED）的单次使用的集成控制模块和导管组件，以将光传送到患者体内的靶细胞。 集成光导管和控制模块与光活化药物组合使用。 所选择的操作参数可以被编程到控制模块中，或者可以在使用之前在现场进行无线可编程，以允许用户灵活地为特定患者或病症定制治疗。 防止重用的功能之一是控制模块缺少对电源进行再充电的功能，并且可能包括在触发时破坏电路或软件的停用模块。 为了在使用时防止患者干扰，控制模块还可以被配置为选择性地停用。

公开(公告)号：US20020087205A1

公开(公告)日：2002-07-04

申请号：US09905501

申请日：2001-07-13

申请人： Light Sciences Corporation

发明人： James Chen

IPC分类号： A61B018/18 ,  A61N001/00

CPC分类号： A61K41/0057 ,  A61K41/0061 ,  A61K41/0071 ,  A61K47/6817 ,  A61K47/6835 ,  A61K47/6849 ,  A61K47/6867 ,  A61N5/062

摘要： The present invention is drawn to methods and compounds for photodynamic therapy (PDT) of a target tissue or compositions in a mammalian subject, using a light source that preferably transmits light to a treatment site transcutaneously. The method provides for administering to the subject a therapeutically effective amount of a targeted substance, which is either a targeted photosensitizing agent, or a photosensitizing agent delivery system, or a targeted prodrug. This targeted substance preferably selectively binds to the target tissue. Light at a wavelength or waveband corresponding to that which is absorbed by the targeted substance is then administered. The light intensity is relatively low, but a high total fluence is employed to ensure the activation of the targeted photosensitizing agent or targeted prodrug product. Transcutaneous PDT is useful in the treatment of specifically selected target tissues, such as vascular endothelial tissue, the abnormal vascular walls of tumors, solid tumors of the head and neck, tumors of the gastrointestinal tract, tumors of the liver, tumors of the breast, tumors of the prostate, tumors of the lung, nonsolid tumors, malignant cells of the hematopoietic and lymphoid tissue and other lesions in the vascular system or bone marrow, and tissue or cells related to autoimmune and inflammatory disease.

摘要翻译： 本发明涉及使用优选将光透射至治疗部位的光源的哺乳动物受试者中靶组织或组合物的光动力疗法（PDT）的方法和化合物。 该方法提供向受试者施用治疗有效量的靶向物质，其为靶向光敏剂或光敏剂递送系统或靶向前药。 该靶向物质优选选择性地结合靶组织。 然后施用对应于被靶向物质吸收的波长或波段的光。 光强度相对较低，但采用高总能量密度来确保目标光敏剂或靶向前药产品的活化。 经皮PDT可用于特异性选择的靶组织如血管内皮组织，肿瘤异常血管壁，头颈部实体瘤，胃肠道肿瘤，肝肿瘤，乳腺肿瘤， 前列腺肿瘤，肺肿瘤，非固体肿瘤，造血和淋巴组织的恶性细胞以及血管系统或骨髓中的其他损伤，以及与自身免疫性和炎性疾病相关的组织或细胞。

公开(公告)号：US20010045785A1

公开(公告)日：2001-11-29

申请号：US09910364

申请日：2001-07-20

申请人： Light Sciences Corporation

发明人： James C. Chen ,  Darrin Huston ,  Brian D. Wilkerson

IPC分类号： H02K016/02 ,  H02K007/10

CPC分类号： A61N1/08 ,  A47J36/02 ,  A47J36/26 ,  A61F2250/0001 ,  A61N1/3787 ,  H01F38/12 ,  H01F38/14 ,  H01M10/46 ,  H01M10/48 ,  H02K5/1282 ,  H02K7/1807 ,  H02K7/1876 ,  H02K21/12 ,  H02K21/24 ,  H02K35/02 ,  H05B6/1236 ,  Y02B40/123

摘要： A flux generator base unit electromagnetically coupled with a receiving unit to transfer energy into the receiving unit. The base unit includes one or more permanent magnets that produce a magnetic flux, which passes through a receiver coil in the receiving unit. The receiver coil is either disposed in a separate housing that is electrically connected with a portable device, or integrated into the housing of the portable device. Either the permanent magnets or a flux shunt is moved in the base unit to produce the varying magnetic flux that is coupled to the receiver coil. As a result of the varying magnetic field experienced by the receiver coil, an electric current is induced in the receiver coil, which is conditioned (e.g., rectified, filtered, and regulated) by a conditioning circuit to charge a battery or energize electronics contained in the portable device. Various embodiments of both the base unit and receiving unit are disclosed, including nulluniversalnull base units suitable for operation with different size receiving units.

摘要翻译： 与接收单元电磁耦合以将能量传递到接收单元中的通量发生器基座单元。 基座单元包括产生磁通的一个或多个永久磁铁，其通过接收单元中的接收器线圈。 接收器线圈或者被布置在与便携式设备电连接或者集成到便携式设备的外壳中的分离的外壳中。 永磁体或磁通分流器在基本单元中移动以产生耦合到接收器线圈的变化的磁通量。 作为接收器线圈所经历的变化的磁场的结果，在接收器线圈中感应出电流，该接收器线圈由调节电路调节（例如，整流，滤波和调节），以对电池充电或激励包含在 便携式设备。 公开了基本单元和接收单元的各种实施例，包括适用于具有不同尺寸接收单元的操作的“通用”基本单元。

公开(公告)号：US07018395B2

公开(公告)日：2006-03-28

申请号：US10802284

申请日：2004-03-16

申请人： James Chen

发明人： James Chen

IPC分类号： A61N5/067 ,  A61K9/127

CPC分类号： A61K41/0057 ,  A61K41/0061 ,  A61K41/0071 ,  A61K47/6817 ,  A61K47/6835 ,  A61K47/6849 ,  A61K47/6867 ,  A61N5/062

摘要： The present invention is drawn to methods for photodynamic therapy (PDT) of a target cell, target tissue or target composition in a mammalian subject, using a therapeutically effective amount of a targeted substance, which is either a targeted photosensitizing agent, or a photosensitizing agent delivery system, or a targeted prodrug. This targeted substance preferably selectively binds to the target cell, target tissue or target composition. Light at a wavelength or waveband corresponding to that which is absorbed by the targeted substance is then administered. The light intensity is relatively low, but a high total fluence is employed to ensure the activation of the targeted photosensitizing agent or targeted prodrug product.

摘要翻译： 本发明涉及使用治疗有效量的靶向物质作为靶向细胞，靶组织或目标组合物的光动力学治疗（PDT）的方法，所述目标物质是靶向光敏剂或光敏剂 递送系统或靶向前药。 该靶向物质优选选择性地结合靶细胞，靶组织或靶组成。 然后施用对应于被靶向物质吸收的波长或波段的光。 光强度相对较低，但采用高总能量密度来确保目标光敏剂或靶向前药产品的活化。

公开(公告)号：US20040243198A1

公开(公告)日：2004-12-02

申请号：US10677645

申请日：2003-10-02

申请人： Light Sciences Corporation

发明人： Gregory L. Heacock ,  Darrin Huston ,  James C. Chen ,  Steven R. Daly

IPC分类号： A61N001/00

CPC分类号： A61F9/008 ,  A61F9/009 ,  A61F2009/00844 ,  A61F2009/00863 ,  A61F2009/00868 ,  A61F2009/00891 ,  A61N5/062 ,  A61N2005/0652

摘要： A system and method for excitation of photosensitizers is configured to provide desired illumination on targeted eye tissue. The excitation system includes an optical module that generates illumination and a controller to power the optical module and control the shape, intensity or energy level, and duration of the illumination. The optical module includes a contact portion for interfacing with the eye, a treatment beam portion including a light emitter array to generate shaped light patterns and optics to focus the light patterns onto the eye, and a visualization portion to provide visual feedback of treatment through a visualization interface coupled with a microscope. A typical treatment involves the optical module being placed on a diseased eye of a patient by a clinician to project illumination on a diseased portion of the eye. The clinician typically views the eye through the microscope and the optical module during treatment.

摘要翻译： 用于激发光敏剂的系统和方法被配置为在目标眼睛组织上提供期望的照明。 励磁系统包括产生照明的光学模块和用于为光学模块供电并控制形状，强度或能量水平以及照明持续时间的控制器。 光学模块包括用于与眼睛接口的接触部分，包括光发射器阵列以产生成形光图案的光束部分和用于将光图案聚焦到眼睛上的光学元件，以及可视化部分，以通过以下方式提供治疗的视觉反馈： 可视化界面与显微镜相结合。 典型的治疗包括光学模块被临床医生放置在患者的患病眼睛上以在眼睛的患病部分上投影照明。 临床医生通常在治疗期间通过显微镜和光学模块观察眼睛。