Instrument for determining a quantity associated with a force exerted on a rotor
    3.
    发明授权
    Instrument for determining a quantity associated with a force exerted on a rotor 有权
    用于确定与施加在转子上的力相关联的量的仪器

    公开(公告)号:US08806951B2

    公开(公告)日:2014-08-19

    申请号:US12997508

    申请日:2009-06-10

    IPC分类号: G01N3/00

    摘要: Rheometer, also usable for stress-strain-investigations, with at least one bearing (28; 35) having an adjustable stiffness in a direction normal to the bearing surfaces (19, 20, 21, 22, 23, 24, 26, 27). The instrument further includes a system (31, 32, 33, 34; 36, 37) for controlling a parameter for adjusting the stiffness of the at least one bearing (28; 35); a system (10) for determining a value of a quantity associated with a second force exerted between the rotor (8, 5, 6,7) and the stator (2) and opposing the force associated with the quantity to be determined; and a data processing system for correcting the determined value of the quantity associated with the second force by a bias value, obtained using a mapping having as a parameter a variable representative of the parameter for adjusting the stiffness.

    摘要翻译: 流变仪还可用于应力应变研究,其中至少一个轴承(28; 35)在垂直于支承表面(19,20,21,22,23,24,26,27)的方向上具有可调节的刚度, 。 该仪器还包括用于控制用于调节至少一个轴承(28; 35)的刚度的参数的系统(31,32,33,34; 36,37); 用于确定与施加在所述转子(8,5,7)和所述定子(2)之间的第二力相关联的量的值并且与所确定的量相关联的力相反的系统(10) 以及数据处理系统,用于通过使用具有代表用于调节刚度的参数的变量作为参数的映射获得的偏置值来校正与第二力相关联的量的确定值。

    Continuous particle and macro-molecular zeta potential measurements using field flow fractionation combined micro-electrophoresis
    4.
    发明授权
    Continuous particle and macro-molecular zeta potential measurements using field flow fractionation combined micro-electrophoresis 有权
    连续粒子和大分子ζ电位测量使用场流分离联合微电泳

    公开(公告)号:US08573404B2

    公开(公告)日:2013-11-05

    申请号:US12972318

    申请日:2010-12-17

    IPC分类号: B03B5/00

    摘要: In one general aspect, an instrument for measuring characteristics of particles suspended in a fluid is disclosed. It includes a closed wall surface defining a fractionation channel having a input opening, an output opening, and a flow axis that spans downstream from the input opening for the channel to the output opening. A force application subsystem has a force application output oriented perpendicular to at least part of the flow axis of the fractionation channel. A particle characteristic measurement subsystem is located hydraulically downstream from at least a portion of the closed wall surface defining the fractionation channel, and includes a sensor positioned to sense a property of the suspended particles in the potential measurement subsystem as well as a signal output responsive to the sensor. A result processor has a signal input responsive to the signal output of the particle characteristic measurement subsystem, zeta potential processing logic responsive to the particle characteristic measurement subsystem, and a particle characteristic signal output responsive to the particle characteristic processing logic.

    摘要翻译: 在一般的方面,公开了一种用于测量悬浮在流体中的颗粒的特性的仪器。 它包括封闭的壁表面,其限定了具有输入开口的分馏通道,输出开口和流动轴线,该流动轴线从用于通道的输入开口的下游跨越到输出开口。 力应用子系统具有垂直于分馏通道的流动轴的至少一部分定向的力施加输出。 颗粒特征测量子系统位于限定分馏通道的封闭壁表面的至少一部分的液压下游,并且包括定位成感测潜在测量子系统中的悬浮颗粒的性质的传感器以及响应于 传感器。 结果处理器具有响应于粒子特性测量子系统的信号输出的信号输入,响应于粒子特性测量子系统的ζ电位处理逻辑,以及响应于粒子特征处理逻辑的粒子特征信号输出。

    Spectrometric investigation of heterogeneity
    5.
    发明授权
    Spectrometric investigation of heterogeneity 有权
    异质性光谱测量

    公开(公告)号:US08564774B2

    公开(公告)日:2013-10-22

    申请号:US13367359

    申请日:2012-02-06

    申请人: E. Neil Lewis

    发明人: E. Neil Lewis

    IPC分类号: G01J3/28

    摘要: In one general aspect, a spectroscopic apparatus is disclosed for investigating heterogeneity of a sample area. The apparatus includes an image acquisition system operative to acquire images of a plurality of sub-areas in the sample area and a sub-area selection interface operative to receive a selection designating one of the sub-areas for which an image has been obtained. A spectrometer has a field of view and is operative to acquire a spectrum of at least part of one of the sub-areas in its field of view, and a positioning mechanism is responsive to the sub-area selection interface and operative to position the field of view of the spectrometer relative to the sample area based on a received selection.

    摘要翻译: 在一般的方面,公开了一种用于调查样品区域的异质性的分光装置。 所述装置包括:图像采集系统,用于采集所述采样区域中的多个子区域的图像;以及子区域选择接口,用于接收指定已获得图像的子区域之一的选择。 光谱仪具有视场,并且可操作以在其视野中获取一个子区域的至少一部分的光谱,并且定位机构响应于子区域选择界面并且可操作地定位场 基于接收到的选择,相对于样品区域的光谱仪的视图。

    Spectrometric investigation of heterogeneity
    6.
    发明授权
    Spectrometric investigation of heterogeneity 有权
    异质性光谱测量

    公开(公告)号:US08111395B2

    公开(公告)日:2012-02-07

    申请号:US12006677

    申请日:2008-01-04

    申请人: E. Neil Lewis

    发明人: E. Neil Lewis

    IPC分类号: G01J3/28

    摘要: In one general aspect, a spectroscopic apparatus is disclosed for investigating heterogeneity of a sample area. The apparatus includes an image acquisition system operative to acquire images of a plurality of sub-areas in the sample area and a sub-area selection interface operative to receive a selection designating one of the sub-areas for which an image has been obtained. A spectrometer has a field of view and is operative to acquire a spectrum of at least part of one of the sub-areas in its field of view, and a positioning mechanism is responsive to the sub-area selection interface and operative to position the field of view of the spectrometer relative to the sample area based on a received selection.

    摘要翻译: 在一般的方面,公开了一种用于调查样品区域的异质性的分光装置。 所述装置包括:图像采集系统,用于采集所述采样区域中的多个子区域的图像;以及子区域选择接口,用于接收指定已获得图像的子区域之一的选择。 光谱仪具有视场,并且可操作以在其视野中获取一个子区域的至少一部分的光谱,并且定位机构响应于子区域选择界面并且可操作地定位场 基于接收到的选择,相对于样品区域的光谱仪的视图。

    Broad-range spectrometer
    7.
    发明授权
    Broad-range spectrometer 有权
    宽范围光谱仪

    公开(公告)号:US07869038B2

    公开(公告)日:2011-01-11

    申请号:US12228871

    申请日:2008-08-15

    IPC分类号: G01N15/02 G01N21/00

    摘要: In one general aspect, a particle characterization instrument is disclosed that includes a first spatially coherent light source with a beam output aligned with an optical axis. A focusing optic is positioned along the optical axis after the coherent light source, and a sample cell is positioned along the optical axis after the focusing optic. The instrument also includes a diverging optic positioned along the optical axis after the sample cell, and a detector positioned outside of the optical axis to receive scattered light within a first range of scattering angles from the diverging optic. In another general aspect, an instrument can direct at least a portion of a first beam and at least a portion of a second beam along a same optical axis and a can receive scattered light from the sample cell resulting from interaction between the sample and either the first beam or the second beam.

    摘要翻译: 在一个一般方面,公开了一种粒子表征仪器,其包括具有与光轴对准的光束输出的第一空间相干光源。 在相干光源之后,聚焦光学器件沿着光轴定位,并且在聚焦光学器件之后沿着光轴定位样品池。 该仪器还包括在样品池之后沿着光轴定位的发散光学器件,以及位于光轴外侧的检测器,以在来自发散光学器件的散射角度的第一范围内接收散射光。 在另一个总体方面,仪器可以引导第一光束的至少一部分和沿着相同光轴的第二光束的至少一部分,并且可以从样品与第二光束之间的相互作用接收来自样品池的散射光 第一光束或第二光束。

    Multi-sample scattering measurements
    8.
    发明授权
    Multi-sample scattering measurements 有权
    多样本散射测量

    公开(公告)号:US08634076B2

    公开(公告)日:2014-01-21

    申请号:US12857878

    申请日:2010-08-17

    IPC分类号: G01N21/00

    CPC分类号: G01N21/51

    摘要: In one general aspect, a multi-sample liquid scattering measurement apparatus is disclosed. It includes a coherent light source having an optical output axis, with sample cells that each include a volume that intersects with the optical output axis. Detectors are each positioned to detect scattered light resulting from an interaction between light from the coherent light source and one of the cells. Light scattering analysis logic is responsive to the detectors and operative to determine a property of a liquid sample in each of the sample cells based on the detected scattered light.

    摘要翻译: 在一般的方面,公开了一种多样品液体散射测量装置。 它包括具有光输出轴的相干光源,每个样本单元包括与光输出轴相交的体积。 检测器各自被定位成检测由相干光源和其中一个单元之间的相互作用产生的散射光。 光散射分析逻辑响应于检测器并且可操作以基于检测到的散射光来确定每个样品池中的液体样品的性质。

    Spectrometric characterization of pharmaceutical heterogeneity
    9.
    发明授权
    Spectrometric characterization of pharmaceutical heterogeneity 有权
    药物异质性的光谱测定

    公开(公告)号:US07864316B2

    公开(公告)日:2011-01-04

    申请号:US11986548

    申请日:2007-11-20

    IPC分类号: G01J3/28

    摘要: In one general aspect, a spectroscopic method for monitoring heterogeneity of a sample is disclosed. In this method, sampled spectroscopic measurements are acquired over a range of different micro locations in a macro-sample of the sample. This step is repeated for micro-locations in further macro-samples of the sample, and a statistical measure of chemical heterogeneity is derived from the acquisitions. In another general aspect, differently sized samples are acquired, and a statistical measure of chemical heterogeneity is derived from these acquisitions.

    摘要翻译: 在一般的方面,公开了一种用于监测样品异质性的光谱方法。 在该方法中,在样本的宏观样本中的不同微位置的范围上获取采样的光谱测量。 对于样品的其他宏观样品中的微位置重复此步骤,并且从采集中得出化学异质性的统计量度。 在另一个一般方面,获得不同大小的样品,并且从这些获取中得出化学异质性的统计量度。

    Laser doppler electrophoresis using a diffusion barrier
    10.
    发明授权
    Laser doppler electrophoresis using a diffusion barrier 有权
    使用扩散屏障的激光多普勒电泳

    公开(公告)号:US08702942B2

    公开(公告)日:2014-04-22

    申请号:US12972412

    申请日:2010-12-17

    CPC分类号: G01N27/44721 G01N27/44739

    摘要: In one general aspect, an electrophoretic measurement method is disclosed that includes providing a vessel that holds a dispersant, providing a first electrode immersed in the dispersant, and providing a second electrode immersed in the dispersant. A sample is placed at a location within the dispersant between the first and second electrodes with the sample being separated from the electrodes, an alternating electric field is applied across the electrodes, and the sample is illuminated with temporally coherent light. A frequency shift is detected in light from the step of illuminating that has interacted with the sample during the step of applying an alternating electric field, and a property of the sample is derived based on results of the step of detecting.

    摘要翻译: 在一个一般方面,公开了一种电泳测量方法,其包括提供容纳分散剂的容器,提供浸入分散剂中的第一电极,以及提供浸入分散剂中的第二电极。 将样品放置在第一和第二电极之间的分散剂内的位置处,其中样品与电极分离,在电极之间施加交变电场,并且用时间相干光照射样品。 在施加交变电场的步骤期间,从与样品相互作用的照明步骤的光中检测频移,并且基于检测步骤的结果导出样品的性质。