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公开(公告)号：US20210061814A1
公开(公告)日：2021-03-04
申请号：US16924037
申请日：2020-07-08
申请人： St. Louis College of Pharmacy , University of Southern California , The University of North Carolina at Chapel Hill , Memorial Sloan Kettering Cancer Center , University of Florida Research Foundation, Incorporated , Memorial Sloan Kettering Cancer Center
发明人： Susruta MAJUMDAR , Vsevolod KATRITCH , Bryan ROTH , JAY MCLAUGHLIN , Saheem ZAIDI , Gavril W. PASTERNAK , Rajendra UPRETY
IPC分类号： C07D489/00 , C07D221/28
摘要： In some aspects, the present disclosure provides compounds of the formula: wherein the variables are as defined herein. In some embodiments, these compounds may be used to reduce the pain of a patient. These compounds may be used in pain relief and show an improved pharmaceutical profile relative to other commonly used opiates and opioid derivatives.
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公开(公告)号：US20170304470A1
公开(公告)日：2017-10-26
申请号：US15511701
申请日：2015-09-17
发明人： Mark Dunphy , Gabriela Chiosis
IPC分类号： A61K51/04 , A61K31/52 , A61B6/00 , A61B6/03 , A61B5/0275 , A61B5/00 , A61B5/08 , A61B5/0402 , A61K49/18
CPC分类号： A61K51/0459 , A61B5/02755 , A61B5/0402 , A61B5/0813 , A61B5/4255 , A61B5/441 , A61B6/032 , A61B6/037 , A61B6/4417 , A61B6/503 , A61B6/5288 , A61B6/541 , A61K31/52 , A61K49/0004 , A61K49/1884 , A61P35/00
摘要： The present invention provides new methods for inflammation and infection imaging and related medical applications thereof. In some embodiments, the present invention provides a method for the diagnosis of inflammation and/or infection. In some embodiments, the present invention provides a method for the treatment or prevention of inflammation and/or infection. In some embodiments, the present invention provides methods for monitoring the effect of inflammation and/or infection treatment, and/or methods for monitoring an inflammation and/or infection treatment regimen. In some embodiments, the present invention provides a method for selecting subjects for an inflammation and/or infection treatment. In some embodiments, the present invention provides a method for determining the dosage of a drug for the treatment of inflammation and/or infection.
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公开(公告)号：US11613547B2
公开(公告)日：2023-03-28
申请号：US16924037
申请日：2020-07-08
申请人： University of Health Sciences & Pharmacy in St. Louis , University of Southern California , The University of North Carolina at Chapel Hill , Memorial Sloan Kettering Cancer Center , University of Florida Research Foundation, Incorporated , Memorial Sloan Kettering Cancer Center
发明人： Susruta Majumdar , Vsevolod Katritch , Bryan Roth , Jay McLaughlin , Saheem Zaidi , Gavril W. Pasternak , Rajendra Uprety
IPC分类号： C07D489/00 , C07D221/28
摘要： In some aspects, the present disclosure provides compounds of the formula: wherein the variables are as defined herein. In some embodiments, these compounds may be used to reduce the pain of a patient. These compounds may be used in pain relief and show an improved pharmaceutical profile relative to other commonly used opiates and opioid derivatives.
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公开(公告)号：US20180140584A1
公开(公告)日：2018-05-24
申请号：US15573446
申请日：2016-05-13
发明人： Craig B. Thompson , Wilhelm Palm
IPC分类号： A61K31/436 , A61K31/366 , A61K31/7036 , A61K45/06 , A61K47/64 , A61P35/00 , G01N33/574
CPC分类号： A61K31/436 , A61K31/365 , A61K31/366 , A61K31/7036 , A61K45/06 , A61K47/643 , A61K2300/00 , A61P35/00 , C07K14/76 , C07K2319/55 , G01N33/5748 , G01N2800/52
摘要： Disclosed herein are compositions and methods for detecting and treating cancer. In some embodiments, the cancer is characterized by activation of Ras.
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公开(公告)号：US20240350547A1
公开(公告)日：2024-10-24
申请号：US18749852
申请日：2024-06-21
申请人： Memorial Sloan-Kettering Cancer Center , Sloan-Kettering Institute for Cancer Research , Memorial Hospital for Cancer and Allied Diseases
发明人： Michel Sadelain , Karlo Perica
IPC分类号： A61K35/17 , A61K39/00 , A61P35/00 , C07K14/705 , C07K14/725
CPC分类号： A61K35/17 , A61K39/4611 , A61K39/4631 , A61K39/464438 , A61P35/00 , C07K14/7051 , C07K14/70575
摘要： The presently disclosed subject matter provides cells, compositions and methods for enhancing immune responses toward tumor. It relates to cells comprising: an antigen-recognizing receptor (e.g., a chimeric antigen receptor, a TCR, or a TCR like fusion molecule), a Fas ligand polypeptide (FasL), and a gene disruption of a Fas locus. The gene disruption of the Fas locus can improve the activity and/or efficiency of the cells. The presently disclosed cells, compositions, and methods can be used in allogeneic settings.
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公开(公告)号：US20240350504A1
公开(公告)日：2024-10-24
申请号：US18530663
申请日：2023-12-06
发明人： Eulalia Baselga , Pau Castel , Jose Baselga
IPC分类号： A61K31/5377 , A61K31/427 , A61K31/4375 , A61K31/4439 , A61K31/444 , A61K31/519 , A61P9/00
CPC分类号： A61K31/5377 , A61K31/427 , A61K31/4375 , A61K31/4439 , A61K31/444 , A61K31/519 , A61P9/00
摘要： The present disclosure relates to methods of treating a vascular malformation in a subject expressing a gain-of-function mutation in a PIK3CA gene comprising administering, to the subject, an effective amount of an agent that inhibits phosphoinositide 3-kinase (“PI3K”).
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公开(公告)号：US20240336698A1
公开(公告)日：2024-10-10
申请号：US18283547
申请日：2022-03-22
申请人： Memorial Sloan Kettering Cancer Center , Sloan-Kettering Institute For Cancer Research , Memorial Hospital For Cancer and Allied Diseases , Stichting VUmc
IPC分类号： C07K16/28 , A61K39/00 , A61P35/00 , C07K14/705 , C07K14/725
CPC分类号： C07K16/2896 , A61K39/4611 , A61K39/4631 , A61K39/464417 , A61K39/464426 , A61P35/00 , C07K14/7051 , C07K14/70521 , C07K16/2878 , A61K2239/13 , A61K2239/21 , A61K2239/28 , C07K2317/24 , C07K2317/622
摘要： The presently disclosed subject matter provides uses of a chimeric costimulatory receptor (CCR) targeting CD38, and cells comprising a CD38 CCR and an antigen-recognizing receptor, and uses of such cells.
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8.发明公开公开(公告)号：US20240335475A1
公开(公告)日：2024-10-10
申请号：US18749513
申请日：2024-06-20
发明人： Renier J. Brentjens , Eric L. Smith , Cheng Liu
IPC分类号： A61K35/17 , A61P35/00 , C07K14/705 , C07K14/725 , C07K16/28
CPC分类号： A61K35/17 , A61P35/00 , C07K14/7051 , C07K14/70521 , C07K16/2878 , C07K2317/34 , C07K2317/622 , C07K2317/73 , C07K2317/92 , C07K2319/02 , C07K2319/03 , C07K2319/33 , C12N2740/10043 , C12N2840/203
摘要： The presently disclosed subject matter provides for methods and compositions for treating multiple myeloma. It relates to chimeric antigen receptors (CARs) that specifically target B cell maturation antigen (BCMA), and immunoresponsive cells comprising such CARs. The presently disclosed BCMA-specific CARs have enhanced immune-activating properties, including anti-tumor activity.
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公开(公告)号：US20240327443A1
公开(公告)日：2024-10-03
申请号：US18733207
申请日：2024-06-04
发明人： David Y. GIN , Eric CHEA , Alberto FERNANDEZ-TEJADA , Jeffrey GARDNER , Jason LEWIS , Philip LIVINGSTON , J. Tyler MARTIN , Lars NORDSTROEM , Naga Vara Kishore PILLARSETTY , Govind RAGUPATHI , Derek TAN
IPC分类号： C07H1/00 , A61K31/7024 , A61K39/00 , A61K39/02 , A61K39/08 , A61K39/10 , A61K39/39 , A61P31/04 , C07H13/04 , C07H13/06 , C07H13/08 , C07J63/00
CPC分类号： C07H1/00 , A61K31/7024 , A61K39/08 , A61K39/099 , A61K39/39 , A61P31/04 , C07H13/04 , C07H13/06 , C07H13/08 , C07J63/008 , A61K2039/10 , A61K2039/55583
摘要： The present application relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, and intermediates thereto. The application also provides pharmaceutical compositions comprising compounds of the present invention and methods of using said compounds or compositions in the treatment of and immunization for infectious diseases.
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10.发明公开公开(公告)号：US20240321396A1
公开(公告)日：2024-09-26
申请号：US18575530
申请日：2022-06-29
申请人： Memorial Sloan-Kettering Cancer Center , Memorial Hospital for Cancer and Allied Diseases , Sloan-Kettering Institute for Cancer Research
IPC分类号： G16B30/00 , C12Q1/6874 , C12Q1/6883 , C12Q1/6886 , G16B40/20
CPC分类号： G16B30/00 , C12Q1/6874 , C12Q1/6883 , C12Q1/6886 , G16B40/20
摘要： The present technology relates to methods, computing devices, and systems for identifying somatic mutational signatures (e.g., cancer, aging) from whole genome sequencing (e.g., low coverage WGS) of cell-free DNA (cfDNA) obtained from subjects. Machine learning techniques may be applied to cfDNA mutational profiles, permitting accurate discrimination between cancer patients and healthy individuals or discrimination between different cancer types.
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