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    PRIMERS FOR ISOTHERMAL AMPLIFICATION
    1.
    发明申请
    PRIMERS FOR ISOTHERMAL AMPLIFICATION 有权

    公开(公告)号：US20220275431A1

    公开(公告)日：2022-09-01

    申请号：US17627166

    申请日：2020-07-14

    申请人： NATIONAL UNIVERSITY OF IRELAND, GALWAY

    发明人： OWEN HIGGINS ,  TERRY SMITH

    IPC分类号： C12Q1/6827 ,  C12Q1/6858

    摘要： The present invention relates to primers for isothermal amplification, in particular primers for loop-mediated isothermal amplification (LAMP). Also disclosed are methods for identifying a target nucleic acid, and methods for identifying a nucleic acid modification or substitution of a target nucleic acid. The invention finds utility in the diagnosis of diseases or disorders.

    DEVICES AND METHODS FOR TREATING A VESSEL IN A SUBJECT
    2.
    发明申请
    DEVICES AND METHODS FOR TREATING A VESSEL IN A SUBJECT 有权

    公开(公告)号：US20220133286A1

    公开(公告)日：2022-05-05

    申请号：US17547723

    申请日：2021-12-10

    申请人： National University of Ireland, Galway

    发明人： Sean CUMMINS ,  Nigel PHELAN ,  Stephen COX ,  Martin O'HALLORAN

    IPC分类号： A61B17/00 ,  A61B17/3207 ,  A61B18/14

    摘要： A method of treating a vessel in a subject comprises the steps of advancing a device distally across a treatment zone in a vessel, wherein the device comprises an elongated catheter having a lumen and a distal end, and a radially expansive treatment element disposed in the lumen and configured for axial movement relative to the catheter; deploying the radially expansive treatment element proud of the distal end of the catheter to radially expand and circumferentially impress against the vessel lumen at a distal end of the treatment zone; and withdrawing the deployed radially expansive treatment element proximally along the treatment zone with the treatment element circumferentially impressed against the vessel lumen to mechanically and circumferentially denude the treatment zone of the vessel. The radially expansive treatment element is then recaptured into the lumen of the catheter, before the device is withdrawn from the treated vessel.

    Vortex generator
    4.
    发明授权
    Vortex generator 有权

    公开(公告)号：US11067054B2

    公开(公告)日：2021-07-20

    申请号：US16626205

    申请日：2018-06-21

    申请人： NATIONAL UNIVERSITY OF IRELAND, GALWAY

    发明人： Eoghan Clifford ,  Sean Mulligan

    IPC分类号： F03B3/18 ,  B01F3/04

    摘要： A vortex generator apparatus including a fluid intake duct, a fluid tank including: a first fluid inlet port, a second fluid inlet port, and a fluid outlet port. A turbine is provided outside of the fluid tank in fluid communication with the fluid outlet port.

    Implant for a bone joint
    6.
    发明授权
    Implant for a bone joint 有权

    公开(公告)号：US10265186B2

    公开(公告)日：2019-04-23

    申请号：US15429635

    申请日：2017-02-10

    申请人： National University of Ireland, Galway

    发明人： Gerry Clarke ,  Brendan Boland ,  Mark Bruzzi ,  Amy L. Ladd ,  Arnold-Peter C. Weiss ,  Filip Stockmans

    IPC分类号： A61F2/42 ,  A61F2/30

    摘要： An implant (30) for a mammalian bone joint (3) for spacing a first bone (2) of the joint from a second bone (1) of the joint while allowing translational movement of the second bone in relation to the first bone is described. The implant comprises (a) a distal part (31) configured for intramedullary engagement with an end of the second bone, (b) a proximal part (34) having a platform (15) configured for non-engaging abutment of an end of the first bone and translational movement thereon, and (c) an articulating coupling (10, 16) provided between the distal and proximal ends allowing controlled articulation of the first and second bones. The bone-abutting platform is shaped to conform to and translate upon the end of the first bone. A kit for assembly to form the implant of the invention, and the use of the implant to treat osteoarthritis in a bone joint, are also described.

    Diagnostic method
    8.
    发明授权
    Diagnostic method 有权

    公开(公告)号：US09994918B2

    公开(公告)日：2018-06-12

    申请号：US14935250

    申请日：2015-11-06

    申请人： National University of Ireland, Galway

    发明人： Kate Mary Reddington ,  Thomas Gerard Barry ,  Justin Joseph O'Grady ,  Terence James Smith

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/689 ,  C12Q1/686 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12Q2600/16

    摘要： The present invention relates to a multiplex in vitro nucleic acid amplification method for identifying a species of the Mycobacterium tuberculosis complex present in a sample. The method includes detecting the presence or absence of a plurality of nucleic acid molecule targets in the sample in one reaction, wherein at least one of the nucleic acid molecule targets is present in the genome of one or more, but not all, of the species of the Mycobacterium tuberculosis complex. The invention also includes kits containing primers or probes for conducting this method, nucleic acids useful for performing this method and diagnostic techniques using these nucleic acids.