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公开(公告)号：US08932539B2
公开(公告)日：2015-01-13
申请号：US14137395
申请日：2013-12-20
发明人： James Plante , David Becker , Edgar MacBean , Kathryn J. Elliott
CPC分类号： C12Q1/6806 , A61B10/0051 , A61B10/0096 , A61B2010/0006 , B01L3/50825 , B01L2200/18 , B01L2300/044 , B01L2300/047 , B01L2300/0672 , B01L2300/0832 , B01L2300/0858 , B01L2300/0867 , Y10T436/2575
摘要： Saliva sample collection systems are configured with special attention to ease-of-use for the unskilled user and safe transport and delivery by a conventional delivery services such as Federal Express. A sealed cavity is formed by tight coupling of two primary elements: a receiving vessel element and a sealing cap element. The receiving vessel has integrated therewith: a standing means, a fill-line window, a funnel system, a knife, a threadset, and containment tube among others. A complementary cap element includes a cooperating threadset, label receiving surface, gripping surface, seal means and reservoir with piercable thin-film membrane. These two primary elements may be accommodated in an application-specific shipping container which support two shipping modes whereby the system may be shipped safely to and from a donor user each way in a different shipping mode.
摘要翻译： 唾液样本收集系统被配置为特别注意非熟练用户的易用性，并通过常规传送服务（如联邦快递）进行安全的传输和传送。 通过紧密耦合两个主要元件形成密封空腔：接收容器元件和密封帽元件。 接收容器与其结合：立式装置，填充线窗，漏斗系统，刀，螺纹组和容纳管等。 互补盖元件包括协作螺纹组件，标签接收表面，抓握表面，密封装置和具有可撕裂薄膜膜的储存器。 这两个主要元件可以容纳在特定于应用的运输容器中，其支持两种运送模式，由此系统可以以不同的运送模式每次以方式运送给和来自捐赠者的用户。
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公开(公告)号：US20130035954A1
公开(公告)日：2013-02-07
申请号：US12387782
申请日：2009-05-07
申请人： James Plante , David Becker
发明人： James Plante , David Becker
IPC分类号： G06Q50/24
CPC分类号： G06F16/245 , G06Q10/00 , G16H50/30 , G16H50/70
摘要： A computer alert to system and apparatus is arranged about DNA sequence markers whereby the genome of a specific human subject is considered in view of a plurality of discrete rules to affect alerts which may be generated and transmitted in electronic form over standardized e-mail systems (Internet/SMTP protocol for example) to a user workstation which may be equipped with a browser or custom application (includes a special genome viewers, review tools; etc.). Alerting systems described in this disclosure included mechanical/a chemical systems for analyzing a human DNA sample to produce a genomic data set representing genetic indicators or markers on alleles of interest including those as well SNPs associated with important trial traits disease and characteristics. A genome dataset is stored as a portion of a data a record having a one-to-one correspondence with membership in a membership database. A dynamic rules that of its reality of discrete rules provides a query engine with logic which can be executed against membership data stored in accordance with standardized database procedures to produce a genomic result set from which appropriate alerts may be formed in an alert to module computer apparatus. These alerts may be characterized as including multimedia information and they may be prefer to play conveyed to membership with whom the underlying data is associated.
摘要翻译： 针对系统和装置安排关于DNA序列标记的计算机警报，由此考虑到多个离散规则来考虑特定人类受试者的基因组，以影响可以通过标准化电子邮件系统以电子形式产生和传送的警报（ 互联网/ SMTP协议）到可能配备浏览器或定制应用程序的用户工作站（包括特殊的基因组查看器，查看工具等）。 本公开中描述的警报系统包括用于分析人类DNA样品的机械/化学系统，以产生代表感兴趣的等位基因的遗传指标或标志物的基因组数据集，包括与重要的试验性状疾病和特征相关的SNP。 基因组数据集作为数据的一部分存储在与成员数据库中的隶属关系一一对应的记录上。 其离散规则的现实的动态规则为查询引擎提供了可根据标准化数据库过程存储的成员数据执行的逻辑，以产生基因组结果集合，从而可以在模块计算机设备的警报中形成适当的警报 。 这些警报可以被表征为包括多媒体信息，并且他们可能更喜欢播放传达给与基础数据相关联的会员。
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公开(公告)号：US20130011832A1
公开(公告)日：2013-01-10
申请号：US13068384
申请日：2011-05-10
申请人： Tanya Moreno , Cindy Wang , David Becker
发明人： Tanya Moreno , Cindy Wang , David Becker
CPC分类号： G01N21/6428 , B01L7/52 , G01N21/6452 , G01N2201/061
摘要： Dual mode genetics testing systems are devised about a single element testing platform. A microfluidic network and system of interconnected receiving cells and reaction vessels supports at the same time genotyping and copy number analysis where the platform may be subject to a common thermal cycle schedule to cause the proper reactions (DNA replication) necessary in both test types. Further, the microfluidic platform which includes reaction vessels for genotyping which are spatially removed from reaction vessels for copy number analysis, is coupled to optical scanner and detection systems specifically arranged to apply test specific detection routines on each of these distinct regions or portions of the dual mode test platform.
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公开(公告)号：US20120325721A1
公开(公告)日：2012-12-27
申请号：US12383535
申请日：2009-03-25
申请人： James Plante , David Becker , Edgar MacBean , Kathryn J. Elliott
发明人： James Plante , David Becker , Edgar MacBean , Kathryn J. Elliott
CPC分类号： C12Q1/6806 , A61B10/0051 , A61B10/0096 , A61B2010/0006 , B01L3/50825 , B01L2200/18 , B01L2300/044 , B01L2300/047 , B01L2300/0672 , B01L2300/0832 , B01L2300/0858 , B01L2300/0867 , Y10T436/2575
摘要： Saliva sample collection systems are configured with special attention to ease-of-use for the unskilled user and safe transport and delivery by a conventional delivery services such as Federal Express. A sealed cavity is formed by tight coupling of two primary elements: a receiving vessel element and a sealing cap element. The receiving vessel has integrated therewith: a standing means, a fill-line window, a funnel system, a knife, a threadset, and containment tube among others. A complementary cap element includes a cooperating threadset, label receiving surface, gripping surface, seal means and reservoir with piercable thin-film membrane. These two primary elements may be accommodated in an application-specific shipping container which support two shipping modes whereby the system may be shipped safely to and from a donor user each way in a different shipping mode.
摘要翻译： 唾液样本收集系统被配置为特别注意非熟练用户的易用性，并通过常规传送服务（如联邦快递）进行安全的传输和传送。 通过紧密耦合两个主要元件形成密封空腔：接收容器元件和密封帽元件。 接收容器与其结合：立式装置，填充线窗，漏斗系统，刀，螺纹组和容纳管等。 互补盖元件包括协作螺纹组件，标签接收表面，抓握表面，密封装置和具有可撕裂薄膜膜的储存器。 这两个主要元件可以容纳在特定于应用的运输容器中，其支持两种运送模式，由此系统可以以不同的运送模式每次以方式运送给和来自捐赠者的用户。
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公开(公告)号：US20170246625A1
公开(公告)日：2017-08-31
申请号：US15491248
申请日：2017-04-19
发明人： David Becker , James Plante , Tanya Moreno , Cindy Wang
CPC分类号： B01L3/508 , A61B10/0051 , A61B10/0096 , A61B2010/0006 , B01L3/502 , B01L3/50825 , B01L99/00 , B01L2200/185 , B01L2300/042 , B01L2300/044 , B01L2300/047 , B01L2300/06 , B01L2300/0672 , C12N15/1006 , C12Q1/6806
摘要： Biological sample collection kits are devised with physical features to enable a high performance collection system which delivers preprocessed biological matter via conventional shipping means to a testing laboratories. In particular, untrained and unskilled users deposit biological matter such as saliva or blood into a receiving vessel. By sealing the container, the user causes release of a premixed solution containing preservatives and optionally lysis reagents. In addition, a purification agent is arranged to bind to target molecules and facilitate their removal from solution. These time consuming processes occur while the sample is in transit to the testing facility such that when it arrives, it is in a preconditioned state immediately ready for execution of washing steps. Thus, the high performance containers taught herein are useful for collection biological samples and performing initial process steps on received matter—steps which are largely effected during the shipping stage of the transfer process.
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6.发明申请公开(公告)号：US20150292014A1
公开(公告)日：2015-10-15
申请号：US14443045
申请日：2014-03-12
发明人： Guangdan Zhu , Cindy Wang , Tanya Moreno , Andrew Hellman , Alok Tomar , Svetlana Ivanova Gramatikova , Aditi Chawla , Russell Kuo-fu Chan , Andria Del Tredici , Adrian Vilalta , K. David Becker , Michael Nova
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , G16C20/30 , G16H50/30
摘要： The present inventions relates to methods and assays to predict the response of an individual to psychiatric treatment and to a method to improve medical treatment of a disorder, which responsive to treatment with a psychiatric treatment.
摘要翻译： 本发明涉及用于预测个体对精神病治疗的反应的方法和测定法，以及改善对精神病治疗治疗反应的病症治疗方法。
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公开(公告)号：US20130164738A1
公开(公告)日：2013-06-27
申请号：US13333883
申请日：2011-12-21
申请人： David Becker , James Plante , Moreno Tanya , Cindy Wang
发明人： David Becker , James Plante , Moreno Tanya , Cindy Wang
CPC分类号： B01L3/508 , A61B10/0051 , A61B10/0096 , A61B2010/0006 , B01L3/502 , B01L3/50825 , B01L99/00 , B01L2200/185 , B01L2300/042 , B01L2300/044 , B01L2300/047 , B01L2300/06 , B01L2300/0672 , C12N15/1006 , C12Q1/6806
摘要： Biological sample collection kits are devised with physical features to enable a high performance collection system which delivers preprocessed biological matter via conventional shipping means to a testing laboratories. In particular, untrained and unskilled users deposit biological matter such as saliva or blood into a receiving vessel. By sealing the container, the user causes release of a premixed solution containing preservatives and optionally lysis reagents. In addition, a purification agent is arranged to bind to target molecules and facilitate their removal from solution. These time consuming processes occur while the sample is in transit to the testing facility such that when it arrives, it is in a preconditioned state immediately ready for execution of washing steps. Thus, the high performance containers taught herein are useful for collection biological samples and performing initial process steps on received matter—steps which are largely effected during the shipping stage of the transfer process.
摘要翻译： 生物样本收集套件设计有物理特征，以实现高性能收集系统，其通过常规运输方式将预处理的生物物质提供给测试实验室。 特别是，未经训练和不熟练的使用者将诸如唾液或血液的生物物质沉积到接收容器中。 通过密封容器，使用者引起含有防腐剂和任选裂解试剂的预混溶液的释放。 此外，将净化剂配置成与靶分子结合并促进它们从溶液中的去除。 这些耗时的过程发生在样品转运到测试设备时，使得当其到达时，它处于预处理状态，立即准备好执行洗涤步骤。 因此，本文中教导的高性能容器对于收集生物样品是有用的，并且在接收的物质步骤上执行初始的处理步骤，这些步骤主要是在转移过程的运输阶段中实现的。
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公开(公告)号：US20130138447A1
公开(公告)日：2013-05-30
申请号：US12804363
申请日：2010-07-19
IPC分类号： G06F19/00
CPC分类号： G06F19/3475 , G06F19/3481 , G16B20/00 , G16B40/00 , G16B50/00 , G16H10/60 , H04L67/02
摘要： Apparatus and methods are devised and provided to receive genetic material from a human test subject and further to characterize that genetic material into an electronic representation of a genome. In particular, with respect to many genetic features which relate to diet, nutrition and exercise with a view to weight control. Based upon the presence of certain genetic features, genetic markers or polymorphisms, a rules based logic path is executed to arrive at a action plan set of recommendations. These recommendations relate to lifestyle actions which may be taken up by a person and these actions thus relate to that person's particular genetic composition. These apparatus and methods produce an easy-to-consume visual presentation describing genetic based traits and conditions, the personal status of a test subject as it relates to these genetic dependent traits and conditions, and possible lifestyle actions which may be performed by the user.
摘要翻译： 设计和提供装置和方法以从人类测试对象接收遗传物质，并进一步将遗传物质表征为基因组的电子表示。 特别地，关于与饮食，营养和运动相关的许多遗传特征，以便控制体重。 基于某些遗传特征，遗传标记或多态性的存在，执行基于规则的逻辑路径以得到一组建议的行动计划。 这些建议涉及到一个人可能会采取的生活方式行为，因此这些行为与该人的特定遗传成分有关。 这些装置和方法产生描述基于遗传的特征和条件的容易消费的视觉呈现，与这些遗传依赖性状和条件相关的测试对象的个人状态以及用户可能执行的可能的生活方式动作。
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公开(公告)号：US20130018279A1
公开(公告)日：2013-01-17
申请号：US12584153
申请日：2009-09-01
申请人： James Plante , Michael Nova , David Becker , Luke Noaek
发明人： James Plante , Michael Nova , David Becker , Luke Noaek
IPC分类号： A61B5/151
CPC分类号： A61B5/157 , A61B5/145 , A61B5/14539 , A61B5/150022 , A61B5/150305 , A61B5/150358 , A61B5/150404 , A61B5/150427 , A61B5/150503 , A61B5/150717 , A61B5/150755 , A61B5/150969 , A61B5/150984 , A61B5/15105 , A61B5/15142 , A61B5/6833 , A61M37/0015
摘要： Blood sample collection apparatus and kits are devised as easy-to-use, reduced pain devices operable by persons not having medical training or other expertise or knowledge. A flexible strip having adhesives on two portions of a first side accommodate therebetween and absorbent pad and substrate with microstructures. The substrate includes microstructures arranged to gently penetrate or pierce skin and cause a small amount of blood to pass to the external surface of a user's flesh. An absorbent pad receives and absorbs a blood sample therein. The absorbent pad may additionally support a plurality of chemical agents which further advances mobility of blood in the collection system. These chemical agents may include anticoagulants and blood anticlotting agents to facilitate blood transfer from a donor to the absorbent pad. Additionally, these systems may also include a blood preservative to stabilize blood collected for an extended shipping and transfer period. These blood sample collection systems may further include a numbing agent to improve comfort of use.
摘要翻译： 血液采集仪器和试剂盒被设计为易于使用，减少的疼痛装置可由没有医疗培训或其他专业知识或知识的人操作。 在第一侧的两部分上具有粘合剂的柔性条带容纳在其间并具有微结构的吸收垫和基底。 衬底包括布置成轻轻地穿透或刺穿皮肤并导致少量血液传递到使用者肉体的外表面的微结构。 吸收垫接收并吸收血样。 吸收垫可另外支撑多个化学试剂，这进一步提高了收集系统中血液的移动性。 这些化学试剂可以包括抗凝剂和血液抗凝胶剂，以促进从供体到吸收垫的血液转移。 此外，这些系统还可以包括防水剂以稳定在延长的运输和转移期间收集的血液。 这些血液样品收集系统可以进一步包括麻醉剂以改善使用的舒适性。
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公开(公告)号：US20210166794A1
公开(公告)日：2021-06-03
申请号：US17174092
申请日：2021-02-11
摘要： Systems have been devised for health management based upon genetic markers. Specifically, systems are arranged to compute genetic risk for several factors relating to metabolism and weight gain in view of various genotypes at particular markers in an individual's genome. An algorithm which depends upon these risk calculations and in further view of the presence of additional variants in the genome under test is executed to arrive at a diet type selection for the particular user. In additions to diet type selections, specific supporting diet related recommendations related to eating behaviors, food reactions and nutritional needs, based upon markers found in the genetic profile, are additionally included in a diet action plan.
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