公开(公告)号：USD1049419S1

公开(公告)日：2024-10-29

申请号：US29832160

申请日：2022-03-25

申请人： Roche Molecular Systems, Inc.

设计人： Maximilian Ruhstorfer ,  Christian Thalmann ,  Adnan Wahid William Aksoy

摘要： FIG. 1 is a top perspective view of the first embodiment of a microwell plate assembly.
FIG. 2 is a bottom perspective view of the microwell plate assembly.
FIG. 3 is a top view of the microwell plate assembly.
FIG. 4 is a bottom view of the microwell plate assembly.
FIG. 5 is a front view of the microwell plate assembly.
FIG. 6 is a back view of the microwell plate assembly.
FIG. 7 is a side view of the microwell plate assembly.
FIG. 8 is an opposite side view of the microwell plate assembly.
FIG. 9 is a top view of the microwell plate assembly;
FIG. 10 is a cross sectional view of the microwell plate assembly taken along line 10-10 of FIG. 9.
FIG. 11 is a cross sectional view of the microwell plate assembly taken along line 11-11 of FIG. 9.
FIG. 12 is a top perspective view of the second embodiment of a microwell plate assembly.
FIG. 13 is a bottom perspective view of the assembly of FIG. 12.
FIG. 14 is a top view of the microwell plate assembly of FIG. 12.
FIG. 15 is a bottom view of the microwell plate assembly of FIG. 12.
FIG. 16 is a front view of the microwell plate assembly of FIG. 12.
FIG. 17 is a back view of the microwell plate assembly of FIG. 12.
FIG. 18 is a side view of the microwell plate assembly of FIG. 12.
FIG. 19 is an opposite side view of the microwell plate assembly of FIG. 12.
FIG. 20 is a top view of the microwell plate assembly;
FIG. 21 is a cross sectional view of the microwell plate assembly of FIG. 12 taken along line 21-21 of FIG. 20.
FIG. 22 is a cross sectional view of the microwell plate assembly of FIG. 12 taken along line 22-22 of FIG. 20.
FIG. 23 is a detail cross sectional view of an individual sample well of the microwell plate assembly shown within area 23 in FIG. 21.
FIG. 24 is a detail cross sectional view of an individual sample well of the microwell plate assembly shown within area 24 in FIG. 22; and,
FIG. 25 is a detail cross sectional view of the bottom of an individual sample well of the microwell plate assembly shown within area 25 in FIG. 21.
The broken lines depict portions of the microwell plate assembly that form no part of the claimed design.

公开(公告)号：US12066311B2

公开(公告)日：2024-08-20

申请号：US17456946

申请日：2021-11-30

申请人： Roche Molecular Systems, Inc.

发明人： Sven Ebert ,  Michal Karol Dobrzynski ,  Paul Federer ,  Arnulf Staib ,  Lukas Schneider

IPC分类号： G01F1/58 ,  G01F1/64

CPC分类号： G01F1/584 ,  G01F1/58 ,  G01F1/64

摘要： The present disclosure provides for a sensor system for determining a flow rate of a fluid flow within a fluid channel comprising an elastic segment arranged next to a rigid segment, wherein a first pair of electrodes is provided at the rigid segment and a second pair of electrodes is provided at the elastic segment of the fluid channel. The system further comprises a sensor unit for detecting a capacitance of the first and second electrode pairs, and a processing unit for calculating and monitoring a distance between the electrodes of the second electrode pair based on the detected capacitance of the first electrode pair and the second electrode pair, wherein the first electrode pair is in contact with the rigid segment and the second electrode pair is in contact with the elastic segment. Moreover, a respective method for determining a flow rate of a fluid flow within a fluid channel is provided by the present disclosure, as well as a use of the sensor system.

公开(公告)号：US20240229141A1

公开(公告)日：2024-07-11

申请号：US17447978

申请日：2021-09-17

申请人： Roche Molecular Systems, Inc.

发明人： Rajiv Dua ,  Marcel Fontecha ,  Yan Li ,  Wei-min Liu ,  Christopher Santini ,  Lori Steiner ,  Yu Chuan Tai

IPC分类号： C12Q1/6886

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/158 ,  C12Q2600/16

摘要： Provided herein are methods and compositions to classify DLBCL subtypes using quantitative RT-PCR.

公开(公告)号：US12013318B2

公开(公告)日：2024-06-18

申请号：US17735466

申请日：2022-05-03

申请人： Roche Molecular Systems, Inc.

发明人： Carolin Bier ,  Stefan Lange ,  Pirmin Hans Loetscher

IPC分类号： G01N1/28 ,  A01N31/02 ,  A01N31/08 ,  C12Q1/04

CPC分类号： G01N1/28 ,  A01N31/02 ,  A01N31/08 ,  C12Q1/04

摘要： The present disclosure relates to a composition and its use for treating a sputum sample suspected to contain mycobacteria. The composition comprises thymol, a linear or branched alcohol, a chaotropic agent, a reducing agent, a detergent, and a buffer, and has a pH value between 8.5 and 10. Also disclosed is a method for treating a sputum sample suspected to contain mycobacteria.

公开(公告)号：US20240139747A1

公开(公告)日：2024-05-02

申请号：US18545923

申请日：2023-12-19

申请人： Roche Molecular Systems, Inc.

发明人： Lawrence Chiu ,  Ion Iordanoaia ,  Reiner Hitt ,  Vijay Namasivayam ,  Eduard Nawrocki ,  Michael Neugebauer ,  Tim Moulton ,  Sam Palmer ,  Gerd Schmieta

IPC分类号： B01L9/06 ,  C12M3/00

CPC分类号： B01L9/06 ,  C12M23/48 ,  B01L2200/023 ,  B01L2200/028 ,  B01L2200/16 ,  B01L2300/0806

摘要： The present invention describes a base module (100) and a tray insert (200, 300, 400) of a multipurpose tray (100) for an automated processing system, such as an analytical, pre-analytical or post-analytical processing system, as well as to a multipurpose tray comprising such base module and such tray insert, wherein the tray insert can be particularly used for holding a plurality of reagent or sample tubes to be processed in the automated processing system. The present invention further relates to a method of simplified loading/unloading of such a multipurpose tray into/from the automated processing system.

公开(公告)号：USD1024093S1

公开(公告)日：2024-04-23

申请号：US29811751

申请日：2021-10-15

申请人： Roche Molecular Systems, Inc.

设计人： Cindy K. Barnard ,  Sambasivarao Byrapuneni ,  Diwakar Chapagain ,  Archana P. Dorge ,  Catherine M. Jeu ,  Rengaraja Kesavan ,  Kaushal D. Parekh ,  Raman Ramanathan ,  David M. Schlossman ,  Vishakha Sharma

摘要： FIG. 1 is a front view of a first image in a sequence of a display screen or portion thereof with graphical user interface for patient timeline navigation showing our new design;
FIG. 2 is a front view of a second image thereof;
FIG. 3 is a front view of a third image thereof;
FIG. 4 is a front view of a fourth image thereof;
FIG. 5 is a front view of a fifth image thereof;
FIG. 6 is a front view of a sixth image thereof; and,
FIG. 7 is a front view of a seventh image thereof.
The outermost broken line rectangular indicates a boundary of a display screen or a portion thereof and forms no part of the claimed design. The broken lined text, patterns, and characters form no part of the claimed design. The appearance of the animated images sequentially transition from FIG. 1 to FIG. 7. The process or period in which one image transitions to another forms no part of the claimed design.

公开(公告)号：US20240110162A1

公开(公告)日：2024-04-04

申请号：US18219045

申请日：2023-07-06

申请人： Roche Molecular Systems, Inc.

发明人： Feruz Kurbanov

IPC分类号： C12N9/12 ,  C12Q1/6844

CPC分类号： C12N9/1252 ,  C12Q1/6844 ,  C12Y207/07007

摘要： Disclosed are DNA polymerases having increased 5′-3′ strand displacement activity and substantially reduced 5′-3′ exonuclease and endonuclease activity relative to a corresponding, unmodified polymerase. The polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the DNA polymerases.

公开(公告)号：US20240086460A1

公开(公告)日：2024-03-14

申请号：US18516212

申请日：2023-11-21

申请人： Genentech, Inc. ,  Roche Molecular Systems, Inc. ,  Hoffmann-La Roche Inc.

发明人： Ido BEN SHAUL ,  Marta CANAMERO ,  Ofir ETZ HADAR ,  Jacob GILDENBLAT ,  Fang-Yao HU ,  Eldad KLAIMAN

IPC分类号： G06F16/583 ,  G06F16/51 ,  G06F16/532 ,  G06F16/535 ,  G06F16/538 ,  G06T7/11

CPC分类号： G06F16/583 ,  G06F16/51 ,  G06F16/532 ,  G06F16/535 ,  G06F16/538 ,  G06T7/11

摘要： In one embodiment, a method includes indexing a whole slide image dataset to generate one or more dataset embeddings corresponding to one or more respective regions of one or more whole slide images. Each dataset embedding includes a feature vector mapping the respective region to a feature embedding space. The method includes accessing a query image and generating an embedding for the query image that includes a feature vector mapping the query image to the feature embedding space. The method includes identifying result tiles by comparing the embedding for the query image to one or more of the dataset embeddings. The comparison is based on one or more distances between the embedding for the query image and the one or more of the dataset embeddings in the feature embedding space. The method includes generating a user interface including a display of the result tiles.

公开(公告)号：US20240085442A1

公开(公告)日：2024-03-14

申请号：US18235272

申请日：2023-08-17

申请人： Ventana Medical Systems, Inc. ,  Roche Molecular Systems, Inc.

发明人： Meg E. Creasey ,  Matthew D. Mette ,  Denny Osswald ,  James E. Phillips-Portillo ,  Clayton Reynolds ,  Curtis C. Rose ,  Alexander Schmelzer ,  Franklin R. Ventura

IPC分类号： G01N35/00

CPC分类号： G01N35/00029 ,  G01N35/0099

摘要： A slide carrier includes: a base support; and a slide platform having a surface that is parallel to a first plane defined by a first vector and a second vector, wherein a vector extending in a direction opposite to the direction of gravity is normal with respect to a second plane defined by a third vector and a fourth vector, an angle between the first vector and the third vector is greater than zero degrees and less than 90 degrees, and an angle between the second vector and the fourth vector is greater than zero degrees and less than 90 degrees.

公开(公告)号：US11920185B2

公开(公告)日：2024-03-05

申请号：US17233744

申请日：2021-04-19

申请人： Roche Molecular Systems, Inc.

发明人： Ellen Fiss

IPC分类号： C12Q1/6806 ,  C07D307/60 ,  C12Q1/6809 ,  C12Q1/6844 ,  C12Q1/6888

CPC分类号： C12Q1/6806 ,  C07D307/60 ,  C12Q1/6809 ,  C12Q1/6846 ,  C12Q1/6888 ,  C12Q2527/125

摘要： The present invention provides inactivated microbes, methods of preparing and using the same, as well as compositions and kits containing the same. The inactivated microbes are useful in the formulation of internal control reagents for use in recombinant nucleic acid techniques, especially nucleic acid amplification, e.g., by the polymerase chain reaction (PCR).