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1.发明公开公开(公告)号：US20240344124A1
公开(公告)日：2024-10-17
申请号：US18509355
申请日：2023-11-15
发明人： Christopher M. Green , Joseph R. Spangler , Tomasz A. Leski , Kimihiro Susumu , Sebastian A. Diaz , Igor L. Medintz , David A. Stenger , Scott N. Dean
IPC分类号： C12Q1/6874 , C12Q1/6806
CPC分类号： C12Q1/6874 , C12Q1/6806 , C12Q2600/156
摘要： One can enrich nucleic acid (RNA or DNA) from within a complex mixture in a sequence-specific manner by using a mutant of a Cas enzyme lacking nuclease activity, for example a mutant of Cas13a (dCas) from Leptotrichia wadeii. The nucleic acid is bound by the mutant protein as directed by guide RNA molecules (crRNA) and purified after association with an appropriate surface, such as quantum dots or functionalized beads. The nucleic acid is separated from the Cas and purified after precipitation or interaction with another surface. The resulting product can be directly processed via long-read sequencing.
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公开(公告)号：US12080984B2
公开(公告)日：2024-09-03
申请号：US17412339
申请日：2021-08-26
发明人： Michael H. Helle
IPC分类号： H01S3/00 , G02B5/18 , G02F1/39 , H01S3/1106
CPC分类号： H01S3/0057 , G02B5/1819 , G02F1/39 , G02F1/392 , H01S3/0085 , H01S3/1106
摘要： A laser architecture for selectively producing short high-energy laser pulses having octave-spanning, continuous tunability. Two oppositely chirped pulses are used in combination with a pair of tunable pulse stretcher/compressors to produce a short, high-energy, tunable, broadband pulse.
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公开(公告)号：US20240282906A1
公开(公告)日：2024-08-22
申请号：US18650512
申请日：2024-04-30
CPC分类号： H01M4/0433 , H01M4/48 , H01M10/32
摘要： A method of making an electrode by providing a mixture of first particles of silver or silver oxide and second particles of an inorganic porogen, molding the mixture, cohering the mixture to form a green body, demolding the green body, heating the green body to form a monolith, to convert any silver oxide to silver, and to fuse the first particles together, and submerging the monolith in a liquid that removes the second particles.
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4.发明公开公开(公告)号：US20240175076A1
公开(公告)日：2024-05-30
申请号：US18346973
申请日：2023-07-05
发明人： Sebastián A. Díaz , Christopher M. Green , Joseph R. Spangler , Divita Mathur , Kimihiro Susumu , David A. Stenger , Igor L. Medintz
IPC分类号： C12Q1/6818 , C12Q1/6876 , C12Q1/6806
CPC分类号： C12Q1/6818 , C12Q1/6876 , C12Q1/6806
摘要： A flexible strategy for assembling luminescent and colorimetric quantum dot/nucleic acid hairpin (QD-HP) molecular beacons for use in CRISPR/Cas diagnostics uses chimeric peptide/peptide nucleic acid (PNA) to conjugate fluorescently labeled DNA or RNA hairpins to ZnS-coated QDs.
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公开(公告)号：US11994635B2
公开(公告)日：2024-05-28
申请号：US17233441
申请日：2021-04-17
发明人： Zishan Hameed , John Gats , Jin-Woo Han , Meyya Meyyappan
CPC分类号： G01T3/08 , B81B7/0058 , B81B2201/031 , B81B2203/04 , B82Y30/00
摘要： A MEMS nanotube based radiation sensor that is low cost, low power, compact, reliable and is applicable across many fields and a method for fabricating such a sensor are described. Each sensor may be connected to an array of similar but distinct sensors that leverage different materials and nanotube technology to detect radiation.
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公开(公告)号：US11993615B2
公开(公告)日：2024-05-28
申请号：US17961585
申请日：2022-10-07
CPC分类号： C07F15/045
摘要： Tunable thermochromic materials comprise a metal salt with a varying proportion of two different anions and an organic ligand. Partial substitution via doping during the initial synthesis with a macro-structurally similar (generating an isostructural material) yet chemically different anion creates a material with altered thermochromic properties. For example, in bromide-doped bis(N,N′-diethylethylenediamine)nickel(II)) tetrafluoroborate; both the tetrafluoroborate (BF4-) and bromide (Br—) derivatives are isostructural. Substitution of BF4- for Br— causes a decrease in the materials' thermochromic transition temperature by approximately 10° C.
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公开(公告)号：US11971290B2
公开(公告)日：2024-04-30
申请号：US17524120
申请日：2021-11-11
发明人： Raymond Mark Gamache
CPC分类号： G01F23/683 , G01F23/76 , G08B21/182 , G08B21/088
摘要： A water submersion detection system that may include a buoyant device having a conductive surface, and a housing enclosing the buoyant device and having conductive elements. The conductive elements may include a first set of one or more nonadjacent conductive elements that are electrically connected, and a second set of one or more nonadjacent conductive elements that are electrically connected. The system may include a submersion alert device that activates responsive to the buoyant device contacting the housing.
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公开(公告)号：US20240133741A1
公开(公告)日：2024-04-25
申请号：US18243728
申请日：2023-09-07
CPC分类号： G01J3/4412 , G01J3/12
摘要： An apparatus includes a spectrometer receiving an optical input signal that includes an input optical spectrum. The spectrometer includes a fiber laser cavity pumped by a first optical replica of the optical input signal that generates stimulated Brillouin scattering traveling in a direction opposite to a direction of the optical input signal. The first optical replica of the optical input signal excites at least one lasing mode in the fiber laser cavity. The at least one lasing mode respectively includes at least one lasing mode frequency. The at least one lasing mode frequency is onset by a respective Brillouin frequency shift from the respective at least one input frequency. The spectrometer also includes an optical heterodyne receiver. The optical heterodyne receiver generates the electrical output signal. The spectrometer outputs a measurement of the input optical spectrum based on the respective Brillouin frequency shift and the at least one input frequency.
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公开(公告)号：US20240120776A1
公开(公告)日：2024-04-11
申请号：US18375505
申请日：2023-09-30
摘要： Systems and methods are provided for power beaming that increase power density at the target location by exploiting scattering from terrain. The disclosed systems and methods further provide a variable focus feature allowing the beam power to be concentrated at specified standoff distances from the transmitter and increase the radio frequency (RF) power handling of the receiver using an overvoltage protection circuit in the DC load.
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公开(公告)号：US20240120201A1
公开(公告)日：2024-04-11
申请号：US18193862
申请日：2023-03-31
IPC分类号： H01L21/225
CPC分类号： H01L21/2258
摘要： A technique for selective-area diffusion doping of III-N epitaxial material layers and for fabricating power device structures utilizing this technique. Dopant species such as Mg are introduced into the III-N material layer and are diffused into the III-N material by annealing under stable or metastable conditions. The dopant species can be introduced via deposition of a metal or alloy layer containing such species using sputtering, e-beam evaporation or other technique known to those skilled in the art. The dopant material layer is capped with a thermally stable layer to prevent decomposition and out-diffusion, and then is annealed under stable or metastable conditions to diffuse the dopant into the III-N material GaN without decomposing the surface.
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