公开(公告)号：US20070218036A1

公开(公告)日：2007-09-20

申请号：US10593762

申请日：2005-03-23

申请人： Toshihiro Nakai

发明人： Toshihiro Nakai

IPC分类号： A01N63/00

CPC分类号： A61K39/12 ,  A23K10/18 ,  A23K20/10 ,  A23K50/80 ,  A61K35/76 ,  A61K2039/552 ,  C12N2720/10034 ,  C12N2770/30034

摘要： The present invention provides a method for the prevention or the treatment of an infection of fishes with nodaviruses or a disease such as, for example, viral nervous necrosis or the like, caused by an infection with nodaviruses. The infection of fishes with nodavirus or the outbreak of a disease including viral nervous necrosis or the like caused by the infection with nodaviruses can be prevented or treated by transdermally administering fishes with aquabirnaviruses, for example, by injection, or dipping fishes in a solution containing an aquabirnavirus or supplying fishes with a feed containing an aquabirnavirus.

摘要翻译： 本发明提供了一种预防或治疗由诺托维链病毒感染引起的诺如病毒感染或诸如病毒性神经坏死等疾病的感染的方法。 可以通过例如通过注射或将鱼浸入含有水溶蛋白病毒的溶液中的方法来预防或治疗由转染病毒感染的鱼类或包括由诺托维西病毒感染引起的病毒性神经坏死等的疾病的爆发， 一种aquabirnavirus或向鱼提供含有一种aquabirnavirus的饲料。

公开(公告)号：US20190040354A1

公开(公告)日：2019-02-07

申请号：US16074501

申请日：2017-02-02

申请人： BENCHMARK ANIMAL HEALTH LIMITED

发明人： Lindsey Ann TOON ,  Ralf HOFFMANN

IPC分类号： C12N5/071

CPC分类号： C12N5/0602 ,  C12N2510/02 ,  C12N2700/00 ,  C12N2720/10034 ,  C12N2720/10051 ,  C12N2720/10061 ,  C12N2770/30034 ,  C12N2770/30051

摘要： Methods of producing, propagating and multiplying viruses, methods of identifying the presence of a virus in a sample, specifically methods using Japanese eel cell cultures. Also provided are an isolated Japanese eel cell culture, optionally infected with a virus, vaccines comprising viruses grown according to the methods of the invention, and a kit for propagating viruses comprising the Japanese eel cell culture. The virus may be a fish virus such as nodavirus, Infectious Pancreatic Necrosis Virus (IPNV) and Salmon Pancreas Disease Virus (SPDV).

公开(公告)号：US20170028051A1

公开(公告)日：2017-02-02

申请号：US14775938

申请日：2014-03-17

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Shou-Wei Ding ,  Yang Li

IPC分类号： A61K39/12 ,  C12N7/00

CPC分类号： A61K39/12 ,  A61K2039/5254 ,  A61K2039/57 ,  C12N7/00 ,  C12N15/1131 ,  C12N2310/14 ,  C12N2760/14122 ,  C12N2760/14162 ,  C12N2770/30022 ,  C12N2770/30034 ,  C12N2770/30062 ,  C12N2770/32222 ,  C12N2770/32262

摘要： The disclosure provides recombinant viral vectors and attenuated viruses and viral vaccines comprising a virus lacking a functional viral RNA suppressor of host RNAi.

摘要翻译： 本公开提供重组病毒载体和减毒病毒和病毒疫苗，其包含缺乏宿主RNAi的功能性病毒RNA抑制剂的病毒。

公开(公告)号：US09884103B2

公开(公告)日：2018-02-06

申请号：US14888995

申请日：2014-05-26

申请人： Elanco Tiergesundheit AG

发明人： Juan Jose Borrego ,  Carlos Carballo Perez ,  Maria Del Carmen Alonso ,  Esther Garcia Rosado ,  Benjamin Lopez-Jimena ,  Jose F Rodriguez

IPC分类号： A61K39/12 ,  A61K39/00

CPC分类号： A61K39/12 ,  A61K2039/5252 ,  A61K2039/552 ,  C12N2770/30034

摘要： Disclosed are interactions between different betanodaviruses during infection of cells “in vitro” and in European sea bass. More specifically, fish administered striped jack nervous necrosis viruses (SJNNV), which are then exposed to red-spotted grouper nervous necrosis viruses (RGNNV), have fewer symptoms of disease associated with RGNNV and/or increased survival as compared to fish not administered SJNNV prior to exposure to RGNNV.

公开(公告)号：US08124100B2

公开(公告)日：2012-02-28

申请号：US12425135

申请日：2009-04-16

申请人： Nuno Dos Santos ,  Jacqueline Ireland ,  Andrew Cartner Barnes ,  Michael Horne

发明人： Nuno Dos Santos ,  Jacqueline Ireland ,  Andrew Cartner Barnes ,  Michael Horne

IPC分类号： A61K39/00 ,  A61K39/12 ,  C12N7/06 ,  C12N15/74

CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K2039/5252 ,  A61K2039/552 ,  A61K2039/55566 ,  C12N2770/30034 ,  C12N2770/30063

摘要： A vaccine against nodavirus infection in fish can be produced by inactivating the virus using an aziridine compound. This vaccine can be used to prevent Viral Nervous Necrosis (VNN) in a variety of fish species.

摘要翻译： 可以通过使用氮丙啶化合物灭活病毒来产生针对鱼类中的转染病毒感染的疫苗。 该疫苗可用于预防各种鱼类中的病毒性神经坏死（VNN）。

公开(公告)号：US20080286294A1

公开(公告)日：2008-11-20

申请号：US11596860

申请日：2005-05-19

申请人： Richard Thiery ,  Marine Baud ,  Joelle Cabon ,  Joelle Cozien ,  Francois Lamour ,  Chan-Shing Lin ,  Neel Krishna ,  John E. Johnson ,  Anette Schneemann

发明人： Richard Thiery ,  Marine Baud ,  Joelle Cabon ,  Joelle Cozien ,  Francois Lamour ,  Chan-Shing Lin ,  Neel Krishna ,  John E. Johnson ,  Anette Schneemann

IPC分类号： A61K39/12

CPC分类号： A61K39/12 ,  A23K20/00 ,  A23K50/80 ,  A61K2039/5258 ,  A61K2039/54 ,  A61K2039/552 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/14143 ,  C12N2770/30022 ,  C12N2770/30023 ,  C12N2770/30034 ,  C12N2770/30051

摘要： The present invention relates to an immunogenic composition for fish comprising nodavirus virus-like particles (VLPs) formed with nodavirus capsid protein assembly, for use as a vaccine. This composition is suitable for administration to fish via the intramuscular or intraperitoneal route, or by bath and/or via the oral route. The invention also relates to the use of such VPLs for the manufacturing of a vaccine for treating or preventing fish against a nodavirus infection. Fish farming baths and concentrates comprising the nodavirus VLP composition, as well as fish farming methods, are also encompassed in the present invention.

摘要翻译： 本发明涉及一种用于鱼类的免疫原性组合物，其包含用转染病毒衣壳蛋白组装形成的用于疫苗的转染病毒样颗粒（VLP）。 该组合物适用于通过肌内或腹膜内途径或通过浴和/或通过口服途径给予鱼。 本发明还涉及这种VPL用于制造用于治疗或预防鱼抵抗诺托病毒感染的疫苗的用途。 包含转染病毒VLP组合物的养鱼浴和浓缩物以及养鱼方法也包括在本发明中。

公开(公告)号：US10034929B2

公开(公告)日：2018-07-31

申请号：US14775938

申请日：2014-03-17

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Shou-Wei Ding ,  Yang Li

IPC分类号： C07H21/02 ,  C07H21/04 ,  A61K48/00 ,  A61K39/12 ,  C12N15/113 ,  C12N7/00 ,  A61K39/00

CPC分类号： A61K39/12 ,  A61K2039/5254 ,  A61K2039/57 ,  C12N7/00 ,  C12N15/1131 ,  C12N2310/14 ,  C12N2760/14122 ,  C12N2760/14162 ,  C12N2770/30022 ,  C12N2770/30034 ,  C12N2770/30062 ,  C12N2770/32222 ,  C12N2770/32262

摘要： The disclosure provides recombinant viral vectors and attenuated viruses and viral vaccines comprising a virus lacking a functional viral RNA suppressor of host RNAi.

公开(公告)号：US20170268011A1

公开(公告)日：2017-09-21

申请号：US15505252

申请日：2014-12-30

申请人： CHUNG-ANG UNIVERSITY INDUSTRY-ACADEMY COOPERATION FOUNDATION

发明人： Hyun Ah KANG ,  Hye Yun MOON ,  Hong Jin KIM

IPC分类号： C12N15/81 ,  C07K14/005 ,  A61K39/12 ,  A61K9/00 ,  C12N15/70

CPC分类号： C12N15/81 ,  A61K9/0053 ,  A61K39/00 ,  A61K39/12 ,  A61K2039/523 ,  A61K2039/54 ,  C07K14/005 ,  C12N15/70 ,  C12N2770/30022 ,  C12N2770/30034 ,  C12N2770/30071 ,  C12R1/865

摘要： Disclosed is a gene multiple insertion cassette set including rDNA NTS fragments and an auxotrophic selection marker having an incomplete promoter is developed, and a safe oral recombinant strain having no antibiotic resistant marker is constructed by multiple insertion of an optimum number of the developed gene multiple insertion cassette sets into chromosomes of a Saccharomyces cerevisiae strain, a vaccine composition including, as an active ingredient, the above strain, a culture product thereof, a cell lysate, or nodavirus capsid protein (NNVcp) isolated and purified therefrom, and a composition for feed addition including, as an active ingredient, the above strain, a culture product thereof, a cell lysate, or squalene or oxidosqualene isolated and purified therefrom.

公开(公告)号：US20150273036A1

公开(公告)日：2015-10-01

申请号：US14435258

申请日：2013-10-11

申请人： GLAXOSMITHKLINE BIOLOGICALS SA

发明人： Lorenzo Tarli ,  Mario Contorni ,  Alessandro Bartalesi

IPC分类号： A61K39/00 ,  C12N7/00 ,  A61K39/29 ,  A61K39/02 ,  A61K39/13

CPC分类号： A61K39/0018 ,  A61K39/0016 ,  A61K39/099 ,  A61K39/13 ,  A61K39/292 ,  A61K2039/55505 ,  A61K2039/70 ,  C12N7/00 ,  C12N2730/10134 ,  C12N2770/30034 ,  Y02A50/466

摘要： The present invention relates to stable compositions comprising acellular pertussis antigens that have not been cross-linked with a cross-linking agent such as formaldehyde or glutaraldehyde and their use as acellular pertussis components in combination vaccines. Processes for preparing these antigens and compositions are also disclosed.

摘要翻译： 本发明涉及包含不与交联剂如甲醛或戊二醛交联的无细胞百日咳抗原及其作为组合疫苗中的无细胞百日咳组分的用途的稳定组合物。 还公开了制备这些抗原和组合物的方法。

公开(公告)号：US20050118194A1

公开(公告)日：2005-06-02

申请号：US10725188

申请日：2003-12-01

申请人： Yoke Sin ,  Hsiao Teh ,  Sze Lim

发明人： Yoke Sin ,  Hsiao Teh ,  Sze Lim

IPC分类号： A61K9/00 ,  A61K9/08 ,  A61K38/16 ,  A61K39/104 ,  A61K39/116 ,  A61K47/44 ,  A61K39/00 ,  A61K35/78 ,  A61K39/295

CPC分类号： A61K9/0056 ,  A61K9/08 ,  A61K38/164 ,  A61K39/0208 ,  A61K39/0216 ,  A61K39/104 ,  A61K39/107 ,  A61K39/12 ,  A61K47/44 ,  A61K2039/521 ,  A61K2039/5252 ,  A61K2039/542 ,  A61K2039/552 ,  A61K2039/55566 ,  A61K2039/70 ,  C12N2720/12034 ,  C12N2770/30034 ,  A61K2300/00

摘要： A composition for oral immunization comprising recombinant proteins AHMA and FP that afford protection from bacteria and protozoan ectoparasites respectively is disclosed. Also disclosed are compositions that have in addition, inactivated viruses and killed bacteria affording a wider spectrum of protection against infections that predominantly afflict aquatic species. Method of making these compositions and administering them either directly or by incorporating them into feed, as also the use of such compositions for treating animals in need of such treatment are also disclosed.

摘要翻译： 公开了一种用于口服免疫的组合物，其包含分别提供细菌和原生动物体外寄生虫保护的重组蛋白质AHMA和FP。 还公开了另外具有灭活病毒和杀死的细菌的组合物，其提供更广泛的保护以防止主要影响水生物种的感染。 还公开了制备这些组合物并直接施用它们或通过将其并入饲料中的方法，以及用于治疗需要这种治疗的动物的这种组合物的用途。