公开(公告)号：US20190232197A1

公开(公告)日：2019-08-01

申请号：US16259705

申请日：2019-01-28

申请人： Waters Technologies Corporation

发明人： Matthew A. Lauber ,  Jennifer M. Nguyen ,  Ximo Zhang ,  Nilini Ranbaduge ,  Robert Birdsall ,  Henry Shion

IPC分类号： B01D15/42 ,  B01D15/32 ,  G01N30/72 ,  G01N30/84 ,  B01J20/283 ,  B01J20/287

CPC分类号： B01D15/426 ,  B01D15/166 ,  B01D15/305 ,  B01D15/325 ,  B01D15/327 ,  B01J20/283 ,  B01J20/287 ,  G01N30/34 ,  G01N30/7233 ,  G01N30/7266 ,  G01N30/84 ,  G01N2030/8452

摘要： The present disclosure relates to the determination of analytes in a sample using chromatography. The present disclosure provides methods of separating an analyte from a sample. A mobile phase is flowed through a chromatography column. The mobile phase includes about 0.005% (v/v) to about 0.20% (v/v) difluoroacetic acid and less than about 100 ppb of any individual metal impurity. A sample including the analyte is injected into the mobile phase. The analyte is separated from the sample.

公开(公告)号：US07586091B2

公开(公告)日：2009-09-08

申请号：US10549587

申请日：2004-03-15

申请人： Katsutoshi Takahashi ,  Kazuhiro Iida ,  Masakazu Baba ,  Noriyuki Iguchi ,  Toru Sano ,  Hisao Kawaura ,  Toshitsugu Sakamoto ,  Wataru Hattori ,  Hiroko Someya

发明人： Katsutoshi Takahashi ,  Kazuhiro Iida ,  Masakazu Baba ,  Noriyuki Iguchi ,  Toru Sano ,  Hisao Kawaura ,  Toshitsugu Sakamoto ,  Wataru Hattori ,  Hiroko Someya

IPC分类号： H01J49/00

CPC分类号： H01J49/0418 ,  B01L3/502746 ,  B01L3/502753 ,  B01L2200/0663 ,  B01L2200/10 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/16 ,  B01L2400/086 ,  G01N1/22 ,  G01N30/84 ,  G01N2030/8452

摘要： After a sample is previously separated into plural components in a channel formed in a microchip (353), the channel is irradiated along a separation direction with a laser beam from a laser oscillator (361) to sequentially ionize each fraction separated in the channel. The ionized fraction is detected by a mass spectrometry unit (363) and analyzed by an analytical result analyzing unit (371). The analytical result is stored in a memory (369) while associated with position information in a driver control unit (367) and information on laser beam irradiation condition in a laser control unit (373), and the analytical result is imaged by an imaging unit (375). The imaged analytical result is displayed on a display (377).

摘要翻译： 在将样品预先分离成在微芯片（353）中形成的通道中的多个部件之后，通过激光振荡器（361）的激光束沿着分离方向照射通道，以顺序地电离通道中分离的每个部分。 通过质谱分析单元（363）检测离子化分数，用分析结果分析单元（371）进行分析。 分析结果与激光控制单元（373）中的驱动器控制单元（367）中的位置信息和激光束照射条件的信息相关联地存储在存储器（369）中，并且分析结果由成像单元 （375）。 成像分析结果显示在显示器上（377）。

公开(公告)号：US06568245B2

公开(公告)日：2003-05-27

申请号：US10098936

申请日：2002-03-13

申请人： Stanley L. Kaufman

发明人： Stanley L. Kaufman

IPC分类号： G01N3700

CPC分类号： G01N30/84 ,  G01N30/64 ,  G01N2030/8452 ,  G01N2030/847 ,  G01N2030/8482 ,  Y10T436/25125 ,  Y10T436/25375

摘要： An aerosol detector, particularly well suited for liquid chromatography applications, includes a corona discharge source controlled to selectively charge the non-volatile residue particles of an aerosol. The aerosol initially is composed of droplets of a liquid sample, with the residue particles resulting from droplet evaporation. The selectively charged residue particles, each carrying a charge in proportion to its size, are collected at a conductive filter. The electrical current along a conductor coupled to the filter is measured repeatedly or continuously to provide an indication of concentrations of the non-volatile material. Preferably, a pneumatic nebulizer is used to generate the aerosol. When used in a liquid chromatography system, the detector can yield several separated areas of relatively high electrical current, corresponding to concentrations of several different analytes in the liquid sample.

公开(公告)号：US20240096612A1

公开(公告)日：2024-03-21

申请号：US18271386

申请日：2021-09-22

申请人： SHIMADZU CORPORATION

发明人： Keisuke SHIMA ,  Yuko FUKUYAMA

IPC分类号： H01J49/04 ,  G01N30/84

CPC分类号： H01J49/0431 ,  G01N30/84 ,  G01N2030/8452

摘要： The present invention provides a method for mass spectrometry of a negatively charged organic synthetic compound, and a matrix that can be used in said method. A method for mass spectrometry of a negatively charged organic synthetic compound, the method comprising using, as a liquid matrix, an ionic liquid comprising an amine ion and an acidic group-containing organic substance ion. For example, the amine is 3-aminoquinoline (3-AQ), and the acidic group-containing organic substance is p-coumaric acid (p-CA). The negatively charged organic synthetic compound to be analyzed is, for example, an organic synthetic polymer compound or a complex compound.

公开(公告)号：US20180100840A1

公开(公告)日：2018-04-12

申请号：US15838081

申请日：2017-12-11

申请人： DIONEX CORPORATION

发明人： Alan Daniel YIM ,  Paul H. GAMACHE ,  Ryan S. McCARTHY

IPC分类号： G01N30/84 ,  G01N30/64

CPC分类号： G01N30/84 ,  B05B7/0012 ,  B05B7/0876 ,  G01N30/64 ,  G01N2030/8452 ,  G01N2030/8464 ,  G01N2030/847

摘要： A nebulizer for a charged aerosol detection (CAD) system is disclosed. The nebulizer is provided with a spray emitter for generating a spray of droplets within a central region of a spray chamber. The central region is separated from an upper region by a horizontally projecting rib, which defines a passageway between the central and upper regions. The major direction of droplet travel within the upper region is substantially reversed with respect to the major direction of droplet travel within the central region. Larger droplets are unable to negotiate the turn from the central to upper regions and impinge on a rear surface of the spray chamber. Removal of larger droplets has the advantageous effect of enabling the detector to sense a smaller range of particle sizes, which establishes a relatively steady electrical current at the detector.

公开(公告)号：US20140352411A1

公开(公告)日：2014-12-04

申请号：US14288693

申请日：2014-05-28

申请人： DIONEX CORPORATION

发明人： Alan Daniel YIM ,  Paul H. GAMACHE ,  Ryan S. McCARTHY

IPC分类号： G01N30/84 ,  B05B7/00

CPC分类号： G01N30/84 ,  B05B7/0012 ,  B05B7/0876 ,  G01N30/64 ,  G01N2030/8452 ,  G01N2030/8464 ,  G01N2030/847

摘要： A nebulizer for a charged aerosol detection (CAD) system is disclosed. The nebulizer is provided with a spray emitter for generating a spray of droplets within a central region of a spray chamber. The central region is separated from an upper region by a horizontally projecting rib, which defines a passageway between the central and upper regions. The major direction of droplet travel within the upper region is substantially reversed with respect to the major direction of droplet travel within the central region. Larger droplets are unable to negotiate the turn from the central to upper regions and impinge on a rear surface of the spray chamber. Removal of larger droplets has the advantageous effect of enabling the detector to sense a smaller range of particle sizes, which establishes a relatively steady electrical current at the detector.

摘要翻译： 公开了一种用于带电气溶胶检测（CAD）系统的雾化器。 雾化器设置有用于在喷雾室的中心区域内产生液滴喷雾的喷射发射器。 中心区域通过水平突出的肋条从上部区域分离，该肋条限定了中心区域和上部区域之间的通道。 在上部区域内的液滴行进的主要方向相对于中心区域内的液滴行进的主要方向基本上是相反的。 较大的液滴不能协调从中心到上部区域的转弯并撞击在喷雾室的后表面上。 去除更大的液滴具有使检测器能够感测更小范围的粒度的有利效果，其在检测器处建立相对稳定的电流。

公开(公告)号：US20020132362A1

公开(公告)日：2002-09-19

申请号：US10098936

申请日：2002-03-13

发明人： Stanley L. Kaufman

IPC分类号： G01N030/02 ,  G01N001/22

CPC分类号： G01N30/84 ,  G01N30/64 ,  G01N2030/8452 ,  G01N2030/847 ,  G01N2030/8482 ,  Y10T436/25125 ,  Y10T436/25375

摘要： An aerosol detector, particularly well suited for liquid chromatography applications, includes a corona discharge source controlled to selectively charge the non-volatile residue particles of an aerosol. The aerosol initially is composed of droplets of a liquid sample, with the residue particles resulting from droplet evaporation. The selectively charged residue particles, each carrying a charge in proportion to its size, are collected at a conductive filter. The electrical current along a conductor coupled to the filter is measured repeatedly or continuously to provide an indication of concentrations of the non-volatile material. Preferably, a pneumatic nebulizer is used to generate the aerosol. When used in a liquid chromatography system, the detector can yield several separated areas of relatively high electrical current, corresponding to concentrations of several different analytes in the liquid sample.

摘要翻译： 特别适用于液相色谱应用的气溶胶检测器包括电晕放电源，其被控制以选择性地对气溶胶的非挥发性残余物颗粒进行充电。 气溶胶最初由液体样品的液滴组成，残余物颗粒由液滴蒸发产生。 在导电过滤器上收集每个带有与其尺寸成比例的电荷的带电荷的残余物颗粒。 沿着耦合到过滤器的导体的电流被重复地或连续地测量以提供非挥发性材料的浓度的指示。 优选地，气动雾化器用于产生气溶胶。 当用于液相色谱系统时，检测器可以产生相当高的电流的几个分离区域，对应于液体样品中几种不同分析物的浓度。

公开(公告)号：US12105067B2

公开(公告)日：2024-10-01

申请号：US16694995

申请日：2019-11-25

申请人： DIONEX SOFTRON GMBH

发明人： Joachim Wiechers

IPC分类号： G01N30/84 ,  G01N30/64 ,  G01N15/00 ,  G01N30/02

CPC分类号： G01N30/84 ,  G01N30/64 ,  G01N2015/0003 ,  G01N2030/027 ,  G01N2030/8452

摘要： A detector system includes a droplet generator system, wherein the droplet generator system includes a droplet generator unit. The droplet generator unit is configured to create droplets from a liquid supplied to the droplet generator unit with a droplet generator liquid flow. The droplet generator unit is configured to create the droplets with a defined droplet generation frequency.

公开(公告)号：US09851333B2

公开(公告)日：2017-12-26

申请号：US14288693

申请日：2014-05-28

申请人： DIONEX CORPORATION

发明人： Alan Daniel Yim ,  Paul H. Gamache ,  Ryan S. McCarthy

IPC分类号： G01N30/96 ,  G01N30/84 ,  G01N30/64 ,  B05B7/00 ,  B05B7/08

CPC分类号： G01N30/84 ,  B05B7/0012 ,  B05B7/0876 ,  G01N30/64 ,  G01N2030/8452 ,  G01N2030/8464 ,  G01N2030/847

摘要： A nebulizer for a charged aerosol detection (CAD) system is disclosed. The nebulizer is provided with a spray emitter for generating a spray of droplets within a central region of a spray chamber. The central region is separated from an upper region by a horizontally projecting rib, which defines a passageway between the central and upper regions. The major direction of droplet travel within the upper region is substantially reversed with respect to the major direction of droplet travel within the central region. Larger droplets are unable to negotiate the turn from the central to upper regions and impinge on a rear surface of the spray chamber. Removal of larger droplets has the advantageous effect of enabling the detector to sense a smaller range of particle sizes, which establishes a relatively steady electrical current at the detector.

公开(公告)号：US20170176401A1

公开(公告)日：2017-06-22

申请号：US15387133

申请日：2016-12-21

申请人： Micromass UK Limited

发明人： Stevan BAJIC ,  David S DOUCE ,  Gordon A JONES

IPC分类号： G01N30/72 ,  H01J49/04 ,  B05B17/06 ,  G01N30/06

CPC分类号： G01N30/724 ,  B05B17/0607 ,  B05B17/0623 ,  G01N30/06 ,  G01N2030/8447 ,  G01N2030/8452 ,  G01N2030/8458 ,  H01J49/0445 ,  H01J49/045 ,  H01J49/0454

摘要： A secondary ultrasonic nebulisation device is disclosed comprising: a liquid sample delivery capillary; a sample receiving surface arranged for receiving a liquid sample from the capillary; and an ultrasonic transducer configured for oscillating the surface so as to nebulise the liquid sample received thereon, wherein the device is configured such that the oscillations of the surface by the ultrasonic transducer cause charged droplets and/or gas phase ions to be generated from the sample.