公开(公告)号：US07234365B2

公开(公告)日：2007-06-26

申请号：US11331719

申请日：2006-01-12

申请人： Eric D. Carlson ,  Miroslav Petro ,  Son Hoai Nguyen

发明人： Eric D. Carlson ,  Miroslav Petro ,  Son Hoai Nguyen

IPC分类号： G01N33/15

CPC分类号： C40B40/04 ,  G01N33/15 ,  Y10T436/119163 ,  Y10T436/255

摘要： Methods and systems for determining a dissolution profile of a sample material, and for solubilization screening of a library defined by an array comprising multiple sample materials are disclosed. The methods and systems are particularly advantageous for sampling and evaluation of very small samples, and can be advantageously applied in connection with evaluation of drug candidates.

摘要翻译： 公开了用于确定样品材料的溶出曲线以及由包含多个样品材料的阵列限定的文库的溶解筛选的方法和系统。 所述方法和系统对于非常小样品的取样和评估特别有利，并且可以有利地应用于药物候选物的评价。

公开(公告)号：US07024955B2

公开(公告)日：2006-04-11

申请号：US10414185

申请日：2003-04-14

申请人： Eric D. Carlson ,  Miroslav Petro ,  Son Hoai Nguyen

发明人： Eric D. Carlson ,  Miroslav Petro ,  Son Hoai Nguyen

IPC分类号： G01N33/15 ,  G01N33/00

CPC分类号： C40B40/04 ,  G01N33/15 ,  Y10T436/119163 ,  Y10T436/255

摘要： Methods and systems for determining a dissolution profile of a sample material, and for solubilization screening of a library defined by an array comprising multiple sample materials are disclosed. The methods and systems are particularly advantageous for sampling and evaluation of very small samples, and can be advantageously applied in connection with evaluation of drug candidates.

摘要翻译： 公开了用于确定样品材料的溶出曲线以及由包含多个样品材料的阵列限定的文库的溶解筛选的方法和系统。 所述方法和系统对于非常小样品的取样和评估特别有利，并且可以有利地应用于药物候选物的评价。

公开(公告)号：US06260407B1

公开(公告)日：2001-07-17

申请号：US09285333

申请日：1999-04-02

申请人： Miroslav Petro ,  Adam Safir ,  Ralph B. Nielsen ,  G. Cameron Dales ,  Eric D. Carlson ,  Thomas S. Lee

发明人： Miroslav Petro ,  Adam Safir ,  Ralph B. Nielsen ,  G. Cameron Dales ,  Eric D. Carlson ,  Thomas S. Lee

IPC分类号： G01N3108

CPC分类号： G01N35/1097 ,  B01D15/08 ,  B01D15/14 ,  B01D15/161 ,  B01D15/26 ,  B01D15/265 ,  B01D15/325 ,  B01D15/34 ,  B01J19/0046 ,  B01J19/26 ,  B01J2219/00274 ,  B01J2219/00585 ,  B01J2219/00587 ,  B01J2219/00707 ,  B01J2219/00722 ,  C40B40/14 ,  G01N15/0205 ,  G01N30/02 ,  G01N30/16 ,  G01N30/24 ,  G01N30/30 ,  G01N30/461 ,  G01N30/466 ,  G01N30/54 ,  G01N30/6052 ,  G01N30/88 ,  G01N33/44 ,  G01N33/442 ,  G01N35/028 ,  G01N35/085 ,  G01N2015/0288 ,  G01N2015/0294 ,  G01N2030/324 ,  G01N2030/885 ,  Y10S210/13

摘要： Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems and methods, including liquid chromatography and flow-injection analysis systems and methods are preferably employed. High throughput, automated sampling systems and methods, high-temperature characterization systems and methods, and rapid, indirect calibration compositions and methods are also disclosed. In preferred high-temperature embodiments, the polymer sample is maintained at a temperature of not less than about 75° C. during sample preparation, loading into a liquid chromatography or flow-injection analysis system, injection into a mobile phase of a liquid chromatography or flow-injection analysis system, and/or elution from chromatographic column. The described methods, systems, and device have primary applications in combinatorial polymer research and in industrial process control.

摘要翻译： 公开了聚合物样品的快速表征和筛选以确定平均分子量，分子量分布和其它性质。 优选采用快速流动表征系统和方法，包括液相色谱和流动注射分析系统和方法。 还公开了高通量，自动采样系统和方法，高温表征系统和方法以及快速，间接校准组合物和方法。 在优选的高温实施方案中，在样品制备期间，将聚合物样品保持在不低于约75℃的温度，加载到液相色谱或流动注射分析系统中，注入液相色谱的流动相或 流动注射分析系统和/或从色谱柱洗脱。 所描述的方法，系统和装置在组合聚合物研究和工业过程控制中具有主要应用。

公开(公告)号：US4991869A

公开(公告)日：1991-02-12

申请号：US416181

申请日：1989-10-02

申请人： Philip W. Hopf ,  Robert L. Jones ,  Eric D. Carlson

发明人： Philip W. Hopf ,  Robert L. Jones ,  Eric D. Carlson

IPC分类号： B60R21/2165

CPC分类号： B60R21/21656

摘要： A cover assembly for an occupant restraint system is formed of relatively irrupturable material and includes longitudinal and lateral portions which overlie like portions of a container housing an inflatable occupant restraint cushion. The juxtaposed edges of these portions are arranged which are juxtaposed to each other across a tear line of the container. One edge of each pair terminates in a U shaped return bent flange and the other edge of each pair terminates in an S shaped return bent flange having a flap which extends across the tear line and abuts the U shaped flange.

摘要翻译： 用于乘员约束系统的盖组件由相对可燃的材料形成，并且包括纵向和侧部，其覆盖容纳可充气乘员约束垫的容器的类似部分。 这些部分的并列边缘布置成彼此跨过容器的撕裂线并置。 每一对的一个边缘终止于U形的返回弯曲凸缘，并且每对的另一个边缘终止于具有延伸穿过撕裂线并邻接U形凸缘的翼片的S形复位弯曲凸缘。

公开(公告)号：US4756513A

公开(公告)日：1988-07-12

申请号：US929328

申请日：1986-11-10

申请人： Eric D. Carlson ,  Jack E. Smith ,  Richard A. Muzechuk

发明人： Eric D. Carlson ,  Jack E. Smith ,  Richard A. Muzechuk

IPC分类号： F16F13/20 ,  F16F13/26 ,  F16M5/00 ,  B60G15/04

CPC分类号： F16F13/26 ,  F16F13/20

摘要： A hydraulic mount assembly is disclosed having a partition including a hydraulic damping decoupler between two hydraulic chambers. One chamber is formed by an elastomeric member and the other by a resilient diaphragm. During dynamic loading of the mount, fluid passes between the two chambers of the mount causing expansion and contraction of the diaphragm. A pneumatic bladder is positioned to exert external pressure against the diaphragm in order to change the damping characteristics of the mount. As the bladder is expanded, the diaphragm is stiffened and the fluid flow between the two chambers in the hydraulic mount is restricted. When the bladder is deflated, the pressure against the diaphragm is reduced or effectively removed thereby restoring full freedom of movement of the fluid in the hydraulic mount. By actively controlling the diaphragm expansion in this manner, the dynamic characteristics of the mount are varied. A control circuit with on-board transducers is provided to monitor vehicle operating and road response conditions and modulate the pressure to the bladder for maximum damping effect. The on-board transducers sense selected parameters to indicate unusual conditions for which modulation is required, such as rough engine operation, engine lugging, rough road conditions, sudden turning and/or rapid acceleration/deceleration.

摘要翻译： 公开了一种液压安装组件，其具有包括两个液压室之间的液压阻尼解耦器的分隔件。 一个室由弹性构件形成，另一个由弹性隔膜形成。 在安装件的动态加载期间，流体在安装件的两个室之间通过，导致隔膜的膨胀和收缩。 定位气囊以对隔膜施加外部压力，以改变底座的阻尼特性。 当囊膨胀时，隔膜被加强并且液压座中两个腔室之间的流体流动受到限制。 当气囊放气时，减小或有效地去除隔膜的压力，从而恢复液压支架中的流体的完全自由运动。 通过以这种方式积极地控制膜片膨胀，安装座的动态特性是变化的。 提供具有车载换能器的控制电路以监测车辆操作和道路响应条件，并且调节膀胱的压力以获得最大阻尼效果。 车载换能器检测所选参数，以指示需要调制的异常情况，例如发动机运转粗糙，发动机悬挂，粗糙的道路状况，突然转动和/或快速加速/减速。

公开(公告)号：US20100080733A1

公开(公告)日：2010-04-01

申请号：US12489159

申请日：2009-06-22

申请人： Eric D. Carlson ,  Peijun Cong ,  William H. Chandler, JR. ,  Peter J. Desrosiers ,  J. Christopher Freitag ,  John F. Varni

发明人： Eric D. Carlson ,  Peijun Cong ,  William H. Chandler, JR. ,  Peter J. Desrosiers ,  J. Christopher Freitag ,  John F. Varni

IPC分类号： G01N1/02 ,  B01L3/02

CPC分类号： B01L3/50255 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/00315 ,  B01J2219/00335 ,  B01J2219/00364 ,  B01J2219/00373 ,  B01J2219/00423 ,  B01J2219/00481 ,  B01J2219/00484 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00689 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/00725 ,  B01J2219/00756 ,  B01L3/06 ,  B01L7/00 ,  B01L2300/0829 ,  B01L2300/185 ,  C40B40/04 ,  C40B40/10 ,  C40B60/10 ,  C40B60/14 ,  G01N5/045 ,  G01N21/23 ,  G01N21/65 ,  G01N25/04 ,  G01N33/15 ,  G01N33/54366 ,  G01N35/028 ,  G01N2013/006 ,  G01N2021/651 ,  G01N2500/00 ,  G16C20/20 ,  G16C20/90 ,  Y10T117/10

摘要： A needle assembly has at least one guide member supported by a first body for sliding movement between an extended position and a retracted position. A second body is attached to the guide member. A biasing member biases the guide member to the extended position. A liquid handling needle is coupled to the first body so sliding movement of the guide member toward the retracted position retracts the second body relative to the liquid handling needle. The second body is adapted to contact a sealed receptacle. The biasing member urges the guide member toward said extended position during insertion and during said removal of the needle from the receptacle whereby the second body remains in contact with the sealed receptacle as the guide member moves from its extended position to its retracted position during said insertion and from its retracted position to its extended position during said removal.

摘要翻译： 针组件具有由第一主体支撑的至少一个引导构件，用于在延伸位置和缩回位置之间滑动。 第二主体附接到引导构件。 偏置构件将引导构件偏压到延伸位置。 液体处理针联接到第一主体，使得引导构件朝向缩回位置的滑动运动使第二主体相对于液体处理针退回。 第二主体适于接触密封的容器。 偏置构件在插入期间以及在从插座中取出针时将引导构件推向所述延伸位置，由此当引导构件在插入期间从其延伸位置移动到其缩回位置时，第二主体与密封容器保持接触 并且在所述移除期间从其缩回位置到其延伸位置。

公开(公告)号：US20090155920A1

公开(公告)日：2009-06-18

申请号：US12269508

申请日：2008-11-12

申请人： Eric D. Carlson

发明人： Eric D. Carlson

IPC分类号： G01N21/00 ,  G01N21/75 ,  G01N31/02 ,  G01N1/18

CPC分类号： G01N21/11 ,  B01J19/0046 ,  B01J2219/00315 ,  B01J2219/00423 ,  B01J2219/00585 ,  B01J2219/00756 ,  B01J2219/00759 ,  B01L3/5025 ,  B01L3/5085 ,  B01L2300/044 ,  B01L2300/0681 ,  B01L2300/0864 ,  B01L2400/0487 ,  G01N33/15 ,  G01N2035/00198 ,  Y10T436/25375 ,  Y10T436/255

摘要： A dissolution and precipitation system includes an array of reactors. Each reactor has a mother well and a daughter well having a volume between about one microliter and one milliliter. A fluid transfer system is operable to transfer fluid between the mother well and daughter well and purify the fluid that is transferred to the daughter well from the mother well. A method of testing a plurality of samples includes dissolving a plurality of first solids in each of the mother wells to form a plurality of first solutions in the mother wells. The first solutions are purified in the reactors. The first solutions are distributed from the mother wells to one or more daughter wells. A plurality of second solids are precipitated in the daughter wells and the second solids are analyzed.

摘要翻译： 溶解和沉淀系统包括一系列反应器。 每个反应器具有母体阱和具有约1微升至1毫升之间体积的母体。 流体输送系统可操作以在母井和子宫之间传输流体并净化从母井转移到子女的流体。 测试多个样品的方法包括将多个第一固体溶解在每个母井中以在母井中形成多个第一溶液。 第一溶液在反应器中纯化。 第一个解决方案从母井分配到一个或多个子孔。 多个第二固体在子孔中沉淀，并分析第二固体。

公开(公告)号：US06939515B2

公开(公告)日：2005-09-06

申请号：US10156245

申请日：2002-05-24

申请人： Eric D. Carlson ,  Peijun Cong ,  William H. Chandler, Jr. ,  Peter J. Desrosiers ,  J. Christopher Freitag ,  John F. Varni

发明人： Eric D. Carlson ,  Peijun Cong ,  William H. Chandler, Jr. ,  Peter J. Desrosiers ,  J. Christopher Freitag ,  John F. Varni

IPC分类号： G01N21/64 ,  B01J19/00 ,  B01L3/00 ,  B01L3/06 ,  B01L7/00 ,  C07B61/00 ,  C07D209/20 ,  C07D293/00 ,  C40B40/10 ,  C40B60/08 ,  C40B60/14 ,  G01N5/04 ,  G01N13/00 ,  G01N21/23 ,  G01N21/27 ,  G01N21/33 ,  G01N21/35 ,  G01N21/47 ,  G01N21/65 ,  G01N21/78 ,  G01N24/08 ,  G01N25/04 ,  G01N30/88 ,  G01N33/15 ,  G01N33/483 ,  G01N33/50 ,  G01N33/53 ,  G01N33/543 ,  G01N35/02 ,  G01N37/00 ,  B01L11/00

CPC分类号： B01L3/50255 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/00315 ,  B01J2219/00335 ,  B01J2219/00364 ,  B01J2219/00373 ,  B01J2219/00423 ,  B01J2219/00481 ,  B01J2219/00484 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00689 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/00725 ,  B01J2219/00756 ,  B01L3/06 ,  B01L7/00 ,  B01L2300/0829 ,  B01L2300/185 ,  C40B40/04 ,  C40B40/10 ,  C40B60/10 ,  C40B60/14 ,  G01N5/045 ,  G01N21/23 ,  G01N21/65 ,  G01N25/04 ,  G01N33/15 ,  G01N33/54366 ,  G01N35/028 ,  G01N2013/006 ,  G01N2021/651 ,  G01N2500/00 ,  G06F19/703 ,  G06F19/709 ,  Y10T117/10

摘要： The invention provides methods, apparatus, and systems for performing high-throughput preparation and screening of salts and polymorphs of drug candidates. The invention is directed towards enhancing the pre-formulation discovery process used for drug development. In particular, processes that determine suitable salts and processes that discover substantially every polymorph that can form from a particular drug candidate are provided. The processes are performed using several apparatuses that are specifically configured to carry-out various steps in a high-throughput characterization process. One such apparatus is configured for synthesizing a plurality of library members based on, for example, a library model generated by a computer system. Another apparatus may filter the synthesized solution to provide a substantially pure mixture that can be subjected to salt or polymorph testing. Yet another apparatus may be used to crystallize mixtures on a substrate such that the crystallized mixture can be screened by one or more screening devices.

摘要翻译： 本发明提供了用于进行候选药物的盐和多晶型物的高通量制备和筛选的方法，装置和系统。 本发明旨在增强用于药物开发的预配制发现过程。 特别地，提供了确定基本上发现可从特定药物候选物形成的每个多晶型物的合适的盐和方法的方法。 使用特定配置为在高吞吐量表征过程中执行各种步骤的几个装置来执行处理。 一种这样的装置被配置为基于例如由计算机系统生成的库模型来合成多个库成员。 另一种装置可以过滤合成的溶液以提供可以进行盐或多晶型测试的基本上纯的混合物。 可以使用另一种装置将混合物在基底上结晶，使得结晶的混合物可以被一个或多个筛选装置筛选。

公开(公告)号：US06881363B2

公开(公告)日：2005-04-19

申请号：US10291108

申请日：2002-11-08

申请人： Eric D. Carlson ,  Damian A. Hajduk ,  Leonid Matsiev ,  Adam Safir ,  Paul Mansky

发明人： Eric D. Carlson ,  Damian A. Hajduk ,  Leonid Matsiev ,  Adam Safir ,  Paul Mansky

IPC分类号： B01F5/10 ,  B01F7/00 ,  B01F7/08 ,  B01F13/10 ,  B01J19/00 ,  B01L3/00 ,  G01N1/28 ,  G01N35/00 ,  G01N35/02 ,  G01B1/00

CPC分类号： B01L3/5085 ,  B01F5/104 ,  B01F7/00341 ,  B01F7/00416 ,  B01F7/082 ,  B01F13/1013 ,  B01F13/1022 ,  B01J19/0046 ,  B01J2219/00274 ,  B01J2219/00756 ,  B01L2200/12 ,  B01L2300/0812 ,  B01L2300/0829 ,  G01N1/286 ,  G01N35/00 ,  G01N35/00009 ,  G01N35/021 ,  G01N2001/2866 ,  G01N2035/00495 ,  G01N2035/00534

摘要： A rapid throughput method for the preparation, analysis or both of libraries of material samples is provided. According to the method, a plurality of samples is provided. Providing the plurality of samples can include a variety of sample formation techniques including, but not limited to, extruding, milling, compression preparation, rotary mixing, microcentrifugation, molding and casting. Preferably, the samples are solidified into a near net shape configuration appropriate for testing of properties or characteristics of the samples.

摘要翻译： 提供了用于材料样品库的制备，分析或两者的快速通量方法。 根据该方法，提供多个样品。 提供多个样品可以包括各种样品形成技术，包括但不限于挤出，研磨，压缩制备，旋转混合，微量离心，模塑和铸造。 优选地，样品被固化成适合于测试样品的性质或特性的近净形状构型。

公开(公告)号：US07603889B2

公开(公告)日：2009-10-20

申请号：US11278340

申请日：2006-03-31

申请人： Stephen Cypes ,  Mark Uhrich ,  Eric D. Carlson ,  Oleg Kolosov ,  David Padowitz ,  James Bennett ,  Leonid Matsiev

发明人： Stephen Cypes ,  Mark Uhrich ,  Eric D. Carlson ,  Oleg Kolosov ,  David Padowitz ,  James Bennett ,  Leonid Matsiev

IPC分类号： G01N29/00 ,  G01N29/04

CPC分类号： B01D5/009 ,  B01D3/00 ,  B01D3/06 ,  B01D3/14 ,  B01D3/22 ,  B01D3/322 ,  B01J19/0006 ,  B01J2219/00191 ,  G01N9/002 ,  G01N29/022 ,  G01N29/036 ,  G01N29/222 ,  G01N2291/0226 ,  G01N2291/0253 ,  G01N2291/0254 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/02818 ,  G01N2291/0426 ,  G01N2291/0427 ,  G01N2291/101 ,  G01N2291/106

摘要： Fluid sensor methods and systems adapted for monitoring and/or controlling distillation operations in fluidic systems, such as batch distillation operations or continuous distillation operations, are disclosed. Preferred embodiments are directed to process monitoring and/or process control for unit operations involving endpoint determination of a distillation, for example, as applied to a liquid-component-switching operation (e.g., a solvent switching operation), a liquid-liquid separation operation, a solute concentration operation, a dispersed-phase concentration operation, among others.

摘要翻译： 公开了用于监测和/或控制流体系统中的蒸馏操作的流体传感器方法和系统，例如间歇式蒸馏操作或连续蒸馏操作。 优选的实施方案涉及涉及终点确定蒸馏的单元操作的过程监控和/或过程控制，例如应用于液体成分切换操作（例如，溶剂切换操作），液 - 液分离操作 溶质浓缩操作，分散相浓缩操作等。