X-RAY LASER MICROSCOPY SAMPLE ANALYSIS SYSTEM AND METHOD

    公开(公告)号:US20170169910A1

    公开(公告)日:2017-06-15

    申请号:US15442670

    申请日:2017-02-26

    IPC分类号: G21K7/00 G01N23/00

    摘要: Improved system and method of X-ray laser microscopy that combines information obtained from both X-ray diffraction and X-ray imaging methods. At least one sample is placed in an ultra-cold, ultra-low pressure vacuum chamber, often using a sample administration device configured to present a plurality of samples. The sample is exposed to brief bursts of coherent X-ray illumination, often further concentrated using X-ray mirrors and pinhole collimation methods. Higher resolution data from the samples is obtained using hard X-ray lasers, such as free electron X-ray lasers, and X-ray diffraction methods. Lower resolution data from the same samples can be obtained using any of hard or soft X-ray laser sources, and X-ray imaging methods employing nanoscale etched zone plate technology. In some embodiments both diffraction and imaging data can be obtained simultaneously. Data from both sources are combined to create a more complete representation of the samples.

    Low-temperature goniometer for X-ray and neutron diffractometry
    2.
    发明授权
    Low-temperature goniometer for X-ray and neutron diffractometry 失效
    低温测角仪用于X射线和中子衍射

    公开(公告)号:US4644761A

    公开(公告)日:1987-02-24

    申请号:US699731

    申请日:1985-02-08

    IPC分类号: G01N23/20 F25B19/00

    摘要: An Euler's goniometer for low-temperature diffractometry is rotatable about two turning circles and is arranged within a chamber filled with a coolant. Each of the turning circles - that is the chi-circle and the phi-circle - is constituted by a worm wheel which is driven in a stepwise manner by a worm and a stepper motor driving the worm. For providing a compact construction, the stepper motors and the actuated worms are arranged within the chamber as well.

    摘要翻译: 用于低温衍射的欧拉测角仪可围绕两个旋转圆旋转并且布置在填充有冷却剂的腔室内。 每个旋转圆圈 - 即圆圈和圆圈 - 由蜗轮构成,蜗轮由蜗杆和驱动蜗杆的步进马达逐步驱动。 为了提供紧凑的结构,步进电机和致动的蜗杆也布置在腔室内。

    Apparatus and methods for low temperature small angle X-ray scattering

    公开(公告)号:US09927336B2

    公开(公告)日:2018-03-27

    申请号:US14405253

    申请日:2013-06-04

    IPC分类号: G01N23/00 G01N1/42 G01N23/201

    摘要: Apparatus and methods for performing small angle X-ray scattering (SAXS) at low (cryogenic) temperatures for determining the structure of and changes in the structure of proteins, DNA, RNA, and other biological molecules and biomolecular assemblies and structures. A cryogenic, small angle X-ray scattering (SAXS) application sample holder, includes a sample cell including a base portion and at least two parallel walls disposed on the base, wherein the sample cell has a liquid volume capacity defined by the walls and the base portion of 0.001 to 10 microliters. A method for performing cryogenic SAXS on a sample includes the steps of providing a sample biomolecule solution containing an aqueous buffer, a biomolecule, and a cryoprotectant agent, wherein the cryoprotectant agent comprises up to 60% (w/w) of the biomolecule solution, and other known components as necessary to solubilize and stabilize the biomolecule, in a sample holder of claim 1, cryogenically cooling the sample solution in the sample holder at a rate equal to or greater than 100 K/sec without ice formation, and examining the cooled sample using small angle X-ray scattering by passing a beam of X-rays through the sample.

    X-RAY ANALYTICAL INSTRUMENT WITH IMPROVED CONTROL OF DETECTOR COOLING AND BIAS SUPPLY

    公开(公告)号:US20170123075A1

    公开(公告)日:2017-05-04

    申请号:US14931921

    申请日:2015-11-04

    申请人: Marc Battyani

    发明人: Marc Battyani

    IPC分类号: G01T1/175 G01N23/223

    摘要: Disclosed is a circuit for controlling the temperature and the bias voltage of a detector used by an X-ray analytical instrument. The circuit uses a single common reference voltage for the temperature measurement and for all the ADCs and DACs in the circuit, resulting in reduced drift and improved reproducibility of detector temperature and bias voltage. ADCs with a larger number of bits are used to produce precision values of the temperature, the bias voltage, and their respective setpoints. The setpoints are digitally varied until the precision setpoint values correspond to desired values of temperature and bias setpoints.

    RADIATION IMAGING SYSTEM, RADIATION IMAGING METHOD, AND NON-TRANSITORY COMPUTER-READABLE STORAGE MEDIUM

    公开(公告)号:US20180275075A1

    公开(公告)日:2018-09-27

    申请号:US15923093

    申请日:2018-03-16

    IPC分类号: G01N23/04 G06T5/50

    摘要: A radiation imaging system stabilizes a change in temperature of a radiation imaging apparatus, obtains a radiation image of an object based on radiation applied from a radiation source and reaching through the object, obtains a correction image by performing imaging without irradiation with the radiation from the radiation source, performs, using the correction image, image processing for correcting an offset component appearing in the radiation image on the radiation image, and determines whether stabilization of a change in temperature of the radiation imaging apparatus is effectively functioning. The radiation imaging system switches modes of obtaining the correction image based on determination.

    Analysis of fluids
    10.
    发明授权
    Analysis of fluids 失效
    液体分析

    公开(公告)号:US4795903A

    公开(公告)日:1989-01-03

    申请号:US921498

    申请日:1986-10-22

    申请人: Colin G. Clayton

    发明人: Colin G. Clayton

    摘要: A method and apparatus are provided for analysing a fluid, especially an oil/water/gas mixture of unknown composition flowing in a pipeline (10). The apparatus can operate remotely, for example on the sea bed. A gamma-ray source (12) and a diametrically arranged scintillator (20) enable the density to be determined; while a fast neutron source (14) and a diametrically arranged germanium gamma spectrometer (22) cooled by a cryo-cooler (26) enable the concentrations of the elements present to be determined. The apparatus also includes a pulsed fast neutron source and a gamma detector to determine the flow velocity of the fluid. The apparatus enables the weight fractions of oil, water and gas to be derived.

    摘要翻译: 提供了一种用于分析流体,特别是在管道(10)中流动的未知组成的油/水/气/混合物的方法和装置。 该装置可以远程操作,例如在海床上。 γ射线源(12)和直径排列的闪烁体(20)使得能够确定密度; 而由低温冷却器(26)冷却的快速中子源(14)和直径排列的锗伽马光谱仪(22)使得能够确定存在的元素的浓度。 该装置还包括脉冲快中子源和伽马检测器以确定流体的流速。 该装置能够得到油,水和气体的重量分数。