Multi-Color Nanoscale Imaging Based On Nanoparticle Cathodoluminescence
    6.
    发明申请
    Multi-Color Nanoscale Imaging Based On Nanoparticle Cathodoluminescence 有权
    基于纳米粒子阴极发光的多色纳米成像

    公开(公告)号:US20140194314A1

    公开(公告)日:2014-07-10

    申请号:US14125934

    申请日:2012-06-13

    IPC分类号: G01N23/225 G01N33/543

    摘要: Multi-color CL images of nanoparticle samples may be generated, by irradiating with a scanning electron beam a nanoparticle sample that containing a plurality of spectrally distinct optical emitters configured to generate CL light at respective different color channels, then detecting the CL light from the nanoparticles to generate multi-color NP-CL images of the nanoparticle sample. In some embodiments, SE (secondary electron) images of the sample may be acquire, substantially simultaneously with the acquisition of the CL images, so as to generate correlative NP-CL and SE images of the nanoparticle sample. In some embodiments, the nanoparticles may be surface-functionalized so that the nanoparticles selectively bind only to particular structures of interest.

    摘要翻译: 可以通过用扫描电子束照射纳米颗粒样品来产生纳米颗粒样品的多色CL图像,所述纳米颗粒样品包含被配置为在各个不同颜色通道产生CL光的多个光谱不同的光发射器,然后检测来自纳米颗粒的CL光 以产生纳米颗粒样品的多色NP-CL图像。 在一些实施例中,样本的SE(二次电子)图像可以在获取CL图像的同时获取,以便产生纳米颗粒样品的相关NP-CL和SE图像。 在一些实施方案中,纳米颗粒可以被表面官能化,使得纳米颗粒选择性地仅结合特定的感兴趣结构。