公开(公告)号：US10203286B2

公开(公告)日：2019-02-12

申请号：US12422081

申请日：2009-04-10

申请人： Charles M. Clinton ,  Eli N. Glezer ,  Sharon West ,  George Sigal ,  Carl Stevens ,  Michael L. Vock

发明人： Charles M. Clinton ,  Eli N. Glezer ,  Sharon West ,  George Sigal ,  Carl Stevens ,  Michael L. Vock

IPC分类号： G01N35/00 ,  G01N21/76 ,  G01N21/69 ,  G01N35/02 ,  G01N35/10 ,  G01N35/04

摘要： We describe a method for conducting an assay in a multi-well assay plate using an apparatus comprising a light detection subsystem, a liquid handling subsystem, and a plate handling subsystem. This is particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, it may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.

公开(公告)号：US20130316928A1

公开(公告)日：2013-11-28

申请号：US13956841

申请日：2013-08-01

申请人： Sudeep Kumar ,  George Sigal ,  Michael Tsionsky

发明人： Sudeep Kumar ,  George Sigal ,  Michael Tsionsky

IPC分类号： G01N33/53

CPC分类号： G01N33/54386 ,  C12Q1/6823 ,  C12Q1/6832 ,  C12Q1/6834 ,  G01N33/5306 ,  G01N2446/00 ,  G01N2458/30

摘要： The invention relates to methods for conducting binding assays in an assay device that includes one or more storage and use zone. The storage zones of the assay device are configured to house one or more reagents used in an assay conducted in the use zone of the device.

摘要翻译： 本发明涉及用于在包括一个或多个储存和使用区域的测定装置中进行结合测定的方法。 测定装置的存储区被配置为容纳在装置的使用区域中进行的分析中使用的一种或多种试剂。

公开(公告)号：US20120190591A1

公开(公告)日：2012-07-26

申请号：US13439309

申请日：2012-04-04

申请人： Jacob N. Wohlstadter ,  Eli Glezer ,  James Wilbur ,  George Sigal ,  Kent Johnson ,  Charles Clinton ,  Alan Kishbaugh ,  Bandele Jeffrey-Coker ,  Jeff D. Debad ,  Alan B. Fischer

发明人： Jacob N. Wohlstadter ,  Eli Glezer ,  James Wilbur ,  George Sigal ,  Kent Johnson ,  Charles Clinton ,  Alan Kishbaugh ,  Bandele Jeffrey-Coker ,  Jeff D. Debad ,  Alan B. Fischer

IPC分类号： C40B60/12

CPC分类号： G01N21/253 ,  B01L3/5085 ,  B01L9/50 ,  B01L2300/021 ,  B01L2300/0645 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/12 ,  G01N21/645 ,  G01N21/66 ,  G01N21/76 ,  G01N2035/042 ,  G01N2035/0425 ,  G01N2035/0494 ,  Y10T29/49155 ,  Y10T83/04

摘要： Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.

公开(公告)号：US20110143947A1

公开(公告)日：2011-06-16

申请号：US12844440

申请日：2010-07-27

申请人： Ian Chamberlin ,  Charles M. Clinton ,  Eli N. Glezer ,  Bandele Jeffrey-Coker ,  Manish Kochar ,  Sandor Kovacs ,  DT Le ,  Aaron Leimkuehler ,  Greg Pinckney ,  Kristian Roth ,  George Sigal ,  Fei Yin

发明人： Ian Chamberlin ,  Charles M. Clinton ,  Eli N. Glezer ,  Bandele Jeffrey-Coker ,  Manish Kochar ,  Sandor Kovacs ,  DT Le ,  Aaron Leimkuehler ,  Greg Pinckney ,  Kristian Roth ,  George Sigal ,  Fei Yin

IPC分类号： C40B30/00 ,  C40B60/12 ,  B08B9/00

CPC分类号： G01N33/5304 ,  B01L3/5085 ,  B01L2200/16 ,  B01L2300/021 ,  B01L2300/022 ,  B01L2300/0829 ,  B01L2300/105 ,  G01N21/6452 ,  G01N21/66 ,  G01N21/76 ,  G01N33/54326 ,  G01N33/54366 ,  G01N33/56983 ,  G01N2035/0425 ,  Y02A90/26

摘要： We describe apparatuses, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of liquid samples in a clinical point of care setting.

摘要翻译： 我们描述用于进行测定的装置，方法，试剂和试剂盒以及其制备方法。 它们特别适合进行多孔板测定格式的自动采样，样品制备和分析。 例如，它们可用于临床护理设置中的液体样品的自动分析。

公开(公告)号：US07807448B2

公开(公告)日：2010-10-05

申请号：US11642970

申请日：2006-12-21

申请人： Eli N. Glezer ,  Bandele Jeffrey-Coker ,  Jeff D. Debad ,  Sudeep M. Kumar ,  George Sigal ,  Gisbert Spieles ,  Michael Tsionsky ,  Michael Warnock

发明人： Eli N. Glezer ,  Bandele Jeffrey-Coker ,  Jeff D. Debad ,  Sudeep M. Kumar ,  George Sigal ,  Gisbert Spieles ,  Michael Tsionsky ,  Michael Warnock

IPC分类号： C12M1/34

CPC分类号： B01L3/5025 ,  B01L3/5085 ,  B01L2200/12 ,  B01L2200/16 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/0858 ,  B01L2300/105 ,  G01N33/54366 ,  G01N33/54393 ,  Y10S436/809

摘要： We describe assay modules (e.g., assay plates, cartridges, multi-well assay plates, reaction vessels, etc.), processes for their preparation, and method of their use for conducting assays. Reagents may be present in free form or supported on solid phases including the surfaces of compartments (e.g., chambers, channels, flow cells, wells, etc.) in the assay modules or the surface of colloids, beads, or other particulate supports. In particular, dry reagents can be incorporated into the compartments of these assay modules and reconstituted prior to their use in accordance with the assay methods. A desiccant material may be used to maintain and stabilize these reagents in a dry state.

摘要翻译： 我们描述测定模块（例如，测定板，盒，多孔测定板，反应容器等），其制备方法及其用于进行测定的方法。 试剂可以以游离形式存在或在固相上负载，包括测定模块或胶体，珠粒或其它颗粒载体表面的隔室（例如，室，通道，流动池，孔等）的表面。 特别地，干试剂可以并入到这些测定模块的隔室中，并根据测定方法在使用之前重构。 干燥剂材料可用于在干燥状态下维持和稳定这些试剂。

公开(公告)号：US20090263904A1

公开(公告)日：2009-10-22

申请号：US12422081

申请日：2009-04-10

申请人： Charles M. Clinton ,  Eli N. Glezer ,  Sharon West ,  George Sigal ,  Carl Stevens ,  Michael L. Vock

发明人： Charles M. Clinton ,  Eli N. Glezer ,  Sharon West ,  George Sigal ,  Carl Stevens ,  Michael L. Vock

IPC分类号： G01N35/02 ,  G01N21/76

CPC分类号： G01N21/76 ,  G01N21/69 ,  G01N35/0092 ,  G01N35/028 ,  G01N35/1079 ,  G01N2035/0425 ,  Y10T436/114165

摘要： We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.

摘要翻译： 我们描述用于进行测定的装置，系统，方法，试剂和试剂盒以及其制备方法。 它们特别适合进行多孔板测定格式的自动采样，样品制备和分析。 例如，它们可用于在环境监测中对其中衍生的空气和/或液体样品中的颗粒进行自动分析。

公开(公告)号：US20060172340A1

公开(公告)日：2006-08-03

申请号：US11300808

申请日：2005-12-14

申请人： Jacob Wohlstadter ,  James Wilbur ,  George Sigal ,  Mark Martin ,  Liang-Hong Guo ,  Alan Fischer ,  Jon Leland ,  Mark Billadeau

发明人： Jacob Wohlstadter ,  James Wilbur ,  George Sigal ,  Mark Martin ,  Liang-Hong Guo ,  Alan Fischer ,  Jon Leland ,  Mark Billadeau

IPC分类号： G01N33/53 ,  C12M1/34

CPC分类号： G01N21/66 ,  B82Y15/00 ,  B82Y30/00 ,  G01N21/76 ,  G01N33/54313 ,  G01N33/5438 ,  G01N33/582 ,  G01N33/585 ,  Y10S435/808 ,  Y10S435/81 ,  Y10S435/968 ,  Y10S435/975 ,  Y10S436/805

摘要： Materials and methods are provided for producing patterned multi-array, multi-specific surfaces for use in diagnostics. The invention provides for electrochemiluminescence methods for detecting or measuring an analyte of interest. It also provides for novel electrodes for ECL assays. Materials and methods are provided for the chemical and/or physical control of conducting domains and reagent deposition for use multiply specific testing procedures.

公开(公告)号：US07015046B2

公开(公告)日：2006-03-21

申请号：US10693441

申请日：2003-10-24

申请人： Jacob N. Wohlstadter ,  James Wilbur ,  George Sigal ,  Mark Martin ,  Liang-Hong Guo ,  Alan Fischer ,  Jon Leland ,  Mark A. Billadeau ,  Larry R. Helms ,  Ramin Darvari

发明人： Jacob N. Wohlstadter ,  James Wilbur ,  George Sigal ,  Mark Martin ,  Liang-Hong Guo ,  Alan Fischer ,  Jon Leland ,  Mark A. Billadeau ,  Larry R. Helms ,  Ramin Darvari

IPC分类号： G01N21/76

CPC分类号： G01N21/76 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2300/0636 ,  B01L2300/0645 ,  B82Y15/00 ,  B82Y30/00 ,  C12Q1/6825 ,  G01N21/253 ,  G01N21/66 ,  G01N33/54313 ,  G01N33/5438 ,  G01N33/582 ,  G01N33/585 ,  Y10S435/808 ,  Y10S435/817 ,  Y10S436/805 ,  Y10S436/806 ,  Y10S436/807

摘要： Materials and methods are provided for producing patterned multi-array, multi-specific surfaces for use in diagnostics. The invention provides for electrochemiluminescence methods for detecting or measuring an analyte of interest. It also provides for novel electrodes for ECL assays. Materials and methods are provided for the chemical and/or physical control of conducting domains and reagent deposition for use multiply specific testing procedures.

公开(公告)号：US20050136048A1

公开(公告)日：2005-06-23

申请号：US11054672

申请日：2005-02-09

申请人： Michael Tsionsky ,  Eli Glezer ,  Selen Altunata ,  George Sigal ,  Jonathan Leland ,  Mark Billadeau ,  Svetlana Leytner ,  Mark Martin ,  Larry Helms

发明人： Michael Tsionsky ,  Eli Glezer ,  Selen Altunata ,  George Sigal ,  Jonathan Leland ,  Mark Billadeau ,  Svetlana Leytner ,  Mark Martin ,  Larry Helms

IPC分类号： G01N33/53 ,  C12Q1/42 ,  C12Q1/48 ,  G01N21/76 ,  G01N33/531 ,  G01N33/543 ,  G01N33/58 ,  G01N33/68 ,  A61K39/395

CPC分类号： G01N33/573 ,  C12Q1/485 ,  G01N21/76 ,  G01N33/5306 ,  G01N33/54386 ,  G01N33/58 ,  G01N33/582 ,  G01N2333/91205 ,  G01N2458/30 ,  G01N2458/40 ,  Y10S435/967 ,  Y10S435/968 ,  Y10T436/10 ,  Y10T436/108331

摘要： Compositions, reagents, kits, systems, system components, and methods for performing assays. More particularly, the invention relates to the use of novel combinations of reagents to provide improved assay performance.

摘要翻译： 组合物，试剂，试剂盒，系统，系统组分和用于进行测定的方法。 更具体地说，本发明涉及使用新颖的试剂组合来提供改进的测定性能。

公开(公告)号：US10295539B2

公开(公告)日：2019-05-21

申请号：US13642347

申请日：2011-04-18

申请人： George Sigal

发明人： George Sigal

IPC分类号： G01N33/569 ,  G01N33/543 ,  G01N33/566

摘要： The invention provides methods and kits for measuring the ability of a test sample to inhibit the binding of a receptor expressed by a pathogen to a host cell ligand of the pathogen.