公开(公告)号：US20240307474A1

公开(公告)日：2024-09-19

申请号：US18577643

申请日：2022-07-06

申请人： APEX MEDICAL DEVICE DESIGN, LLC

发明人： Nedaa Abdulghani Nasif Al Jasim ,  Noor Z. Ahmed

IPC分类号： A61K36/71 ,  A61K8/35 ,  A61K8/60 ,  A61K8/9789 ,  A61K8/9794 ,  A61K9/107 ,  A61K31/00 ,  A61K31/122 ,  A61K31/575 ,  A61K31/704 ,  A61K36/9066 ,  A61K47/24 ,  A61Q19/08

CPC分类号： A61K36/71 ,  A61K8/355 ,  A61K8/604 ,  A61K8/9789 ,  A61K8/9794 ,  A61K9/1075 ,  A61K31/122 ,  A61K31/575 ,  A61K31/658 ,  A61K31/704 ,  A61K36/3482 ,  A61K36/9066 ,  A61K47/24 ,  A61Q19/08

摘要： A botanical uni-sourced drug-loaded lipid-based nanoemulsion produced from one single medicinal herb such as Nigella sativa, Cannabis sativa, or Curcuma longa, wherein the herb acts as a comprehensive provider for the bioactive phytochemicals, oil phase, saponin surfactant, co-surfactant, proteins, and carbohydrates to produce the uni-sourced safe, clear, stable lipid-based drug delivery system. The nanoemulsion can be formulated into oral dosage form including nanoemulsion, microemulsion and liposomes, wherein the extraction and emulsification are carried out by the addition of water-soluble organic solvent, wherein the product can be further fermented and esterified for improved stability, wherein Nigella sativa uni-sourced nanocompositions are used as first-in-class oral formulation to relax coily hair targeting the arrector pili muscle in the hair root, anticancer, anti-tuberculosis, anti-COVID-19; and antiviral treatment, Cannabis nanocompositions are used for medical or recreational purposes, and Curcuma longa is used for nutraceutical and treatment purposes.

公开(公告)号：US11793851B2

公开(公告)日：2023-10-24

申请号：US17010883

申请日：2020-09-03

申请人： Chen-Yu Lee

发明人： Hsuan-Ching Tseng ,  Da-Tong Ju ,  Sung-Sen Yang ,  Wei-Te Cheng ,  Chen-Yu Lee ,  Yan-Chih Liao

IPC分类号： A61K36/515 ,  A61P1/14 ,  A61K36/744 ,  A61K36/232 ,  A61K36/64 ,  A61K36/71 ,  A61K36/233 ,  A61K36/68 ,  A61K36/284 ,  A61K36/884 ,  A61K36/484 ,  A61K36/899 ,  A61K36/65 ,  A61K36/488 ,  A61K36/708 ,  A61K36/734 ,  A61K35/57 ,  A61P13/10 ,  A61P13/02 ,  A61P25/00 ,  A61K36/539

CPC分类号： A61K36/515 ,  A61K35/57 ,  A61K36/232 ,  A61K36/233 ,  A61K36/284 ,  A61K36/484 ,  A61K36/488 ,  A61K36/539 ,  A61K36/64 ,  A61K36/65 ,  A61K36/68 ,  A61K36/708 ,  A61K36/71 ,  A61K36/734 ,  A61K36/744 ,  A61K36/884 ,  A61K36/899 ,  A61P1/14 ,  A61P13/02 ,  A61P13/10 ,  A61P25/00

摘要： The present invention relates to a method for treating a side effect caused by bacillus Calmette-Guérin (BCG) perfusion therapy for bladder cancer. The method includes: administering a Chinese medicine composition to a subject in need thereof; wherein the Chinese medicine composition is an extract of a first mixture comprising Gentiana scabra, Scutellariae Radix, Gardeniae Fructus, Angelicae Sinensis Radix, Rehmanniae radix, Akebiae Caulis, Bupleurum chinense, Plantaginis Semen, Atractylodes lancea, Rhizoma alismatis, and Glycyrrhiza uralensis.

公开(公告)号：US20230302136A1

公开(公告)日：2023-09-28

申请号：US18201171

申请日：2023-05-23

申请人： Velos Media, LLC

发明人： Jing Wang ,  Xiang Yu ,  Dake He

IPC分类号： A61K45/06 ,  A61K36/185 ,  A61K36/28 ,  A61K36/76 ,  A61K36/88 ,  H04N11/04 ,  H04N19/40 ,  A61K31/7048 ,  A61K36/324 ,  A61K36/53 ,  H04N19/51 ,  A61K36/71 ,  H04N11/02 ,  A61K31/12 ,  A61K36/38 ,  A61K36/74 ,  A61K36/82 ,  A61K36/9066 ,  A61K36/9068

CPC分类号： A61K45/06 ,  A61K31/12 ,  A61K31/7048 ,  A61K36/185 ,  A61K36/28 ,  A61K36/324 ,  A61K36/38 ,  A61K36/53 ,  A61K36/71 ,  A61K36/74 ,  A61K36/76 ,  A61K36/82 ,  A61K36/88 ,  A61K36/9066 ,  A61K36/9068 ,  H04N11/02 ,  H04N11/04 ,  H04N19/40 ,  H04N19/51 ,  H04N19/176

摘要： Methods of encoding and decoding for video data are described for encoding or decoding coefficients for a transform unit. In particular, the sign bits for the non-zero coefficients are encoded using sign bit hiding. Two or more sets of coefficients are defined for the transform unit and a sign bit may be hidden for each set, subject to satisfaction of a threshold test. The sets may correspond to coefficient groups that are otherwise used in multi-level significance map encoding and decoding.

公开(公告)号：US20230301938A1

公开(公告)日：2023-09-28

申请号：US18106925

申请日：2023-02-07

申请人： Therapeutic Solutions International, Inc.

发明人： Thomas ICHIM ,  Timothy G. DIXON

IPC分类号： A61K31/09 ,  A61K31/122 ,  A61K31/26 ,  A61K36/71 ,  A61K36/82

CPC分类号： A61K31/09 ,  A61K31/122 ,  A61K31/26 ,  A61K36/71 ,  A61K36/82

摘要： Disclosed are means and methods of treating cognitive dysfunction associated with COVID-19 and/or other associated with inflammatory conditions. In one embodiment treatment of COVID-19 cognitive dysfunction performed by administration of nutraceutical means, wherein said nutraceuticals are administered at a frequency and/or concentration sufficient to induce proliferation of endogenous neural progenitor cells and/or protect cells from inflammatory damage. In one embodiment said nutraceuticals are comprised of green tea extract, and/or nigella sativa, and/or pterostilbene, and/or sulforaphane. In some embodiments nutraceutical compositions are utilized to overcome treatment resistant of currently used antidepressants.

公开(公告)号：US20230210933A1

公开(公告)日：2023-07-06

申请号：US18000714

申请日：2021-06-04

申请人： Ju Youn BACK

发明人： Soong Jin KIM ,  Yu Yeon ROH

IPC分类号： A61K36/71 ,  A61K45/06 ,  A61P29/00

CPC分类号： A61K36/71 ,  A61K45/06 ,  A61P29/00 ,  A61K2236/19 ,  A61K2236/333

摘要： The present invention provides a composition, for preventing or treating an inflammatory disease, comprising, as an active ingredient, a self-hydrolysis extract using a hydrolase in a plant cell from one or more plants selected from Pulsatilla koreana, Pulsatilla chinensis, Pulsatilla cernua, Anemone raddeana, Aralia elata, Akebia quinata, Lonicera species, Adonis amurensis, Hedera helix, Hedera colchica and Patrinia scabiosifolia, and/or additionally an angiogenesis inhibitor.

公开(公告)号：US11684648B2

公开(公告)日：2023-06-27

申请号：US16492473

申请日：2018-03-08

申请人： LAILA NUTRACEUTICALS

发明人： Ganga Raju Gokaraju ,  Rama Raju Gokaraju ,  Trimurtulu Golakoti ,  Kiran Bhupathiraju ,  Venkata Kanaka Ranga Raju Gokaraju ,  Krishanu Senguptha ,  Venkata Krishna Raju Alluri ,  Venkateswarlu Somepalli

IPC分类号： A61K36/54 ,  A61K36/22 ,  A61K36/31 ,  A61K36/71 ,  A61K36/8962 ,  A61P5/24 ,  A61K36/48

CPC分类号： A61K36/54 ,  A61K36/22 ,  A61K36/31 ,  A61K36/71 ,  A61K36/8962 ,  A61P5/24 ,  A61K36/48 ,  A61K2300/00

摘要： Synergistic herbal compositions for Testosterone boosting comprising at least two ingredients selected from the extracts, fractions or pure phytochemicals derived from Punica granatum, Cinnamomum zeylanicum, Nigella sativa, Brassica nigra and Mangifera indica for improving testosterone levels and alleviating symptoms associated with low levels of testosterone hormone in humans. The present invention also describes a synergistic composition comprising at least one testosterone booster ingredient selected from the extracts, fractions or pure phytochemical derived from Punica granatum, Cinnamomum zeylanicum, Nigella sativa, Brassica nigra and Mangifera indica and at least one aromatase inhibitor ingredient selected from the extracts, fractions or pure phytochemicals derived from Allium cepa, Tamarindus indica and Cinnamomum tamala for improving testosterone levels and alleviating symptoms associated with low levels of testosterone hormone in humans. The invention further provides methods of improving testosterone levels and alleviating symptoms associated with low levels of testosterone hormone in humans.

公开(公告)号：US11638738B2

公开(公告)日：2023-05-02

申请号：US17123636

申请日：2020-12-16

申请人： Benny Antony

发明人： Benny Antony

IPC分类号： A61K36/00 ,  A61K36/81 ,  A61K9/16 ,  A61K9/20 ,  A61K9/50 ,  A61K36/21 ,  A61K9/14 ,  A61K9/28 ,  A61K36/185 ,  A61K36/23 ,  A61K36/47 ,  A61K36/48 ,  A61K36/53 ,  A61K36/534 ,  A61K36/54 ,  A61K36/67 ,  A61K36/71 ,  A61K36/82 ,  A61K36/87 ,  A61K36/9066 ,  A61K36/9068

摘要： The invention relates to an extract of Ashwagandha that exhibit enhanced bioactivity and bioavailability comprising of enriched withanolide glycosides and saponins; with negligible amount of alkaloids, withanolide aglycones and oligosaccharides. The extract as disclosed prepared from root, stems, leaves and whole plant of Ashwagandha further shows improved immunomodulatory activity, anti-inflammatory activity, anti stress activity, antidiabetic activity and sleep quality. The disclosure also provides a method of improving bioactivity of withanolide glycosides even at lower doses, by the administration of an enteric coated formulation of extract of Ashwagandha to humans. The enteric coating protects the composition from hydrolysis in the acidic environment of the stomach to release the withanolide glycoside in neutral/alkaline pH in gastrointestinal tract (GIT) thus enhancing the absorption. Further the process of preparation of the extract of Ashwagandha enriched with withanolide glycosides and saponins are disclosed along with various formulations.

公开(公告)号：US20230102251A1

公开(公告)日：2023-03-30

申请号：US17897536

申请日：2022-08-29

申请人： TRINUTRA LTD.

发明人： Yoram SELA ,  Mor Zeilkha ,  Itschak Lamensdorf

IPC分类号： A61K31/122 ,  A61K31/202 ,  A61P29/00 ,  A61K31/404 ,  A61K36/71 ,  A61K36/53

摘要： The present invention provides a composition comprising a synergistic combination of thymoquinone and one or more omega-3 fatty acids, wherein the molar ratio between said thymoquinone and said one or more omega-3 fatty acids is at least 1:7. The present invention also provides a method of using said composition to treat or prevent inflammatory conditions.

公开(公告)号：US20230085607A1

公开(公告)日：2023-03-16

申请号：US17931872

申请日：2022-09-13

申请人： Therapeutic Solutions International, Inc.

发明人： Thomas E. Ichim ,  Famela Ramos ,  James Veltmeyer ,  Timothy G. Dixon ,  Feng Lin ,  Wais Kaihani

IPC分类号： A61K31/7048 ,  A61K31/353 ,  A61K31/09 ,  A61K31/122 ,  A61K31/26 ,  A61K36/82 ,  A61K36/45 ,  A61K36/71 ,  A61K36/31

摘要： Disclosed are novel mechanisms of action of ivermectin therapy as related to treatment of COVID-19 and means of augmenting therapeutic activities by co-administration with one or more of the following: pterostilbene, thymoquinone, epigallocatechin-3-gallate, and sulforaphane. In one embodiment the invention provides enhanced reduction of inflammation induced pulmonary leakage without augmenting immune suppressive mechanisms.

公开(公告)号：US20230077994A1

公开(公告)日：2023-03-16

申请号：US17719912

申请日：2022-04-13

申请人： NOAH GRAY ,  Joel Douglas

发明人： NOAH GRAY ,  Joel Douglas

IPC分类号： A61K36/71 ,  A61K31/352 ,  A61K31/05 ,  A61K36/752 ,  A61K47/40 ,  A61K9/00 ,  A24B15/167

摘要： The invention relates to a vaping compound which is comprised of a vaporizing base which is formed from the following ingredients propylene glycol, MCT oil and vegetable glycerin, or combination of the oils, flavoring, water and one or more active ingredients.