公开(公告)号：US12102730B2

公开(公告)日：2024-10-01

申请号：US17352189

申请日：2021-06-18

申请人： University of Connecticut

发明人： Nikoo Saveh Shemshaki ,  Cato Laurencin

IPC分类号： A61L27/00 ,  A61L27/08 ,  A61L27/18 ,  A61L27/22 ,  A61L27/24 ,  A61L27/50

CPC分类号： A61L27/08 ,  A61L27/18 ,  A61L27/222 ,  A61L27/24 ,  A61L27/50 ,  A61L2400/12 ,  A61L2430/30

摘要： The disclosure is directed to scaffolds comprising nanofibers of graphene nanoplatelets and a biocompatible polymer, as well as methods for making and using such scaffolds.

公开(公告)号：US11986572B2

公开(公告)日：2024-05-21

申请号：US16754434

申请日：2017-10-17

申请人： Nicolas Perren ,  Alice Perren

发明人： Nicolas Perren ,  Stephan Perren

IPC分类号： A61L27/36 ,  A61L27/04 ,  A61L27/06 ,  A61L27/08 ,  A61L27/38

CPC分类号： A61L27/365 ,  A61L27/042 ,  A61L27/045 ,  A61L27/06 ,  A61L27/08 ,  A61L27/3608 ,  A61L27/3691 ,  A61L27/3821 ,  A61L27/3847 ,  A61L2430/02

摘要： The device is intended for the noninvasive induction of dynamic deformation of body tissue to differentiate tissue cells. It comprises the following components: (i) a suspension of particles suspended in solution; and (ii) an external actuator which is capable of magnetically, electrically, vibrationally, or thermally stimulating the suspended particles.

公开(公告)号：US20240016975A1

公开(公告)日：2024-01-18

申请号：US18373603

申请日：2023-09-27

申请人： DiFusion, Inc.

发明人： Derrick Johns ,  Joseph J. Crudden ,  Sriram Sankar

IPC分类号： A61L27/02 ,  A61L27/18 ,  A61L27/08 ,  A61K33/38 ,  A61K33/34 ,  A61K33/06 ,  A61K33/00 ,  A61K33/30

CPC分类号： A61L27/025 ,  A61L27/18 ,  A61L27/08 ,  A61K33/38 ,  A61K33/34 ,  A61K33/06 ,  A61K33/00 ,  A61K33/30 ,  A61L2300/102 ,  A61L2300/404 ,  A61L2430/10 ,  A61L2300/104

摘要： Anti-biofilm osseointegrating and/or tissue-integrating implantable biomaterial devices that optionally can elute therapeutic ions such as magnesium, silver, copper and/or zinc. In certain embodiments, the devices are engineered to produce structures suitable as implants having a relatively high surface population of zeolite. Methods of producing the devices are also disclosed.

公开(公告)号：US20230040370A1

公开(公告)日：2023-02-09

申请号：US17815485

申请日：2022-07-27

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： Avnesh S. Thakor ,  Mehdi Razavi

IPC分类号： A61L27/08 ,  A61L27/18 ,  A61L27/38 ,  A61P3/10 ,  A61L27/54 ,  A61L27/56 ,  A61K31/573 ,  A61K35/28 ,  A61K35/39 ,  A61K9/70 ,  A61L27/58

摘要： A bioscaffold comprising a graphene matrix for use in cellular therapy is disclosed. In particular, a bioscaffold having a coating of dexamethasone on a three-dimensional graphene matrix is provided, wherein the bioscaffold elutes dexamethasone to reduce inflammatory responses following implantation of the bioscaffold in a subject. Having the dexamethasone released locally in the vicinity of the bioscaffold avoids the systemic side effects from conventional intravenous delivery while allowing the dexamethasone to modulate the inflammatory milieu within the transplantation microenvironment.

公开(公告)号：US11419725B2

公开(公告)日：2022-08-23

申请号：US16194729

申请日：2018-11-19

申请人： Zimmer, Inc.

发明人： Joseph Peter Zitelli ,  Robert Joseph Gill ,  Steven Seelman

IPC分类号： A61F2/28 ,  A61L27/56 ,  A61L27/30 ,  A61L27/08 ,  A61F2/30

摘要： Various embodiments disclosed relate to an implant. The implant includes a substrate. The implant further includes a monolithic layer comprising a biocompatible metallic material, having at least one of an amorphous and a crystalline microstructure contacting the substrate.

公开(公告)号：US11324611B2

公开(公告)日：2022-05-10

申请号：US16482843

申请日：2018-05-08

申请人： Massachusetts Institute of Technology

发明人： Victor Prost ,  Amos G. Winter ,  Kathryn Michelle Olesnavage

IPC分类号： A61F2/66 ,  A61F2/50 ,  A61L27/08 ,  A61L27/10

摘要： A prosthesis, including a prosthetic foot, a prosthetic talocrural joint, a prosthetic ankle pivotally coupled to the prosthetic foot and a four-area bending beam. The four-area bending beam includes a U-shaped or other spring. One end of the spring is mechanically coupled via two of the four areas to the prosthetic foot. The other end of the spring is mechanically coupled via the other two areas to the prosthetic ankle. The spring resiliently resists pivoting of the prosthetic ankle about the prosthetic talocrural joint. The four-area bending beam exhibits an at least approximately constant moment along its length to maximize strain energy density, storing about four times as much elastic energy as a comparable cantilevered beam, thereby providing high stiffness and high range of motion to the ankle. The spring is modular, being easily replaced with another spring exhibiting a different stiffness, ex., to tailor the prosthesis to a user.

公开(公告)号：US20220110753A1

公开(公告)日：2022-04-14

申请号：US17558826

申请日：2021-12-22

申请人： Loubert S. Suddaby

发明人： Loubert S. Suddaby

IPC分类号： A61F2/28 ,  A61K38/20 ,  A61K39/108 ,  A61K39/085 ,  A61L27/12 ,  A61L27/08 ,  A61L27/02 ,  A61L27/18 ,  A61L27/54 ,  A61L27/56 ,  A61L27/06 ,  A61L27/36 ,  A61K38/21

摘要： An extended release immunomodulatory implant operatively arranged to facilitate bone morphogenesis, including an inner portion including one or more interleukins, and an outer portion surrounding the inner portion, the outer portion including an antigen operatively arranged to activate an innate immune system.

公开(公告)号：US20210346570A1

公开(公告)日：2021-11-11

申请号：US17277341

申请日：2019-09-19

申请人： Queen Mary University of London

发明人： Yuanhao Wu ,  Wen Wang ,  Alvaro Mata Chavarria

IPC分类号： A61L27/08 ,  A61L27/22 ,  A61L27/38 ,  A61L27/50 ,  B33Y10/00 ,  B33Y80/00

摘要： The present invention relates to a stable self-assembling graphene oxide-protein matrix comprising a disordered protein (DP) and graphene oxide (GO), wherein the DP has an opposite charge to the GO, further wherein the graphene oxide-protein matrix is in the form of a 3D structure having a lumen defined by a membrane having an inner and outer surface. The invention further relates to methods and kits for preparing such a graphene oxide-protein matrix and its uses.

公开(公告)号：US20210108098A1

公开(公告)日：2021-04-15

申请号：US16608714

申请日：2018-04-25

申请人： Paul Gatenholm ,  Erdem Karabulut

发明人： Paul Gatenholm ,  Erdem Karabulut

IPC分类号： C09D11/14 ,  A61L27/08 ,  A61L27/20 ,  A61L27/36 ,  A61L27/38 ,  A61L27/44 ,  A61L27/50 ,  C09D11/037

摘要： The present invention relates to preparation and use of nanocellulose fibrils or crystals such as disintegrated bacterial nanocellulose, tunicate-derived nanocellulose, or plant-derived nanocellulose, together with carbon nanotubes, as a biocompatible and conductive ink for 3D printing of electrically conductive patterns. Biocompatible conductive bioinks described in this invention were printed in the form of connected lines onto wet or dried nanocellulose films, bacterial cellulose membrane, or tunicate decellularized tissue. The devices were biocompatible and showed excellent mechanical properties and good electrical conductivity through printed lines (3.8·10−1 S cm−1). Such scaffolds were used to culture neural cells. Neural cells attached selectively on the printed pattern and formed connective networks. The devices prepared by this invention are suited as bioassays to screen drugs against neurodegenerative diseases such as Alzheimer's and Parkinson's, study brain function, and/or be used to link the human brain with electronic and/or communication devices. They can also be implanted to replace neural tissue or stimulate guiding of neural cells. They can also be used to stimulate the heart by using electrical signaling or to repair myocardial infarction and/or damage related thereto.

公开(公告)号：US10926002B2

公开(公告)日：2021-02-23

申请号：US16230184

申请日：2018-12-21

申请人： Toyota Motor Engineering & Manufacturing North America, Inc.

发明人： Michael Paul Rowe

IPC分类号： A61F2/28 ,  A61L27/42 ,  A61L27/08 ,  A61L27/04 ,  A61L27/10

摘要： Orthopedic replacements include are formed at least partially of composite materials including a metal matrix with reinforcing carbon fiber integrated into the matrix. The composite materials have substantially lower density than metal, and are expected to have appreciable strength. The orthopedic replacements can include a bone attachment portion and a load bearing portion. In some versions, the orthopedic replacements can include a core formed of the composite material, with a shape completion portion, formed for example from plastic, at least partially coating the core.