公开(公告)号：US20120277654A1

公开(公告)日：2012-11-01

申请号：US13097301

申请日：2011-04-29

申请人： Robert Olson ,  John L. Knoll

发明人： Robert Olson ,  John L. Knoll

IPC分类号： A61M1/18 ,  A61M1/16

CPC分类号： B23P19/04 ,  A61M1/1698 ,  A61M1/3627 ,  B01D63/025 ,  B01D2319/06 ,  Y10T29/49826

摘要： A combination oxygenator and arterial filter device for treating blood in an extracorporeal circuit includes a housing, an oxygenator, and a depth filter. The oxygenator includes a hollow fiber bundle forming an oxygenator exterior face. The depth filter is disposed (e.g., wound) directly over the exterior face, and includes a plurality of filaments arranged to define filter layers of level wound filaments. A first layer directly abuts the oxygenator exterior face. The oxygenator bundle differs from the depth filter in terms of: fiber and filament materials, construction of the fibers and filaments, and/or minimum gap spacings between axially adjacent ones of the fibers and the filaments. An oxygenator with integrated arterial filtering capability is provided that minimally impacts the extracorporeal blood circuit prime volume.

摘要翻译： 用于在体外循环中治疗血液的组合式氧合器和动脉过滤装置包括壳体，氧合器和深度过滤器。 氧合器包括形成氧合器外表面的中空纤维束。 深度过滤器直接设置在外表面上（例如，缠绕），并且包括布置成限定水平缠绕细丝的过滤层的多根细丝。 第一层直接邻接氧合器外表面。 充氧器束与深度过滤器的不同之处在于：纤维和长丝材料，纤维和长丝的构造，和/或轴向相邻的纤维和长丝之间的最小间隙间隔。 提供具有综合动脉过滤功能的充氧器，其最小程度地影响体外血液回路原始体积。

公开(公告)号：US07776219B2

公开(公告)日：2010-08-17

申请号：US12015420

申请日：2008-01-16

申请人： James M. Brugger ,  Jeffrey H. Burbank ,  Martin Stillig

发明人： James M. Brugger ,  Jeffrey H. Burbank ,  Martin Stillig

IPC分类号： B01D61/00 ,  B01D61/14 ,  B01D61/24 ,  B01D61/28 ,  A61M1/18 ,  A61M1/34

CPC分类号： B01D63/02 ,  A61M1/342 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3672 ,  B01D61/20 ,  B01D61/30 ,  B01D2313/21

摘要： Devices, methods, and system that prevent clotting of blood during blood-processing procedures such as hemofiltration, hemodialysis, and hemodiafiltration are described. A filter with a cap has a housing that is shaped to receive a blood filter. The housing has an inlet for blood and may have an outlet for waste and ultrafiltrate. The cap is attached to the housing. The cap has an outlet for blood and a port adjacent the outlet for receiving dilution fluid. Methods of use during blood-processing procedures to provide immediate hemodilution to blood exiting entering and/or exiting a filter are also described.

摘要翻译： 描述了在血液过滤，血液透析和血液透析过滤等血液处理过程中防止血液凝结的装置，方法和系统。 具有帽的过滤器具有被成形为接收血液过滤器的壳体。 外壳有血液入口，可能有废物和超滤的出口。 盖子连接到外壳。 盖具有用于血液的出口和邻近出口的用于接收稀释液的口。 还描述了在血液处理过程中为进入和/或离开过滤器的血液立即进行血液稀释的使用方法。

公开(公告)号：US06960297B2

公开(公告)日：2005-11-01

申请号：US10404099

申请日：2003-04-02

申请人： Hidetoshi Kozawa ,  Hidekazu Nakashima ,  Shigehisa Wada

发明人： Hidetoshi Kozawa ,  Hidekazu Nakashima ,  Shigehisa Wada

IPC分类号： A61M1/14 ,  A61M1/00 ,  A61M1/16 ,  A61M1/18 ,  B01D61/28 ,  B01D63/02 ,  B01D67/00 ,  B01D69/02 ,  B01D69/08 ,  B01D71/00 ,  B01D71/06 ,  B01D71/58 ,  B01D71/68 ,  D01D5/24

CPC分类号： B01D67/0088 ,  A61M1/16 ,  B01D63/021 ,  B01D67/009 ,  B01D67/0095 ,  B01D69/02 ,  B01D69/084 ,  B01D2325/36 ,  B01D2325/38

摘要： A dialyzer for blood treatment including a semipermeable membrane which is made of a hydrophobic polymer and a hydrophilic polymer, and has a water permeating performance drying of ½ or higher relative to that before drying. The dialyzer has a vitamin B12 clearance not smaller than 135 ml/mm per 1.6 m2 or the amount of the hydrophilic polymer eluted from the semipermeable membrane is not higher than 10 ppm. A dialyzer for blood treatment is light-weight, easy to handle, and exhibits a reduced elution of the hydrophilic polymer procedures for producing a dialyzer containing the semipermeable membrane and a process for producing a hollow fiber membrane for use in blood treatment are described.

摘要翻译： 一种用于血液处理的透析器，包括由疏水性聚合物和亲水性聚合物制成的半透膜，并且相对于干燥前的水渗透性能干燥为1/2或更高。 透析器的维生素B12间隙不小于135ml / mm 2 / 1.6m 2，或者从半透膜洗脱的亲水性聚合物的量不高于10ppm。 用于血液处理的透析器重量轻，易于处理，并且表现出用于制备含有半透膜的透析器的亲水聚合物方法的减少的洗脱以及用于血液处理的中空纤维膜的制造方法。

公开(公告)号：US06890315B1

公开(公告)日：2005-05-10

申请号：US09618759

申请日：2000-07-18

申请人： Howard R. Levin ,  Mark Gelfand ,  John O'Mahony ,  Hans-Dietrich Polaschegg

发明人： Howard R. Levin ,  Mark Gelfand ,  John O'Mahony ,  Hans-Dietrich Polaschegg

IPC分类号： A61M1/14 ,  A61M1/18 ,  A61M1/22 ,  A61M1/34 ,  A61M1/36 ,  A61M37/00 ,  C02F1/44

CPC分类号： A61M1/341 ,  A61M1/1692 ,  A61M1/34 ,  A61M1/361 ,  A61M1/3612 ,  A61M2205/3393 ,  A61M2205/50 ,  A61M2205/7563

摘要： A method and apparatus for ultrafiltration of blood operating by removing blood from a peripheral blood vessel at a rate of less than two percent of total cardiac output of a patient, extracting fluid at a rate of 0.1 liter to 1.0 liters per hour while retaining cells and proteins in the blood, and returning the concentrated blood to a secondary blood vessel is disclosed. Blood is removed and returned using small gage needles. As a pump circulates blood from the patient, a filter removes ultrafiltrate from the blood using duty cycle or pump control, and a transparent container collects the removed fluid.

摘要翻译： 一种通过以小于患者总心输出量的百分之二的速率从外周血管中除血的血液超滤操作的方法和装置，以每小时0.1升至1.0升的速率提取液体，同时保留细胞和 公开了血液中的蛋白质，并将浓缩血液返回到二次血管。 使用小规格针头取出血液并返回。 当泵从患者循环血液时，过滤器使用占空比或泵控制从血液中除去超滤液，并且透明容器收集去除的流体。

公开(公告)号：US20050015044A1

公开(公告)日：2005-01-20

申请号：US10488135

申请日：2002-08-30

申请人： Herbert Harttig ,  Reinhold Buck

发明人： Herbert Harttig ,  Reinhold Buck

IPC分类号： A61M1/18 ,  A61M25/00 ,  A61M25/16 ,  B01D61/28 ,  B01D69/08 ,  A61M1/00

CPC分类号： A61M25/0043 ,  A61B5/14528 ,  A61M25/0009 ,  A61M2025/0059

摘要： The present invention concerns a catheter with a hollow fiber membrane (10) bent essentially in U-shape or such a hollow fiber membrane (10) comprising two legs (11, 13) and a bent section (15). According to the invention the hollow fiber membrane (10) is heat-treated and/or treated with at least one solvent in its bent section (15). The catheter according to the invention has a small overall diameter, is simple to manufacture and easy to implant and explant. The bent section (15) does not kink so that the lumen remains open. The present invention also concerns a method for producing such a catheter or such a hollow fiber membrane.

摘要翻译： 本发明涉及具有基本上弯曲成U形的中空纤维膜（10）的导管，或者包括两个腿（11,13）和弯曲部分（15）的中空纤维膜（10）。 根据本发明，中空纤维膜（10）在其弯曲部分（15）中用至少一种溶剂进行热处理和/或处理。 根据本发明的导管具有小的总体直径，易于制造并且易于植入和外植。 弯曲部分（15）不会扭曲，使得内腔保持打开。 本发明还涉及制造这种导管或这种中空纤维膜的方法。

公开(公告)号：US5863501A

公开(公告)日：1999-01-26

申请号：US705711

申请日：1996-08-30

申请人： Louis C. Cosentino

发明人： Louis C. Cosentino

IPC分类号： A61M1/16 ,  A61M1/18

CPC分类号： A61M1/1698 ,  A61M1/1625 ,  A61M2205/366

摘要： A method for improving priming of an integrated oxygenator and heat exchanger which includes pretreating the integrated hollow fiber oxygenator and heat exchanger device with a surfactant. Pretreating the device coats the interior surfaces of the integrated hollow fiber oxygenator and heat exchanger with the surfactant, which facilitates the removal of entrapped air. An integrated hollow fiber oxygenator and heat exchanger having a surfactant coating on the interior surfaces is provided which subsequently allows for more efficient priming with an aqueous priming media.

摘要翻译： 一种用于改善整合式氧合器和热交换器起动的方法，其包括用表面活性剂预处理整合的中空纤维氧合器和热交换器装置。 预处理装置用表面活性剂涂覆集成的中空纤维充氧器和热交换器的内表面，这有助于去除夹带的空气。 提供了一种在内表面上具有表面活性剂涂层的集成中空纤维氧合器和热交换器，其随后允许用水性起动介质更有效地起动。

公开(公告)号：US5718871A

公开(公告)日：1998-02-17

申请号：US586517

申请日：1996-01-16

申请人： Roger J. Elgas

发明人： Roger J. Elgas

IPC分类号： A61M1/18 ,  B01D63/02 ,  B29C70/84 ,  F28F21/06 ,  A61M1/14 ,  F28F9/02

CPC分类号： B29C70/845 ,  B01D63/02 ,  B01D63/021 ,  B01D63/022 ,  F28F21/067

摘要： A tight seal is achieved in a blood oxygenator between the potting of the heat exchanger fibers and the rim of the heat exchanger container by extending the potting material over the rim and down, so that when the potting material shrinks during cure, the potting will become prestressed in the sealing direction against an outwardly facing wall of the container. The invention also provides a ring coextensive with the rim and spaced therefrom. The potting extends into the ring. This forms an air gap between the rim and the ring through which potting can extend. As a result, there is no possible leakage path between the blood and the heat exchange medium. Any leak that does occur discharges to atmosphere outside the container.

摘要翻译： 通过将灌封材料在边缘上延伸并向下延伸，在热交换器纤维的灌封和热交换器容器的边缘之间的血液充氧器中实现紧密密封，使得当灌封材料在固化期间收缩时，灌封将变为 在密封方向上预紧在容器的向外的壁上。 本发明还提供了与轮缘共同延伸的环并与其间隔开的环。 灌封盆延伸到环中。 这在灌封可以延伸的边缘和环之间形成气隙。 结果，在血液和热交换介质之间没有可能的泄漏路径。 任何泄漏都会泄漏到集装箱外面的大气中。

公开(公告)号：US5706889A

公开(公告)日：1998-01-13

申请号：US703857

申请日：1996-08-27

申请人： Ulf-Eiel F. Bach ,  Paul D. Brinda ,  Louis C. Cosentino

发明人： Ulf-Eiel F. Bach ,  Paul D. Brinda ,  Louis C. Cosentino

IPC分类号： A61M1/14 ,  A61M1/16 ,  A61M1/18 ,  A61M1/36 ,  B01D63/02 ,  B01D63/04 ,  F28F21/06 ,  F28F1/10

CPC分类号： B01D63/026 ,  A61M1/1629 ,  A61M1/1698 ,  B01D63/02 ,  B01D63/021 ,  B01D63/043 ,  F28F21/062 ,  B01D2313/105 ,  B01D2313/38

摘要： A low prime, high heat exchange efficiency oxygenator is provided which includes an oxygenation portion and a heat exchanger portion. Disposed within the heat exchanger portion is a hollow tube heat exchanger wound bundle which includes a plurality of hollow tubes knitted into a mat, the mat wound under tension into a bundle which includes from 16 to 24 layers of the mat. The oxygenator provided permits prime volumes of 180 to 240 mLs.

公开(公告)号：US5501663A

公开(公告)日：1996-03-26

申请号：US87487

申请日：1993-07-02

申请人： Brack G. Hattler ,  Harvey S. Borovetz ,  Gary D. Reeder ,  Patricia J. Sawzik ,  Frank R. Walters

发明人： Brack G. Hattler ,  Harvey S. Borovetz ,  Gary D. Reeder ,  Patricia J. Sawzik ,  Frank R. Walters

IPC分类号： A61M1/14 ,  A61M1/16 ,  A61M1/18 ,  A61M1/26 ,  A61M37/00

CPC分类号： A61M1/1678 ,  A61M1/1698 ,  A61M1/26 ,  Y10S128/03 ,  Y10S261/28

摘要： An intravenous fiber membrane oxygenator is disclosed in several embodiments wherein the fibers either run at a transverse angle relative to the longitudinal axis of the oxygenator and/or are of a reduced length to optimize the gas transfer efficiency of the oxygenator. Various helical or spiral wraps of fibers are disclosed. One embodiment utilizes two sets of longitudinally extending fibers wherein the oxygen gas is moved in opposite directions from a central location of the oxygenator.

摘要翻译： 在几个实施方案中公开了静脉内纤维膜氧合器，其中纤维相对于氧合器的纵向轴线以横向角度运行和/或具有减小的长度以优化氧合器的气体转移效率。 公开了各种螺旋或螺旋形的纤维卷。 一个实施例使用两组纵向延伸纤维，其中氧气从氧合器的中心位置沿相反方向移动。

公开(公告)号：US5480552A

公开(公告)日：1996-01-02

申请号：US194213

申请日：1994-02-09

申请人： Paul Soltys ,  Norma Ofsthun

发明人： Paul Soltys ,  Norma Ofsthun

IPC分类号： C12M1/12 ,  A61M1/18 ,  A61M1/34 ,  B01D61/14 ,  B01D61/24 ,  B01D61/30 ,  B01D63/02 ,  B01D65/08 ,  B01D69/02 ,  B01D69/08 ,  B01D69/12 ,  C12M3/06 ,  B01D61/28

CPC分类号： B01D69/08 ,  B01D61/147 ,  B01D61/243 ,  B01D65/08 ,  B01D69/02 ,  C12M25/10 ,  C12M29/16 ,  B01D2321/2083

摘要： Dual-skinned membranes are provided useful as one-way or rectifying membranes which reduce back filtration of solute molecules in dialysis and which improve nutrient supply and product recovery in membrane bioreactors. The membranes are dual-skinned polymeric materials preferably in the form of hollow fibers. The membranes have skins of polymer on the opposite sides with differing permeability to solutes and sieving coefficient characteristics. The skin on each side have pores that are invisible at 10,000 times magnification. A microporous structure between the skins contains pores capable of retaining solutes in a molecular weight range of about 5000 to 200,000 in an increased concentration between the interior and the exterior skins. Improved dialysis devices are formed by using bundles of the hollow fiber membranes as a dialysis member having rectifying properties.

摘要翻译： 提供双皮膜可用作单向或整流膜，其减少透析中溶质分子的反向过滤，并改善膜生物反应器中的营养供应和产物回收。 膜是双面聚合材料，优选为中空纤维的形式。 膜在相对侧具有聚合物的表面，对溶质和筛分系数特性具有不同的渗透性。 每侧的皮肤都有10,000倍放大倍率的毛孔。 皮肤之间的微孔结构包含能够以内在和外表皮之间增加的浓度保持在约5000至200,000的分子量范围内的溶质的孔。 通过使用中空纤维膜束作为具有矫正特性的透析构件形成改进的透析装置。