公开(公告)号：US20220135514A1

公开(公告)日：2022-05-05

申请号：US17431341

申请日：2020-02-21

申请人： HAGIHARA FARM PRODUCTION INSTITUTE CO., LTD. ,  KINKI UNIVERSITY ,  MIE UNIVERSITY

发明人： Toshiharu HASHIZUME ,  Takashi KITAYAMA ,  Gengo KASHIWAZAKI ,  Satoru HIRABAYASHI ,  Yoshimi UTAKA ,  Keigo TANEDA ,  Tomohiro ITOH

IPC分类号： C07C233/09 ,  C07C211/21 ,  C07C233/05 ,  A61P35/00 ,  A23L33/175

摘要： Phytol contained in watermelon sprouts is known to have a cancer cell growth inhibiting effect. However, there is a problem that an amount of phytol to be taken for exhibiting cancer cell growth inhabition is large.
A cancer cell growth inhibiting composition comprising at least one of compounds having a structure represented by Formula (1), Formula (2), Formula (6), Formula (7) or Formula (8), or a pharmaceutically acceptable salt thereof as main components has a higher cancer cell growth inhibiting effect than phytol.

公开(公告)号：US20220089521A1

公开(公告)日：2022-03-24

申请号：US17418693

申请日：2019-12-26

申请人： ACADEMY OF MILITARY MEDICAL SCIENCES

发明人： Wu Zhong ,  Song Li ,  Hongjie Xiao ,  Mengdie Zhou

IPC分类号： C07C233/09 ,  C07C317/28 ,  C07D213/38 ,  C07D209/20 ,  C07D209/42 ,  A61P31/06 ,  C07C317/32

摘要： The present invention relates to the field of medicinal chemistry, and relates to an ethylenediamine compound represented by Formula A, pharmaceutically acceptable salts, stereoisomers, tautomers or isomer mixtures, hydrates thereof, solvates thereof, or prodrugs thereof, and use thereof in the treatment of tuberculosis.

公开(公告)号：US10975035B2

公开(公告)日：2021-04-13

申请号：US16379487

申请日：2019-04-09

申请人： Recurium IP Holdings, LLC

发明人： Kevin Duane Bunker ,  Chuangxing Guo ,  Mark Charles Grier ,  Chad Daniel Hopkins ,  Joseph Robert Pinchman ,  Deborah Helen Slee ,  Peter Qinhua Huang ,  Mehmet Kahraman

IPC分类号： C07D213/89 ,  A61K31/164 ,  C07C233/05 ,  C07C233/14 ,  A61K31/27 ,  A61K31/13 ,  C07C211/38 ,  A61K31/444 ,  A61K45/06 ,  C07C317/30 ,  C07C215/42 ,  C07C233/06 ,  C07C233/09 ,  C07C233/13 ,  C07C233/23 ,  A61K31/145 ,  A61K31/16

摘要： Disclosed herein are compounds of Formulae (I) and (II), methods of synthesizing compounds of Formulae (I) and (II), and methods of using compounds of Formulae (I) and (II) as an analgesic.

公开(公告)号：US10674755B2

公开(公告)日：2020-06-09

申请号：US14916815

申请日：2013-10-02

申请人： GIVAUDAN SA

发明人： Adri De Klerk ,  Jacob Elings ,  Eric Houben ,  Feng Shi

IPC分类号： A23L27/20 ,  C07C233/09 ,  C07D295/185 ,  C07C233/04 ,  A23L27/00

摘要： This disclosure relates to flavour modification and to compounds of formula (I) wherein R1 is selected from C6-C20 alkyl, and C9-C25 alkenyl, and i) R3 and R4 are hydrogen and R2 the residue of a proteinogenic amino acid; ii) R2 and R3 are methyl and R4 is hydrogen; or R4 is hydrogen and R2 and R3 form together with the carbon atom to which they are attached cyclopropyl; iii) R2 is hydrogen, and R3 and R4 together are —CH2—CH2—CH2—, useful in modifying flavours.

公开(公告)号：US20190330516A1

公开(公告)日：2019-10-31

申请号：US16509057

申请日：2019-07-11

申请人： CHINA PETROLEUM & CHEMICAL CORPORATION ,  SHANGHAI RESEARCH INSTITUTE OF PETROCHEMICAL TECHNOLOGY, SINOPEC

发明人： Yingcheng LI ,  Songyuan GU ,  Weidong ZHANG ,  Xinning BAO ,  Ou SHA ,  Zhiqin SHEN ,  Yiqing YANG ,  Xiaodong ZHAI

IPC分类号： C09K8/584 ,  C09K8/60 ,  C07C233/36 ,  C07C217/08 ,  C07C309/10 ,  C07C233/05 ,  C07C303/22 ,  C07C231/14 ,  C07C233/09 ,  C07C237/08 ,  C07C237/40 ,  C07C213/06

摘要： This invention relates to an anionic-cationic-nonionic surfactant as substantially represented by the formula (I), production and use thereof in tertiary oil recovery. The anionic-cationic-nonionic surfactant of this invention exhibits significantly improved interfacial activity and stability as compared with the prior art. With the present anionic-cationic-nonionic surfactant, a flooding fluid composition for tertiary oil recovery with improved oil displacement efficiency and oil washing capability as compared with the prior art could be produced. In the formula (I), each group is as defined in the specification.

公开(公告)号：US10294205B2

公开(公告)日：2019-05-21

申请号：US15303670

申请日：2015-03-27

申请人： Nanyang Technological University

发明人： Ata Abbas ,  Teck Peng Loh ,  Bengang Xing

IPC分类号： C07D209/14 ,  C07D311/16 ,  C07D403/06 ,  C07C233/09 ,  C07C233/38 ,  C07D493/10 ,  C07C233/07 ,  C07C233/49 ,  C07D209/18 ,  C07K1/13 ,  C07K1/107 ,  C07B59/00 ,  A61K47/54

摘要： There is provided a compound of formula I, having the structure: wherein R1 to R5 have the meanings given in the description.

公开(公告)号：US20180079713A1

公开(公告)日：2018-03-22

申请号：US15820632

申请日：2017-11-22

申请人： Arkema France

发明人： Yves Bernardin ,  Xavier MARCARIAN ,  Romain BILLON

IPC分类号： C07C231/12 ,  C07C305/06 ,  B01J14/00 ,  C07C235/06 ,  C07C233/09 ,  C07C231/06 ,  C07C69/54 ,  C07C67/20 ,  C07C57/04 ,  C07C51/08 ,  C07C303/24 ,  B01J19/00 ,  B01J19/02 ,  B01J19/24

CPC分类号： C07C231/12 ,  B01J14/00 ,  B01J19/0013 ,  B01J19/002 ,  B01J19/006 ,  B01J19/02 ,  B01J19/245 ,  B01J19/249 ,  B01J2219/0004 ,  B01J2219/00058 ,  B01J2219/00063 ,  B01J2219/00065 ,  B01J2219/00162 ,  B01J2219/00166 ,  B01J2219/00182 ,  B01J2219/0027 ,  B01J2219/00272 ,  B01J2219/00768 ,  B01J2219/0286 ,  B01J2219/029 ,  B01J2219/182 ,  B01J2219/1943 ,  B01J2219/2475 ,  C07C51/08 ,  C07C57/04 ,  C07C67/20 ,  C07C69/54 ,  C07C231/06 ,  C07C233/09 ,  C07C235/06 ,  C07C303/24 ,  C07C305/06

摘要： The invention relates to a thermal conversion vessel (200) used during amidification step of acetone cyanohydrin (ACH), in the industrial process for production of a methyl methacrylate (MMA) or methacrylic acid (MAA). The thermal conversion vessel (200) is used for converting an hydrolysis mixture of α-hydroxyisobutyramide (HIBAM), α-sulfatoisobutyramide (SIBAM), 2-methacrylamide (MACRYDE) and methacrylique acid (MAA), into a mixture of 2-methacrylamide (MACRYDE). It comprises: at least one compartment (C1, C2, C3, . . . Ci) comprising an inner wall (206a, 206b, 206i) separating said compartment into two communicating parts (C1a, C1b) by a passage provided between the bottom of said vessel and said inner wall, said compartment having a space above said inner wall, for separating gas phase from liquid phase during thermal conversion, said compartment being connected to an outlet valve (204a, 204b, . . . 204i). Such vessel allows obtaining a high yield thermal conversion in very safe conditions.

公开(公告)号：US20170210756A1

公开(公告)日：2017-07-27

申请号：US15227527

申请日：2016-08-03

申请人： Gilead Sciences, Inc.

发明人： Amy Cagulada ,  Johann Chan ,  Lina Chan ,  Denise A. Colby ,  Kapil Kumar Karki ,  Darryl Kato ,  Katie Ann Keaton ,  Sudha Kondapally ,  Christopher Levins ,  Adam Littke ,  Ruben Martinez ,  Dominika Pcion ,  Troy Reynolds ,  Bruce Ross ,  Michael Sangi ,  Adam J. Schrier ,  Pamela Seng ,  Dustin Siegel ,  Nathan Shapiro ,  Donald Tang ,  James G. Taylor ,  Jonathan Tripp ,  Andrew W. Waltman ,  Lawrence Yu

IPC分类号： C07D498/18 ,  C07C271/34 ,  C07C255/61 ,  C07C205/57 ,  C07C233/09 ,  C07C251/12 ,  C07D403/12 ,  C07D241/44

CPC分类号： C07D498/18 ,  C07C51/09 ,  C07C205/57 ,  C07C209/00 ,  C07C227/02 ,  C07C233/09 ,  C07C251/12 ,  C07C255/61 ,  C07C271/34 ,  C07C2601/02 ,  C07D241/44 ,  C07D403/12 ,  C07D453/02 ,  C07D498/16 ,  C07K5/0808

摘要： The present disclosure provides processes for the preparation of a compound of formula I: which is useful as an antiviral agent. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.

公开(公告)号：US09579617B2

公开(公告)日：2017-02-28

申请号：US14655549

申请日：2013-12-05

申请人： Rohm and Haas Company ,  Dow Global Technologies LLC

发明人： Mechelle Ann Churchfield ,  Timothy J. Young ,  Mai Chen ,  Thomas L. Tomczak

IPC分类号： B01F17/00 ,  C07C233/09

CPC分类号： B01F17/0092 ,  C07C233/09

摘要： A composition is provided comprising dispersed particles in an aqueous medium, wherein said dispersed particles comprise fatty amide and one or more fatty acid, wherein 50 mole % or more of said fatty acid in is the carboxylate form, and wherein the weight ratio of said fatty amide to said fatty acid is from 0.12:1 to 2.3:1. Also provided is method of making that composition, comprising the step of applying shear to a mixture that comprises said fatty amide, said fatty acid, and water, wherein said applying shear is performed at a temperature above 59° C., and wherein the amount of water in said mixture is 70% or less by weight based on the weight of said mixture.

摘要翻译： 提供了一种组合物，其包含在水性介质中的分散颗粒，其中所述分散颗粒包含脂肪酰胺和一种或多种脂肪酸，其中所述脂肪酸的50摩尔％或更多是羧酸盐形式，并且其中所述脂肪酸 酰胺与所述脂肪酸的比例为0.12:1至2.3:1。 还提供了制备该组合物的方法，包括对包含所述脂肪酰胺，所述脂肪酸和水的混合物施加剪切的步骤，其中所述施加剪切在高于59℃的温度下进行，并且其中所述量 基于所述混合物的重量，所述混合物中的水的重量为70％或更少。

公开(公告)号：US20170029373A1

公开(公告)日：2017-02-02

申请号：US15303670

申请日：2015-03-27

申请人： Nanyang Technological University

发明人： Ata Abbas ,  Teck Peng Loh ,  Bengang Xing

IPC分类号： C07D209/14 ,  C07C233/49 ,  A61K47/48 ,  C07C233/38 ,  C07D493/10 ,  C07B59/00 ,  C07C233/09 ,  C07D311/16

CPC分类号： C07D209/14 ,  A61K47/54 ,  C07B59/002 ,  C07B59/004 ,  C07B2200/05 ,  C07C233/07 ,  C07C233/09 ,  C07C233/38 ,  C07C233/49 ,  C07C2601/14 ,  C07D209/18 ,  C07D311/16 ,  C07D403/06 ,  C07D493/10 ,  C07K1/1077 ,  C07K1/13

摘要： There is provided a compound of formula I, having the structure: wherein R1 to R5 have the meanings given in the description.

摘要翻译： 提供具有以下结构的式I化合物：其中R1至R5具有在说明书中给出的含义。