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    Ophthalmic composition containing compounds found in Harderian gland secretions
    4.
    发明授权
    Ophthalmic composition containing compounds found in Harderian gland secretions 有权

    公开(公告)号：US11339114B2

    公开(公告)日：2022-05-24

    申请号：US15985305

    申请日：2018-05-21

    Applicant: RestorTears, LLC

    Inventor： Daniel M. Albert ,  Arthur S. Polans

    IPC: C07C69/708 ,  C07C69/28 ,  C07C69/593 ,  A61K45/06 ,  A61K9/00 ,  A61K31/22 ,  A61K31/225

    Abstract: The present invention is directed to pharmaceutical compositions comprising compounds found in Harderian gland secretions, a method of treating dry eye in a human comprising ophthalmically administering an effective amount of a compound, e.g. a lipid compound, found in Harderian gland secretions, pharmaceutical compositions comprising said lipid compounds, as identified by characteristic chemical data and mass spectra of said lipid compounds, said lipid compound in essentially pure form, and an ophthalmic vehicle comprising a therapeutic agent and a compound present in the secretions of the Harderian gland, e.g. a lipid compound, found in the secretions of the Harderian gland, e.g. a rabbit Harderian gland.

    Biodegradable surfactants and related compositions, methods and systems
    8.
    发明授权
    Biodegradable surfactants and related compositions, methods and systems 有权

    公开(公告)号：US11066359B2

    公开(公告)日：2021-07-20

    申请号：US16484817

    申请日：2018-02-08

    Applicant: LAWRENCE LIVERMORE NATIONAL SECURITY, LLC

    Inventor： Mathew Gerald Lyman ,  Lawrence Dugan ,  Roald N. Leif ,  Bonnee Rubinfeld ,  Brian E. Souza ,  Carlos A. Valdez

    IPC: C07C305/06 ,  C07C69/675 ,  C07C69/708

    Abstract: Biodegradable surfactants are described, in which an amphiphilic heteroatom containing hydrocarbon optionally comprising at least one counterion (Z), and related compositions, methods and systems. Biodegradable surfactant described herein has an aHLB value in accordance with equation (1): aHLB=20*Gh/(Gh−Gt) (1) wherein Gh is the Group Number of a hydrophilic head portion of the biodegradable surfactant optionally comprising the at least one counterion (Z), and Gt is the Group Number of a hydrophobic tail portion of the biodegradable surfactant. A biodegradable surfactant in the sense of the disclosure can be tuned to a set hydrophilic-lipophilic balance (aHLB) by selectively modifying at least one tuning moiety of the biodegradable surfactants to provide tuned biodegradable surfactants having an increase or decrease in their adjusted hydrophilic-lipophilic balance (aHLB).

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