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公开(公告)号:US20210238127A1
公开(公告)日:2021-08-05
申请号:US17233488
申请日:2021-04-18
发明人: Niu Huang , Shiming Peng
IPC分类号: C07C255/34 , A61P25/28 , A61P3/04 , C07D277/30 , C07D277/46 , C07D213/57 , C07D237/14 , C07D239/36 , C07D241/24 , C07D251/16 , C07D241/52 , C07D471/04 , C07D213/80 , C07D241/20 , C07D285/08 , C07D295/185 , C07D241/12 , C07D249/08 , C07D261/12 , C07D239/42 , C07D215/233 , C07D277/56 , C07D249/12 , C07D211/82 , C07D487/04 , C07D235/08 , C07D231/14 , C07D209/08 , C07D239/26 , C07D233/56 , C07D277/24 , C07D261/08 , C07D307/46 , C07D257/04 , C07D213/75 , C07D277/64 , C07C255/43
摘要: The invention provides compounds that inhibit FTO (fat mass and obesity), including pharmaceutically acceptable salts, hydrides and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof, particularly obesity, with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.
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公开(公告)号:US20210171475A1
公开(公告)日:2021-06-10
申请号:US17272268
申请日:2019-08-30
申请人: UCL BUSINESS LTD
发明人: Paul Vincent Fish , William Mahy , Nicky John Willis , Hannah Woodward , Benjamin N Atkinson , Elliott D Bayle , James Sipthorp , Edith Yvonne Jones , Yuguang Zhao , Luca Vecchia , Reinis Reinholds Ruza
IPC分类号: C07D249/06 , C07D405/04 , C07D401/04 , C07D403/04 , C07D249/08 , C07D285/135 , C07D271/113 , C07D413/04 , C07D413/10 , C07D261/08 , C07D233/64 , C07D257/04 , C07D231/12 , C07D271/06 , C07D271/07 , C07D213/16 , C07D213/64 , C07D239/36 , C07D239/34 , C07D285/06 , C07D249/12 , C07D233/56 , C07D263/32 , C07D237/14 , C07D207/34 , C07D231/20 , C07D403/10
摘要: A compound for use in the treatment of a disease ameliorated by the inhibition of Notum of formula (I): (I)
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公开(公告)号:US10584141B2
公开(公告)日:2020-03-10
申请号:US16442025
申请日:2019-06-14
IPC分类号: B01J31/00 , C07F15/00 , B01J31/16 , B01J31/18 , B01J31/22 , B01J31/24 , B01J31/40 , C07C6/02 , C07C29/00 , C07C67/293 , C07D233/56 , C08F290/00 , C08G83/00 , C08L51/04 , C08L51/08 , B01J23/46 , B01J31/28
摘要: Highly active, recoverable and recyclable transition metal-based metathesis catalysts and their organometallic complexes including dendrimeric complexes are disclosed, including a Ru complex bearing a 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene and styrenyl ether ligand. The heterocyclic ligand significantly enhances the catalytic activity, and the styrenyl ether allows for the easy recovery of the Ru complex. Derivatized catalysts capable of being immobilized on substrate surfaces are also disclosed. The present catalysts can be used to catalyze ring-closing metathesis (RCM), ring-opening (ROM) and cross metatheses (CM) reactions, and promote the efficient formation of various trisubstituted olefins at ambient temperature in high yield.
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公开(公告)号:US10513504B2
公开(公告)日:2019-12-24
申请号:US16294259
申请日:2019-03-06
申请人: Apotex Inc.
发明人: Prabhudas Bodhuri , Alfredo Paul Ceccarelli , Michael R. Emmett , Avedis Karadeolian , Fabio E. S. Souza , Gamini Weeratunga , Boris Gorin
IPC分类号: C07D401/04 , C07C231/12 , C07D249/04 , C07D207/40 , C07D233/56 , C07C237/30
摘要: The present invention provides processes for the preparation of Apalutamide (1), as well as intermediates useful in the preparation thereof. In particular, the process of the invention utilizes the intermediate compound of Formula (2), wherein G is OH or a leaving group, which provides improvements over the known processes for the preparation of Apalutamide (1).
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公开(公告)号:US10512881B2
公开(公告)日:2019-12-24
申请号:US15619577
申请日:2017-06-12
申请人: Evonik Degussa GmbH
摘要: The invention relates to a process for dehumidifying a moist gas mixture. The invention further relates to an apparatus for dehumidifying a moist gas mixture and to the use of said apparatus in the process according to the invention.
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公开(公告)号:US20190276424A1
公开(公告)日:2019-09-12
申请号:US16294259
申请日:2019-03-06
申请人: Apotex Inc.
发明人: Prabhudas Bodhuri , Alfredo Paul Ceccarelli , Michael R. Emmett , Avedis Karadeolian , Fabio E. S. Souza , Gamini Weeratunga , Boris Gorin
IPC分类号: C07D401/04 , C07C231/12 , C07C237/30 , C07D207/40 , C07D233/56 , C07D249/04
摘要: The present invention provides processes for the preparation of Apalutamide (1), as well as intermediates useful in the preparation thereof. In particular, the process of the invention utilizes the intermediate compound of Formula (2), wherein G is OH or a leaving group, which provides improvements over the known processes for the preparation of Apalutamide (1).
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公开(公告)号:US10398028B2
公开(公告)日:2019-08-27
申请号:US15351898
申请日:2016-11-15
IPC分类号: H05K3/28 , C23C22/52 , H05K1/09 , B23K35/365 , C07D233/56 , C07D235/08 , C07D409/04 , C07D409/06 , C23F11/14 , C23F11/16 , H05K13/00 , H05K1/03 , C23C22/00 , H05K3/00 , H05K1/00 , B23K101/42 , B23K103/12
摘要: A surface treating composition for copper or a copper alloy comprising an imidazole compound and means for using the composition in the soldering of electronic parts to printed wiring boards are disclosed.
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8.
公开(公告)号:US10370327B2
公开(公告)日:2019-08-06
申请号:US15323218
申请日:2015-07-02
IPC分类号: C07D233/56 , C07D403/06 , A61L27/28 , C07D207/44 , C07D233/54 , A61C8/02 , A61C8/00 , A61L27/06 , A61L27/22 , A61L27/54 , C07C229/06 , C07C229/36 , C07C323/58 , C07C333/12 , C07D233/64 , C07H3/02
摘要: The present disclosure relates ionic liquids which are used as lubricants for medical devices. In some aspects, the ionic liquids of the present disclosure can exhibit antimicrobial or host cell integrative activity or a combination of functionalities. In some aspects, the present disclosure also provides devices coated with the ionic liquid.
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9.
公开(公告)号:US09790198B2
公开(公告)日:2017-10-17
申请号:US14877972
申请日:2015-10-08
发明人: Hui Huang , Gee-Hong Kuo , Mark R. Player , Shyh-Ming Yang , Yue-Mei Zhang
IPC分类号: C07D333/56 , C07D333/54 , C07D409/04 , C07D409/10 , C07D409/12 , C07D409/14 , C07D495/10 , A61K31/381 , A61K31/4436 , C07D233/56 , C07D409/02
CPC分类号: C07D333/54 , A61K31/381 , A61K31/4436 , C07D233/56 , C07D333/56 , C07D409/02 , C07D409/04 , C07D409/10 , C07D409/12 , C07D409/14 , C07D495/10
摘要: Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR40 receptor. Such compounds are represented by Formula (I) as follows: wherein R1, R2, R3, R5, R6, W, and A are defined herein.
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公开(公告)号:US09750730B2
公开(公告)日:2017-09-05
申请号:US15140204
申请日:2016-04-27
发明人: Gregory Notte
IPC分类号: A61K31/44 , C07D213/56 , A61K31/4439 , C07D401/14 , C07D233/56 , C07D401/04 , A61K9/00 , A61K9/20 , A61K45/06
CPC分类号: C07D401/14 , A61K9/0053 , A61K9/20 , A61K31/4439 , A61K45/06 , C07D213/56 , C07D233/56 , C07D401/04
摘要: The present invention relates to a compound of formula (I): The compound has apoptosis signal-regulating kinase (“ASK1”) inhibitory activity, and is thus useful in the treatment of diseases such as kidney disease, diabetic nephropathy and kidney fibrosis.
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