公开(公告)号：US12038650B2

公开(公告)日：2024-07-16

申请号：US17651810

申请日：2022-02-21

申请人： ZEON CORPORATION

发明人： Masakazu Saito ,  Kazuhiro Osato ,  Masashi Aimatsu ,  Kei Sakamoto

IPC分类号： G02F1/13363 ,  B29D11/00 ,  C07C251/88 ,  C07D333/10 ,  C07D333/22 ,  C08F22/20 ,  C08F22/22 ,  C08F22/24 ,  C08J5/18 ,  G02B5/30

CPC分类号： G02F1/13363 ,  B29D11/00644 ,  C07C251/88 ,  C07D333/10 ,  C07D333/22 ,  C08F22/20 ,  C08F22/22 ,  C08F22/24 ,  C08J5/18 ,  G02B5/30 ,  G02B5/3016 ,  G02F1/133633 ,  G02F1/133635 ,  C08J2335/02

摘要： A phase difference plate includes a phase difference plate P1 and a phase difference plate P2. An in-plane slow axis of the phase difference plate P1 is orthogonal to an in-plane slow axis of the phase difference plate P2. The phase difference plate P2 includes a layer of a liquid crystal material oriented in an in-plane direction. An in-plane retardation ReP2(λ) at a wavelength A nm of the phase difference plate P2 satisfies the following formulae (e1) and (e2): {Re2 (400)−Re2(550)}/{Re2(550)−Re2(700)} 1.13 (e2). An in-plane retardation ReP1(λ) of the phase difference plate P1 at a wavelength λ nm and the in-plane retardation ReP2(λ) of the phase difference plate P2 at the wavelength λ nm satisfy the following formulae (e4) and (e5): ReP1(550)>ReP2(550) (e4), and ReP1(400)/ReP1(700)

公开(公告)号：US11569530B2

公开(公告)日：2023-01-31

申请号：US16890576

申请日：2020-06-02

申请人： Enevate Corporation

发明人： Liwen Ji ,  Benjamin Yong Park ,  Younes Ansari ,  Giulia Canton

IPC分类号： H01M10/0567 ,  C07F1/02 ,  C07F7/08 ,  C07D333/10 ,  C07D333/16 ,  C07D333/34 ,  C07D333/38 ,  C07D409/04 ,  C07D333/78 ,  C07D495/04 ,  C07F5/02 ,  C07D409/10 ,  C07D409/14 ,  H01M4/38 ,  H01M4/36 ,  H01M4/62 ,  H01G11/52 ,  H01G11/64 ,  H01G11/86 ,  H01G11/30 ,  C07F9/6553 ,  C07F9/6561 ,  C07D409/12

摘要： Electrolytes and electrolyte additives for energy storage devices comprising functional thiophene compounds are disclosed. The energy storage device comprises a first electrode and a second electrode, wherein at least one of the first electrode and the second electrode is a Si-based electrode, a separator between the first electrode and the second electrode, an electrolyte, and at least one electrolyte additive selected from a thiophene compound.

公开(公告)号：US20210017110A1

公开(公告)日：2021-01-21

申请号：US16977793

申请日：2019-03-04

申请人： Board of Regents of the Nevada System Higher Education, on behalf of the University of Nevada, Reno

发明人： Wesley Chalifoux ,  Wenlong Yang ,  Khagendra Hamal ,  Paban Sitaula

IPC分类号： C07C43/205 ,  C08F132/08 ,  C07C323/21 ,  C07D333/10 ,  C07D333/76 ,  C07D213/06 ,  C07B37/10

摘要： Disclosed herein are embodiments of polycyclic aromatic compounds and methods of making and using the same. Various different types of polycyclic ring systems are disclosed, including, but not limited to, polymeric aromatic compounds (e.g., nanographene compounds), pentacene-like compounds, chiral aromatic compounds, asymmetric arene compounds formed from naphthalene-, anthracene-, phenanthrene-, and pyrene-based starting compounds, and dimerized aromatic compounds. Also disclosed herein are novel benzannulation-based methods for making the disclosed polycyclic aromatic compounds.

公开(公告)号：US10525031B2

公开(公告)日：2020-01-07

申请号：US16110778

申请日：2018-08-23

申请人： Avoscience, LLC

发明人： Richard Huber

IPC分类号： A61K31/341 ,  C07D307/36 ,  A61K45/06 ,  C07D333/10 ,  A61K31/381 ,  C07D207/32 ,  A61K31/40 ,  A61K31/443

摘要： Compounds, methods, and compositions are provided for the treatment of cancer, neurological disorders, and fibrotic disorders. Specifically, the invention includes administering an effective amount of a compound of Formula I, II, or III, or a pharmaceutically acceptable composition, salt, isotopic analog, prodrug, or combination thereof, to a subject suffering from a cancer, neurological disorder, or fibrotic disorder.

公开(公告)号：US20190135733A1

公开(公告)日：2019-05-09

申请号：US16099989

申请日：2017-05-11

申请人： Chia Tai Tianqing Pharmaceutical Group Co., Ltd. ,  Medshine Discovery Inc.

发明人： Haiying He ,  Songliang Wu ,  Zhi Luo ,  Jianfeng Mou ,  Fengying Guo ,  Chuan Wang ,  Guoqing Li ,  Minggao Zeng ,  Shuhui Chen

IPC分类号： C07C225/22 ,  C07D205/04 ,  C07D207/06 ,  C07D227/04 ,  C07D265/30 ,  C07D223/04 ,  C07D221/22 ,  C07D221/04 ,  C07D239/26 ,  C07D333/10 ,  C07D333/72 ,  C07D413/06 ,  C07D401/06

摘要： Disclosed are a class of compounds as a caspase inhibitor, and in particular the compound as shown in formula (I) or a pharmaceutically acceptable salt thereof, and the use of the compound in treating caspase-related diseases.

公开(公告)号：US20180057737A1

公开(公告)日：2018-03-01

申请号：US15584826

申请日：2017-05-02

申请人： Samsung Display Co., Ltd.

发明人： Sunwoo Kang ,  Sangho Jeon ,  Youngmi Cho

IPC分类号： C09K11/63 ,  C07F5/02 ,  C07D333/10 ,  C07D317/10 ,  C07D251/14 ,  C09K11/06 ,  C09K11/56 ,  C07D333/50 ,  C07D333/32

CPC分类号： C09K11/63 ,  C07C2603/72 ,  C07D251/14 ,  C07D317/10 ,  C07D333/10 ,  C07D333/32 ,  C07D333/50 ,  C07F5/02 ,  C07F5/027 ,  C09K11/06 ,  C09K11/56 ,  C09K11/632

摘要： A borole compound is represented by Formula 1: X11—(R11)b11. X11, R11, and b11 are as defined herein. An organic light-emitting device includes the borole compound. The organic light-emitting device includes a first electrode, a second electrode, and an organic layer between the first electrode and the second electrode, the organic layer including an emission layer. The organic layer includes the borole compound.

公开(公告)号：US09603833B2

公开(公告)日：2017-03-28

申请号：US14631477

申请日：2015-02-25

申请人： R-Tech Ueno, Ltd.

发明人： Tatsuya Matsukawa ,  Kazuhiro Masuzaki ,  Akiko Kawasaki ,  Akiko Akasaka ,  Yosuke Kawai

IPC分类号： A61K31/381 ,  C07D333/10 ,  A61K31/4427 ,  A61K31/497 ,  A61K31/506 ,  A61K31/44 ,  A61K31/505 ,  A61K31/425 ,  A61K31/4025 ,  A61K31/422 ,  A61K31/427 ,  C07C243/32 ,  C07C243/34 ,  C07C281/02 ,  C07C281/06 ,  C07D213/74 ,  C07D233/88 ,  C07D237/20 ,  C07D239/42 ,  C07D241/20 ,  C07D241/24 ,  C07D265/36 ,  C07D333/36 ,  C07D401/04 ,  C07D409/06 ,  C07D417/04 ,  C07D487/08 ,  C07D213/72 ,  C07D213/75 ,  C07D233/64

CPC分类号： A61K31/381 ,  A61K31/4025 ,  A61K31/422 ,  A61K31/425 ,  A61K31/427 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/497 ,  A61K31/505 ,  A61K31/506 ,  C07C243/32 ,  C07C243/34 ,  C07C281/02 ,  C07C281/06 ,  C07D213/72 ,  C07D213/74 ,  C07D213/75 ,  C07D233/64 ,  C07D233/88 ,  C07D237/20 ,  C07D239/42 ,  C07D241/20 ,  C07D241/24 ,  C07D265/36 ,  C07D333/10 ,  C07D333/36 ,  C07D401/04 ,  C07D409/06 ,  C07D417/04 ,  C07D487/08

摘要： The present invention provides a novel benzene derivative or thiophene derivative useful as a VAP-1 inhibitor, or a medicament for the prophylaxis or treatment of a VAP-1 associated disease and the like, namely, a compound represented by the formula (I): wherein each symbol is as defined in the present specification, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20160257674A1

公开(公告)日：2016-09-08

申请号：US14392304

申请日：2014-09-23

申请人： CHDI FOUNDATION, INC.

发明人： Celia Dominguez ,  Leticia M. Toledo-Sherman ,  Michael Prime ,  William Mitchell ,  Naomi Went

IPC分类号： C07D413/12 ,  C07D277/64 ,  C07D217/02 ,  C07D239/74 ,  C07D237/28 ,  C07D241/42 ,  C07D263/56 ,  C07D235/08 ,  C07D209/08 ,  C07D231/56 ,  C07D261/20 ,  C07D407/12 ,  C07D333/28 ,  C07D333/10 ,  C07D277/24 ,  C07D307/79

CPC分类号： C07D413/12 ,  C07D209/08 ,  C07D213/46 ,  C07D215/18 ,  C07D217/02 ,  C07D231/56 ,  C07D235/08 ,  C07D237/28 ,  C07D239/74 ,  C07D241/42 ,  C07D261/20 ,  C07D263/56 ,  C07D277/24 ,  C07D277/64 ,  C07D307/79 ,  C07D319/18 ,  C07D333/06 ,  C07D333/10 ,  C07D333/28 ,  C07D407/12

摘要： Certain compounds, or pharmaceutically acceptable salts or prodrugs thereof, are provided herein. Also provided are pharmaceutical compositions comprising at least one compound, or pharmaceutically acceptable salt or prodrug thereof, described herein and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one compound, or pharmaceutically acceptable salt or prodrug thereof, described herein effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one compound, or pharmaceutically acceptable salt or prodrug thereof, described herein as a single active agent or administering at least one compound, or pharmaceutically acceptable salt or prodrug thereof, described herein in combination with one or more other therapeutic agents. Also provided are methods for screening compounds capable of inhibiting KMO activity.

公开(公告)号：US20150080451A1

公开(公告)日：2015-03-19

申请号：US14344450

申请日：2012-09-12

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： Ernesto Freire ,  Patrick C. Ross ,  Rogelio Siles

IPC分类号： C07D333/10 ,  A61K45/06 ,  A61K31/381 ,  C07C311/13 ,  A61K31/18

CPC分类号： C07D333/10 ,  A61K31/18 ,  A61K31/381 ,  A61K45/06 ,  C07C311/13

摘要： Potent low molecular weight, highly selective, competitive non-peptidic serine protease inhibitors and their use in treating serine protease-associated diseases are disclosed.

摘要翻译： 公开了有效的低分子量，高选择性，竞争性的非肽性丝氨酸蛋白酶抑制剂及其在治疗丝氨酸蛋白酶相关疾病中的用途。

公开(公告)号：US20110172432A1

公开(公告)日：2011-07-14

申请号：US12596388

申请日：2008-04-11

申请人： Claude Le Drian ,  Jean-Michel Becht ,  Stéphane Schweizer

发明人： Claude Le Drian ,  Jean-Michel Becht ,  Stéphane Schweizer

IPC分类号： B01J31/06 ,  C07C45/61 ,  C07D213/16 ,  C07D401/04 ,  C07D333/10 ,  C07D411/04 ,  C07C1/32

CPC分类号： B01J31/2404 ,  B01J31/1658 ,  B01J31/2447 ,  B01J2231/4211 ,  B01J2231/4227 ,  B01J2531/824 ,  C07F9/5027 ,  C07F15/006

摘要： The invention relates to the field of chemistry, especially organic chemistry, and more specifically the field of heterogeneous palladium catalysts used to catalyse chemical reactions involving the formation of carbon-carbon bonds. The invention also relates to a method for synthesising a heterogeneous palladium catalyst that can catalyse a C—C coupling reaction, the method essentially including steps of providing a solid substrate onto which groups of formula —PR1R2, wherein R1 is an optionally substituted alkyl group, or an optionally substituted cycloalkyl group, et R2 is an optionally substituted aryl group or an optionally substituted heteroaryl group, have been covalently bonded, and incorporating a catalytically effective amount of palladium into the resulting substituted substrate. The invention further relates to the resulting catalysts and to the uses thereof in C—C coupling reactions.

摘要翻译： 本发明涉及化学领域，特别是有机化学领域，更具体地涉及用于催化涉及形成碳 - 碳键的化学反应的异相钯催化剂领域。 本发明还涉及一种合成可催化C-C偶联反应的非均相钯催化剂的方法，该方法基本上包括提供固体底物的步骤，其中R 1为任选取代的烷基的式-PR 1 R 2基团， 或任选取代的环烷基，和R 2是任选取代的芳基或任选取代的杂芳基，已经共价键合，并将催化有效量的钯并入所得的取代的底物中。 本发明进一步涉及所得催化剂及其在C-C偶联反应中的用途。