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公开(公告)号：US20240309057A1
公开(公告)日：2024-09-19
申请号：US18633982
申请日：2024-04-12
发明人： James A. Baum , Thomas A. Cerruti , Crystal L. Dart , Leigh H. English , Stanislaw Flasinski , Xiaoran Fu , Victor M. Guzov , Arlene R. Howe , Jay P. Morgenstern , James K. Roberts , Sara A. Salvador , Jinling Wang
IPC分类号： C07K14/325 , A01N37/46 , C12N15/62 , C12N15/82
CPC分类号： C07K14/325 , A01N37/46 , C12N15/8286 , C07K2319/00 , C12N15/62 , Y02A40/146
摘要： Nucleotide sequences are disclosed that encode novel chimeric insecticidal proteins exhibiting Lepidopteran inhibitory activity. Particular embodiments provide compositions and transformed plants, plant parts, and seeds containing the recombinant nucleic acid molecules encoding one or more of the chimeric insecticidal proteins.
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公开(公告)号：US20240301441A1
公开(公告)日：2024-09-12
申请号：US18635866
申请日：2024-04-15
IPC分类号： C12N15/82 , A01N63/50 , C07K14/24 , C07K14/325
CPC分类号： C12N15/8286 , A01N63/50 , C07K14/24 , C07K14/325
摘要： A pesticidal protein class of PirA, PirB, and PirAB fusion proteins exhibiting toxic activity against Coleopteran, Lepidopteran, and Hemipteran pest species is disclosed. DNA constructs are provided which contain a recombinant nucleic acid sequence encoding the PirA, PirB, and PirAB fusion proteins. Transgenic plants, plant cells, seed, and plant parts resistant to Coleopteran, Lepidopteran, and Hemipteran infestation are provided which contain recombinant nucleic acid sequences encoding the PirA, PirB, and PirAB fusion proteins. Methods for detecting the presence of the recombinant nucleic acid sequences or the proteins of the present invention in a biological sample, and methods of controlling Coleopteran, Lepidopteran, and Hemipteran species pests using the PirA, PirB, and PirAB fusion proteins are also provided.
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公开(公告)号：US20240240199A1
公开(公告)日：2024-07-18
申请号：US18289473
申请日：2022-05-03
发明人： Ailing Zhou , Kasimalai Azhakanandam , Jared Conville , Yan Zhang
IPC分类号： C12N15/82 , C07K14/325 , C12Q1/6895
CPC分类号： C12N15/8286 , C07K14/325 , C12Q1/6895 , C12Q2600/13
摘要： The present disclosure is related to a nucleic acid sequence which confers expression of insecticidal proteins when introduced into a cell, as well as related compositions and methods of use thereof. In some aspects, the disclosure provides a plant comprising the nucleic acid sequence.
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公开(公告)号：US12037368B2
公开(公告)日：2024-07-16
申请号：US17468311
申请日：2021-09-07
IPC分类号： C07K14/32 , A61K38/16 , A61K45/06 , C07K14/195 , C07K14/325 , G16B30/10
CPC分类号： C07K14/32 , A61K38/164 , A61K45/06 , C07K14/195 , C07K14/325 , G16B30/10
摘要： Computational systems and methods are described for identifying new type-II bacteriocins using a systemic consensus formula and other related criteria. Newly identified type-II bacteriocin peptides are tested experimentally and show potent microbiocidal activities.
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公开(公告)号：US12011000B2
公开(公告)日：2024-06-18
申请号：US18346437
申请日：2023-07-03
发明人： Heba Mohamed Yassen Abdelgaffar , Constanze Hahnfeld , Juan Luis Jurat-Fuentes , Erik Jongedijk , Jeffrey M. Staub , Stefan Meldau
IPC分类号： A01N63/50 , A01P7/04 , C07K14/325 , C07K16/12 , C07K16/28
CPC分类号： A01N63/50 , A01P7/04 , C07K14/325 , C07K16/1278 , C07K16/28 , C07K2317/31 , C07K2317/569 , C07K2317/92 , C07K2319/55
摘要： Affinity constructs and affinity molecules to direct insecticidal toxins to insect specific structures of target insects are presented herein. The affinity constructs comprise of at least one affinity molecule that is capable of recognizing, or capable of binding to, or binding to, or being directed to, or being designed to bind to an insect-specific structure in and/or on a target insect, and at least one other affinity molecule capable of binding to, or binding to, or being directed to, or being designed to bind to an insecticidal protein (toxin) wherein the at least two affinity molecules are operably coupled. Presented herein are also methods of making and using these affinity constructs and affinity molecules.
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公开(公告)号：US11981709B2
公开(公告)日：2024-05-14
申请号：US17742215
申请日：2022-05-11
发明人： James A. Baum , Artem G. Evdokimov , Farhad Moshiri , Timothy J. Rydel , Eric J. Sturman , Moritz von Rechenberg , Halong Vu , Andrew M. Wollacott , Meiying Zheng , Stanislaw Flasinski
IPC分类号： C12N15/62 , A01N37/46 , C07K14/00 , C07K14/32 , C07K14/325 , C07K14/435 , C12N15/82
CPC分类号： C07K14/325 , A01N37/46 , C07K14/001 , C07K14/32 , C07K14/43577 , C12N15/8286 , Y02A40/146
摘要： The present invent in discloses Hemipteran insect inhibitory proteins, methods of using such proteins, nucleotide sequences encoding such proteins, methods of detecting and isolating such proteins, and their use in agricultural systems.
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公开(公告)号：US11945843B2
公开(公告)日：2024-04-02
申请号：US16321904
申请日：2017-08-01
IPC分类号： C07K14/42 , C07K14/325 , C07K16/18 , C12N9/42 , C12N15/82
CPC分类号： C07K14/42 , C07K14/325 , C07K16/18 , C12N9/2442 , C12N15/8218 , C12N15/8286 , C12Y302/01014 , Y02A40/146
摘要： Disclosed are double stranded RNA molecules that are toxic to coleopteran insects. In particular, interfering RNA molecules capable of interfering with pest target genes and that are toxic to the target pest are provided. Further, methods of making and using the interfering RNA, for example in transgenic plants or as the active ingredient in a composition, to confer protection from insect damage are disclosed.
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公开(公告)号：US20240081343A1
公开(公告)日：2024-03-14
申请号：US18235247
申请日：2023-08-17
发明人： Joseph M WATTS
IPC分类号： A01N63/50 , A01N37/46 , A01N63/10 , C07K14/195 , C07K14/32 , C07K14/325 , C12N15/82
CPC分类号： A01N63/50 , A01N37/46 , A01N63/10 , C07K14/195 , C07K14/32 , C07K14/325 , C12N15/8279 , C12N15/8286 , C07K2319/20 , C07K2319/55 , Y02A40/146
摘要： The present invention is directed to vegetative insecticidal proteins (Vips) modified to comprise heterologous carbohydrate binding modules and methods of use thereof.
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公开(公告)号：US20240041049A1
公开(公告)日：2024-02-08
申请号：US18346437
申请日：2023-07-03
发明人： Heba Mohamed Yassen ABDELGAFFAR , Constanze HAHNFELD , Juan Luis JURAT-FUENTES , Erik JONGEDIJK , JEFFREY M. STAUB , Stefan MELDAU
IPC分类号： A01N63/50 , C07K16/28 , C07K16/12 , C07K14/325 , A01P7/04
CPC分类号： A01N63/50 , C07K16/28 , C07K16/1278 , C07K14/325 , A01P7/04 , C07K2317/569 , C07K2319/55 , C07K2317/31 , C07K2317/92
摘要： Affinity constructs and affinity molecules to direct insecticidal toxins to insect specific structures of target insects are presented herein. The affinity constructs comprise of at least one affinity molecule that is capable of recognizing, or capable of binding to, or binding to, or being directed to, or being designed to bind to an insect-specific structure in and/or on a target insect, and at least one other affinity molecule capable of binding to, or binding to, or being directed to, or being designed to bind to an insecticidal protein (toxin) wherein the at least two affinity molecules are operably coupled. Presented herein are also methods of making and using these affinity constructs and affinity molecules.
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公开(公告)号：US20240018537A1
公开(公告)日：2024-01-18
申请号：US18459547
申请日：2023-09-01
发明人： CAROLINE HORN , SABINA LAU , MICHI IZUMI WILLCOXON , TAKASHI YAMAMOTO , YI ZHENG
IPC分类号： C12N15/82 , A01N37/46 , C07K14/325
CPC分类号： C12N15/8286 , A01N37/46 , C07K14/325 , Y02A40/146
摘要： The disclosure provides nucleic acids, and variants and fragments thereof, derived from strains of Bacillus thuringiensis encoding variant polypeptides having increased pesticidal activity against insect pests, including Lepidoptera and Coleopteran. Particular embodiments of the disclosure provide isolated nucleic acids encoding pesticidal proteins, pesticidal compositions, DNA constructs, and transformed microorganisms and plants comprising a nucleic acid of the embodiments. These compositions find use in methods for controlling pests, especially plant pests.
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