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公开(公告)号：US20240140992A1
公开(公告)日：2024-05-02
申请号：US18547321
申请日：2022-02-22
发明人： Maria Diarey TIANERO-MCINTOSH , Arlene Atup SY-CORDERO , Bradley Morgan HOVER , Steven L. COLLETTI , Gayatri GOLLAPUDI
CPC分类号： C07K11/02 , C07K14/36 , C12N9/1029 , C12N9/93 , C12N15/52 , C12N15/76 , C12P21/02 , A61K38/00
摘要： The present disclosure provides compounds of Formula (I):
or a pharmaceutically acceptable salt, solvate, or tautomer thereof, and uses of the same in treating a disease or disorder (e.g., cancer or fibrosis).-
公开(公告)号：US20240043854A1
公开(公告)日：2024-02-08
申请号：US18477069
申请日：2023-09-28
申请人： Eligo Bioscience
CPC分类号： C12N15/76 , A61P17/10 , A61K39/05 , C12N9/22 , C12N15/11 , A61K39/02 , C12N2310/20 , A61K2039/53
摘要： The invention relates to C. acnes carrying DNA vectors with a C. acnes phage packaging signal and a gene of interest. The invention encompasses a C. acnes producer cell carrying DNA vectors, with a C. acnes phage packaging signal and a gene of interest, for the production of phage-derived particles that can robustly transduce C. acnes receiver cell allowing transgene expression. The invention encompasses C. acnes phage-derived particles carrying these vectors, C. acnes containing these vectors or modified by transduction of these phage-derived particles, and methods of using these phage-derived particles.
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公开(公告)号：US20240035038A1
公开(公告)日：2024-02-01
申请号：US18478500
申请日：2023-09-29
申请人： Eligo Bioscience
CPC分类号： C12N15/76 , A61P17/10 , A61K39/05 , C12N9/22 , C12N15/11 , A61K39/02 , C12N2310/20 , A61K2039/53
摘要： The invention relates to C. acnes strains carrying DNA vectors for the production of recombinant C. acnes phages. The invention encompasses a C. acnes producer cell carrying DNA vectors, with a template for recombination with C. acnes phage genome leading to the insertion of a gene of interest, for the production of recombinant phages that can lead to the transgene expression into C. acnes infected by the recombinant phage. The invention encompasses, C. acnes strains containing these vectors, C. acnes recombinant phages and methods of using these recombinant phages.
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公开(公告)号：US11858967B2
公开(公告)日：2024-01-02
申请号：US17817413
申请日：2022-08-04
发明人： T. Mark Zabriskie , Xihou Yin
CPC分类号： C07K14/36 , C12N15/71 , C12P21/02 , C12N1/205 , C12R2001/465
摘要： This disclosure describes compositions and methods for enhanced production of enduracidin in genetically engineered strains of Streptomyces fungicidicus. In particular, the present disclosure describes the genetic manipulation of regulatory genes orf24 and orf18 associated with the enduracidin (enramycin) biosynthesis gene cluster from Streptomyces fungicidicus to generate vector constructs and recombinant strains producing greater yields of enduracidin.
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公开(公告)号：US20230120672A1
公开(公告)日：2023-04-20
申请号：US17817413
申请日：2022-08-04
发明人： T. Mark Zabriskie , Xihou Yin
摘要： This disclosure describes compositions and methods for enhanced production of enduracidin in genetically engineered strains of Streptomyces fungicidicus. In particular, the present disclosure describes the genetic manipulation of regulatory genes orf24 and orf18 associated with the enduracidin (enramycin) biosynthesis gene cluster from Streptomyces fungicidicus to generate vector constructs and recombinant strains producing greater yields of enduracidin.
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公开(公告)号：US20220090100A1
公开(公告)日：2022-03-24
申请号：US17426621
申请日：2020-01-30
发明人： Kazuo SHINYA , Haruo IKEDA , Mamoru KOMATSU , Junko HASHIMOTO , Ikuko KOZONE , Takuya HASHIMOTO , Kei KUDO
摘要： The present invention provides a method for producing a modified compound, including the following steps: (1) a step of cleaving in vitro using a CRISPR/Cas9 system, a target site in a gene cluster involved in the biosynthesis of a compound, (2) a step of connecting using Gibson assembly in vitro the gene cluster cleaved in step (1) and a polynucleotide for modification, and (3) a step of expressing the modified gene cluster obtained in step (2) in a microorganism expression system.
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公开(公告)号：US20210163964A1
公开(公告)日：2021-06-03
申请号：US17045240
申请日：2019-04-05
摘要： In some aspects, the disclosure relates to production of bacterial secondary metabolites. In some embodiments, the disclosure relates to a genetically engineered Streptomyces J1074 bacterium, wherein the bacterium comprises a nucleic acid having a modification to at least one global regulator gene.
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公开(公告)号：US20210032606A1
公开(公告)日：2021-02-04
申请号：US16301377
申请日：2017-05-08
发明人： Min Zhou , Xing Jiang , Shuang Han , Yingying He , Linghui Zheng
摘要： The present invention relates to a DoxA protein mutant having an amino acid sequence set forth in SEQ ID No. 16, and coding gene thereof. The protein mutant or the coding gene thereof can be used for producing epirubicin. The present invention further relates to a Streptomyces capable of efficiently expressing epirubicin, which is constructed by replacing the dnmV gene of a starting Streptomyces in situ with the avrE gene and mutating the doxA gene of the starting Streptomyces into a gene encoding the protein set forth in SEQ ID No. 16. The fermentation broth of this Streptomyces has an epirubicin potency of up to 102.0 μg/ml.
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公开(公告)号：US20200216852A1
公开(公告)日：2020-07-09
申请号：US16720885
申请日：2019-12-19
申请人： Sanofi
IPC分类号： C12N15/76 , C07K14/36 , C12N15/52 , C07D487/04 , A61K31/445 , C07D519/00
摘要： The present invention provides a tomaymycin biosynthetic gene cluster of Streptomyces species FH6421, and its use for producing 11-de-O-methyltomaymycm.
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公开(公告)号：US10526668B2
公开(公告)日：2020-01-07
申请号：US15562187
申请日：2016-03-25
发明人： Yun Teng , Meidong Xu , Meiyi Mo , Zhihui He , Zhengjie Chen , Lianiqing Jiang , Hua Bai
摘要： Provided are a Streptomyces (Streptomyces hygroscopicus) HS7522 and a method for preparing milbemycin A4 by culturing the Streptomyces. The Streptomyces (Streptomyces hygroscopicus) HS7522 of the present invention is deposited in “China General Microbiological Culture Collection Center” with an accession number of CGMCC No. 9671 on Sep. 16, 2014.
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