公开(公告)号：WO1993023092A1

公开(公告)日：1993-11-25

申请号：PCT/CA1993000201

申请日：1993-05-19

Applicant: WESTAIM TECHNOLOGIES INC. ,  BURRELL, Robert, Edward ,  MORRIS, Larry, R.

Inventor： WESTAIM TECHNOLOGIES INC.

IPC: A61L29/00

CPC classification number: C23C14/225 ,  A01N59/16 ,  A61B2018/00119 ,  A61L17/145 ,  A61L27/306 ,  A61L27/54 ,  A61L29/106 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/102 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2300/602 ,  A61L2300/606 ,  C23C14/0036 ,  C23C14/025 ,  C23C14/06 ,  C23C14/0688 ,  C23C14/086 ,  C23C14/14 ,  C23C14/16 ,  C23C14/205 ,  C23C14/35 ,  C23C14/588 ,  H01H2300/014 ,  Y10S977/781 ,  Y10S977/89 ,  Y10S977/891 ,  Y10S977/904 ,  Y10S977/931

Abstract: Anti-microbial coatings and method of forming same on medical devices are provided. The coatings are formed by depositing a biocompatible metal by vapour deposition techniques to produce atomic disorder in the coating such that a sustained release of metal ions sufficient to produce an anti-microbial effect is achieved. Preferred deposition conditions to achieve atomic disorder include a lower than normal substrate temperature, and one or more of a higher than normal working gas pressure and a lower than normal angle of incidence of coating flux. Anti-microbial powders formed by mechanical working to produce atomic disorder are also provided. The invention extends to other metal coatings and powders similarly formed so as to provide enhanced solubility.

Abstract translation: 提供了抗微生物涂层及其在医疗装置上的形成方法。 通过气相沉积技术沉积生物相容性金属以在涂层中产生原子紊乱形成涂层，从而实现足以产生抗微生物作用的金属离子的持续释放。 实现原子紊乱的优选沉积条件包括低于正常的衬底温度，以及高于正常工作气体压力和低于正常入射角的涂层焊剂的一种或多种。 还提供了通过机械加工形成的产生原子紊乱的抗微生物粉末。 本发明延伸到类似地形成的其它金属涂层和粉末，以提供增强的溶解度。

公开(公告)号：WO2006078700A1

公开(公告)日：2006-07-27

申请号：PCT/US2006/001714

申请日：2006-01-18

Applicant: MEDTRONIC, INC. ,  BRABEC, Scott, J. ,  GARDESKI, Kenneth, C.

Inventor： BRABEC, Scott, J. ,  GARDESKI, Kenneth, C.

IPC: A61N1/05

CPC classification number: A61N1/056 ,  A61N1/0565 ,  Y10S977/905 ,  Y10S977/925 ,  Y10S977/931

Abstract: The present invention relates generally to medical devices; in particular and without limitation, to unique electrodes and/or electrical lead assemblies for stimulating cardiac tissue, muscle tissue, neurological tissue, brain tissue and/or organ tissue; to electrophysiology mapping and ablation catheters for monitoring and selectively altering physiologic conduction pathways; and, wherein said electrodes, lead assemblies and catheters optionally include fluid irrigation conduit(s) for providing therapeutic and/or performance enhancing materials to adjacent biological tissue, and wherein each said device is coupled to or incorporates nanostructure or materials therein. The present invention also provides methods for fabricating, deploying, and operating such medical devices.

Abstract translation: 本发明一般涉及医疗器械; 特别是但不限于用于刺激心脏组织，肌肉组织，神经组织，脑组织和/或器官组织的独特电极和/或电引线组件; 用于电生理测绘和消融导管，用于监测和选择性地改变生理传导途径; 并且其中所述电极，引线组件和导管可选地包括用于向相邻生物组织提供治疗和/或性能增强材料的流体冲洗导管，并且其中每个所述装置与其中的纳米结构或材料耦合或结合。 本发明还提供了制造，部署和操作这种医疗装置的方法。

公开(公告)号：WO2005113432A1

公开(公告)日：2005-12-01

申请号：PCT/EP2005/005293

申请日：2005-05-13

Applicant: SONY DEUTSCHLAND GMBH ,  FORD, William, E. ,  WESSELS, Jurina ,  YASUDA, Akio ,  BARGER, Jack

Inventor： FORD, William, E. ,  WESSELS, Jurina ,  YASUDA, Akio ,  BARGER, Jack

IPC: C01B31/02

CPC classification number: H01M4/583 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/168 ,  C01B32/174 ,  C01B2202/02 ,  C01B2202/04 ,  C01B2202/06 ,  C01B2202/28 ,  H01G11/36 ,  H01J1/304 ,  H01J9/025 ,  H01J2201/30446 ,  H01J2201/30469 ,  H01M4/624 ,  H01M4/96 ,  Y02E60/13 ,  Y10S977/742 ,  Y10S977/745 ,  Y10S977/746 ,  Y10S977/748 ,  Y10S977/778 ,  Y10S977/904 ,  Y10S977/906 ,  Y10S977/919 ,  Y10S977/931 ,  Y10S977/932 ,  Y10T428/24802 ,  Y10T428/30 ,  Y10T428/31504

Abstract: The invention relates to a carbon nanotube composite material, to methods of its production and to uses of such composite material.

Abstract translation: 本发明涉及碳纳米管复合材料，其生产方法和这种复合材料的使用。

公开(公告)号：WO2004085098A3

公开(公告)日：2005-03-24

申请号：PCT/US2004009358

申请日：2004-03-26

Applicant: PURDUE RESEARCH FOUNDATION ,  WEBSTER THOMAS J ,  EJIOFOR JEREMIAH U

Inventor： WEBSTER THOMAS J ,  EJIOFOR JEREMIAH U

IPC: A61F2/00 ,  A61F2/30 ,  A61K33/24 ,  A61L27/06 ,  A61L27/50 ,  C22C1/04 ,  A61F2/28

CPC classification number: A61L27/50 ,  A61F2002/30968 ,  A61F2310/00023 ,  A61F2310/00029 ,  A61K33/24 ,  A61L27/06 ,  A61L2400/12 ,  B22F2998/00 ,  C22C1/045 ,  C22C1/0458 ,  Y10S977/931 ,  B22F1/0018 ,  B22F3/02

Abstract: A composition for use as a prosthetic biomaterial and associated method. The biomaterial exhibits cytocompatibility, mechanical functionality and osteoblast adhesion between the implant and interfacing surface. The biomaterial is metallic, has a grain size less than about 500 nanometers and has a surface roughness of less than about 800 nm rms.

Abstract translation: 用作假体生物材料的组合物及其相关方法。 生物材料表现出植入物和界面表面之间的细胞相容性，机械功能和成骨细胞粘附。 生物材料是金属的，具有小于约500纳米的晶粒尺寸并具有小于约800nm rms的表面粗糙度。

公开(公告)号：WO00066192A1

公开(公告)日：2000-11-09

申请号：PCT/DE2000/001415

申请日：2000-04-28

IPC: A61F2/82 ,  A61L31/02 ,  A61L31/14 ,  A61L31/08

CPC classification number: A61L31/028 ,  A61F2/82 ,  A61F2007/126 ,  A61L31/18 ,  A61L2400/12 ,  Y10S977/775 ,  Y10S977/829 ,  Y10S977/83 ,  Y10S977/904 ,  Y10S977/931

Abstract: The invention relates to a stent which can be implanted in passageways or other body cavities, which is made of a metallic and/or non-metallic material, and which is evenly coated with nanoscalar particles. Said nanoscalar particles consist of a paramagnetic core and of at least one shell absorbed thereon which durably connect to the stent surface. Due to the influence of a magnetic alternating field in a clinically compatible field intensity/frequency combination with a high power consumption, this coating enables a selective homogeneous heating of the implant within a temperature range that promotes the vascularization of the implant by cell regeneration as well as within a temperature range that regenerates a restenosed implant, and enables the position of the stent to be determined.

Abstract translation: 一种在静脉样结构，或由金属和/或非金属材料的可植入支架的其它体腔上设置有纳米级颗粒，其由顺磁芯的并在此吸附的外壳，其经历与支架表面，均匀地涂覆一个永久键的至少一种。 因为通过细胞形成温度范围内输送该涂层/频率组合，制成另一方面，在一restenosiertes可通过的临床上可接受的磁场强度的交变磁场的作用，在所述植入物的高功率选择性，均匀地加热，一方面在其向内生长，并且也是获得植入物的再生温度范围内和 将要执行的定位。

公开(公告)号：WO99040077A3

公开(公告)日：1999-10-28

申请号：PCT/EP1999/000530

申请日：1999-01-27

IPC: B01J23/52 ,  B01J35/00 ,  C07D301/03 ,  C07D301/10 ,  C07D303/04 ,  C07D301/08 ,  B01J23/66

CPC classification number: B01J23/52 ,  B01J35/0013 ,  C07D301/10 ,  Y10S977/775 ,  Y10S977/89 ,  Y10S977/896 ,  Y10S977/931

Abstract: The present invention relates to a method for the oxidation of unsaturated hydrocarbons in gaseous phase, wherein said oxidation is carried out in the presence of a hydrogen-oxygen mixture on a catalyst coated with gold particles. This method comprises using a calcined catalyst which is produced from a titanium oxide hydrate optionally containing sulphate, said catalyst being coated with nanometrical gold particles. This method is preferably used for epoxidising ethene, propene or butene. This invention further relates to a catalyst for oxidising the above-mentioned unsaturated hydrocarbons.

Abstract translation: 公开了一种用于在氢 - 氧混合物的存在下在气相不饱和烃中的占用的与金的氧化的方法颗粒催化剂，其特征在于，使用含有具有纳米级金颗粒从制备任选硫酸氧化钛水合物和煅烧所占据的催化剂。 该方法优选适用于乙烯，丙烯或丁烯的环氧化。 此外，描述了用于氧化所述不饱和烃的催化剂。

公开(公告)号：WO9910022A3

公开(公告)日：1999-06-10

申请号：PCT/US9817754

申请日：1998-08-27

Applicant: CALIFORNIA INST OF TECHN

Inventor： HUBBELL JEFFREY A ,  WINBLADE NATALIE D ,  ELBERT DONALD L

IPC: A61L31/00 ,  A61K31/77 ,  A61K31/78 ,  A61K31/79 ,  A61K31/80 ,  A61L27/34 ,  A61L29/00 ,  A61L31/06 ,  A61L31/10 ,  C08L101/02

CPC classification number: A61L31/06 ,  A61K31/77 ,  A61K31/78 ,  A61K31/79 ,  A61K31/80 ,  A61L27/34 ,  A61L31/10 ,  Y10S525/937 ,  Y10S977/931 ,  C08L71/02 ,  C08L101/02

Abstract: The invention discloses materials that adsorb readily to the surfaces of body tissues in situ and provide a steric barrier between such tissues, so that tissue adhesions, which typically form following surgical procedures, are minimized. These materials contain a polymer of hydrophilic molecules such as polyethylene glycol (PEG) bound to a polymer that spontaneously adsorbs to biological tissue such as phenylboronic acid (PBA). The PEG-PBA co-polymer can be formed in a variety of geometries. The materials can also be used to coat prosthetics and other implants.

Abstract translation: 本发明公开了容易吸附到身体组织表面的材料，并且在这些组织之间提供空间屏障，使得通常形成以下外科手术的组织粘连最小化。 这些材料包含亲水性分子的聚合物，例如与自发吸附到生物组织如苯硼酸（PBA）的聚合物结合的聚乙二醇（PEG）。 PEG-PBA共聚物可以以各种几何形状形成。 这些材料也可用于涂覆假体和其他植入物。

公开(公告)号：WO1998007414A1

公开(公告)日：1998-02-26

申请号：PCT/US1997004695

申请日：1997-03-28

Applicant: RESEARCH TRIANGLE PHARMACEUTICALS LTD.

Inventor： RESEARCH TRIANGLE PHARMACEUTICALS LTD. ,  PARIKH, Indu ,  SELVARAJ, Ulagaraj

IPC: A61K09/51

CPC classification number: A61K9/5123 ,  A61K9/145 ,  A61K9/5146 ,  A61K9/5192 ,  Y10S977/828 ,  Y10S977/883 ,  Y10S977/906 ,  Y10S977/915 ,  Y10S977/931

Abstract: Submicron size particles of pharmaceutical or other water-insoluble or poorly water-insoluble substances are prepared using a combination of one or more surface modifiers/surfactants such as polaxomers, poloxamines, polyoxyethylene sorbitan fatty acid esters and the like together with natural or synthetic phospholipids. Particles so produced have a volume weighted mean particle size at least one-half smaller than obtainable using a phospolipid alone. Compositions so prepared are resistant to particle size growth on storage.

Abstract translation: 使用一种或多种表面改性剂/表面活性剂如聚异构体，泊洛沙胺，聚氧乙烯山梨糖醇酐脂肪酸酯等与天然或合成磷脂的组合制备药物或其它水不溶性或水难溶性不良物质的亚微米尺寸颗粒。 如此生产的颗粒的体积加权平均粒度比使用单独的磷脂可获得的体积加权平均粒度小至少一半。 如此制备的组合物在储存时耐颗粒生长。

公开(公告)号：WO1997046267A1

公开(公告)日：1997-12-11

申请号：PCT/US1997009635

申请日：1997-06-02

Applicant: GORE ENTERPRISE HOLDINGS, INC.

Inventor： GORE ENTERPRISE HOLDINGS, INC. ,  COOK, Alonzo, D. ,  DRUMHELLER, Paul, D.

IPC: A61L27/00

CPC classification number: A61L31/148 ,  A61L27/34 ,  A61L27/38 ,  A61L27/54 ,  A61L27/58 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/414 ,  A61L2300/604 ,  A61L2300/64 ,  Y10S977/788 ,  Y10S977/931

Abstract: The present invention is directed to hydrophobic biodegradable polymeric materials having at least one surface thereof rendered more hydrophilic by attachment of at least one layer of a hydrophilic polymer thereto. The hydrophilic polymer layer is cross-linked together on the surface of the biodegradable material with a cross-linking agent or scheme that is biodegradable. Bioactive species are immobilized to chemically functional groups of the components of the first layer or to unreacted chemically functional groups of the cross-linking agent. Optionally, the bioactive species may be reversibly immobilized through chemically functional linkages that are degradable. The result is an implantable construction with immobilized bioactive species having structural components that are all subject to degradation in the body of a recipient.

Abstract translation: 本发明涉及疏水性可生物降解的聚合材料，其至少一个表面通过至少一层亲水性聚合物与其附着而变得更亲水。 亲水性聚合物层通过可生物降解的交联剂或方案在可生物降解材料的表面上交联在一起。 将生物活性物质固定化为第一层的组分的化学官能团或交联剂的未反应的化学官能团。 任选地，生物活性物质可以通过可降解的化学功能键可逆地固定。 结果是具有固定的生物活性物种的可植入结构，其具有在受体体内都会降解的结构成分。