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    INSTRUMENTATION AND METHOD FOR INSERTING AND DEPLOYING AN EXPANDABLE INTERBODY SPINAL FUSION IMPLANT
    73.
    发明申请
    INSTRUMENTATION AND METHOD FOR INSERTING AND DEPLOYING AN EXPANDABLE INTERBODY SPINAL FUSION IMPLANT 审中-公开

    公开(公告)号：WO2002062272A3

    公开(公告)日：2002-08-15

    申请号：PCT/US2002/002810

    申请日：2002-02-04

    Applicant: MICHELSON, Gary, K.

    Inventor： MICHELSON, Gary, K.

    IPC: A61F2/32

    Abstract: This invention is an implant holder (500) for inserting a spinal implant into a disc space. The implant holder (500) has a shaft (502) and an outer sleeve (504). Shaft (502) has a distal end (506), a proximal end (508), a reduced portion (510) extending towards distal end (506), an intermediate reduced portion (511), and an enlarged portion (512) between intermediate reduced portion (511 ) and proximal end (508). Shaft (502) is preferably hollow and is adapted to permit the passage of other instruments therethrough. Outer sleeve (504) has a distal end (522) and proximal end (524). Distal end (522) has upper and lower extensions (526,528), and side extensions (530) adapted to cooperatively engage trailing end (104) of implant (100). Side extensions (530) each have a flange (532) to cooperatively engage slot (126) of implant (100) and and a stop (534) for limiting further advancement of implant holder (500) into trailing end (104) of implant (100). A method for inserting a spinal implant into an implantation space using the implant holder (500) is disclosed.

    BIOCATALYTIC AND BIOMIMETIC GENERATION OF NITRIC OXIDE IN SITU AT SUBSTRATE/BLOOD INTERFACES
    75.
    发明申请
    BIOCATALYTIC AND BIOMIMETIC GENERATION OF NITRIC OXIDE IN SITU AT SUBSTRATE/BLOOD INTERFACES 审中-公开
    氮氧化物在基板/血液界面的生物化学和生物在线生成

    公开(公告)号：WO02056904A1

    公开(公告)日：2002-07-25

    申请号：PCT/US2002/001687

    申请日：2002-01-16

    IPC: A61B17/58 ,  A61F2/32 ,  A61F2/84 ,  A61K31/555 ,  A61K33/34 ,  A61K38/44 ,  A61L27/00 ,  A61L27/04 ,  A61L27/30 ,  A61L27/54 ,  A61L29/00 ,  A61L29/02 ,  A61L29/08 ,  A61L29/16 ,  A61L31/02 ,  A61L31/08 ,  A61L31/16 ,  A61L33/00 ,  A61M25/00 ,  A61M25/01 ,  A61P7/02 ,  C12N11/02 ,  C12N11/14 ,  C12N11/08 ,  C12N11/16

    CPC classification number: C12N11/02 ,  A61K33/34 ,  C12N11/14

    Abstract: Biocompatible materials that have the ability to release nitric oxide (NO) in situ at the surface-blood interface when in contact with blood. The materials which may be polymers (e.g., polyurethane, poly(vinyl chloride), silicone rubbers), metals, such as stainless steel, carbon, and the like are provided with biocatalysts or biomimetic catalysts on their surface that have nitrite, nitrate and/or nitrosothiol-reducing capability that. Illustratively, the catalysts are adsorbed or immobilized at the surface of the material. The catalysts can act on endogenous nitrite/nitrate or nitrosothiols within the blood creating a local increase in the NO levels at the surface of the material. An illustrative enzymatic biocatalyst is mammalian xanthine oxidase. In another illustrative embodiment, a biomimetic catalyst is a copper (Cu(II)-ligands complex, e.g., dibenzo[e,k]-2,3,8,9-tetraphenyl-1,4,7,10-tetraaza-cyclododeca-1,3,7,9 -tetraene. In some cases, lipophilic salts of nitrite/nitrate (e.g., tridodecylmethylammonium nitrite (TDMA NO2 /NO3 )) or certain salts of nitrosothiols can be doped within a polymer material, or an underlying polymeric film, to create a reservoir of nitrite or nitrosothiol that continuously leaks into the immobilized catalytic layer. Adequate levels of endogenous reducing equivalents are present within blood to provide catalytically-generated surface levels of NO that are above the threshold reportedly required to prevent platelet adhesion or activation.

    Abstract translation: 当与血液接触时，具有在表面 - 血液界面处原位释放一氧化氮（NO）能力的生物相容性材料。 可以是聚合物的材料（例如聚氨酯，聚（氯乙烯），硅橡胶），金属如不锈钢，碳等在其表面上提供生物催化剂或仿生催化剂，其具有亚硝酸盐，硝酸盐和/ 或亚硝硫醇还原能力。 说明性地，催化剂被吸附或固定在材料的表面。 催化剂可以作用于血液内的内源性亚硝酸盐/硝酸盐或亚硝基硫醇，导致材料表面的NO水平的局部增加。 说明性的酶生物催化剂是哺乳动物黄嘌呤氧化酶。 在另一说明性实施方案中，仿生催化剂是铜（Cu（II） - 配位络合物，例如二苯并[e，k] -2,3,8,9-四苯基-1,4,7,10-四氮杂 - 环十二碳 在一些情况下，可以掺杂亚硝酸盐/硝酸盐的亲脂性盐（例如亚硝酸三癸基甲基铵（TDMA + NO 2 - / NO 3 - ））或亚硝基硫醇的某些盐 在聚合物材料或下面的聚合物膜内产生亚硝酸盐或亚硝基硫醇的储存器，其连续地泄漏到固定化的催化剂层中。内部还原当量的足够水平存在于血液内以提供催化产生的上述NO的表面水平 据报道，该阈值需要防止血小板粘附或活化。

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